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Research Article

Recent Advances in the Physiology and Genetics of Amino Acid-Producing Bacteria

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Pages 73-103 | Published online: 27 Sep 2008

References

  • Aiba S., Imanaka T., Tsunekawa H. Enhancement of tryptophan production by Escherichia coli as an application of genetic engineering. Biotechol. Lett. 1980; 2: 525
  • Aiba S., Tsunekawa H., Imanaka T. New approach to tryptophan production by Escherichia coli: genetic manipulation of composite plasmids in vitro. Appl. Environ. Microbiol. 1982; 43: 289
  • Aida K., Chibita L., Nakayama K., Takinami K., Yamada H. Biotechnology of Amino Acids Production. Elsevier, AmsterdamThe Netherlands 1986
  • Archer J. A. C., Sinskey A. J. The DNA sequence and the minimal replicon of the Corynebacterium glutamicum plasmid pSR1: evidence for a common anchestor with plasmids from C. diphtheriae. J. Cen. Microbiol. 1993; 139: 1753
  • Archer J. A. C., Solowcordero D. E., Sinskey A. J. A C-terminal deletion in Corynebacterium glutamicum homoserine dehydrogenase abolishes allosteric inhibition by L-threonine. Gene 1991; 107: 53
  • Archer J. A. C., Follettie M. T., Sinskey A. J. Biology of Corynebacterium glutamicum: a molecular approach. Genetics and Molecular Biology of Industrial Microorganisms, C. L. Hershberger, S. W. Queener, G. Hegeman. ASM, Washington, DC 1989; 27
  • Barak Z., Chipman D. M., Gollop N. Physiological implications of the specificity of acetohydroxy acid synthase isozymes in enteric bacteria. J. Bacteriol. 1987; 169: 3750
  • Batt C. A., Follettie M. T., Shin H. K., Yeh P., Sinskey A. J. Genetic engineering of corynefom bacteria. Trends Biotechnol. 1985; 3: 305
  • Batl C. A., Shanabruch W. S., Sinskey A. J. Expression of pAMal tetracycline resistance gene in Corynebacterium glutamicum. Biotechnol. Lxtt. 1985; 7: 717
  • Bell S. C., Turner J. M. Bacterial catabolism of threonine; threonine degradation initiated by L-threonine NAD' oxidoreductase. Biochem. J. 1976; 156: 449
  • Beppu T. Application of recombinant DNA technology in breeding of amino acid producing strains. Biotechnology of Amino Acids Production, K. Aida, L. Chibita, K. Nakayama, K. Takinami, H. Yamada. Elsevier, Amsterdam 1986; 24
  • Boles E., Ebbinghausen H., Eikmanns B., Kramer R. Unusual regulation of the uptake system for branched-chain amino acids in Corynebacterium glutamicum. Arch. Microbiol. 1993; 159: 147
  • Bonamy C., Guyonvarch A., Reyes O., David F., Leblon G. Interspecies electrotransfomation in Coryne-bacteria. FEMS Microbiol. Lett. 1990; 66: 263
  • Bonnassie S., Burini J. F., Oreglia J., Trautwetter A., Patte, Sicard A. Transfer of plasmid DNA to Brevibacterium lactofermentum by electrotransformation. J. Gen. Microbiol. 1990a; 136: 2107
  • Bonnassie S., Oreglia J., Sicard A. M. Nucleotide sequence of the dapA gene from Corynebacterium glutamicum. Nucleic Acids Res. 1990b; 18: 6421
  • Bormann E. R., Eikmanns B. J., Sahm H. Molecular analysis of the Corynebacterium glutamicum gdh gene encoding glutamate dehydrogenase. Mol. Microbiol. 1992; 6: 317
  • Brcër S., Eggeling L., Kramer R. Strains of Corynebacterium glutamicum with different lysine productivities may have different lysine excretion systems. Appl. Environ. Microbiol. 1993; 59: 316
  • Broër S., Krämer R. Mechanism of lysine uptake and excretion by Corynebacterium glutamicum. Molecular Mechanisms of Transport, E. Quagliariello, F. Palmieri. Elsevier, Amsterdam 1991a; 67
  • Broër S., Krämer R. Lysine excretion by Corynebacterium glutamicum. 1. Identification of a specific carrier system. Eur. J. Biochem. 1991b; 202: 131
  • Broër S., Krämer R. Lysine excretion by Corynebacierium glutamicum. II. Energetics and mechanism of the transport system. Eur. J. Biochem. 1991; 202: 136, c
  • Cardenas R., Martin J. F., Gil J. A. Construction and characterization of promoter probe vectors for Coryne-bacteria using the kanamycin resistance reporter gene. Gene 1991; 98: 117
  • Chan K. C., Duran R., Amaud A., Galzy P. Cloning vectors and antibiotic resistance marken for Brevibacterium sp. R312. Gene 1991; 105: 119
  • Chao Y. P., Liao J. C. Alteration of growth yield by overexpression of phosphoenol pyruvate carboxy-lase and phosphoenol pyruvate carboxykinase in Escherichia coli. Appl. Environ. Microbiol. 1993; 59: 4261
  • Chao Y. P., Patnaik R., Roof W. D., Young R. F., Liao J. C. Control of gluconeogenetic growth by pps, pck in Escherichia coli. J. Bacteriol. 1993; 175: 6939
  • Chen C. C., Liao C. C., Hsu W. H. The cloning and nucleotide sequence of a Corynebacterium glutamicum 3 -deoxy-d-arabinoheptulosonate-7-phosphate synthase gene. FEMS Microbiol. Lett. 1993; 107: 223
