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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 29, 2012 - Issue 6
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Research Article

Ghrelin Induces Time-Dependent Modulation of Thermoregulation in the Cold

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Pages 736-746 | Received 24 Oct 2011, Accepted 05 Mar 2012, Published online: 27 Jun 2012

REFERENCES

  • Boulant JA, Hardy JD. (1974). The effect of spinal and skin temperatures on the firing rate and thermosensitivity of preoptic neurones. J. Physiol. 240:639–660.
  • Cano G, Passerin AM, Schiltz JC, Card JP, Morrison SF, Sved AF. (2003). Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure. J. Comp. Neurol. 460:303–326.
  • Clement JG, Mills P, Brockway B. (1989). Use of telemetry to record body temperature and activity in mice. J. Pharmacol. Methods 21:129–140.
  • Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL. (2003). The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649–661.
  • Freeman DA, Lewis DA, Kauffman AS, Blum RM, Dark J. (2004). Reduced leptin concentrations are permissive for display of torpor in Siberian hamsters. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287:R97–R103.
  • Gamble KL, Ehlen JC, Albers HE. (2005). Circadian control during the day and night: role of neuropeptide Y Y5 receptors in the suprachiasmatic nucleus. Brain Res. Bull. 65:513–519.
  • Gamble KL, Paul KN, Karom MC, Tosini G, Albers HE. (2006). Paradoxical effects of NPY in the suprachiasmatic nucleus. Eur. J. Neurosci. 23:2488–2494.
  • Gavrilova O, Leon LR, Marcus-Samuels B, Mason MM, Castle AL, Refetoff S, Vinson C, Reitman ML. (1999). Torpor in mice is induced by both leptin-dependent and -independent mechanisms. Proc. Natl. Acad. Sci. U. S. A. 96:14623–14628.
  • Gluck EF, Stephens N, Swoap SJ. (2006). Peripheral ghrelin deepens torpor bouts in mice through the arcuate nucleus neuropeptide Y signaling pathway. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291:R1303–R1309.
  • Graf R, Krishna S, Heller HC. (1989). Regulated nocturnal hypothermia induced in pigeons by food deprivation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 256:R733–R738.
  • Guan XM, Hess JF, Yu H, Hey PJ, van der Ploeg LH. (1997). Differential expression of mRNA for leptin receptor isoforms in the rat brain. Mol. Cell. Endocrinol. 133:1–7.
  • Horn T, Wilkinson MF, Landgraf R, Pittman QJ. (1994). Reduced febrile responses to pyrogens after lesions of the hypothalamic paraventricular nucleus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 267:R323–R328.
  • Hosoda H, Kojima M, Matsuo H, Kangawa K. (2000). Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem. Biophys. Res. Commun. 279: 909–913.
  • Inyushkin AN, Bhumbra GS, Dyball RE. (2009). Leptin modulates spike coding in the rat suprachiasmatic nucleus. J. Neuroendocrinol. 21:705–714.
  • Jaszberenyi M, Bujdoso E, Bagosi Z, Telegdy G. (2006). Mediation of the behavioral, endocrine and thermoregulatory actions of ghrelin. Horm. Behav. 50:266–273.
  • Kleiber M. (1947). Body size and metabolic rate. Physiol. Rev. 27:511–541.
  • Kohno D, Gao HZ, Muroya S, Kikuyama S, Yada T. (2003). Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52:948–956.
  • Kohno D, Nakata M, Maekawa F, Fujiwara K, Maejima Y, Kuramochi M, Shimazaki T, Okano H, Onaka T, Yada T. (2007). Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway. Endocrinology 148:2251–2263.
  • Lu J, Zhang YH, Chou TC, Gaus SE, Elmquist JK, Shiromani P, Saper CB. (2001). Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation. J. Neurosci. 21:4864–4874.
  • Luque RM, Park S, Kineman RD. (2007). Severity of the catabolic condition differentially modulates hypothalamic expression of growth hormone-releasing hormone in the fasted mouse: potential role of neuropeptide Y and corticotropin-releasing hormone. Endocrinology 148:300–309.
