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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 14, 1997 - Issue 2
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Original Article

Influences of Melatonin on Human Orcadian Rhythms

Pages 205-220 | Published online: 07 Jul 2009

References

  • Lerner A B, Case J D, Takahashi Y, Lee T H, Mori N. Isolation of melatonin, pineal factor that lightens melanocytes. J Am Chem Soc 1958; 80: 2587
  • Reiter R J. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev 1991; 12: 151–80
  • Arendt J. Mammalian pineal rhythms. Pineal Res Rev 1985; 3: 161–213
  • Cardinali D P. Melatonin. A mammalian pineal hormone. Endocr Rev 1981; 2: 327–46
  • Neuwelt E A, Lewy A J. Disappearance of plasma melatonin after removal of a neoplastic pineal gland. N Engl J Med 1983; 308: 1132–5
  • Preslock J P. The pineal gland: basic implications and clinical correlations. Endocr Rev 1984; 5: 282–308
  • Cardinali D P, Vacas M I. Cellular and molecular mechanisms controlling melatonin release by mammalian pineal gland. Cell Mol Neurobiol 1987; 7: 323–37
  • Krause D N, Dubocovich M L. Regulatory sites in the melatonin system of mammals. Trends Neurosci 1990; 13: 464–70
  • Reiter R J, Seok C S, Fujimori O. Melatonin. Its intracellular and genomic actions. Trends Endocrinol Metab 1996; 7: 22–7
  • Hagan R M, Oakley N R. Melatonin comes of age?. Trends Pharmacol Sci 1995; 16: 81–3
  • Binkley R J. Structures and molecules involved in generation and regulation of biological rhythms in vertebrates and invertebrates. Experentia 1993; 49: 648–53
  • Pang S F, Lee P PN, Tang P L. Sensory receptors as a special class of hormonal cells. Neuroendocrinology 1991; 53(Suppl 1)2–11
  • Falcon J, Bolliet V, Ravault J P, Chesneau D, Ali M A, Collin J P. Rhythmic secretion of melatonin by the superfused pike pineal organ: thermo- and photoperiod interaction. Neuroendocrinology 1994; 60: 535–43
  • Deguchi T. Circadian rhythm of serotonin N-acetyltransferase activity in organ culture of chicken pineal gland. Science 1979; 203: 1245–7
  • Bolliet V, Begay V, Ravault J P, Ali M A, Collin J P, Falcon J. Multiple circadian oscillators in the photosensitive pike pineal gland: a study using organ and cell culture. J Pineal Res 1994; 16: 77–84
  • Binkley S A, Riebman J B, Reilly K B. The pineal gland: a biological clock in vitro. Science 1978; 202: 1198–201
  • Klein D C, Moore R Y. Pineal N-acetyltransferase and hydroxyindole-O-methyl-transferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus. Brain Res 1979; 174: 245–62
  • Takahashi J S, Zatz M. Regulation of circadian rhythmicity. Science 1982; 217: 1104–11
  • Moore R Y, Heller A, Bhatnager R K, Wurtman R J, Axelrod J. Central control of the pineal gland: visual pathways. Arch Neurol 1968; 18: 208–18
  • Sadun A A, Schaechter J D, Smith L EH. A retinohypothalamic pathway in man: light mediation of circadian rhythms. Brain Res 1984; 302: 371–7
  • Moore R Y. Organization and function of a central nervous system circadian oscillator: the suprachiasmatic hypothalamic nucleus. Fed Proc 1983; 42: 2783–9
  • Mess B, Ruzsas C. Central nervous regulation of pineal function. Pineal Res Rev 1987; 5: 191–216
  • Vakkuri O, Leppaluoto J, Kauppila A. Oral administration and distribution of melatonin in human serum, saliva and urine. Life Sci 1985; 37: 489–95
  • Waldhauser F, Lieberman H R, Lynch H J, Waldhauser M, Herkner K, Frisch H, Vierhapper H, Waldhausl W, Schemper M, Wurtman R J, Crowley W F. A pharmacological dose of melatonin increases PRL levels in males without altering those of GH, LH, FSH, TSH, testosterone or Cortisol. Neuroendocrinology 1987; 46: 125–30
  • Sack R L, Lewy A J, Blood M L, Stevenson J, Keith L D. Melatonin administration to blind people: phase advances and entrainment. J Biol Rhythms 1991; 6: 249–61