  • Clement Y., Lanneelle G. Glutamate excretion mechanism in Corynebacterium glutamicum: triggering by biotin starvation or surfactant addition. J. Gen. Microbiol. 1986; 132: 925
  • Clement Y., Escoffier B., Trombe M. C., Lanneelle G. Is glutamate excreted by its uptake system in Corynebacterium glutamicum? A working hypothesis. J. Gen. Microbiol. 1984; 130: 2589
  • Cob G. E., Follettie M. T., Jetten M. S. M., Stephanopoulos G., Sinskey A. J. Redirections of carbon flux at a Corynebacterium glutamicum threonine metabolic branch point by controlled enzyme overexpression. Abstr. Annu. ASM Meet. 1993; 320
  • Cordes C., Mockel B., Eggeling L., Sahm H. Cloning, organization and functional analysis of ilvA, ilvB and ilvC Genes from Corynebacterium glutamicum. Gene 1992; 112: 113
  • Cremer J., Eggeling L., Sahm H. Cloning of the dapA-dapB cluster of the lysine secretion bacterium Corynebacterium glutamicum. Mol. Gen. Genet. 1988a; 224: 317
  • Cremer J., Eggeling L., Sahm H. Control of lysine biosynthesis sequence in Corynebacterium glutamicum as analyzed by overexpression of the individual corresponding genes. Appl. Environ. Microbiol. 1991; 57: 1746
  • Cremer J., Treptow C., Eggeling L., Sahm H. Regulation of enzymes of lysine biosynthesis in Corynebacterium glutamicum. J. Gen. Microbiol. 1988b; 134: 3221
  • Debadov J. Construction of strains producing L-threonine. Genetics of Industrial Microorganisms, Y. Ikeda, T. Beppu. Kodansha, Tokyo 1983; 254
  • Del Real G., Aguilar A., Martin J. F. Cloning and expression of the tryptophan genes from Brevibacterium lactofementum in Escherichia coli. Biochem. Biophys. Res. Commun. 1985; 133: 1013
  • Dominguez H., Nezondet C., Lindley N. D., Cocaign M. Modified carbon flux during oxygen limited growth of Corynebacterium glutamicum and the consequences for amino acid overproduction. Biotechnol. Lett. 1993; 15: 449
  • Dunican L. K., Shivnan E. High frequency transformation of whole cells of amino acid producing coryneform bacteria using high voltage electroporation. Bio/Technology 1990; 7: 1067
  • Duperray F., Jezequel D., Ghazi A., Letelier L., Shechter E. Excretion of glutamate by Corynebacterium glutamicum triggered by surfactants. Biochim. Biophys. Acta 1992; 1103: 250
  • Ebbinghausen H., Weil B., Kramer R. Isoleucine excretion in Corynebacterium glutamicum: evidence for a specific efflux carrier system. Appl. Microbiol. Biotechnol. 1989a; 31: 184
  • Ebbinghausen H., Weil B., Kramer R. Transport of branched chain amino acids in Corynebacterium glutamicum. Arch. Microbiol. 1989b; 151: 238
  • Eggeling I., Cordes C., Eggeling L., Sahm H. Regulation of acetohydroxy acid synthase in Corynebacterium glutamicum during fermentation of 2–α-ketobutyrate to L-isoleucine. Appl. Microbiol. Biotechnol. 1987; 25: 617
  • Eikmanns B. J. Identification, sequence analysis, and expression of a Corynebacterium glutamicum gene cluster encoding the 3 glycolytic enzymes glyceral-dehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and triosephosphate isomerase. J. Bacteriol. 1992; 174: 6076
  • Eikmanns B. J., Eggeling L., Sahm H. Molecular aspects of lysine, threonine, and lysine biosynthesis in Corynebacterium glutamicum. Anthonie van Leeuwenhoek 1993; 64: 145
  • Eikmanns B., Follettie M. T., Griot M. U., Sinskey A. J. The phosphoenol pyruvate carboxylase gene of Corynebacterium glutamicum: molecular cloning, nucleotide sequence, and expression. Mol. Gen. Genet. 1989; 218: 330
  • Eikmanns B., Kircher M., Reinscheid D. J. Discrimination of Corynebacterium glutamicum, Brevibacterium lactofermentum by restriction pattern analysis of DNA adjacent to the hom gene. FEMS Microbiol. Lett. 1991a; 82: 203
  • Eikmanns B. J., Kleinertz E., Liebl W., Sahm H. A family of Corynebacterium glutamicum/Escherichia coli shuttle vectors for cloning, controlled gene expression, and promoter probing. Gene 1991b; 102: 93
  • Eikmanns B., Metz M., Reinscheid D., Kricher M., Sahm H. Amplification of three threonine biosynthetic genes in Corynebacterium glutamicum and its influence on carbon flux in different strains. Appl. Microbiol. Biotechnol. 1991; 34: 617, c
  • Erdmann A., Weil B., Kramer R. Lysine secretion by wild-type Corynebacterium glutamicum triggered by dipeptide uptake. J. Gen. Microbiol 1993; 139: 3115
  • Ertan H. Some properties of glutamate dehydrogenase, glutamine synthetase and glutamate synthase from Corynebacterium callunae. Arch. Microbiol. 1992a; 158: 35
  • Ertan H. The effect of various culture conditions on the levels of ammonia assimilatory enzymes of Corynebacterium callunae. Arch. Microbiol. 1992b; 158: 42
  • Filipula D., Ally A., Nagle J. Complete nucleotide sequence of a native plasmid of Brevibacterium lactofermentum. Nucleic Acids Res. 1986; 14: 514
