Bright light therapy for depression: A review of its effects on chronobiology and the autonomic nervous system

References

• Ako M, Kawara T, Uchida S, et al. (2003). Correlation between electroencephalography and heart rate variability during sleep. Psychiatry Clin Neurosci. 57:59–65
   PubMed Web of Science ®Google Scholar
• Altimus C, Güler A, Villa K, et al. (2008). Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formation. Proc Natl Acad Sci USA. 105:19998–20003
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association Work Group on Major Depressive Disorder. (2010). Practice guideline for the treatment of patients with major depressive disorder. 3rd ed. Accessed at http://psychiatryonline.org/data/Books/prac/PG_Depression3rdEd.pdf on 12 August 2012
   Google Scholar
• An M, Huang J, Shimomura Y, Katsuura T. (2009). Time-of-day-dependent effects of monochromatic light exposure on human autonomic nervous system. J Hum Environ Syst. 12:55–61
   Google Scholar
• Anderson J, Vasile R, Mooney J, et al. (1992). Changes in norepinephrine output following light therapy for fall/winter seasonal depression. Biol Psychiatry. 32:700–4
   PubMed Web of Science ®Google Scholar
• Andruškevičius S. (2009). Parameters of the spectral analysis of the heart rate variability in treating depression. Medicina (Kaunas). 45:214–20
   PubMed Web of Science ®Google Scholar
• Avissar S, Schreiber G, Nechamkin Y, et al. (1999). The effects of seasons and light therapy on G protein levels in mononuclear leukocytes of patients with seasonal affective disorder. Arch Gen Psychiatry. 56:178–83
   PubMed Web of Science ®Google Scholar
• Bär KJ, Greiner W, Jochum T, et al. (2004). The influence of major depression and its treatment on heart rate variability and pupillary light reflex parameters. J Affect Disord. 82:245–52
   PubMed Web of Science ®Google Scholar
• Benedetti F, Colombo C, Pontiggia A, et al. (2003a). Morning light treatment hastens the antidepressant effect of citalopram: A placebo-controlled trial. J Clin Psychiatry. 64:648–58
   PubMed Web of Science ®Google Scholar
• Benedetti F, Colombo C, Serretti A, et al. (2003b). Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Biol Psychiatry. 54:687–92
   PubMed Web of Science ®Google Scholar
• Benedetti F, Calabrese G, Bernasconi A, et al. (2009). Spectroscopic correlates of antidepressant response to sleep deprivation and light therapy: A 3.0 Tesla study of bipolar depression. Psychiatry Res. 173:238–42
   PubMed Web of Science ®Google Scholar
• Berger S, Kliem A, Yeragani V, Bär K. (2012). Cardio-respiratory coupling in untreated patients with major depression. J Affect Disorders. 139:166–71
   PubMed Web of Science ®Google Scholar
• Bonaz B, Picq C, Sinniger V, et al. (2013). Vagus nerve stimulation: From epilepsy to the cholinergic anti-inflammatory pathway. Neurogastroenterol Motil. 25:208–21
   PubMed Web of Science ®Google Scholar
• Borovikova LV, Ivanova S, Zhang M, et al. (2000). Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 405:458–62
   PubMed Web of Science ®Google Scholar
• Brown R, James C, Henderson L Macefield V. (2012). Autonomic markers of emotional processing: Skin sympathetic nerve activity in humans during exposure to emotionally charged images. Front Physiol. 3:1–6
   PubMed Web of Science ®Google Scholar
• Bunney J, Potkin S. (2008). Circadian abnormalities, molecular clock genes and chronobiological treatments in depression. Br Med Bulletin. 86:23–32
   PubMed Web of Science ®Google Scholar
• Bunney B, Bunney W. (2012). Rapid-acting antidepressant strategies: Mechanisms of action. Int J Neuropsychopharmacol. 15:695–713
   PubMed Web of Science ®Google Scholar
• Cajochen C, Zeitzer J, Czeisler C, Dijk D. (2000). Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness. Behav Brain Res. 115:75–83
   PubMed Web of Science ®Google Scholar
