Citric Acid Fermentation

References

• Wehmer C. Chemische Wirkung der Aspergillaceae. Technische Mykologie, H. Lafar. Verlag Gustav, Fischer 1903; 2: 674
   Google Scholar
• Currie J. N. The citric acid fermentation. J. Biol. Chem. 1917; 31: 15
   Google Scholar
• Perquin L. H. C. Bijdrage tot de kennis der Oxydative Dissimilatie van Aspergillus niger van Tieghem. thesis, Meinema, Delft 1938
   Google Scholar
• Röhr M., Kubicek C. P., Kominek J. Citric acid. Biotechnology, H. J. Rehm, G. Reed. Verlag Chemie, Weinheim 1983; 3: 419
   Google Scholar
• Kinoshita S., Tanaka K., British Patent 878, 1961, 152
   Google Scholar
• Waksman S. A., Karow E. O. Production of citric acid in submerged culture. Ind. Eng. Chem. 1946; 39: 821
   Google Scholar
• Kinoshita S., Tanaka K., Akita S., British Patent 878, 151, 1961
   Google Scholar
• Kyowa Hakko Kogyo K. K., British Patent 1,187,334, 1970
   Google Scholar
• Benckiser, Gesmb J. A.H, U.S. Patent 3,843,465, 1974
   Google Scholar
• Bernhauer K. Über die Charakterisierung der Stämme von Aspergillus niger auf Grund ihres biochemischen Verhaltens. I. Vergleichende Untersuchungen über die Säurebildung durch verschiedene Pilzstämme. Biochem. Z. 1928; 197: 278
   Google Scholar
• Wendel K. Zur Frage der Stoffwechselsteigerung und Säuerung bei Aspergillus niger in Abhängigkeit von Züchtungs und Substratbedingungen. I. Verfahren zur Er haltung und Steigerung der Gärleistung säurebildender Pilze, insbesondere der Citronensäuregärstämme. Zbl. Bact. Hyg. Parasitenk. Ser. II 1957; 110: 312
   Google Scholar
• James L. V., Rubbo S. D., Gardner J. F. Isolation of high yielding mutants of Aspergillus niger by a paper culture selection technique. J. Gen. Microbiol. 1956; 14: 223
   PubMedGoogle Scholar
• Röhr M., Stadler P. J., Salzbrunn W. O. J., Kubicek C. P. An improved method for characterization of citrate production by conidia of Aspergillus niger. Biotech. Lett. 1979; 1: 281
   Web of Science ®Google Scholar
• Stadler P. J., Röhr M., unpublished results
   Google Scholar
• Johnston J. R. Strain improvement and strain stability in filamentous fungi. The Filamentous Fungi, J. E. Smith, D. R. Berry. Edward Arnold, London 1975; 1: 59
   Google Scholar
• Musilkova M., Fencl Z. Isolation of auxotrophic mutants of Aspergillus niger by ethylmethane sulphonate treatment. Folia Microbiol. 1978; 15: 34
   Google Scholar
• Ilczuk Z. Genetik der Citronensäure erzeugenden Stämme Aspergillus niger. II. Mitt. Citronensäure-synthese von mittels UV-Strahlen induzierten auxotrophen Mutanten von. A. niger. Die Nahrung 1970; 14: 97
   Google Scholar
• Musilkova M., Panos J., Sedmera P., Fencl Z. Accumulation of 2-oxoacids in mutants of Aspergillus niger requiring lysin. Folia Microbiol. 1980; 25: 324
   PubMedGoogle Scholar
• Das A. Parasexual hybridization and citric acid production by Aspergillus niger. Eur. J. Appl. Microbiol. Biotechnol. 1980; 9: 117
   Google Scholar
• Clutterbuck J. A. Aspergillus niclulans. Handbook of Genetics, Vol. I: Bacteria, Bacteriophages and Fungi, R. C. King. Plenum Press, New York 1974; 447
   Google Scholar
• Pontecorvo G., Roper J. A., Forbes E. Genetic recombination without sexual reproduction in Aspergillus niger. J. Gen. Microbiol. 1953; 8: 198
   PubMedGoogle Scholar
• Lhoas P. Genetic analysis by means of the parasexual cycle in Aspergillus niger. Genet. Res. 1967; 10: 45
   PubMed Web of Science ®Google Scholar
• Pontecorvo G. The parasexual cycle in fungi. Annu. Rev. Microbiol. 1956; 10: 393
   PubMed Web of Science ®Google Scholar
• Bonatelli R., Jr., Azevedo J. L., Umbuzeiro-Valent G. Citric acid production by Aspergillus niger mutants. Rev. Brasil. Genet. 1982; 5: 483
   Google Scholar
• Bonatelli R., Jr., Azevedo J. L., Umbuzeiro-Valent G. Parasexuality in a citric acid producing strain of Aspergillus niger. Rev. Brasil. Genet. 1983; 6: 399
   Google Scholar
• Akiyama S.-I., Suzuki T., Sumino Y., Nakao Y., Fukuda H. Production of citric acid from n-paraffins by fluoroacetate-sensitive mutant strains of Candida lipolytica. 4th Proc. IFS: Fermentation Technology Today. 1972; 613
   Google Scholar
• Ogrydziak D., Bassel J., Mortimer R. Development of a genetic map of the yeast Saccharo-mycopsis lipolytica. Mol. Gen. Genet. 1982; 188: 179
   PubMedGoogle Scholar
• Bassel J. B., Warfel J., Mortimer R. Complementation and genetic recombination in Candida lipolytica. J. Bacteriol. 1971; 109: 609
   Google Scholar
• Stahl U. Zygote formation and recombination between like mating types in the yeast Saccharomycopsis lipolytica by protoplast fusion. Mol. Gen. Genet. 1978; 160: 111