  • Flodin N. W. Lysine supplementations of cereal foods — a retrospective. J. Am. Coll. Nutr. 1993; 12: 486
  • Follettie M. T., Archer J., Peoples O. P., Sinskey A. J. (1991) Metabolic engineering of Corynebacterium. Proceedings of the Sixth International Symposium on Genetics of Industrial Microorganisms. 1991, H. Heslot, J. Davies, J. Horent, L. Bobichon, G. Durand, L. Penasse. Societe Microbiologique Francaise, Paris, 315
  • Follettie M. T., Peoples O. P., Agoropoulou C., Sinskey A. J. Gene structure and expression of the Corynebacterium flavum N13 a sk-asd operon: molecular and evolutionary analysis of aspartokinase. J. Bacteriol. 1993; 175: 4096
  • Follettie M. T., Shin H. K., Sinskey A. J. Organization and regulation of the Corynebacterium glutamicum hom-thrB, thrB loci. Mol. Microbiol. 1988; 2: 53
  • Follettie M. T., Sinskey A. J. Molecular cloning and nucleotide sequence of the Corynebacterium glutamicwn pheA gene. J. Bacteriol. 1986a; 167: 695
  • Follettie M. T., Sinskey A. J. Recombinant DNA technology for Corynebacterium glutamicum. Food Technol. 1986b; 40: 88
  • Follettie M. T., Sinskey A. J. Corynebacterium glutamicum: a model for the use of DNA technology in food grade organisms. Biotechnology and Food Safety, D. D. Bills, S. D. Kung. Butterworth-Heinemann, Boston 1989; 277
  • Frings E., Kunte H. J., Galinski E. A. Compatible solutes in representatives of the genera Brevibacterium, Corynebacterium — Occurrence of tetrahydropyrimidines and glutamine. FEMS Microbiol. Lett. 1993; 107: 25
  • Gubler M. E., Park S. M., Jetten M. S. M., Stephanopoulos G., Sinskey A. J. Effects of phosphoenol pyruvate carboxylase deficiency on metabolism and lysine production of Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 1994a; 40: 857
  • Gubler M. E., Jetten M. S. M., Lee S. H., Sinskey A. J. Cloning of pyruvate kinase gene (pyk) of Corynebacterium glutamicum and site specific inactivatin of pyk in a lysine producing C. lactofermentum strain. Appl. Environ. Microbiol. 1994b; 60: 2494
  • Guerrero C., Mateos L. M., Malumbres M., Martin J. F. The bleomycin resistance gene of transpon Tn5 is an excellent marker for transformation of corynebacteria. Appl. Microbiol. Biotechnol. 1992; 36: 759
  • Gutmann M., Hoischen C., Kramer R. Carrier-mediated glutamate secretion by Corynebacterium glutamicum under biotin limitation. Biochim. Biophys. Actu 1992; 1112: 115
  • Han K. S., Archer J., Sinskey A. J. The molecular structure of the Corynebacterium glutamicum threonine synthase gene. Mol. Microbiol. 1990; 4: 1693
  • Haynes J. A., Britz M. L. Electrotransformation of Brevibacterium lactofermentum, Corynebacterium glutamicum: growth in Tween 80 increases transformation frequency obtained by electroporation. FEMS Microbiol. Lett. 1989; 61: 329
  • Haynes J. A., Britz M. L. The effect of growth conditions of Corynebacterium glutamicum on the transformation frequency obtained by electroporation. J. Gen. Microbiol. 1990; 136: 255
  • Hecry D. M., Dunican L. K. Cloning of the trp gene cluster from a tryptophan-hyperproducing strain of Corynebacterium glutamicum: identification of a mutation in the trp leader sequence. Appl. Environ. Microbiol. 1993; 59: 791
  • Hoischen C., Kramer R. Evidence for an efflux carrier system involved in the secretion of glutamate by Corynebacterium glutamicum. Arch. Microbiol. 1989; 151: 342
  • Hoischen C., Kramer R. Membrane alteration is necessary but not sufficient for effective glutamate secretion by Corynebacterium glutamicum. J. Bacteriol. 1990; 172: 3409
  • Ikeda M., Katsumata R. Metabolic engineering to produce tyrosine or phenylalanine in a tryptophan-producing Corynebacterium glutamicum strain. Appl. Environ. Microbiol. 1992; 58: 781
  • Ikeda M., Ozaki A., Katsumata R. Phenylalanine production by metabolically engineered Corynebacterium glutamicum with the pheA gene of Escherichia coli. Appl. Microbiol. Biotechnol. 1993; 39: 318
  • Ingraham J. I., Maaloe O., Neidhardt F. C. Growth of the Bacterial Cell. Sinauer, Sunderland, MA 1983
  • Ishida M., Sato K., Hashiguchi K., Ito H. High fermentation production of L-threonine from acetate by a Brevibacterium flavum stabilized strain transformed with a recombinant plasmid carrying the Escherichia coli thr operon. Biosci. Biotechnol. Biochem. 1993; 57: 1755
  • Ishino I., Mizukami T., Yamagushi K., Katzumata R., Araki K. Cloning and sequencing of the meso-DAP dehydrogenase gene (ddh) of Corynebacterium glutamicum. Agric. Biol. Chem. 1988; 52: 2903
  • Ishino I., Mizukami T., Yamagushi K., Katzumata R., Araki K. Nucleotide sequence of the meso-DAP dehydrogenase gene (ddh) of Corynebacterium glutamicum. Nucleic Acids Res. 1987; 15: 3917