• Cajochen C, Münch M, Kobialka S, et al. (2005). High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light. J Clin Endocrinol Metab. 90:1311–16
   PubMed Web of Science ®Google Scholar
• Cajochen C. (2007). Alerting effects of light. Sleep Med Rev. 11:453–64
   PubMed Web of Science ®Google Scholar
• Campbell P. (2010). A decade for psychiatric disorders. Nature. 463:9
   PubMed Web of Science ®Google Scholar
• Carney R, Freedland K. (2009). Depression and heart rate variability in patients with coronary heart disease. Cleve Clin J Med. 76:S13–17
   PubMedGoogle Scholar
• Carney R, Freeland K, Stein P, et al. (2000). Change in heart rate and heart rate variability during treatment for depression in patients with coronary heart disease. Psychosom Med. 62:639–47
   PubMed Web of Science ®Google Scholar
• Casher M, Schuldt S, Haq A, Burkhead-Weiner D. (2012). Chronotherapy in treatment-resistant depression. Psychiatric Annals. 42:166–9
   Web of Science ®Google Scholar
• Chambers A, Allen J. (2002). Vagal tone as indicator of treatment response in major depression. Psychophysiology. 39:861–4
   PubMed Web of Science ®Google Scholar
• Chang H, Chang C, Chen C, et al. (2012). Major depression is associated with cardiac autonomic dysregulation. Acta Neuropsychiatrica. 24:318–27
   PubMed Web of Science ®Google Scholar
• Chellappa S, Viola A, Schmidt C, et al. (2012). Human melatonin and alerting response to blue-enriched light depend on a polymorphism in the clock gene PER3. J Clin Endocrinol Metab. 97:E433–7
   PubMed Web of Science ®Google Scholar
• Choi C, Kim K, Kim C, et al. (2011). Reactivity of heart rate variability after exposure to colored lights in healthy adults with symptoms of anxiety and depression. Int J Psychophysiol. 79:83–8
   PubMed Web of Science ®Google Scholar
• Czeisler C, Allan J, Stragatz S, et al. (1986). Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle. Science 233:667–71
   PubMed Web of Science ®Google Scholar
• Dahl K, Avery D, Lewy A, et al. (1993). Dim light melatonin onset and circadian temperature during a constant routine in hypersomnic winter depression. Acta Psychiatr Scand. 88:60–6
   PubMed Web of Science ®Google Scholar
• Dai J, Swaab D, Van der Vliet J, Buijs R. (1998). Postmortem tracing reveals the organization of hypothalamic projections of the suprachiasmatic nucleus in the human brain. J Comp Neurol. 400:87–102
   PubMed Web of Science ®Google Scholar
• Danilenko K, Putilov A, Russkikh G, et al. (1994). Diurnal and seasonal variations of melatonin and serotonin in women with seasonal affective disorder. Arct Med Res. 53:137–45
   PubMedGoogle Scholar
• Dilsaver S. (1989). Neurobiologic effects of bright artificial light. Brain Res Brain Res Rev. 14:311–33
   PubMedGoogle Scholar
• Duman R, Aghajanian G. (2012). Synaptic dysfunction in depression: Potential therapeutic targets. Science. 338:68–72
   PubMed Web of Science ®Google Scholar
• Emens J, Lewy A, Kinzie J, et al. (2009). Circadian misalignment in major depressive disorder. Psychiatry Res. 168:259–61
   PubMed Web of Science ®Google Scholar
• Enezi J, Revell V, Brown T, et al. (2011). A “melanopic” spectral efficiency function predicts the sensitivity of melanopsin photoreceptors to polychromatic lights. J Biol Rhythms. 26:314–23
   PubMed Web of Science ®Google Scholar
• Etain B, Milhiet V, Bellivier F, Leboyer M. (2011). Genetics of circadian rhythms and mood spectrum disorders. Eur Neuropsychopharmacology. 21:S676–82
   PubMed Web of Science ®Google Scholar
• Fabbian F, Smolensky M, Tiseo R, et al. (2013). Dipper and non-dipper blood pressure 24-hour patterns: Circadian rhythm-dependence physiological and pathophysiologic mechanisms. Chronobiol Int. 30:17–30
   PubMed Web of Science ®Google Scholar
• Fischer R, Kasper S, Pjrek E, Winkler D. (2012). On the application of light therapy in German-speaking countries. Eur Arch Psychiatry Clin Neurosci. 262:501–5
   PubMed Web of Science ®Google Scholar