  • Dahlitz M, Alvarez B, Vignau J, English J, Arendt J, Parkes J D. Delayed sleep phase syndrome response to melatonin. Lancet 1991; 337: 1121–4
  • Petrie K, Conaglen J V, Thompson L, Chamberlain K. Effect of melatonin on jet lag after long haul flights. Br Med J 1989; 298: 705–7
  • Cagnacci A, Elliott J A, Yen S SC. Amplification of pulsatile LH secretion by exogenous melatonin in women. J Clin Endocrinol Metab 1991; 73: 210–2
  • Cagnacci A, Soldani R, Yen S SC. Melatonin enhances Cortisol levels in aged but not young women. Eur J Endocrinol 1995; 133: 691–5
  • Strassman R, Peake G, Quails C, Lisansky E. A model for the study of the acute effects of melatonin in man. J Clin Endocrinol Metab 1987; 65: 847–52
  • Anton-Tay F, Wurtman R J. Regional uptake of 3H-melatonin from blood or cerebrospinal fluid by rat brain. Nature 1969; 221: 474–5
  • Cardinali D P, Hyyppa M T, Wurtman R J. Fate of intracisternally injected melatonin in the rat brain. Neuroendocrinology 1973; 12: 30–40
  • Morgan P J, Williams L M. Central melatonin receptors: implications for a mode of action. Experientia 1989; 45: 955–65
  • Morgan P J, Barrett P, Howell H E, Helliwell R. Melatonin receptors: localization, molecular pharmacology and physiological significance. Neurochem Int 1994; 24: 101–46
  • Arendt J, Wetterberg L, Heyden T, Sizoneko P C, Paunier L. Radioimmunoassay of melatonin: human serum and cerebrospinal fluid. Hormone Res 1977; 8: 65–75
  • Brown G M, Young S N, Gauthier S, Tsui H, Grota L J. Melatonin in human cerebrospinal fluid in daytime: its origin and variation with age. Life Sci 1979; 25: 929–36
  • Bruce J, Tamarkin L, Riedel C, Markey S, Oldfield E. Sequential cerebrospinal fluid and plasma sampling in humans: 24-hour melatonin measurements in normal subjects and after peripheral sympathectomy. J Clin Endocrinol Metab 1991; 72: 819–23
  • Vaughan G M, McDonald S D, Jordan R M, Allen J P, Bohfalk G L, Abou-Samra M, Story J L. Melatonin concentration in human blood and cerebrospinal fluid: relationship to stress. J Clin Endocrinol Metab 1978; 47: 220–3
  • Tan C H, Khoo J CM. Melatonin concentrations in human serum, ventricular and lumbar cerebrospinal fluids as an index of the secretory pathway of the pineal gland. Hormone Res 1981; 14: 224–33
  • Smith J A, Mee T JX, Barnes N D, Thorburn R J, Barnes J LC. Melatonin in serum and cerebrospinal fluid. Lancet 1976; 2: 425
  • Shaw P F, Kennaway D J, Seamark R F. Evidence of high concentrations of melatonin in lateral ventricular cerebrospinal fluid of sheep. J Pineal Res 1989; 6: 201–8
  • Kanematsu N, Mori Y, Hayashi S, Hoshino K. Presence of a distinct 24-hour melatonin rhythm in the ventricular cerebrospinal fluid of the goat. J Pineal Res 1989; 7: 143–52
  • Vitte P A, Harthe C, Lestage P, Claustrat B, Bobillier P. Plasma cerebrospinal fluid, and brain distribution of 14C-Melatonin in rat: a biochemical and autoradiographic study. J Pineal Res 1988; 5: 437–53
  • Reppert S M, Perlow M J, Tamarkin L, Klein D C. A diurnal melatonin rhythm in primate cerebrospinal fluid. Endocrinology 1979; 104: 295–301
  • Cowen P J, Fraser S, Sammons R, Green A R. Atenolol reduces plasma melatonin concentration in man. Br J Clin Pharmacol 1983; 18: 579–81
  • Cowen P J, Bevan J S, Gosden B, Elliott S A. Treatment with β-adrenoceptor blockers reduces plasma melatonin concentrations. Br J Clin Pharmacol 1985; 19: 258–60
  • Arendt J, Bojkowski C, Franey C, Wright J, Marks V. Immunoassay of 6-hydroxy-melatonin sulfate in human plasma and urine: abolition of the urinary 24-hour rhythm with atenolol. J Clin Endocrinol Metab 1985; 60: 1166–73
  • Cagnacci A, Soldani R, Romagnolo C, Yen S SC. Melatonin-induced decrease of body temperature in women: a threshold event. Neuroendocrinology 1994; 60: 549–52