   Google Scholar
• Shu P., Johnson M. J. Citric acid production by submerged fermentation with Aspergillus niger. Ind. Eng. Chem. 1948; 40: 1202
   Google Scholar
• Shu P., Johnson M. J. The interdependence of medium constituents in citric acid production by submerged fermentation. J. Bacteriol. 1948; 56: 577
   PubMed Web of Science ®Google Scholar
• Leopold H. Über das Verhalten von Invertase und Glukoseoxydase während der Citronensäuregärung. Die Nahrung 1959; 3: 987
   Google Scholar
• Kubicek C. P., unpublished results
   Google Scholar
• Hossain M., Brooks J. D., Maddox I. S. Production of citric acid from whey permeate by fermentation using Aspergillus niger. N. Z. J. Dairy Sci. Technol. 1983; 18: 161
   Google Scholar
• Somkuti G. A., Bencivengo M. M. Citric acid fermentation in whey permeate. Dev. Ind. Microbiol. 1981; 22: 557
   Google Scholar
• Kiel H., Guvrin R., Henis Y. Citric acid fermentation by Aspergillus niger on low sugar concentrations and cotton waste. Appl. Envir. Microbiol. 1981; 42: 1
   PubMed Web of Science ®Google Scholar
• Al-Obaidy Z., Berry D. R. The use of deionized date syrup as a substrate for citric acid production. Biotechnol. Lett. 1979; 1: 153
   Google Scholar
• Hang Y. D., Splitstoesser D. F., Woodams E. E., Sherman R. M. Citric acid fermentation of brewery waste. J. Food. Sci. 1977; 42: 383
   Web of Science ®Google Scholar
• Macris B. J. Citric acid from purified carob sugars. Biotechnol. Bioeng. 1975; 17: 1373
   Google Scholar
• Matsumura H. Dempun Kogyo Gakkai-Shi 1963; 10: 98
   Google Scholar
• Usami S., Fukutomi N. Hakkokogaku Kaishi 1970; 55: 44
   Google Scholar
• Moyer A. J., U.S. Patent 2,674,561, 1954
   Google Scholar
• Vergnaud P., Niquet R., U.S. Patent 2,883,329, 1959
   Google Scholar
• Gardner J. F., James L. V., Rubbo S. D. Production of citric acid by mutants of Aspergillus niger. J. Gen. Microbiol. 1956; 14: 228
   PubMedGoogle Scholar
• Gaden E. L., Petsiavas D. N., Winoker J. J. Agr. Food. Chem. 1954; 2: 632
   Google Scholar
• Perlman D., Sih C. J. Fungal synthesis of citric, fumaric and itaconic acids. Prog. Ind. Microbiol. 1959; 2: 168
   Google Scholar
• Zakowska Z., Jalocha A. Fraktionierung von Inhaltsstoffen der Zuckerrübenmelasse, die toxisch für die Citronensäureproduktion mit Aspergillus niger sind. Acta Biotechnol. 1984; 4: 171
   Google Scholar
• Singh V. K., Vahedra D. V., Gupta J. K. Occurrence of an organic inhibitor in cane molasses affecting citric acid production by Aspergillus niger. Enzyme Microb. Technol. 1981; 3: 341
   Google Scholar
• Fencl Z., Vintrova E. A new metabolic regulator: its stimulation of citric acid production and anti-sulphonamide and streptomycin effect. Nature (London) 1963; 199: 905
   PubMedGoogle Scholar
• Leopold H., Valtr Z. Über einen die Citronensäureproduktion durch Aspergillus niger stimulierenden Faktor in Melasse. Nahrung 1969; 13: 11
   Google Scholar
• Shepard M. W. Method of Producing Citric Acid by Fermentation. U.S. Patent 308, 3144, 1963
   Google Scholar
• Szücs J., Austrian Patent 101, 009, 1925
   Google Scholar
• Kubicek C. P., Zehentgruber O., Röhr M. An indirect method for studying the fine control of citric acid fermentation by. Aspergillus niger. Biotech. Lett. 1979; 1: 47
   Google Scholar
• Martin S. M., Steel R. Effect of phosphate on production of organic acids by Aspergillus niger. Can. J. Microbiol. 1955; 1: 470
   PubMedGoogle Scholar
• Mischak H., Kubicek C. P., Röhr M., unpublished results
   Google Scholar
• Mischak H., Kubicek C. P., Röhr M. Formation and location of glucose oxidase in citric acid producing mycelia of. Aspergillus niger. Appl. Microbiol. Biotechnol. 1985; 21: 27
   Web of Science ®Google Scholar
• Steinberg R. A. Effect of nitrogen compounds and trace elements on growth of Aspergillus niger. J. Agr. Res. 1939; 59: 731
   Google Scholar
• Steinberg R. A. Relation of carbon nutrition to trace elements and accessory requirements of Aspergillus niger. J. Agr. Res. 1939; 49: 749
   Google Scholar
• Tomlinson N., Campbell J. J. R., Trusell P. C. The influence of zinc, iron, copper and manganese on the production of citric acid by Aspergillus niger. J. Bacteriol. 1950; 59: 217
   PubMed Web of Science ®Google Scholar
• Tomlinson N., Campbell J. J. R., Trussell P. C. The influence of zinc iron, copper and manganese on the production of citric acid by Aspergillus niger. J. Bacteriol. 1951; 61: 17
   PubMedGoogle Scholar