• Germain A, Kupfer D. (2008). Circadian rhythm disturbances in depression. Hum Psychopharmacol. 23:571–85
   PubMed Web of Science ®Google Scholar
• Goetzel R, Pei X, Tabrizi M, et al. (2012). Ten modifiable health risk factors are linked to more than one-fifth of employer-employee health care spending. Health Aff (Millwood). 31:2474–84
   PubMed Web of Science ®Google Scholar
• Golden R, Gaynes B, Ekstrom R, et al. (2005). The efficacy of light therapy in the treatment of mood disorders: A review and meta-analysis of the evidence. Am J Psychiatry. 162:656–62
   PubMed Web of Science ®Google Scholar
• Gooley J, Lu J, Fischer D, Saper C. (2003). A broad role for melanopsin in nonvisual photoreception. J Neurosci. 23:7093–106
   PubMed Web of Science ®Google Scholar
• Guo Y, Stein P. (2002). Circadian rhythm in the cardiovascular system: Considerations in non-invasive electrophysiology. Card Electrophysiol Rev. 6:267–72
   PubMedGoogle Scholar
• Hatanaka M, Tanida M, Shintani N, et al. (2008). Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice. Neurosci Lett. 444:153–6
   PubMed Web of Science ®Google Scholar
• Hattar S, Kumar M, Park A, et al. (2006). Central projections of melanopsin-expressing retinal ganglion cells in the mouse. J Comp Neurol. 497:326–49
   PubMed Web of Science ®Google Scholar
• Hill A. (1965). The environment and disease: Association or causation? Proc R Soc Med. 58:295–300
   PubMed Web of Science ®Google Scholar
• Hilton M, Umali M, Czeisler C, et al. (2000). Endogenous circadian control of the human autonomic nervous system. Comput Cardiol. 27:197–200
   PubMedGoogle Scholar
• Huang J, An M, Shimomura Y, Katsuura T. (2009). Non-visual biological effect of monochromatic light on human circadian rhythm of physiological and psychological parameters. Proc Int Assoc Soc Design Res. 3887–90
   Google Scholar
• Insel T. (2009). Disruptive insights in psychiatry: Transforming a clinical discipline. J Clin Invest. 199:700–5
   Google Scholar
• Ishibashi K, Kitamura S, Kozaki T, Yasukouchi A. (2007). Inhibition of heart rate variability during sleep in humans by 6700 K pre-sleep light exposure. J Physiol Anthropol. 26:39–43
   PubMedGoogle Scholar
• Ishida S, Nakagawa M, Fujino T, et al. (1997). Circadian variation of QT interval dispersion: Correlation with heart rate variability. J Electrocardiol. 30:205–10
   PubMed Web of Science ®Google Scholar
• Ishida A, Mutoh T, Ueyama T, et al. (2005). Light activates the adrenal gland: Timing of gene expression and glucocorticoid release. Cell Metab. 2:297–307
   PubMed Web of Science ®Google Scholar
• Jung C, Khalsa S, Scheer F, et al. (2010). Acute effects of bright light exposure on cortisol levels. J Biol Rhythms. 25:208–16
   PubMed Web of Science ®Google Scholar
• Kasper S, Ruhrmann S, Neumann S, Möller H. (1994). Use of light therapy in German psychiatric hospitals. Eur Psychiatry. 9:288–92
   Web of Science ®Google Scholar
• Kendler K. (2012). The dappled nature of causes of psychiatric illness: Replacing the organic–functional/hardware–software dichotomy with empirically based pluralism. Mol Psychiatry. 17:377–88
   PubMed Web of Science ®Google Scholar
• Kessler R, Chiu W, Demler O, Walters E. (2005). Prevalence, severity, and comorbidity of twelve-month DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R). Arch Gen Psychiatry. 62:617–27
   PubMed Web of Science ®Google Scholar
• Khalsa S, Jewett M, Cajochen C, Czeisler C. (2003). A phase response curve to single bright light pulses in human subjects. J Physiol. 549:945–52
   PubMed Web of Science ®Google Scholar
• Kohsaka M, Kohsaka S, Fukuda N, et al. (2001). Effects of bright light exposure on heart rate variability during sleep in young women. Psychiatry Clin Neurosci. 55:283–4
   PubMed Web of Science ®Google Scholar
• Kraft M, Martin R. (1995). Chronobiology and chronotherapy in medicine. Dis Mon. 41:506–75
   PubMed Web of Science ®Google Scholar