  • Brismar K, Mogensen L, Wetterberg L. Depressed melatonin secretion in patients with nightmares due to P-adrenoceptor blocking drugs. Acta Med Scand 1988; 221: 155–8
  • Rosenthal N E, Jacobsen F M, Sack D A, Arendt J, James S P, Parry B L, Wehr T A. Atenolol in seasonal affective disorders: a test of the melatonin hypothesis. Am J Psychiatry 1988; 145: 52–6
  • Demitrack M A, Lewy A J, Reus V I. Pineal-adrenal interactions: the effect of acute pharmacological blockade of nocturnal melatonin secretion. Psychiatry Res 1989; 32: 183–9
  • Lewy A J, Wehr T A, Goodwin F K, Newsome D A, Markey S P. Light suppresses melatonin secretion in humans. Science 1980; 210: 1267–9
  • McIntyre I M, Norman T R, Burrows G D, Armstrong S M. Quantal melatonin suppression by exposure to low intensity light in man. Life Sci 1989; 45: 327–32
  • Aschoff J, Wever R. The circadian system of man. Handbook of behavioral neurobiology and biological rhythms, J Aschoff. Plenum Press, New York 1981; 311–31
  • Wever R A. Light effects on human circadian rhythms: a review of recent and andechs experiments. J Biol Rhythms 1989; 4: 161–85
  • Cagnacci A, Elliott J A, Yen S SC. Melatonin: a major regulator of the circadian rhythm of core temperature in humans. J Clin Endocrinol Metab 1992; 75: 447–52
  • Shanahan T L, Czeisler C A. Light exposure induces equivalent phase shifts of the endogenous circadian rhythms of circulating plasma melatonin and core body temperature in men. J Clin Endocrinol Metab 1991; 73: 227–35
  • Carman J S, Post R M, Buswell R, Goodwin F K. Negative effect of melatonin on depression. Am J Psychiatry 1976; 133: 1181–3
  • Dollins A B, Zhdanova I V, Wurtman R J, Lynch H J, Deng M H. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci USA 1994; 91: 1824–8
  • Badia P, Myers B, Boecker M, Culpepper J, Harsh J. Bright light effects on body temperature, alertness, EEG and behavior. Physiol Behav 1991; 50: 583–8
  • Strassman R J, Quails C R, Lisansky E J, Peake G T. Elevated rectal temperature produced by all night bright light is reversed by melatonin infusion in men. J Appl Physiol 1991; 71: 2178–82
  • Cagnacci A, Soldani R, Yen S SC. The effect of light on core body temperature is mediated by melatonin in women. J Clin Endocrinol Metab 1993; 76: 1036–8
  • Cagnacci A, Soldani R, Laughlin G A, Yen S SC. Modification of circadian body temperature rhythm during the luteal menstrual phase: role of melatonin. J Appl Physiol 1996; 80: 25–9
  • Lee K A. Circadian temperature rhythms in relation to menstrual cycle phase. J Biol Rhythms 1988; 3: 255–63
  • Krauchi K, Wirz-Justice A. Circadian rhythm of heat production, heart rate, and skin and core temperature under unmasking conditions in men. Am J Physiol (Re-gul Integr Comp Physiol 36) 1994; 267: R818–R829
  • Aschoff J, Heise A. Thermal conductance in man: its dependence on time of day and ambient temperature. Advances in Climactic Physiology, S Itoh, H Og, H Yoshimura. Igako Shoin, Tokio 1972; 334–48
  • Boulant J A. Hypothalamic mechanisms in thermoregulation. Fed Proc 1982; 40: 2843–50
  • Bligh J. The central neurology of mammalian thermoregulation. Neuroscience 1979; 4: 1213–36
  • Anton-Tay F, Chou C, Anton S, Wurtman R J. Brain serotonin concentration: elevation following intraperitoneal administration of melatonin. Science 1968; 162: 277–8
  • Cassone V M, Lane R F, Menaker M. Daily rhythms of serotonin metabolism in the medial basal hypothalamus of the chicken: effects of pinealectomy and exogenous melatonin. Brain Res 1983; 289: 129–34
  • Eison A S, Freeman R F, Guss V B, Mullins U L, Wright R N. Melatonin agonists modulate 5-HT2A receptor-mediated neurotransmission: behavioral and biochemical studies in the rat. J Pharmacol Exp Ther 1995; 273: 304–8
  • Ruzsas C, De Gaetani C, Criscuolo M, Mess B, Trentini G P. Possible role of the midbrain serotonergic raphe nuclei in the regulation of ovulation exerted by melatonin in the rat. Neuroendocrinal Lett 1981; 3: 331–9