• Sanchez-Marroguin A., Carreno R., Ledezma M. Effect of trace elements on citric acid fermentation by Aspergillus niger. Appl. Microbiol. 1970; 20: 888
   PubMedGoogle Scholar
• Choudhary A. Q., Pirt S. J. The influence of metal complexing agents on citric acid production by Aspergillus niger. J. Gen. Microbiol. 1966; 43: 71
   PubMedGoogle Scholar
• Wold W. S. M., Suzuki I. The citric acid fermentation by Aspergillus niger: regulation by zinc of growth and acidogenesis. Can. J. Microbiol. 1976; 22: 1083
   PubMedGoogle Scholar
• Trumpy B. H., Millis N. F. Nutritional requirements of an Aspergillus niger mutant for citric acid production. J. Gen. Microbiol. 1963; 30: 381
   PubMedGoogle Scholar
• Clark D. S., Ito K., Horitsu H. Effect of manganese and other heavy metals on submerged citric acid fermentation of molasses. Biotechnol. Bioeng. 1966; 8: 465
   Web of Science ®Google Scholar
• Kisser M., Kubicek C. P., Röhr M. Influence of manganese on morphology and cell wall composition of Aspergillus niger during citric acid fermentation. Arch. Microbiol. 1980; 128: 26
   PubMed Web of Science ®Google Scholar
• Schweiger L. B. Method of Producing Citric Acid by Fermentation. U. S. Patent 291, 6420, 1959
   Google Scholar
• Zehentgruber O., Kubicek C. P., Röhr M., unpublished results
   Google Scholar
• Sunda W. G., Huntsman S. A. Effect of competitive interactions between manganese and copper on cellular manganese and growth in estuarine and oceanic species of the diatom Thallassiotira. Limnol. Oceanogr. 1983; 28: 924
   Web of Science ®Google Scholar
• Shu P. Oxygen uptake in shake-flask fermentation. J. Agr. Food Chem. 1953; 1: 1118
   Google Scholar
• Clark D. S., Lentz C. P. Submerged citric acid fermentation of beet sugar molasses: effect of pressure and recirculation of oxygen. Can. J. Microbiol. 1961; 7: 447
   PubMedGoogle Scholar
• Khan A. H., Ghose T. K. Kinetics of citric acid fermentation by Aspergillus niger. J. Ferment. Technol. 1973; 51: 734
   Google Scholar
• Kubicek C. P., Zehentgruber O., El-Kalak H., Röhr M. Regulation of citric acid production by oxygen: effects of dissolved oxygen tension on adenylate levels and respiration in Aspergillus niger. Eur. J. Appl. Microbiol. Biotechnol. 1980; 9: 101
   Google Scholar
• Zehentgruber O., Kubicek C. P., Röhr M., unpublished results
   Google Scholar
• Batti M. A. Process for Producing Citric Acid. U. S. Patent 333, 5067, 1967
   Google Scholar
• Noyes R. Citric Acid Production Processes, Chemical Processing Rev. 37. Noyes Data Corp., Park Ridge, N.J. 1969
   Google Scholar
• Horitsu H., Clark D. S. Effect of ferrocyanide on growth and citric acid production by Aspergillus niger. Can. J. Microbiol. 1966; 12: 901
   PubMedGoogle Scholar
• Sakaguchi K., Baba S. Bull. Agr. Chem. Soc. Jpn. 1942; 18: 85
   Google Scholar
• Moyer A. J. Effect of alcohols on the mycological production on citric acid in surface and submerged culture. I. Nature of the alcohol effect. Appl. Microbiol. 1953; 1: 1
   PubMedGoogle Scholar
• Moyer A. J. Effect of alcohols on the mycological production of citric acid in surface and submerged culture, II. Fermentation of crude carbohydrates. Appl. Microbiol. 1953; 1: 8
   Google Scholar
• Ingram L. O., Buttke T. M. Effects of alcohols on microorganisms. Adv. Microbial Physiol. 1984; 25: 253
   PubMed Web of Science ®Google Scholar
• Orthofer R., Kubicek C. P., Röhr M. Lipid levels and manganese deficiency in citric acid producing strains of Aspergillus niger. FEMS Microbiol. Lett. 1979; 5: 403
   Google Scholar
• Meixner O., Mischak H., Kubicek C. P., Röhr M. Effect of manganese deficiency on plasma membrane lipid composition and glucose uptake in Aspergillus niger. FEMS Microbiol. Lett. 1985; 26: 271
   Web of Science ®Google Scholar
• Millis N. F., Trumpy B. H., Palmer B. M. The effect of lipids on citric acid production by an Aspergillus niger mutant. J. Gen. Microbiol. 1963; 30: 365
   Google Scholar
• Gold W., Kieber R. J. Process of Making Citric Acid Fermentation. U. S. Patent 337, 2094, 1968
   Google Scholar
• Lockwood L. B., Batti M. A. Biosynthetic Process for Making Citric Acid. U.S. Patent 3,189,527, 1965
   Google Scholar
• Gold W., Kieber R. J., U.S. Patent 3,285,828, 1966
   Google Scholar
• Batti M. A., U.S. Patent 3,290,227, 1966
   Google Scholar
• Gold W., Kieber R. J., U.S. Patent 3,326,774, 1967
   Google Scholar
• Cimerman A., Johanides V., Skafar S. Effect of native polymer additives on pellet differentiation in submerged citric acid fermentation. 5th Int. Ferment. Symp. Berlin. 1976; 1, 22 (Abstr.)