  • Madden CJ, Morrison SF. (2009). Neurons in the paraventricular nucleus of the hypothalamus inhibit sympathetic outflow to brown adipose tissue. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296:R831–R843.
  • Mano-Otagiri A, Ohata H, Iwasaki-Sekino A, Nemoto T, Shibasaki T. (2009). Ghrelin suppresses noradrenaline release in the brown adipose tissue of rats. J. Endocrinol. 201:341–349.
  • Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Morgan PJ, Trayhurn P. (1996a). Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J. Neuroendocrinol. 8:733–735.
  • Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P. (1996b). Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 387:113–116.
  • Morton GJ, Schwartz MW. (2001). The NPY/AgRP neuron and energy homeostasis. Int. J. Obes. Relat. Metab. Disord. 25:S56–S62.
  • Nagashima K, Nakai S, Matsue K, Konishi M, Tanaka M, Kanosue K. (2003). Effects of fasting on thermoregulatory processes and the daily oscillations in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284:R1486–R1493.
  • Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S. (2001). A role for ghrelin in the central regulation of feeding. Nature 409:194–198
  • Oldfield BJ, Giles ME, Watson A, Anderson C, Colvill LM, McKinley MJ. (2002). The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 110:515–526.
  • Paxinos G, Franklin KBJ. (2001). The mouse brain in stereotaxic coordinates. New York: Academic Press.
  • Portaluppi F, Smolensky MH, Touitou Y. (2010). Ethics and methods for biological rhythm research on animals and human beings. Chronobiol. Int. 27:1911–1929.
  • Rashotte ME, Basco PS, Henderson RP. (1995). Daily cycles in body temperature, metabolic rate, and substrate utilization in pigeons: influence of amount and timing of food consumption. Physiol. Behav. 57:731–746.
  • Sakurada S, Shido O, Sugimoto N, Hiratsuka Y, Yoda T, Kanosue K. (2000). Autonomic and behavioural thermoregulation in starved rats. J. Physiol. 526:417–424.
  • Swoap SJ. (2008). The pharmacology and molecular mechanisms underlying temperature regulation and torpor. Biochem. Pharmacol. 76:817–824.
  • Székely M, Szelényi Z, Kis A. (1997). Fasting and re-feeding: alterations in resting metabolic rate and body temperature. In Nielsen B, Nielsen R (eds.). Thermal physiology. Copenhagen: August Krogh Institute, 235–238.
  • Tokizawa K, Uchida Y, Nagashima K. (2009). Thermoregulation in the cold changes depending on the time of day and feeding condition: physiological and anatomical analyses of involved circadian mechanisms. Neuroscience 164:1377–1386.
  • Trayhurn P, Thurlby PL, James WP. (1977). Thermogenic defect in pre-obese ob/ob mice. Nature 266:60–62.
  • Willesen MG, Kristensen P, Rømer J. (1999). Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70:306–316.
  • Yannielli PC, Molyneux PC, Harrington ME, Golombek DA. (2007). Ghrelin effects on the circadian system of mice. J. Neurosci. 27:2890–2895.
  • Yasuda T, Masaki T, Kakuma T, Yoshimatsu H. (2003). Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats. Neurosci. Lett. 349:75–78.
  • Yi CX, van der Vliet J, Dai J, Yin G, Ru L, Buijs RM. (2006). Ventromedial arcuate nucleus communicates peripheral metabolic information to the suprachiasmatic nucleus. Endocrinology 147:283–294.
  • Yoda T, Crawshaw LI, Yoshida K, Su L, Hosono T, Shido O, Sakurada S, Fukuda Y, Kanosue K. (2000). Effects of food deprivation on daily changes in body temperature and behavioral thermoregulation in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278:R134–R139.
  • Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK. (2006). Expression of ghrelin receptor mRNA in the rat and the mouse brain. J. Comp. Neurol. 494:528–548.

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