• Lam R, Bowering T, Tam E, et al. (2000). Effects of rapid tryptophan depletion in patients with seasonal affective disorder in natural summer remission. Psychol Med. 30:79–87
   PubMed Web of Science ®Google Scholar
• Lam R, Levitt A, Levitan R, et al. (2006). The Can-SAD study: A randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder. Am J Psychiatry. 163:805–12
   PubMed Web of Science ®Google Scholar
• Lanfumey L, Mongeau R, Hamon M. (2013). Biological rhythms and melatonin in mood disorders and their treatments. Pharmacol Ther. 138:176–84
   PubMed Web of Science ®Google Scholar
• Laufer L, Láng E, Izsó L, Németh E. (2009). Psychophysiological effects of coloured lighting in older adults. Lighting Res Technol. 41:371–8
   Web of Science ®Google Scholar
• Leucht S, Hierl S, Kissling W, et al. (2012). Putting the efficacy of psychiatry and general medicine medication into perspective: Review of meta-analyses. Br J Psychiatry. 200:97–106
   PubMed Web of Science ®Google Scholar
• Lewy A, Sack R, Miller L, Hoban T. (1987). Antidepressant and circadian phase-shifting effects of light. Science. 235:352–4
   PubMed Web of Science ®Google Scholar
• Lewy A, Bauer V, Cutler N, et al. (1998). Morning vs. evening light treatment of patients with winter depression. Arch Gen Psychiatry. 55:890–6
   PubMed Web of Science ®Google Scholar
• Licht C, Penninx B, de Geus E. (2012). Effects of antidepressants, but not psychopathology, on cardiac sympathetic control: A longitudinal study. Neuropsychopharmacology. 37:2487–95
   PubMed Web of Science ®Google Scholar
• Licht C, de Geus E, Zitman F, et al. (2008). Association between major depressive disorder and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA). Arch Gen Psychiatry. 65:1358–67
   PubMed Web of Science ®Google Scholar
• Lieberman H, Garfield G, Waldhauser F, et al. (1985). Possible behavioral consequences of light-induced changes in melatonin availability. Ann N Y Acad Sci. 453:242–52
   PubMed Web of Science ®Google Scholar
• Lindsey K, Rohan K, Roecklein K, Mahon J. (2011). Surface facial electromyography, skin conductance, and self-reported emotional responses to light- and season-relevant stimuli in seasonal affective disorder. J Affect Disord. 133:311–19
   PubMed Web of Science ®Google Scholar
• Lockley S, Gooley J. (2006). Circadian photoreception: Spotlight on the brain. Curr Biol. 16:R795–7
   PubMed Web of Science ®Google Scholar
• Martiny K. (2004). Adjunctive bright light in non-seasonal major depression. Acta Psychiatr Scand. 425:7–28
   Google Scholar
• McCarthy M, Welsh D. (2012). Cellular circadian clocks in mood disorders. J Biol Rhythms. 27:339–52
   PubMed Web of Science ®Google Scholar
• McEwen B. (1998). Stress, adaptation, and disease. Allostasis and allostatic load. Ann N Y Acad Sci. 840:33–44
   PubMed Web of Science ®Google Scholar
• Mehta R, Zhu R. (2009). Blue or red? Exploring the effect of color on cognitive task performances. Science. 323:1226–9
   PubMed Web of Science ®Google Scholar
• Myers B, Badia P. (1993). Immediate effects of different light intensities on body temperature and alertness. Physiol Behav. 54:199–202
   PubMed Web of Science ®Google Scholar
• Neumeister A, Praschak-Rieder P, Hesselmann B, et al. (1997). Effects of tryptophan depletion on drug-free patients with seasonal affective disorder during a stable response to bright light therapy. Arch Gen Psychiatry. 554:133–8
   Google Scholar
• Neumeister A, Turner E, Matthews J, et al. (1998). Effects of tryptophan depletion vs catecholamine depletion in patients with seasonal affective disorder in remission with light therapy. Arch Gen Psychiatry. 55:524–30
   PubMed Web of Science ®Google Scholar
• Okamoto-Mizuno K, Mizuno K. (2012). Effects of thermal environment on sleep and circadian rhythm. J Physiol Anthropol. 31:1–9
   PubMed Web of Science ®Google Scholar