   Google Scholar
• Takahashi H., Hidaka H., Yamada K. Effect of mycelial forms of citric acid fermentation in submerged mold culture. Agr. Biol. Chem. 1965; 29: 331
   Web of Science ®Google Scholar
• Bruchmann E. E. Enzymchemische Untersuchungen über Schimmelpilzgärungen. II. Einige Hemmstoffe der Aconitase und ihre Bedeutung für die Citronensäureanhäufung durch Aspergillus niger in Submerskultur. Biochm. Z. 1961; 335: 199
   PubMedGoogle Scholar
• Meyrath J., Ahmed S. A. Reduction of incubation time in citric acid fermentation by vermiculite. Experientia 1966; 22: 806
   PubMedGoogle Scholar
• Gledhill W. E., Hill I. D., Hodson P. H. Citrate production from hydrocarbons by use of a nonsterile, semicontinuous cell recycle system. Biotech. Bioengin. 1973; 15: 963
   Google Scholar
• Fumkawa T., Ogino T., Matsuyoshi T. Fermentative production of citric acid from n-paraffins by Saccharomycopsis lipolytica. J. Ferment. Technol. 1982; 60: 281
   Google Scholar
• Tabuchi T., Hara S. Conversion of citrate fermentation to polyol fermentation in Candida lipolytica. J. Agr. Chem. Soc. Jpn. 1970; 47: 485
   Google Scholar
• Raymond R. L., Jamison V. W., Hudson J. O. Microbial hydrocarbon cooxidation. II. Use of ion-exchange resins. Appl. Microbiol. 1969; 17: 512
   PubMedGoogle Scholar
• Abbot B. J., Gerhardt P. Dialysis fermentation. I. Enhanced production of salicyclic acid from naphthalene by Pseudomonas fluoreszens. Biotech. Bioengin. 1970; 12: 557
   Google Scholar
• Briffaud J., Engasser M. Citric acid production from glucose. I. Growth and excretion kinetics in a stirred fermentor. Biotech. Bioengin. 1979; 21: 2083
   Google Scholar
• Marchal R., Chaude O., Metche M. Production of citric acid from n-paraffins by Saccharomycopsis lipolytica: kinetics and balance of the fermentation. Eur. J. Appl. Microbiol. 1977; 4: 111
   Google Scholar
• Puklowski W. D., Rehm H. J. Sauerstoffeinfluβ auf die Citronensäure und Biomassebildung einer alkanverwertenden Hefe. Biotechnologie, Dechema Monogr., H. J. Rehm. Verlag Chemie, Weinheim 1977; 165, 81
   Google Scholar
• Tabuchi T., Tanaka Y., Tahara Y., Abe M. Production of citric acid from n-paraffins by yeasts. J. Agr. Chem. Soc. Jpn. 1970; 44: 562
   Google Scholar
• Benckiser, Gesmb J. A.H, U.S. Patent 3,843,465, 1974
   Google Scholar
• Kimura K., Nakanishi T., British Patent 1,332,180, 1973
   Google Scholar
• British Patent 1,297,243, 1972, Takeda Chem. Ind. Ltd.
   Google Scholar
• Kornberg H. L., Krebs H. A. A pathway in metabolism. The Metabolic Roles of Citrate, T. W. Goodwin. Academic Press, New York 1968; 13
   Google Scholar
• Prescott S. C., Dunn C. G. The citric acid fermentation. Industrial Microbiology, 3rd ed. McGraw Hill, New York 1959; 533
   Google Scholar
• Cleland W. W., Johnson M. J. Tracer experiments on the mechanism of citric acid formation by Aspergillus niger. J. Biol. Chem. 1954; 208: 679
   PubMed Web of Science ®Google Scholar
• Jagannathan V., Singh K. Carbohydrate metabolism in citric acid fermentation. II. The glycolytic enzymes of Aspergillus niger. Enzymologia 1953; 16: 150
   PubMedGoogle Scholar
• McDonough M. W., Martin S. M. The hexosemonophosphate pathway in. Aspergillus niger. Can. J. Microbiol. 1958; 4: 329
   PubMedGoogle Scholar
• Smith J. E., Valenzuela-Perez J., Ng W. S. Changes in activities of the Embden-Meyerhof-Parnas and pentose phosphate pathways during the growth cycle of. Aspergillus niger. Trans. Br. Mycol. Soc. 1971; 57: 93
   Google Scholar
• Meyrath J. Citric acid production. Proc. Biochem. 1967; 2: 25
   Google Scholar
• Kubicek C. P., Röhr M. Influence of manganese on enzyme synthesis and citric acid accumulation in Aspergillus niger. Eur. J. Appl. Microbiol. 1977; 4: 167
   Web of Science ®Google Scholar
• Miall L. M. Organic acids. Economic Microbiology, A. H. Rose. Academic Press, London 1978; 2: 47
   Google Scholar
• Röhr M., Kubicek C. P., Zehentgruber O., Orthofer R. A balance of carbon and oxygen conversion rates during pilot plant citric acid fermentation by Aspergillus niger: identification of polyols as major byproducts. Int. J. Microbiol. 1983; 1: 19
   Google Scholar
• Wongchai W., Jefferson W. E., Jr. Pyruvate carboxylase of Aspergillus niger: partial purification and some properties. Fed. Proc. 1974; 33: 1378