  • Jäget W., Schäfer A., Puehler A., Labes G., Wohlleben W. Expression of the Bacillus subtilis sacB gene leads to sucrose sensitivity in the Gram positive bacterium Corynebacterium glutamicum but not in Streptomyces lividans. J. Bacteriol. 1992; 174: 5462
  • Jetten M. S. M., Follettie M. T., Sinskey A. J. Metabolic engineering of Corynebacterium glutamicum. Recombinant DNA Technology II, R. Bajpai, A. Prokop. Annals of the New York Academy of Science, New York 1994a; 754
  • Jetten M. S. M., Follettie M. T., Sinskey A. J. Effect of different levels of aspartokinase on the lysine production of Corynebacterium lactofermentum. Appl. Microbiol. Biotechnol 1995, press
  • Jetten M. S. M., Gubler M. E., McConnick M. M., Colon G. E., Follettie M. T., Sinskey A. J. Molecular organization and regulation of the biosynthetic pathway for asparte derived amino acids in Corynebacterium glutamicum. Industrid Microorganisms: Basic and Applied Molecular Genetics, R.H. Baltz, G. Hegeman, P.L. Skatrud. ASM, Washington, DC 1993; 97
  • Jetten M. S. M., Gubler M. E., Lee S. H., Sinskey A. J. Structural and functional analysis of pyruvate kinase from Corynebacterium glutamicum. Appl. Environ. Microbiol. 1994; 60: 2501, c
  • Jetten M. S. M., Pitoc G. A., Follettie M. T., Sinskey A. J. Regulation of phosphoenol pyruvate and oxaloacetate converting enzymes in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol., 40, 420: 3994d
  • Jetten M. S. M., Sinskey A. J. Characterization of phosphoenolpyruvate carboxykinase from Corynebacterium glutamicum. FEMS Microbiol. Lett. 1993; 111: 183
  • Jetten M. S. M., Sinskey A. J. Purification and properties of oxaloacetate decarboxylase from Corynebacterium glutamicum. Anthonie van Leeuwenhoek 1995; 67: 221
  • Kalinowski J., Cremer J., Bachmann B., Eggeling L., Sahm H., Puehler A. Genetic and biochemical analysis of the aspartokinase from Corynebacterium glutamicum. Mol. Microbiol. 1991; 5: 1197
  • Kalinowski J., Bachmann B., Thierbach G., Puehler A. Aspartokinase genes lysCα and lysCb˜ overlap and are adjacent to the aspartate-semialdehyde dehydrogenase gene asd in Corynebacterium glutamicwn. Mol. Gen. Genet. 1990; 224: 317
  • Karasawa M., Tosaka O., Ikeda S., Yoshii H. Application of protoplast fusion to the development of L-threonine and L-lysine producers. Agric. Biol. Chem. 1986; 50: 339
  • Katsumata R., Ozaki A., Oka T., Furuya A. Protoplast formation of glutamate-producing bacteria with plasmid DNA. J. Bacteriol. 1984; 159: 306
  • Katsumata R., Ikeda M. Hyperproduction of tryptophan in Corynebacterium glutamicum by pathway engineering. Bio Technology 1993; 11: 921
  • Keilhauer C., Eggeling L., Sahm H. lsoleucine synthesis in Corynebacterium glutamicum molecular analysis of the ilvB-ilvN-ilvC operon. J. Bacteriol. 1993; 175: 5595
  • Kinoshita S. Glutamatic acid bacteria. Biology of Industrial Microorganisms, A.L. Demain, N.A. Solomon. Benjamin Cummings, London 1985; 115
  • Kiss R. D., Stephanopoulos G. Culture instability of auxotrophic amino acid producers. Biotechnol. Bioeng. 1992; 40: 75
  • Kramer R. Secretion of amino acids by bacteria: physiology and mechanism. FEMS Microbiol. Rev. 1994; 13: 75
  • Krämer R., Lambert C. Uptake of glutamate in Corynebacterium glutamicum. Eur. J. Biochem. 1990; 194: 937
  • Kramer R., Lambert C., Hoischen C., Ebbighausen H. Uptake of glutamate in Corynebacterium glutamicum. Eur. J. Biochem. 1990; 194: 929
  • Krulwich T. A., Pellicione N. J. Catabolic pathways of coryneforms, nocardias and mycobacteria. Annu. Rev. Microbiol. 1979; 33: 95
  • Labarre J., Reyes O., Guyonvarch A., Leblon G. Gene replacement integration, and amplification at the gdhA locus of Corynebacterium glutamicum. J. Bacteriol. 1993; 175: 1001
  • Lee H. S., Jetten M., Williams R., Sinskey A. Molecular characterization of aceB, a gene encoding malate synthase in Corynebacterium glutamicum. Biotechnol. Lett. 1994, submitted
  • Liebl W. The genus Corynebacterium — nonmedical. The Prokaryotes, A. Balows, H.G. Trueper, M. Dworkin, W. Harder, K.H. Schleifer. Springer-Verlag, Berlin 1991, 1157
  • Liebl W., Ehrmann M., Ludwig W., Schleifer K. H. Transfer of Brevibacterium divaricatum DSM 2029T, Brevidacterium flavum DSM 20411, Urevi-bacterium lactofermentum DSM 20412 and DSM 1412, and Corynebacterium lilium DSM20317 to Corynebacterium glutamicum and their distinction by rDNA gene restriction patterns. Int. J. Syst. Bacteriol. 1991; 41: 255
  • Liebl W., Schein B. Isolation of restriction deficient mutants of Corynebacrerium glutamicum. Proc. Dechema Biotechnol. Conf 1991; 4: 102
  • Malin G. M., Bourd G. I. Phosphotransferase-depen-dent glucose transport in Corynebacterium glutamicum. J. Appl Bacteriol. 1991; 71: 517