• Ono H, Taguchi T, Kido Y, et al. (2011). The usefulness of bright light therapy for patients after oesophagectomy. Intensive Crit Care Nurs. 27:158–66
   PubMedGoogle Scholar
• Packard G, Sollars P. (2012). Intrinsically photosensitive retinal ganglion cells. Rev Physiol Biochem Pharmacol. 162:59–90
   PubMed Web of Science ®Google Scholar
• Pail G, Huf W, Pjrek E, et al. (2011). Bright-light therapy in the treatment of mood disorders. Neuropsychobiology 64:152–62
   PubMed Web of Science ®Google Scholar
• Parry B, Maurer E. (2003). Light treatment of mood disorders. Dialogues Clin Neurosci. 5:353–65
   PubMedGoogle Scholar
• Porges S. (2001). The polyvagal theory: Phylogenetic substrates of a social nervous system. Int J Psychophysiol. 42:123–46
   PubMed Web of Science ®Google Scholar
• Portaluppi F, Hermida R. (2007). Circadian rhythms in cardiac arrhythmias and opportunities for their chronotherapy. Adv Drug Deliv Rev. 59:940–51
   PubMed Web of Science ®Google Scholar
• Rajae-Joordens R. (2011). The effects of colored light on valence and arousal: Investigating responses through subjective evaluations and psycho-physiological measurements. In Westerink J, Krans M, Ouwerkerk M, eds. Sensing emotions. Dordrecht, Netherlands: Philips Research Book Series. 12:65–84
   Google Scholar
• Rao M, Müller-Oerlinghausen B, Mackert A, et al. (1990). The influence of phototherapy on serotonin and melatonin in non-seasonal depression. Pharmacopsychiatry. 23:155–8
   PubMed Web of Science ®Google Scholar
• Rechlin T, Weis M, Kaschka W. (1995a). Is diurnal variation of mood associated with parasympathetic activity? J Affect Disord. 34:249–55
   PubMed Web of Science ®Google Scholar
• Rechlin T, Weis M, Schneider K, et al. (1995b). Does bright-light therapy influence autonomic heart-rate parameters? J Affect Disord. 34:131–7
   PubMed Web of Science ®Google Scholar
• Robillard R, Naismith S, Rogers N, et al. (2013). Delayed sleep phase in young people with unipolar or bipolar affective disorders. J Affect Disord. 145:260–3
   PubMed Web of Science ®Google Scholar
• Roecklein K, Rohan K, Duncan W, et al. (2009). A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder. J Affect Disord. 114:279–85
   PubMed Web of Science ®Google Scholar
• Rosenthal N, Levendosky A, Skwerer R, et al. (1990). Effects of light treatment on core body temperature in seasonal affective disorder. Biol Psychiatry. 27:39–50
   PubMed Web of Science ®Google Scholar
• Rosenthal N, Wehr T. (1992). Towards understanding the mechanisms of action of light in seasonal affective disorder. Pharmacopsychiatry. 25:56–60
   PubMed Web of Science ®Google Scholar
• Rottenberg J, Chambers A, Allen J, Manber R. (2007). Cardiac vagal control on the severity and course of depression: The importance of symptomatic heterogeneity. J Affect Disord. 103:173–9
   PubMed Web of Science ®Google Scholar
• Rudorfer M, Skwerer R, Rosenthal N. (1993). Biogenic amines in seasonal affective disorder: Effects of light therapy. Psychiatry Res. 46:19–28
   PubMed Web of Science ®Google Scholar
• Ruhrmann S, Kasper S, Hawellek B, et al. (1998). Effects of fluoxetine versus bright light in the treatment of seasonal affective disorder. Psychol Med. 28:923–33
   PubMed Web of Science ®Google Scholar
• Rüger M, Gordijn M, Beersma D, et al. (2006). Time-of-day-dependent effects of bright light exposure on human psychophysiology: Comparison of daytime and nighttime exposure. Am J Physiol Regul Integr Comp Physiol. 290:R1413–20
   PubMed Web of Science ®Google Scholar
• Rush A, Siefert S. (2009). Clinical issues in considering vagus nerve stimulation for treatment-resistant depression. Exp Neurol. 219:36–43
   PubMed Web of Science ®Google Scholar
• Saito Y, Shimizu T, Takahashi Y, et al. (1996). Effect of bright light exposure on muscle sympathetic nerve activity in human. Neurosci Lett. 219:135–7
   PubMed Web of Science ®Google Scholar