  • Viswanathan M, Laitinen J T, Saavedra J M. Expression of melatonin receptors in arteries involved in thermoregulation. Proc Natl Acad Sci USA 1990; 87: 6200–3
  • Seltzer A, Viswanathan M, Saavedra J M. Melatonin-binding sites in brain and caudal arteries of the female rat during the estrous cycle and after estrogen administration. Endocrinology 1992; 130: 1896–1902
  • Stankov B, Capsoni S, Lucini V, Fauteck J, Gatti S, Gridelli B, Biella G, Cozzi B, Fraschini F. Autoradiographic localization of putative melatonin receptors in the brains of two old world primates: Cercopithecus aethiops and Papio ursinus. Neuroscience 1993; 52: 459–68
  • Cagnacci A, Angiolucci M, Arangino S, Maschio E, Melis G B. The pulsatility index of the internal carotid artery of women is decreased by melatonin. J Endocrinol Invest 1996; 18(Suppl 5)37
  • Cagnacci A, Arangino S, Angiolucci M, Maschio E, Longu G, Melis G B. Potentially beneficial cardiovascular effects of melatonin administration in women. J Pineal Res 1996; 13, in press
  • Hayward J N, Baker M A. A comparative study of the role of the cerebral arterial blood in the regulation of brain temperature in five mammals. Brain Res 1969; 16: 417–40
  • Krause D N, Barrios V E, Duckies S P. Melatonin receptors mediate potentiation of contractile responses to adrenergic nerve stimulation in rat caudal artery. Eur J Pharmacol 1995; 276: 207–13
  • Cagnacci A, Soldani R, Yen S SC. Hypothermic effect of melatonin and nocturnal core body temperature decline are reduced in aged women. J Appl Physiol 1995; 78: 314–7
  • Leduc J. Effect of sympathectomy on heat production in rats exposed to cold. Isr J MedSci 1976; 12: 1099–1103
  • Swanson H E. Interrelationship between thyroxin and adrenalin in the regulation of oxygen consumption in the albino rat. Endocrinology 1956; 59: 217–25
  • Weeklley L B. Effects of melatonin on pulmonary and coronary vessels are exerted through perivascular nerves. Clin Auton Res 1993; 3: 45–7
  • Viswanathan M, Hissa R, George J C. Suppression of sympathetic nervous system by short photoperiod and melatonin in the Syrian hamster. Life Sci 1986; 38: 73–9
  • Melis G B, Cagnacci A, Paoletti A M, Soldani R, Orru M, Secci C. Melatonin administration increases TSH secretion in the follicular but not in the luteal phase of the woman menstrual cycle. J Endocrinol Invest 1996; 18(Suppl 5)37
  • Puig-Domingo M, Guerrero J M, Reiter R J, Tannenbaum M J, Hurlbut E C, Gonza-lez-Brito A, Santana C. Thyroxine 5′-deiodination in brown adipose tissue and pineal gland: implications for thermogenic regulation and role of melatonin. Endocrinology 1988; 123: 677–80
  • Reppert S M, Weaver D R, Ebisawa T. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian response. Neuron 1994; 13: 1177–85
  • Watts A G. The efferent projections of the suprachiasmatic nucleus: anatomical insights into the control of circadian rhythms. Suprachiasmatic nucleus: the mind's clock, D C Klein, R Y Moore, S M Reppert. Oxford University Press, New York 1991; 77–106
  • Moore R Y. Organization and function of a central nervous system circadian oscillator: the suprachiasmatic hypothalamic nucleus. Fed Proc 1983; 42: 2783–9
  • Cassone V M, Roberts M H, Moore R Y. Effects of melatonin on 2-deoxy-(l-14C)glucose uptake within rat suprachiasmatic nucleus. Am J Physiol 1988; 255: R332–R337
  • McArthur A J, Gillette M U, Prosser R A. Melatonin directly resets the rat suprachiasmatic circadian clock in vitro. Brain Res 1991; 565: 158–61
  • Margraf R R, Lynch G R. An in vitro circadian rhythm of melatonin sensitivity in the suprachiasmatic nucleus of the djungarian hamster, Phodopus sungorus. Brain Res 1993; 609: 45–50
  • Jiang Z G, Nelson C S, Allen C N. Melatonin activates an outward current and inhibits in rat suprachiasmatic nucleus neurons. Brain Res 1995; 687: 125–32