  • Marcel T., Archer J. A. C., Mengin-Lecreulx M., Sinskey A. J. Nucleotide sequence and organization of the upstream region of Corynebacterium glutamicum lysA gene. Mol. Microbiol. 1990; 4: 1819
  • Martin J. F., Santamaria R., Sandoval H., Del Real G., Mateos L. M., Gil J. A., Aguilar A. Cloning systems in amino acid-producing corynebacteria. Bio/ Technology 1987; 5: 137
  • Masuda M., Takamatsu S., Nishimura N., Komatsubara S., Tosa T. Improvement of nitrogen supply for L-threonine production by a recombinant strain of Serratia marcescens. Appl. Biochem. Biotechnol. 1992; 37: 255
  • Matsui K., Miwa K., Sano K. Complete nucleotide sequence and deduced amino acid sequences of the Brevibacterium lactofermentum trp operon. Nucleic Acids Res. 1986; 14: 10113
  • Matsui K., Miwa K., Sano K. Two single base pair substitutions causing desensitization to tryptophan feedback inhibition of anthranilate synthase and enhanced expression of tryptophan genes of Urevibacterium lactofermentum. J. Bacteriol. 1987; 109: 5330
  • McCormick M., Follettie M. T., Sinskey A. J. Characterization of the structure/function relationships of Corynebacterium glutamicum promoters, Abstr. Annu. ASM Meet. 1993; 331
  • Miwa K., Matsui H., Terabe M., Nakamori S., Sano K., Momose H. Cryptic plasmids in glutamic acid producing bacteria. Agric. Biol. Chem. 1984a; 48: 2901
  • Miwa K., Matsui H., Terabe M., Ito K., Ishida M., Takagi H., Nakamori S., Sano K. Construction of novel shuttle vectors and a cosmid vector for the glutamic acid producing bacteria Urevibacterium lactofetmentum and Corynebacterium glutamicum. Gene 1985; 39: 281
  • Miwa K., Tsuchida T., Kurahashi D., Nakamori S., Sano K., Momose H. Construction of L-threonine overproducing strains of Escherichia coli K-12 using recombinant DNA techniques. Agric. Biol. Chem. 1983; 47: 2329
  • Miwa K., Nakamori S., Sano K., Momose H. Stability of recombinant plasmids carrying the threonine operon in Escherichiu coli. Agric. Bid. Chem. 1984b; 48: 2233
  • Miyajima R., Shiio I. Regulation of aspartate family amino acid biosynthesis in Brevibacterium flavum. HI. Properties of homoserine dehydrogenase. J. Biochem. 1970; 68: 311
  • Mockel B., Eggeling L., Sahm H. Functional and structural analyses of threonine dehydratase from Corynebacterium glutamicum. J. Bacteriol. 1992; 174: 8065
  • Momose H., Miyashiro S., Oba M. On the transducing phages in glutamic acid producing bacteria. J. Gen. Appl. Microbiol. 1976; 22: 119
  • Mori M., Shiio I. Purification and some properties of phosphoenol pyruvate carboxylase from Brevibacterium flavum and its aspartate overproducing mutant. J. Biochem. 1985; 97: 1119
  • Mori M., Shiio I. Pyruvate formation and sugar metabolism in an amino acid-producing bacterium Urevibacterium flavum. Agric. Biol. Chem. 1987a; 51: 129
  • Mori M., Shiio I. Phosphoenol pyruvate: sugar phosphotransferase system and sugar metabolism in Brevibacterium flavum. Agric. Biol. Chem. 1987b; 51: 2671
  • Morinaga Y., Tsuchiya M., Miwa K., Sano K. Expression of Escherichia coli promoters in Brevibacterium lactofermentum using shuttle vector pEB003. J. Biotechnol. 1987; 5: 305
  • Nakamori K. Threonine and homoserine. Biotechnology of Amino Acids Production, K. Aida, L. Chibita, K. Nakayama, K. Takinami, H. Yamada. Elsevier, Amsterdam 1986; 173
  • Nakamori K., Ishida M., Takagi M., Ito K., Miwa K., Sano K. Improvement of L-threonine production by amplification of the homoserine dehydrogenase gene in Brevibacterium lactofetmentum. Agric. Biol. Chem. 1987; 51: 87
  • Neubeck M., Prenner E., Horvat P., Bona R., Hermetter A., Moser A. Membrane fluidity in glutamic acid-producing bacteria Brevibacterium sp ATCC-13869. Arch. Microbiol. 1993; 160: 101
  • Oguiza J. A., Malumbres M., Eriani G., Pisabarro A., Mateos L. M., Martin F., Martin J. F. A gene encoding arginyl-tRNA synthetase is located in the upstream region of the lysA gene in Brevibacterium lactofermentum: regulation of argS-lysA cluster expression by arginine. J. Bacteriol. 1993; 175: 7356
  • O'Regan M., Thierbach G., Bachmann B., Villeval D., Lepage P., Viret J. F., Lemoine Y. Cloning and nucleotide sequence of the phosphoenol pyruvate car-boxylase coding gene of Corynebucterium glutamicum ATCC 13032. Gene 1989; 77: 237
  • Ozski A., Katsamata R., Oka T., Furuya A. Functional expression of the genes of Escherichia coli in Gram- positive Corynebucterium glutamicum. Mol. Gen. Genet. 1984; 196: 175
  • Ozaki A., Katsumata R., Oka T., Furuya A. Transfection of Corynebacterium glutamicum with temperate phage phiCGl, Agric. Biol. Chem. 1985a; 48: 2597
  • Ozaki A., Katsumata R., Oka T., Furuya A. Cloning of the genes concerned in phenylalanine biosynthesis in Corynebacterium glutamicum and its application to breeding of a phenylalanine-producing strain. Agric. Biol. Chem. 1985b; 49: 2925