• Sakakibara S, Honma H, Kohsaka M, et al. (2000). Autonomic nervous function after evening bright light therapy: Spectral analysis of heart rate variability. Psychiatry Clin Neurosci. 54:363–4
   PubMed Web of Science ®Google Scholar
• Sanacora G, Treccani G, Popoli M. (2012). Towards a glutamate hypothesis of depression: An emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacology. 62:63–77
   PubMed Web of Science ®Google Scholar
• Scalco A, Rondon M, Trombetta I, et al. (2009). Muscle sympathetic nervous activity in depressed patients before and after treatment with sertraline. J Hypertens. 27:2429–36
   PubMed Web of Science ®Google Scholar
• Schäfer A, Kratky K. (2006). The effect of colored illumination on heart rate variability. Forsch Komplementmed. 13:167–73
   PubMedGoogle Scholar
• Scheer F, Ter Horst G, van der Vliet J, Buijs R. (2001). Physiological and anatomic evidence for regulation of the heart by suprachiasmatic nucleus in rats. Am J Physiol Heart Circ Physiol. 280:H1391–9
   PubMed Web of Science ®Google Scholar
• Scheer F, Kalsbeek A, Buijs R. (2003). Cardiovascular control by the suprachiasmatic nucleus: Neural and neuroendocrine mechanism in human and rat. Biol Chem. 384:697–709
   PubMed Web of Science ®Google Scholar
• Scheer F, Van Doornen L, Buijs R. (2004). Light and diurnal cycle affect autonomic cardiac balance in human; possible role for the biological clock. Auton Neurosci. 110:44–8
   PubMed Web of Science ®Google Scholar
• Schwerdtfeger A, Rosenkaimer A. (2011). Depressive symptoms and attenuated physiological reactivity to laboratory stressors. Biol Psychiatry. 87:430–8
   Google Scholar
• Selvi Y, Aydin A, Boysan M, et al. (2010). Associations between chronotype, sleep quality, suicidality, and depressive symptoms in patients with major depression and healthy controls. Chronobiol Int. 27:1813–28
   PubMed Web of Science ®Google Scholar
• Shin K, Minamitani H, Onishi S, et al. (1995). Assessment of training-induced autonomic adaptations in athletes with spectral analysis of cardiovascular variability signals. Jpn J Physiol. 45:1053–69
   PubMedGoogle Scholar
• Simmoneaux V, Ribelayga C. (2003). Generation of the melatonin endocrine message in mammals: A review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev. 55:325–95
   PubMed Web of Science ®Google Scholar
• Sletten T, Vincenzi S, Redman J, et al. (2010). Timing of sleep and its relationship with the endogenous melatonin rhythm. Front Neurol. 1:1–8
   PubMedGoogle Scholar
• Smedh K, Spigset O, Allard P, et al. (1999). Platelet [3H]paroxetine and [3H]lysergic acid diethylamide binding in seasonal affective disorder and the effect of bright light therapy. Biol Psychiatry. 45:464–70
   PubMed Web of Science ®Google Scholar
• Stinson D, Thompson C. (1990). Clinical experience with phototherapy. J Affect Disord. 18:129–35
   PubMed Web of Science ®Google Scholar
• Streeter C, Gerbarg P, Saper R, et al. (2012). Effects of yoga on the autonomic nervous system, gamma-amino-butyric-acid, and allostasis in epilepsy, depression, and post-traumatic stress disorder. Med Hypotheses. 78:571–9
   PubMed Web of Science ®Google Scholar
• Studwell J. (2004). All sleepless and light. Financial Times. Accessed at http://www.cet.org/docs/press/chrono/Financial_Times_2004.pdf on April 9, 2013
   Google Scholar
• Szádóczky E, Falus A, Németh A, et al. (1991). Effect of phototherapy on 3H-imipramine binding sites in patients with SAD, non- SAD and in healthy controls. J Affect Disord. 22:179–84
   PubMed Web of Science ®Google Scholar
• Székely M. (2000). The vagus nerve in thermoregulation and energy metabolism. Auton Neurosci. 85:26–38
   PubMed Web of Science ®Google Scholar
• Task Force of the European Society of Cardiology and the North American Society of Pacing Electrophysiology. (1996). Heart rate variability: Standards of measurement, physiological interpretation and clinical use. Circulation. 93:1043–65