  • Mason R, Rusak B. Neurophysiological responses to melatonin in the SCN of short-day sensitive and refractory hamsters. Brain Res 1990; 533: 15–9
  • Cassone V M, Chesworth M J, Armstrong S M. Entrainment of rat circadian rhythms by daily injection of melatonin depends upon the hypothalamic suprachiasmatic nuclei. Physiol Behav 1986; 36: 1111–21
  • Bartness T J, Goldman B D, Bittman E L. SCN lesions block responses to systemic melatonin infusions in Siberian hamsters. Am J Physiol 1991; 260: R102–R112
  • Armstrong S M. Melatonin and circadian control in mammals. Experientia 1989; 45: 932–8
  • Dahlitz M, Alvarez B, Vignau J, English J, Arendt J, Parkes J D. Delayed sleep phase syndrome response to melatonin. Lancet 1991; 337: 1121–4
  • Petrie K, Dawson A G, Thompson L, Brook R. A double-blind trial of melatonin as a treatment for jet lag in international cabin crew. Biol Psychiatry 1993; 33: 526–30
  • Lewy A J, Ahmed S, Jackson M L, Sack R L. Melatonin shifts human circadian rhythms according to a phase-response curve. Chronobiol Int 1992; 9: 380–92
  • Zaidan R, Geoffriau M, Brun J, Taillard J, Bureau C, Chazot G, Claustrat B. Melatonin is able to influence its secretion in humans: description of a phase-response-curve. Neuroendocrinology 1994; 60: 105–12
  • Deacon S, English J, Arendt J. Acute phase-shifting effects of melatonin associated with suppression of core body temperature in humans. Neurosci Lett 1994; 178: 32–4
  • Owen J, Arendt J. Melatonin suppression in human subjects by bright and dim light in Antarctica: time and season-dependent effects. Neurosci Lett 1992; 137: 181–4
  • Underwood H, Calaban M. Pineal melatonin rhythms in the lizard Anolis caroline-nsis. I. Response to light and temperature cycles. J Biol Rhythms 1987; 2: 179–93
  • Firth B T, Kennaway D J. Thermoperiod and photoperiod interact to affect the phase of the plasma melatonin rhythm in the lizard, Tiliqua rugosa. Neurosci Lett 1989; 106: 125–30
  • Max M, Menaker M. Regulation of melatonin production by light, darkness, and temperature in the trout pineal. J Comp Physiol 1992; 170: 479–89
  • Falcon J, Bolliet V, Ravault J P, Chesneau D, Ali M A, Collin J P. Rhythmic secretion of melatonin by the superfused pike pineal organ: thermo- and photoperiod interaction. Neuroendocrinology 1994; 60: 535–43
  • Wever R A. Zur zeitgeber-staerke eines licht-dunkel-wechels fuer die circadiane periodik des menschen. Eur J Physiol 1970; 321: 133–42
  • Czeisler C A, Allan J S, Strogatz S H, Ronda R, Sanchez R, Rios C D, Freitag W O, Richardson G S, Kronauer R E. Bright light resets the human circadian pacemaker independent on the timing of the sleep-wake cycle. Science 1986; 233: 667–71
  • Minors D S, Waterhouse J W, Wirz-Justice A. A human phase-response curve to light. Neurosci Lett 1991; 133: 36–40
  • Honma K, Honma S. A human phase response curve for bright light pulses. Jpn J Psychiatr Neurol 1988; 42: 167–8
  • Beersma D GM, Daan S. Strong and weak phase resetting by light pulses in humans?. J Biol Rhythms 1993; 8: 340–7
  • Kronauer R E, Jewett M E, Czeisler C A. Commentary: the human circadian response to light. Strong and weak resetting. J Biol Rhythms 1993; 8: 351–60
  • Moore-Ede M C, Czeisler C A, Richardson G S. Circadian time-keeping in health and disease. II. Clinical implications of circadian rhy thmicity. N Engl J Med 1983; 309: 530–6
  • Czeisler C A, Johnson M P, Duffy J F, Brown E N, Ronda J M, Kronauer R E. Exposure to bright light and darkness to treat physiologic maladaptation to night work. N Engl J Med 1990; 332: 1253–9
  • Rosenthal N E, Sack D A, Carpenter C J, Parry B L, Mendelson W B, Wehr T A. Antidepressant effects of light in seasonal affective disorders. Am J Psychol 1985; 142: 163–70