   Google Scholar
• Hossain M., Brooks J. D., Maddox I. S. The effect of the sugar source on citric acid production by Aspergillus niger. Appl. Microbiol. Biotechnol. 1984; 19: 383
   Google Scholar
• Feir H. A., Suzuki I. Pyruvate carboxylase of Aspergillus niger kinetic study of a biotin-containing enzyme. Can. J. Biochem. 1969; 47: 697
   PubMedGoogle Scholar
• Osmani S. A., Scrutton M. C. The subcellular localization of pyruvate carboxylase and of some other enzymes in Aspergillus nidulans. Eur. J. Biochem. 1983; 133: 551
   PubMedGoogle Scholar
• Woronick C. L., Johnson M. J. Carbon dioxide fixation by cell-free extracts of Aspergillus niger. J. Biol. Chem. 1960; 235: 9
   PubMedGoogle Scholar
• Ramakrishnan C. V., Steel R., Lentz C. P. Mechanism of citric acid formation and accumulation in. Aspergillus niger. Arch. Biochem. Biophys. 1955; 55: 270
   PubMedGoogle Scholar
• LaNauze J. M. Aconitase and isocitric dehydrogenases of Aspergillus niger in relation to citric acid production. J. Gen. Microbiol. 1966; 44: 73
   PubMedGoogle Scholar
• Ahmed S. A., Smith J. E., Anderson J. A. Mitochondrial activity during citric acid production by Aspergillus niger. Trans. Br. Mycol. Soc. 1972; 59: 51
   Google Scholar
• Szczodrak J. Biosynthesis of citric acid in relation to activity of selected enzymes of the Krebs cycle in Aspergillus niger mycelium. Eur. J. Appl. Microbiol. Biotechnol. 1981; 13: 107
   Google Scholar
• Agrawal P. K., Bhatt C. S., Viswanathan L. Studies on some enzymes relevant to citric acid accumulation by Aspergillus niger. Enzyme Microb. Technol. 1983; 5: 369
   Google Scholar
• Shu P., Funk A., Neish A. C. Mechanism of citric acid formation from glucose by Aspergillus niger. Can. J. Biochem. 1954; 32: 68
   PubMedGoogle Scholar
• Lockwood L. B. Organic acid production. The Filamentous Fungi, J. E. Smith, D. R. Berry. Edward Arnold, London 1975; 1: 142
   Google Scholar
• Neilson N. E. The presence of aconitase and aconitic hydratase in Aspergillus niger. J. Bacteriol. 1956; 71: 356
   PubMedGoogle Scholar
• Kubicek C. P., Röhr M. Aconitase and citric acid accumulation in Aspergillus niger. Appl. Envir. Microbiol. 1985; 50: 1336
   PubMed Web of Science ®Google Scholar
• Mattey M. Citrate regulation of citric acid production by Aspergillus niger. FEMS Microbiol. Lett. 1977; 2: 71
   Web of Science ®Google Scholar
• Chan M. F., Stachow C. S., Sanwal B. D. The allosteric nature of NAD-specific isocitric dehydrogenase from Aspergilli. Can. J. Biochem. 1965; 43: 111
   PubMedGoogle Scholar
• Sanwal B. D., Zink M. W., Stachow C. S. Nicotinamide adenine dinucleotide specific isocitrate dehydrogenase. J. Biol. Chem. 1964; 239: 1597
   PubMedGoogle Scholar
• Nealon D. A., Cook R. A. Purification and subunit structure of nicotinamide adenine dinucleotide specific isocitrate dehydrogenase from Neurospora crassa. Biochemistry 1979; 18: 3616
   PubMedGoogle Scholar
• Meixner-Monori B., unpublished results
   Google Scholar
• Ottaway J. H. Compartimentation: model and reality. Biochem. Soc. Trans. 1983; 11: 47
   PubMedGoogle Scholar
• Meixner-Monori B., Kubicek C. P., Harrer W., Schreferl G., Röhr M. NADP-specific isocitrate dehydrogenase from the citric acid accumulating fungus Aspergillus niger. Biochem. J., in press
   Google Scholar
• Bowes I., Mattey M. The effect of manganese and magnesium ions on mitochondrial NADP dependent isocitrate dehydrogenase from Aspergillus niger. FEMS Microbiol. Lett. 1979; 6: 219
   Google Scholar
• Habison A., Kubicek C. P., Röhr M. Partial purification and regulatory properties of phosphofructokinse from Aspergillus niger. Biochem. J. 1983; 209: 669
   PubMed Web of Science ®Google Scholar
• Kubicek C. P., Röhr M. The role of the tricarboxylic acid cycle in citric acid accumulation by Aspergillus niger. Eur. J. Appl. Microbiol. Biotechnol. 1978; 5: 263
   Google Scholar
• Mahler H. R., Cordes E. H. Biological Chemistry. Harper and Row, New York 1971
   Google Scholar
• Röhr M., Kubicek C. P. Regulatory aspects of citric acid fermentation by Aspergillus niger. Proc. Biochem. 1981; 16: 34
   Web of Science ®Google Scholar
