Glucose Tolerance in Mice is Linked to the Dose of the p53 Transactivation Domain

REFERENCES

• Eizenberg O, Faber-Elman A, Gottlieb E, Oren M, Rotter V, Schwartz M. Direct involvement of p53 in programmed cell death of oligodendrocytes. EMBO J 1995;14:1136–1144.
   PubMed Web of Science ®Google Scholar
• Mercer J, Figg N, Stoneman V, Braganza D, Bennett MR. Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice. Circ Res 2005;96:667–674.
   PubMed Web of Science ®Google Scholar
• Moon C, Kim S, Wie M, Increased expression of p53 and Bax in the spinal cords of rats with experimental autoimmune encephalomyelitis. Neurosci Lett 2000;289:41–44.
   PubMedGoogle Scholar
• Sakhi S, Bruce A, Sun N, Tocco G, Baudry M, Schreiber SS. p53 induction is associated with neuronal damage in the central nervous system. Proc Natl Acad Sci USA 1994;91:7525–7529.
   PubMedGoogle Scholar
• van Vlijmen BJ, Gerritsen G, Franken AL, Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE*3-Leiden transgenic mice. Circ Res 2001;88:780–786.
   PubMed Web of Science ®Google Scholar
• Yamanishi Y, Boyle DL, Pinkoski MJ, Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis. Am J Pathol 2002;160:123–130.
   PubMed Web of Science ®Google Scholar
• Yeung SJ, Pan J, Lee MH. Roles of p53, MYC and HIF-1 in regulating glycolysis—the seventh hallmark of cancer. Cell Mol Life Sci 2008;65:3981–3999.
   PubMed Web of Science ®Google Scholar
• Fiordaliso F, Leri A, Cesselli D, Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death. Diabetes 2001;50:2363–2375.
   PubMed Web of Science ®Google Scholar
• Keim AL, Chi MM, Moley KH. Hyperglycemia-induced apoptotic cell death in the mouse blastocyst is dependent on expression of p53. Mol Reprod Dev 2001;60:214–224.
   PubMed Web of Science ®Google Scholar
• Gottlieb E, Vousden KH. p53 regulation of metabolic pathways. Cold Spring Harb Perspect Niol 2010;50:a001040.
   Google Scholar
• Schwartzenberg-Bar-Yoseph F, Armoni M, Karnieli E. The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res 2004;64:2627–2633.
   PubMed Web of Science ®Google Scholar
• Werner H, Karnieli E, Rauscher FJ, LeRoith D. Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc Natl Acad Sci USA 1996;93:8318–8323
   PubMed Web of Science ®Google Scholar
• Jiang P, Du W, Wang X, p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol 2011;13:310–316.
   PubMed Web of Science ®Google Scholar
• Matoba S, Kang JG, Patino WD, p53 regulates mitochondrial respiration. Science 2006;312:1650–1653.
   PubMed Web of Science ®Google Scholar
• Kawagishi H, Wakoh T, Uno H, Hzf regulates adipogenesis through translational control of C/EBPalpha. EMBO J 2008;27:1481–1490.
   PubMed Web of Science ®Google Scholar
• Minamino T, Orimo M, Shimizu I, A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 2009;15:1082–1087.
   PubMed Web of Science ®Google Scholar
• Zheng SJ, Lamhamedi-Cherradi SE, Wang P, Xu L, Chen YH. Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes 2005;54:1423–1428.
   PubMedGoogle Scholar
• Bar RS, Levis WR, Rechler MM, Extreme insulin resistance in ataxia telangiectasia: defect in affinity of insulin receptors. N Engl J Med 1978;298:1164–1171.
   PubMed Web of Science ®Google Scholar
• Miles PD, Treuner K, Latronica M, Olefsky JM, Barlow C. Impaired insulin secretion in a mouse model of ataxia telangiectasia. Am J Physiol Endocrinol Metab 2007;293:E70–74.
   Google Scholar
• Schalch DS, McFarlin DE, Barlow MH. An unusual form of diabetes mellitus in ataxia telangiectasia. N Engl J Med 1970;282:1396–1402.
   PubMed Web of Science ®Google Scholar
• Schneider JG, Finck BN, Ren J, ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab 2006;4:377–389.
   PubMed Web of Science ®Google Scholar
• Yang DQ, Kastan MB. Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nat Cell Biol 2000;2:893–898.
   PubMed Web of Science ®Google Scholar
• Armata HL, Golebiowski D, Jung DY, Ko HJ, Kim JK, Sluss HK. Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis. Mol Cell Biol 2010;30:5787–5794.
   PubMed Web of Science ®Google Scholar
• Sluss HK, Armata H, Gallant J, Jones SN. Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol Cell Biol 2004;24:976–984.
   PubMedGoogle Scholar
• Donehower LA, Harvey M, Slagle BL, Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992;356:215–221.
   PubMed Web of Science ®Google Scholar
• Maier B, Gluba W, Bernier B, Modulation of mammalian life span by the short isoform of p53. Genes Dev 2004;18:306–319.
   PubMed Web of Science ®Google Scholar
• Garcia-Cao I, Garcia-Cao M, Martin-Caballero J, “Super p53” mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J 2002;21:6225–6235.
   PubMed Web of Science ®Google Scholar
• Kim HJ, Higashimori T, Park SY, Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 2004;53:1060–1067.
   PubMed Web of Science ®Google Scholar
• Borst SE. The role of TNF-alpha in insulin resistance. Endocrine 2004;23:177–182.
   PubMed Web of Science ®Google Scholar
• Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 2005;115:1111–1119.
   PubMed Web of Science ®Google Scholar
• Turenne GA, Paul P, Laflair L, Price BD. Activation of p53 transcriptional activity requires ATM’s kinase domain and multiple N-terminal serine residues of p53. Oncogene 2001;20:5100–5110.
   PubMed Web of Science ®Google Scholar
• Hinault C, Kawamori D, Liew CW, Delta40 isoform of p53 controls beta-cell proliferation and glucose homeostasis in mice. Diabetes 2011;60:1210–1222.
   PubMed Web of Science ®Google Scholar
• Shoelson SE. Banking on ATM as a new target in metabolic syndrome. Cell Metab 2006;4:337–338.
   PubMedGoogle Scholar
• Ungewitter E, Scrable H. Delta40p53 controls the switch from pluripotency to differentiation by regulating IGF signaling in ESCs. Genes Dev 2010;24:2408–2419.
   PubMed Web of Science ®Google Scholar
• Hinault C, Kawamori D, Liew CW, Δ40 isoform of p53 controls β-cell proliferation and glucose homeostasis in mice. Diabetes 2011;60:1210–1222.
   PubMed Web of Science ®Google Scholar