   PubMed Web of Science ®Google Scholar
• Terman J, Terman M, Lo E, Cooper T. (2001). Circadian time of morning light administration and therapeutic response in winter depression. Arch Gen Psychiatry. 58:69–75
   PubMed Web of Science ®Google Scholar
• Terman M, Terman J. (2005). Light therapy for seasonal and nonseasonal depression: Efficacy, protocol, safety, and side effects. CNS Spectr. 10:647–63
   PubMed Web of Science ®Google Scholar
• Thapan K, Arendt J, Skene D. (2001). An action spectrum for melatonin suppression: Evidence for a novel non-rod, non-cone photoreceptor system in humans. J Physiol. 535:261–7
   PubMed Web of Science ®Google Scholar
• Thayer J, Lane R. (2009). Claude Bernard and the heart-brain connection: Further elaboration of a model of neurovisceral integration. Neurosci Biobehav Rev. 33:81–8
   PubMed Web of Science ®Google Scholar
• Thayer J, Brosschot J. (2005). Psychosomatics and psychopathology: Looking up and down from the brain. Psychoneuroendocrinology. 30:1050–8
   PubMed Web of Science ®Google Scholar
• Trestman R, Yehuda R, Coccaro E, et al. (1995). Diurnal neuroendocrine and autonomic function in acute and remitted depressed male patients. Biol Psychiatry. 37:448–56
   PubMed Web of Science ®Google Scholar
• Trevizani G, Benchimol-Barbosa P, Nadal J. (2012). Effects of age and aerobic fitness on heart rate recovery in adult men. Arq Bras Cardiol. 99:802–10
   PubMed Web of Science ®Google Scholar
• Tsunoda M, Endo T, Hashimoto S, et al. (2001). Effects of light and sleep stages on heart rate variability in humans. Psychiatry Clin Neurosci. 55:285–6
   PubMed Web of Science ®Google Scholar
• Udupa K, Sathyaprabha T, Thirthalli J, et al. (2007). Alteration of cardiac autonomic functions in patients with major depression: A study using heart rate variability measures. J Affect Disord. 100:137–41
   PubMed Web of Science ®Google Scholar
• Viola A, James L, Archer S, Dijk D. (2008). PER3 polymorphism and cardiac autonomic control: Effects of sleep debt and circadian phase. Am J Physiol Heart Circ Physiol. 295:H2156–63
   PubMed Web of Science ®Google Scholar
• Vos T, Flaxman A, Naghavi M, et al. (2012). Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 380:2163–96
   PubMed Web of Science ®Google Scholar
• Warthen D, Provencio I. (2012). The role of intrinsically photosensitive retinal ganglion cells in nonimage-forming responses to light. Eye Brain. 4:43–8
   PubMedGoogle Scholar
• Wirz-Justice A. (1998). Beginning to see the light. Arch Gen Psychiatry. 55:861–2
   PubMed Web of Science ®Google Scholar
• Wirz-Justice A, Benedetti F, Berger M, et al. (2005). Chronotherapeutics (light and wake therapy) in affective disorders. Psychol Med. 35:939–44
   PubMed Web of Science ®Google Scholar
• Wirz-Justice A. (2008). Diurnal variation of depressive symptoms. Dialogues Clin Neurosci. 10:337–43
   PubMedGoogle Scholar
• Wirz-Justice A, Benedetti F, Terman M. (2009). Chronotherapeutics for affective disorders: A clinician’s manual for light and wake therapy. Basel: Karger
   Google Scholar
• Wirz-Justice A, Bader A, Frisch U, et al. (2011). A randomized, double-blind, placebo-controlled study of light therapy for antepartum depression. J Clin Psychiatry. 72:986–93
   PubMed Web of Science ®Google Scholar
• Wu YH, Ursinus J, Zhou J, et al. (2013). Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression. J Affect Disord. 148:357–67
   PubMed Web of Science ®Google Scholar
• Wulff K, Gatti S, Wettstein J, Foster R. (2010). Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease. Nat Rev Neurosci. 11:1–12
   Web of Science ®Google Scholar
• Xhyheri B, Manfrini O, Mazzolini M, et al. (2012). Heart rate variability today. Prog Cardiovasc Dis. 55:321–31
   PubMed Web of Science ®Google Scholar
• Zhou L, Zhu D. (2009). Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical applications. Nitric Oxide. 20:223–30
   PubMed Web of Science ®Google Scholar