• Kubicek C. P., Röhr M. Novel trends in physiology and technology of citric acid production. Overproduction of Microbial Metabolites, V. Kumphanzl, B. Sikyta, Z. Vanek. Academic Press, New York 1982; 263
   Google Scholar
• Meixner-Monori B., Kubicek C. P., Habison A., Kubicek-Pranz E. M., Röhr M. Presence and regulation of the α-ketoglutarate dehydrogenase multienzyme complex in the filamentous fungus Aspergillus niger. J. Bacteriol. 1985; 161: 265
   PubMedGoogle Scholar
• Kubicek C. P., Röhr M. Regulation of citrate synthase from the citric acid accumulating fungus Aspergillus niger. Biochim. Biophys. Acta 1980; 615: 449
   PubMed Web of Science ®Google Scholar
• Evans C. T., Scragg A. H., Ratledge C. A comparative study of citrate efflux from mitochondria of oleagineous and non-oleagineous yeasts. Eur. J Biochem. 1983; 130: 195
   PubMedGoogle Scholar
• Scrutton M., personal communication
   Google Scholar
• Ma H., Kubicek C. P., Röhr M. Malate dehydrogenase isoenzymes in Aspergillus niger. FEMS Microbiol. Lett. 1981; 12: 147
   Google Scholar
• Klingenberg M. Metabolite transport in mitochondria: an example for intracellular membrane function. Essays Biochem. 1970; 6: 119
   PubMedGoogle Scholar
• Habison A., Kubicek C. P., Röhr M. Phosphofructokinase as a regulatory enzyme in citric acid producing Aspergillus niger. FEMS Microbiol. Lett. 1979; 5: 39
   Web of Science ®Google Scholar
• Kubicek C. P., Hampel W., Röhr M. Manganese deficiency leads to elevated amino acid pool in citric acid accumulating Aspergillus niger. Arch. Microbiol. 1979; 123: 73
   PubMed Web of Science ®Google Scholar
• Meixner-Monori B., Kubicek C. P., Röhr M. Pyruvate kinase from Aspergillus niger: a regulatory enzyme in glycolysis?. Can. J. Microbiol. 1984; 30: 16
   PubMed Web of Science ®Google Scholar
• Mischak H., Kubicek C. P., Röhr M. Citrate inhibition of glucose uptake in Aspergillus niger. Biotechnol. Lett. 1984; 6: 425
   Google Scholar
• Ma H., Kubicek C. P., Röhr M. Metabolic effects of manganese deficiency in Aspergillus niger: evidence for increased protein degradation. Arch. Microbiol. 1985; 141: 266
   PubMed Web of Science ®Google Scholar
• Lammers M., Follmann H. Deoxyribonukleotide biosynthesis in yeast (Saccharomyces cerevisiae). A ribonucleotide reductase system of sufficient activity for DNA synthesis. Eur. J. Biochem. 1984; 140: 281
   PubMedGoogle Scholar
• Schreferl G., Kubicek C. P., Röhr M., in press
   Google Scholar
• Lammers M., Follmann H. The ribonucleotide reductases – a unique group of metalloenzymes essential for cell proliferation. Struct. Bonding 1983; 54: 27
   Google Scholar
• Zehentgruber O., Kubicek C. P., Röhr M. Alternative respiration of Aspergillus niger. FEMS Microbiol. Lett. 1980; 8: 71
   Google Scholar
• Henry M. F., Nyns E. J. Cyanide insensitive respiration. An alternative mitochondrial pathway. Sub. Cell. Biochem. 1975; 4: 1
   PubMedGoogle Scholar
• Rustin P., Dupont J., Lance C. A role for fatty acid peroxy radicals in the cyanide-insensitive pathway of plant mitochondria?. Trends Biochem. Sci. 1983; 6: 155
   Google Scholar
• Wold W. S. M., Suzuki I. Cyclic AMP and citric acid accumulation by Aspergillus niger. Biochim. Biophys. Res. Commun. 1973; 50: 237
   PubMedGoogle Scholar
• Wold W. S. M., Suzuki I. Regulation by zinc and adenosine 3′5′ cyclic monophosphate of growth and citric acid accumulation in. Aspergillus niger. Can. J. Microbiol. 1976; 22: 1093
   PubMedGoogle Scholar
• Demain A. L. Catabolite regulation in industrial microbiology. Overproduction of Microbial Products, V. Krumphanzl, B. Sikyta, Z. Vanek. Academic Press, New York 1982; 1
   Google Scholar
• Al-Obaidy Z., Berry D. R. cAMP concentration, morphological differentiation and citric acid production in Aspergillus niger. Biotechnol. Lett. 1980; 2: 5
   Google Scholar
• Tabuchi T., Tanaka M., Abe M. Production of citric acid by Candida lipolytica strain 228. J. Agr. Chem. Soc. Jpn. 1969; 43: 154
   Google Scholar
• Marchal R., Vandecasteele J. P., Metche M. Regulation of the central metabolism in relation to citric acid production in Saccharomycopsis lipolytica. Arch. Microbiol. 1977; 113: 99
   PubMedGoogle Scholar
• Mitsushima K., Shinmyo A., Enatsu T. Control of citrate and 2-oxoglutarate formation in Candida lipolytica mitochondria by adenine nucleotides. Biochim. Biophys. Acta 1978; 538: 481