  • Ozaki H., Shiio I. Regulation of the TCA and glyoxylate cycles in Brevibucterium flavum. J. Biochem. 1969; 66: 297
  • Patck M., Hochmannova J., Nesvera J. Production of threonine by Brevibacterium flavum containing threonine biosynthetic genes from Escherichia coli. Folia Microbiol. 1993; 38: 355
  • Patek M., Krumbach K., Eggeling L., Sahm H. Leucine synthesis in Corynebacterium glutamicum: enzyme activities, structure of leuA, and effect of leuA inactivation on lysine synthesis. Appl. Environ. Microbiol. 1994; 60: 133
  • Patek M., Navratil O., Hochmannova J., Nesvera J., Krumphanzl V., Bucko M. Expression of the threonine operon from Escherichia coli in Brevibacterium Jflavum and Corynebucterium glutamicum. Biotechnol. Lett. 1989; 11: 231
  • Patek M., Nesvera J., Hochmannova J., Stockrova J. Transfection of Brevibacterium flavum with bacterio-phage BFB10 DNA. Folia Microbiol. 1988; 333: 247
  • Peoples O. P., Liebl W., Bodis M., Maeng P. J., Follettie M. T., Archer J. A. C., Sinskey A. J. Nucleotide sequence and fine structural analysis of the Corynebacterium glutamicum hom-thrB operon. Mol. Microbiol. 1988; 2: 63
  • Peterswendisch P. G., Eikmanns B. J., Thierbach G., Bachmann B., Sahm H. Phosphoenol pyruvate carboxylase in Corynebacterium glutamicum is dispensable for growth and lysine production. FEMS Microbiol. Lett. 1993; 112: 269
  • Pisabarro A., Malumbres M., Mateos L. M., Oguiza J. A., Martin J. F. A cluster of 3 genes (dapA, orf 2, and dapB) of Brevibacterium lactofermentum encodes dihydrodipicolinate synthase, dihydrodipicolinate reduc-tase, and a 3rd polypeptide of unknown function. J. Bacteriol. 1993; 175: 2743
  • Plakunov V. K., Volkova I. M., Lebedeva Z. D. Role of excretion in the overproduction of glutamic acid by Corynebacterium glutamicum. Microbiology 1992; 61: 118
  • Plamann M. D., Stauffer G. V. Characterization of the Escherichia coli gene for serine hydroxymethyltrans-ferase. Gene 1983; 22: 9
  • Randall J. R., Andreas D. O. Archer Daniels Midland Annual Report. ADM, Decatur, IL 1992; 16
  • Reinscheid D. J., Eikmanns B. J., Sahm H. Analysis of Corynebacterium glutamicum hom gene coding for a feedback resistant homoserine dehydrogenase. J. Bacteriol. 1991; 173: 3228
  • Reinscheid D. J., Eikmanns B. J., Sahm H. Isolation and analysis of the Corynebacterium glutamicum genes encoding isocitrate lyase and malate synthase. Bio Engineering 1993; 9: 32
  • Reinscheid D. J., Eikmanns B. J., Sahm H. Characterization of the isocitrate lyase gene from Corynebacterium glutamicum and biochemical analysis of the enzyme. J. Bacteriol. 1994b; 176: 3474
  • Reinscheid D. J., Kronemeyer W., Eggeling L., Eikmanns B. J., Sahm H. Stable expression of hom-1-thrB in Corynebucterium glutamicum and its effect on the carbon flux to threonine and related amino acids. Appl. Environ. Microbiol. 1994a; 60: 126
  • Reyes O., Guyonvarch A., Bonamy C., Salti V., David F., Leblon G. Integron-bearing vectors: a method suitable for stable chromosomal integration in highly restrictive Corynebacteria. Gene 1991; 107: 61
  • Rossol I., Puehler A. The Corynebacterium glutamicum aecD gene encodes a C-S lyase with alphabeta-elimination activity that degrades aminoethylcysteine. J. Bacteriol. 1992; 174: 2968
  • Sanchez F., Penalva M., Patino C., Rubio V. An efficient method for the introduction of viral DNA into Brevibacterium lactofermentum protoplasts. J. Gen. Microbiol. 1986; 132: 1767
  • Sandoval H., Aguilar A., Paniagua C., Martin J. F. Isolation and physical characterization of plasmid pCC1 from Corynebacterium callunnae and construction of hybrid derivatives. Appl. Microbiol. Biotechnol. 1984; 19: 409
  • Sandoval H., Del Real G., Mateos L. M., Aguilar A., Martin J. F. Screening of plasmids in non-pathogenic corynebacteria. FEMS Microbiol. Lett. 1985; 27: 93
  • Sano K., Ito K., Miwa K., Nakamori S. Amplification of the phosphoenol pyruvate carboxylase gene of Brevibacterium lactofermentum to improve amino acid production. Agric. Biol. Chem. 1987; 51: 597
  • Sano K., Matsui K. Structure and function of the trp operon control regions in Brevibacterium laclofementum, a glutamic acid producing bacterium. Gene 1987; 53: 191
  • Santamaria R., Gil J. A., Martin J. F. High frequency transformation of Brevibacterium lactofermentum protoplasts by plasmid DNA. J. Bacteriol. 1985; 162: 463
  • Santamaria R., Gil J. A., Mesas J. M., Martin J. F. Characterization of an endogeneous plasmid and development of cloning vectors and a transformation system in Brevibacterium lactofennentum. J. Gen. Microbiol. 1985; 130: 2237
