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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 33, 2016 - Issue 5
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Short Communication

The chondrocyte-intrinsic circadian clock is disrupted in human osteoarthritis

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References

  • Bouchard-Cannon P, Mendoza-Viveros L, Yuen A, Kærn M, Cheng H-Ying M (2013). The Circadian Molecular Clock Regulates Adult Hippocampal Neurogenesis by Controlling the Timing of Cell-Cycle Entry and Exit. Cell Reports. 5(4):961–973.
  • Brown SA (2014). Circadian clock-mediated control of stem cell division and differentiation: beyond night and day. Dev. 141:3105–3111.
  • Goldring MB (2012). Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Therap Adv Musculoskeletal Dis. 4:269–285.
  • Gossan N, Zeef L, Hensman J, Hughes A, Bateman JF, Rowley L, Little CB, Piggins HD, Rattray M, Boot-Handford RP Meng Q-J (2013). The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis. Arthritis Rheumatism 65:2334–2345.
  • Ingle K, Kain V, Goel M, Prabhu S, Young M Halade G (2015). Cardiomyocyte specific Bmal1 deletion triggers extracellular matrix response associated with markers of impaired inflammation resolution and diastolic dysfunction. FASEB J. 29:(Meeting abstract) 1035.
  • Khapre RV, Kondratova AA, Patel S, Dubrovsky Y, Wrobel M, Antoch MP, Kondratov RV (2014). BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging-Us 6:48–57.
  • Khapre RV, Samsa WE, Kondratov RV (2010). Circadian regulation of cell cycle: Molecular connections between aging and the circadian clock. Ann Med. 42:404–415.
  • Kondratov RV, Kondratova AA, Gorbacheva VY, Vykhovanets OV Antoch MP (2006). Early aging and age-related pathologies in mice deficient in BMAL1, the core component of the circadian clock. Genes Dev. 20:1868–1873.
  • Lin F, Chen Y, Li X, Zhao Q, Tan Z (2013). Over-expression of circadian clock gene Bmal1 affects proliferation and the canonical Wnt pathway in NIH-3T3 cells. Cell Biochem Funct. 31:166–172.
  • Livak KJ, Schmittgen TD (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402–408.
  • Masri S, Cervantes M, Sassone-Corsi P (2013). The circadian clock and cell cycle: interconnected biological circuits. Curr Opinion Cell Biol. 25:730–734.
  • Price JS, Waters JG, Darrah C, Pennington C, Edwards DR, Donell ST Clark IM (2002). The role of chondrocyte senescence in osteoarthritis. Aging Cell 1:57–65.
  • Snelling S, Rout R, Davidson R, Clark I, Carr A, Hulley PA, Price AJ (2014). A gene expression study of normal and damaged cartilage in anteromedial gonarthrosis, a phenotype of osteoarthritis. Osteoarthritis Cartilage 22:334–343.
  • Takarada T, Kodama A, Hotta S, Meida M, Shimba S, Hinoi E, Yoneda Y (2012). Clock genes influence gene expression in growth plate and endochondral ossification in mice. J Biol Chem. 287:36081–36095.

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