  • Lewy A J, Sack R L, Miller S, Hoban T M. Antidepressant and circadian phase-shifting effects of light. Science 1987; 235: 352–4
  • Bovin D B, Duffy J F, Kronauer R E, Czeisler C A. Dose-response relationships for resetting of human circadian clock by light. Nature 1996; 379: 540–2
  • McIntyre I M, Norman T R, Burrows G D, Armstrong S M. Human melatonin suppression by light is intensity dependent. J Pineal Res 1989; 6: 149–56
  • Cassone V M, Chesworth M J, Armstrong S M. Dose-dependent entrainment of rat circadian rhythms by daily injection of melatonin. J Biol Rhythms 1986; 1: 219–29
  • Cagnacci A, Soldani R, Yen S SC. Bright light induced circadian phase-shift is antagonized by contemporaneous melatonin administration. 77th Annual Meeting of the Endocrine Society, Washington, DC, June, 14–171995, 1–97
  • Cagnacci A, Soldani R, Yen S SC. Contemporaneous melatonin administration modifies the circadian response to nocturnal bright light stimuli. Am J Physiol 1997; 272, in press
  • Hofman M A, Swaab D F. Diurnal and seasonal rhythms of neuronal activity in the suprachiasmatic nucleus of humans. J Biol Rhythms 1993; 8: 283–95
  • Green D J, Gillette R. Circadian rhythm of firing rate recorded from single cell in the rat suprachiasmatic brain slice. Brain Res 1982; 245: 192–200
  • Gauer F, Masson-Pevet M, Pevet P. Melatonin receptor density is regulated in rat pars tuberalis and suprachiasmatic nuclei by melatonin itself. Brain Res 1993; 602: 153–6
  • Yuan H, Pang S F. (125I)Iodomelatonin binding sites in the chicken brain: diurnal variation and effects of melatonin injection or pinealectomy. Biol Signals 1992; 1: 208–18
  • Iigo M, Furukawa K, Hattori A, Hara M, Ohtani-Kaneko R, Suzuki T, Tabata M, Aida K. Effects of pinealectomy and constant light exposure on day-night changes of melatonin binding sites in the goldfish brain. Neurosci Lett 1995; 197: 61–4
  • Vacas M I, Cardinali D P. Diurnal changes in melatonin binding sites of hamster and rat brains: correlation with neuroendocrine responsiveness. Neurosci Lett 1979; 15: 173–9
  • Margraf R R, Lynch G R. Melatonin injections affects circadian behavior and SCN neurophysiology in Djungarian hamsters. Am J Physiol 1993; 264: R615–21
  • Yu G D, Rusak B, Piggins H D. Regulation of melatonin-sensitivity and firing-rate rhythms of hamster suprachiasmatic nucleus neurons: constant light effects. Brain Res 1993; 602: 191–9
  • Rusak B, Yu G D. Regulation of melatonin-sensitivity and firing-rate rhythms of hamster suprachiasmatic nuclei neurons: pinealectomy effects. Brain Res 1993; 602: 200–4
  • Warren W S, Hodges D B, Cassone V M. Pinealectomized rats entrain and phase shift to melatonin injections in a dose-dependent manner. J Biol Rhythms 1993; 8: 233–45
  • Chesworth M J, Cassone V M, Armstrong S M. Effects of daily melatonin injections on activity rhythms of rats in constant light. Am J Physiol 1987; 253: R101–R107
  • Hau M, Gwinner E. Continuous melatonin administration accelerates resynchroni-zation following phase shifts of a light-dark cycle. Physiol Behav 1995; 58: 89–95
  • Illnerova H. The suprachiasmatic nucleus and rhythmic pineal melatonin production. Suprachiasmatic nucleus, the mind clock, D C Klein, R Y Moore, S M Reppert. Oxford University Press, Oxford, New York 1991; 197–216
  • Elliott J A, Tamarkin L. Complex circadian regulation of pineal melatonin and wheel-running in Syrian hamsters. J Comp Physiol A 1994; 174: 469–84
  • Wehr T A, Moul D E, Barbato G, Giesen H A, Seidel J A, Barker C, Bender C. Conservation of photoperiod-responsive mechanisms in humans. Am J Physiol 1993; 265: R846–R857
  • Wehr T A, Schwartz P J, Turner E H, Feldman-Naim S, Drake C L, Rosenthal N E. Bimodal patterns of human melatonin secretion consistent with a two-oscillator model of regulation. Neurosci Lett 1995; 194: 105–8

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