  • Santamaria R., Martin J. F., Gil J. A. Identification of a promoter sequence in the plasmid pUL340 of Brevibacterium lactofennentum and construction of new cloning vectors for corynebacteria containing two selectable markers. Gene 1987; 56: 199
  • Schafer A., Kalinowski J., Puehler A. Increased fertility of Corynebacterium glutamicum recipients in intergenic mating with Escherichia coli after stress exposure. Appl. Environ. Microbiol. 1994; 60: 756
  • Schafer A., Kalinowski J., Simon R., Seep-Feldhaus R. A., Puehler A. High-frequency conjugal transfer from Gram-negative Escherichia coli to various Gram-positive coryneform bacteria. J. Bacteriol. 1990; 172: 1663
  • Schirch L., Hopkins S., Villar E., Angelaccio S. Serine hydroxy methylltransferase from Escherichia coli: purification and properties. J. Bacteriol. 1985; 163: 1
  • Scheer E., Cordes C., Eggeling L., Sahm H. Regulation of acetohydroxy acid synthase in Corynebacterium glutamicum during isoleucine formation from 2-hydroxybutyric acid. Arch. Microbiol. 1987; 149: 173
  • Schrumpf B., Eggeling L., Sahm H. Isolation and prominent characteristics of an L-lysine hyperproducing strain of Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 1992; 37: 566
  • Schrumpf B., Schwarzer A., Kalinowski J., Puehler A., Eggeling L., Sahm H. A functionally split pathway for lysine synthesis in Corynebacterium glutamicum. J. Bacteriol. 1991; 173: 4510
  • Schwarzer A., Puehler A. Manipulation of Corynebacterium glutamicum by gene disruption and replacement. Bio/Technology 1991; 9: 84
  • Schwinde J. W., Thumschmitz N., Eikmanns B. J., Sahm H. Transcriptional analysis of the gap-pgk-tpippc gene cluster of Corynebacterium glutamicum. J. Bacteriol. 1993; 175: 3905
  • Seep-Feldhaus A. H., Kalinowski J., Puehler A. Molecular analysis of the Corynebacterium glutamicum lysI gene involved in lysine uptake. Mol. Microbiol. 1991; 5: 2995
  • Serwold-Davis T. M., Groman N., Kao C. C. Localization of an origin of replication in Corynebacterium diphtheriae broad host range plasmid pNG2 that also functions in Escherichia coli. FEMS Microbiol. Lett. 1990; 66: 119
  • Serwold-Davis T. M., Groman N., Rabin M. Transformation of Corynebacterium diphtheriae, Corynebacterium ulcerans, Corynebacterium glutamicum, Escherichia coli with the C. diphtheriae plasmid pNG2. Proc. Natl. Acad. Sci. U.S.A. 1987; 84: 4464
  • Sharp P. M., Mitchell K. J. Corynebacterium glutamicum arginyl-transfer RNA synthetase. Mol. Microbiol. 1993; 8: 200
  • Shaw P. C. Transformation of a Corynebacterium callunae-Escherichia coli hybrid plasmid to various Gram-positive coryneform bacteria. Agric. Biol. Chem. 1989; 53: 1717
  • Shaw P. C., Hartley B. S. A host vector system for an Arthrobacter species. J. Gen. Microbiol. 1988; 134: 903
  • Shiio I. Tryptophan, phenylalanine and tyrosine. Biotechnology of Amino Acids Production, K. Aida, L. Chibita, K. Nakayama, K. Takinami, H. Yamada. Elsevier, Amsterdam 1986; 188
  • Shiio I., Miyajima R. Concerted inhibition and its reversal by end-products of aspartokinase in Brevibacterium flavum. J. Biochem. 1969; 65: 849
  • Shiio I., Otsuka S. I., Takahashi M. Effect of biotin on the bacterial fermentation of glutamic acid. J. Biochem. 1963; 51: 56
  • Shiio I., Sugimoto S., Kawamura K. Isolation and properties of α-ketobutyrate-resistant lysine-producing mutants from Brevibacterium flavum. Biosci. Biotechnol. Biochem. 1993; 57: 51
  • Shiio I., Ujigawa-Takeda K. Presence and regulation of α-ketoglutarate dehydrogenase complex in a glutamate producing Brevibacterium flavum. Agric. Biol. Chem. 1980; 44: 1897
  • Shiio I., Yokota A., Toride Y., Sugimoto S. Threonine production by dihydropiconilate synthase mutant of Brevibacterium flavum. Agric. Biol. Chem. 1989; 53: 41
  • Shiio I., Yoshino H., Sugimoto S. Isolation and properties of lysine producing mutants with feedback resistant aspartokinase derived from a Brevibacterium flavum strain with citrate synthase and pyruvate kinase defects and feedback resistant phosphoenol pyruvate carboxylase. Agric. Biol. Chem. 1990; 54: 3275
  • Smith M. D., Flickinger J. L., Lieberger P. W., Schmid B. Protoplast transformation in coryneform bacteria and introduction of an α-amylase gene from Bacillus amyloliquefaciens into Brevibacterium lactofermentum. Appl. Environ. Microbiol. 1986; 51: 634
  • Sonnen H., Thierbach G., Kautz S., Kalinowski J., Scheider J., Puehler A., Kutzner H. J. Characterization of pCA1, a new plasmid from Corynebacterium glutamicum LP-6. Gene 1991; 107: 69
  • Sonnen H. Unusual phage/host relationship in the amino acid producing Corynebacterium glutamicum. Bioengineering 1992; 3: 53
  • Sonnen H., Schneider J., Kutzner H. J. Characterization of phiGA1, an inducible phage particle from Brevibacterium flavum. J. Gen. Microbiol. 1990a; 136: 567