   PubMedGoogle Scholar
• Bartels P., Jensen P. K. Role of AMP in regulation of the citric acid cycle in mitochondria from bakers yeast. Biochim. Biophys. Acta 1979; 582: 246
   PubMedGoogle Scholar
• Evans C. T., Scragg A. H., Ratledge C. A comparative study of citrate efflux from mitochondria of oleaginous and non-oleaginous yeasts. Eur. J. Biochem. 1983; 130: 195
   PubMedGoogle Scholar
• Evans C. T., Scragg A. H., Ratledge C. Regulation of citrate efflux from mitochondria of oleaginous and non-oleaginous yeasts by adenine nucleotides. Eur. J. Biochem. 1983; 132: 609
   PubMedGoogle Scholar
• Treton B., Heslot H. Etude de quelques proprietes de l'aconitase de la leuvre Saccharomycopsis lipolytica. Agric. Biol. Chem. 1978; 42: 1201
   Web of Science ®Google Scholar
• Boulton C. A., Ratledge C. ATP-citrate lyase – the regulatory enzyme for lipid biosynthesis in. Lipomyces starkeyi?, J. Gen. Microbiol. 1981; 127: 423
   Google Scholar
• Aiba S., Matsuoka M. Identification of metabolic model: citrate production from glucose by Candida lipolytica. Biotech. Bioeng. 1979; 21: 1373
   Google Scholar
• Rehm H. J., Reiff I. Mechanisms and occurrence of microbial oxidation of long chain alcanes. Adv. Biochem. Eng. 1981; 19: 175
   Google Scholar
• Fukui S., Tanaka A. Metabolism of alkanes by yeasts. Adv. Biochem. Eng. 1981; 19: 217
   Google Scholar
• Behrens U., Hirzel K., Schulze E. Enzymatische Untersuchungen zur Citrat-Isocitrat Akkumulation bei Hefen. Nahrung 1977; 21: 525
   PubMedGoogle Scholar
• Matsuoka M., Ueda Y., Aiba S. Role and control of isocitrate lyase in Candida lipolytica. J. Bacteriol. 1980; 144: 692
   PubMedGoogle Scholar
• Matsuoka M., Himeno T., Aiba S. Characterization of Saccharomycopsis lipolytica mutants that express temperature-sensitive synthesis of isocitrate lyase. J. Bacteriol. 1984; 157: 899
   PubMedGoogle Scholar
• Tanaka A., Nabeshima S., Tokuda M., Fukui S. Partial purification of isocitrate lyase from Candida tropicalis and some kinetic properties of the enzyme. Agric. Biol. Chem. 1977; 41: 795
   Web of Science ®Google Scholar
• Marchal R., Metche M., Vandecasteele J. P. Intracellular concentrations of citric and isocitric acids in cultures of the citric acid excreting yeast Saccharomycopsis lipolytica grown on alkanes. J. Gen. Microbiol. 1980; 116: 535
   Google Scholar
• Akiyama S.-I., Suzuki T., Sumino Y., Nakao Y., Fukuda H. Production of citric acid from n-paraffins by fluoroacetate-sensitive mutant strains of Candida lipolytica. 4th Proc. IFS: Fermentation Technology Today. 1972; 613
   Google Scholar
• Omar S. H., Rehm H. J. Physiology and metabolism of two alkane oxidizing and citric acid producing strains of Candida parapsilosis. I. Activities of the tricaroxylic and glyoxylate cycle enzymes. Eur. J. Appl. Microbiol. Biotechnol. 1980; 11: 35
   Google Scholar
• Aiba S., Matsuoka M. Metabolic control in overproduction of citrate and isocitrate by yeasts. Overproduction of Microbial Products, V. Krumphanzl, B. Sikyta, Z. Vanek. Academic Press, New York 1982; 263
   Google Scholar
• Akimenko V. K., Finogenova T. V., Ermakova I. T., Shishkanova N. V. The cyanide resistance of respiration and the overproduction of citric acids in Candida lipolytica. Mikrobiologiya 1979; 48: 632
   Google Scholar
• Messing T., Wamser K., German Patent Appl. 2, 543, 307, 1975
   Google Scholar
• Jefferson W. E., Jr. The isolation and characterization of Asperenone, a new phenylpolyene from Aspergillus niger. Biochemistry 1967; 6: 3479
   PubMedGoogle Scholar
• Zehentgruber O., Kubicek C. P., Röhr M., unpublished observations
   Google Scholar
• Tveit M. T., U.S. Patent 3,105,015, 1963
   Google Scholar
• Berovic M., Cimerman A. Foaming in submerged citric acid fermentation on beet molasses. Eur. J. Appl. Microbiol. Biotechnol. 1979; 7: 313
   Google Scholar
• Hisanoga W., Nakamura S., Japanese Patent 66,16,555, 1966
   Google Scholar
• Siebert D., Hustede H. Citronensäure-Fermentation – biotechnologische Probleme und Möglichkeiten der Rechnersteuerung. Chem. Ing. Technol. 1982; 54: 659
   Google Scholar
• Bull A. T., Bushell M. E. Environmental control of fungal growth. The Filamentous Fungi, J. E. Smith, D. R. Berry. Edward Arnold, London 1975; 2: 1
   Google Scholar
• Kristiansen B., Sinclair C. G. Production of citric acid in continuous culture. Biotechnol. Bioeng. 1979; 21: 297
   Web of Science ®Google Scholar
• Kristiansen B., Charley R. Continuous process for production of citric acid. Advances in Biotechnology, M. Moo-Young. Pergamon Press, New York 1981; 1: 221
   Google Scholar
• Kristiansen B., Charley R. C., Seviour B., Harvey L., Habeeb S., Smith J. E. Overproduction of metabolites by filamentous fungi. Overproduction of Microbial Products, V. Kumphanzl, B. Sikyta, Z. Vanek. Academic Press, New York 1982; 221
   Google Scholar
• Vieth W., Venkatsubramanian K. Immobilized microbial cells in complex biocatalysis. Immobilized Microbial Cells, K. Venkatasubramanian. ACS Symp. Ser. 106, American Chemical Society, Washington, D.C. 1979; 1
   Google Scholar
• Heinrich M., Rehm H. J. Formation of gluconic acid at low pH-values by free and immobilized Aspergillus niger cells during citric acid fermentation. Eur. J. Appl. Microbiol. Biotechnol. 1982; 15: 88
   Google Scholar
• Vaija J., Linko Y. Y., Linko P. Citric acid production with alginate bead entrapped Aspergillus niger ATCC 9142. Appl. Biochem. Biotechnol. 1982; 7: 51
   PubMedGoogle Scholar
• Eikmeier H., Rehm H. J. Production of citric acid with immobilized Aspergillus niger. Appl. Microbiol. Biotechnol. 1984; 20: 365
   Web of Science ®Google Scholar
• Al-Obaidy Z., Berry D. R. Extended production of citric acid using an exchange filtration technique. Biotechnol. Lett. 1979; 1: 221
   Google Scholar
• Anderson J. A., Blain J. A., Divers S. M., Todd J. R. Use of the disc fermenter to examine production of citric acid by Aspergillus niger. Biotechnol. Lett. 1980; 2: 99
   Google Scholar
• Colin P., French Patent 1,211,066, 1960
   Google Scholar
• Colin P., Moundlic J., French Patent 1,494,958, 1967
   Google Scholar
• Colin P., French Patent 1,548,328, 1968
   Google Scholar
• Muzzarelli R. A. A., Tanfani F., Scarpini G. Chelating, film-forming and coagulating ability of the chitosan-glucan complex from Aspergillus niger industrial wastes. Biotechnol. Bioeng. 1980; 22: 885
   PubMed Web of Science ®Google Scholar
• Vidmar S., Turk V., Kregar I. Cellulolytic complex of Aspergillus niger under conditions for citric acid production. Isolation and characterization of two β-1,4-glucan hydrolases. Appl. Microbiol. Biotechnol. 1984; 20: 326
   Google Scholar
• Suhar A., Maljevac I., Poljsak Z., Kotnik M., Derencin M., Puidar V., Turk V. Pectinases and proteinases from industrial waste broth of Aspergillus niger used to produce citric acid. Use of Enzymes in Food Industry, P. Dupuy. Technique and Documentation Lavoisier, Paris 1982; 399
   Google Scholar
• Hamissa F. A., Mabrouk S. S., Abdel-Fattah A. F. Formation of polygalacturonase activities in citric acid fermentation by Aspergillus niger 599. J. Gen. Appl. Microbiol. 1977; 23: 23
   Google Scholar
• Anon. Citric acid. Kirk-Othmer Encyclopedia of Chemical Technology, H. F. Mark, D. F. Othmer, C. G. Ovenberger, G. T. Seaborg. John Wiley & Sons, New York 1979; 6: 150
   Google Scholar
• Gaden E. L., Jr. Fermentation kinetics and productivity. Chem. Ind. 1955; 154, Feb. 12
   Google Scholar
• Chmiel A. Kinetic studies on citric acid production by Aspergillus niger. I. Phases of mycelium growth and product formation. Acta Microbiol. Pol. Ser. B. 1975; 7: 185
   PubMedGoogle Scholar
• Röhr M., Zehentgruber O., Kubicek C. P. Kinetics of biomass and citric acid production by Aspergillus niger on a pilot plant scale. Biotech. Bioeng. 1981; 23: 2433
   Google Scholar
• Koliander B., Hampel W., Röhr M. Indirect estimation of biomass by rapid ribonucleic acid determination. Appl. Microbiol. Biotechnol. 1984; 19: 272
   Google Scholar
• Kubicek C. P., Röhr M., unpublished data
   Google Scholar
• Luedeking R., Piret E. L. A kinetic study of the lactic acid fermentation bath process at controlled pH. Biotech. Bioeng. 1959; 1: 393
   Web of Science ®Google Scholar
• Brown D. E., Vass R. C. Maturity and product formation in cultures of microorganisms. Biotech. Bioeng. 1973; 15: 321
   Google Scholar
• Behrens U., Weissbrodt E., Lehmann W. Zur Kinetik der Citronensäurebildung bei Candida lipolytica. Z. Allg. Microbiol. 1978; 18: 549
   PubMedGoogle Scholar