  • Sonnen H., Schneider J., Kutzner H. J. Corynephage Cog, a virulent bateriophage of Corynebacterium glutamicum, and its relation to phiGA1, an inducible phage particle from Brevibacterium flavum. J. Gen. Virol. 1990b; 71: 1629
  • Sonntag K., Eggeling L., Degraaf A. A., Sahm H. Flux partitioning in the split pathway of lysine synthesis in Corynebacterium glutamicum: quantification by C-13-NMR and H-1-NMR spectroscopy. Eur. J. Biochem. 1993; 213: 1325
  • Stephanopoulos G., Vallino J. J. Network rigidity and metabolic engineering in metabolite overproduction. Science 1991; 252: 1675
  • Takagi H., Morinaga Y., Miwa K., Nakamori S., Sano K. Versatile cloning vectors constructed with genes indigenous to glutamic acid producer Brevibacterium lactofermentum. Agric. Biol. Chem. 1986; 50: 2597
  • Takeda Y., Fujii M., Nakajyoh Y., Nishimura T., Isshiki S. Isolation of a tetracycline resistance plasmid from a glutamate producing Corynebacterium melassecola. J. Fermen. Bioeng. 1990; 70: 117
  • Takeda Y., Nakajyoh Y., Isshiki S. Cloning and expression in Escherichia coli of the glutamate dehydrogcnase gene, gdh, from Corynebacterium melassecola. J. Fermen. Bioeng. 1990; 69: 317
  • Thierbach G., Schwarzer A., Puehler A. Transformation of spheroplasts and protoplasts of Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 1988; 29: 356
  • Tosaka O., Morioka H., Takinami K. The role of biotin-dependent pyruvate carboxylase in L-lysine production. Agric. Biol. Chem. 1979; 43: 1513
  • Tosaka O., Takinami K. Pathway and regulation of lysine biosynthesis in Brevibacterium lactofermentum. Agric. Biol. Chem. 1978; 42: 95
  • Trautwetter A., Blanco C. Structural organization of the Corynebacterium glutamicum plasmid pGC100. J. Gen. Microbiol. 1991; 137: 2093
  • Trautwetter A., Blanco C., Bonnaissie S. Characterization of the corynebacteriophage CG33. J. Gen. Microbiol. 1987; 133: 2945
  • Trautwetter A., Blanco C., Sicard A. M. Structural characteristics of the Corynebacterium lillium bacte-riophage, CL31. J. Virol. 1987; 61: 1540
  • Tsuchiya M., Morinaga T. Genetic control systems of Escherichia coli can confer inducible expression of cloned genes in coryneform bacteria. Bio/Technology 1988; 6: 428
  • Vallino J. J., Stephanopoulos G. Metabolic flux distribution in Corynebacterium glutamicum during growth and lysine overproduction. Biotechnol. Bioeng. 1993; 41: 633
  • von der Osten C. H., Barbas C., Wong C., Sinskey A. J. Molecular cloning, nucleotide sequence and fine structural analysis of the Corynebacterium glutamicum fda gene: structural comparison of C. glutamicum fructose- 1,6-biphosphate aldolase to class I and class I aldo-lases. Mol. Microbiol. 1989; 3: 1625
  • Wehrmann A., Ruether K., Eggeling L., Sahm H. Role of split pathway in lysine synthesis of Corynebacterium glutamicum: a genetical and physiological approach. BioEngineering 1993; 9: 33
  • Weinstock O., Sella C., Chipman D. M., Barak Z. Properties of subcloned subunits of bacterial acetohydroxy acid synthases. J. Bacteriol. 1992; 174: 5560
  • Wohlleben W., Muth G., Kalinowski J. Genetic engineering of Gram positive bacteria. Biotechnology: Generics and Fundamentals of Genetic Engineering, H.J. Rehm, G. Reed, A. Puehler, H. Sahm. VCH Puglishers, WeinheimGermany 1993; 477
  • Wolf H., Puehler A., Neumann E. Electrotransformation of intact and osmotically sensitive cells of Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 1989; 30: 283
  • Yamaguchi R., Terabe M., Miwa K., Tshuchiya M., Takagi H., Morinaga Y., Nakamori S., Sano K., Momose H., Yamazaki A. Determination of the complete nucleotide sequence of Brevibacterium lactofermentum plasmid pAM330, and analysis of its genetic information. Agric. Biol. Chem. 1986; 50: 2771
  • Yeh P., Oreglia J., Prevots F., Sicard A. A shuttle vector system for Brevibacterium lactofermentum. Gene 1986; 47: 301
  • Yeh P., Sicard A. M., Sinskey A. J. General organization of the genes specifically involved in the diaminopimelate-lysine biosynthetic pathway of Corynebacterium glutamicum. Mol. Gen. Genet. 1988; 212: 105
  • Yeh P., Sicard A. M., Sinskey A. J. Nucleotide sequence of the lysA gene of Corynebacterium glutamicum and possible mechanism for modulation of expression. Mol. Gen. Genet. 1988; 212: 112
  • Yoon K. H., Park S. C., Oh T. K. Cloning and characterization of the gene encoding enzyme II of the Brevibacterium lactofernentum phosphoenol pyruvate dependent sugar phosphotransferase system. Abstr. Annu. ASM Meet. 1993; 323
  • Yoshihama M., Higashiro K., Rao E. A., Akedo M., Shanabruch W. G., Follettie M. T., Walker G. C., Sinskey A. J. Cloning vector system for Corynebacterium glutamicum. J. Bacteriol. 1985; 162: 591

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