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Original Articles

Mitochondrial DNA content and function, childhood obesity, and insulin resistance

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Pages 49-56 | Received 21 Oct 2014, Accepted 24 Jun 2015, Published online: 29 Oct 2015

References

  • Weiss R, Kaufman FR. Metabolic complications of childhood obesity. Diabetes Care 2008;31:S310–16
  • Franks PW, Hanson RL, Knowler WC, et al. Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med 2010;62:485–93
  • Morrison JA, Glueck CJ, Horn PS, et al. Childhood predictors of adult type 2 diabetes at 9- and 26-year follow-ups. Arch Pediatr Adolesc Med 2010;164:53–60
  • Morrison JA, Glueck CJ, Umar M, et al. Hyperinsulinemia and metabolic syndrome at mean age of 10 years in black and white schoolgirls and development of impaired fasting glucose and type 2 diabetes mellitus by mean age of 24years. Metabolism 2011;60:24–31
  • Ren J, Pulakat L, Whaley-Connell A, et al. Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease. J Mol Med (Berl) 2010;88:993–1001
  • Nisoli E, Clementi E, Carruba MO, et al. Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome? Circ Res 2007;100:795–806
  • Barrientos A, Casademont J, Cardellach F, et al. Qualitative and quantitative changes in skeletal muscle mtDNA and expression of mitochondrial-encoded genes in the human aging process. Biochem Mol Med 1997;62:165–71
  • Lee HC, Lim ML, Lu CY, et al. Concurrent increase of oxidative DNA damage and lipid peroxidation together with mitochondrial DNA mutation in human lung tissues during aging – smoking enhances oxidative stress on the aged tissues. Arch Biochem Biophys 1999;362:309–16
  • Lee HC, Yin PH, Lu CY, et al. Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells. Biochem J 2000;348:425–32
  • De Naeyer H, Ouwens DM, Van Nieuwenhove Y, et al. Combined gene and protein expression of hormone-sensitive lipase and adipose triglyceride lipase, mitochondrial content, and adipocyte size in subcutaneous and visceral adipose tissue of morbidly obese men. Obes Facts 2011;4:407–16
  • Kaaman M, Sparks LM, Harmelen VV, et al. Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue. Diabetologia 2007;50:2526–33
  • Hancock CR, Han DH, Chen M, et al. High-fat diets cause insulin resistance despite an increase in muscle mitochondria. Proc Natl Acad Sci USA 2008;105:7815–20
  • Turner N, Bruce CR, Beale SM, et al. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes 2007;56:2085–92
  • Igosheva N, Abramov AY, Poston L, et al. Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PLoS One 2010;5:e10074
  • Lee HK, Song JH, Shin CS, et al. Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 1998;42:161–7
  • Lee HK, Park KS, Cho YM, et al. Mitochondria-based model for fetal origin of adult disease and insulin resistance. Ann NY Acad Sci 2005;1042:1–18
  • Weng SW, Lin TK, Liou CW, et al. Peripheral blood mitochondrial DNA content and dysregulation of glucose metabolism. Diabetes Res Clin Pract 2009;83:94–9
  • Malik AN, Shahni R, Iqbal MM. Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy. Diabetes Res Clin Pract 2009;86:e22–4
  • Centers for Disease Control and Prevention. Introducing to Epi Info™. Available at:http://wwwn.cdc.gov/epiinfo/
  • Willis JH, Capald RA, Huigsloot M, et al. Isolated deficiencies of OXPHOS complexes I and IV are identified accurately and quickly by simple enzyme activity immunocapture assays. Biochim Biophys Acta 2009;1787:533–8
  • Goldenthal MJ, Kuruvilla T, Damle S, et al. Non-invasive evaluation of buccal respiratory chain enzyme dysfunction in mitochondrial disease: comparison with studies in muscle biopsy. Mol Genet Metab 2012;105:457–62
  • Yakes FM, Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA 1997;94:514–19
  • Malik A, Czajka A. Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction? Mitochondrion 2013 Sep;13:481–92
  • Mieldazis SF, Azzalis LA, Junqueira VB, et al. Hyperinsulinism assessment in a sample of prepubescent children. J Pediatr 2010;86:245–9
  • Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412–19
  • Yeckel CW, Weiss R, Dziura J, et al. Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescents. J Clin Endocrinol Metab 2004;89:1096–101
  • Danadian K, Balasekaran G, Lewy V, et al. Insulin sensitivity in African-American children with and without family history of type 2 diabetes. Diabetes Care 1999;22:1325–9
  • G*Power 3. Available at:http://www.psycho.uni- duesseldorf.de /abteilungen /aap/gpower3/
  • DiMauro S, Schon EA. Mitochondrial respiratory-chain diseases. NEJM 2003;348:2656–68
  • Wilms L, Larsen J, Pedersen P, et al.Evidence of mitochondrial dysfunction in obese adolescents. Acta Paediatr2009;http://www3.interscience.wiley.com/cgi-bin/help?page=HELP_syndication99:906-911
  • Kim JA, Wei Y, Sowers JR. Role of mitochondrial dysfunction in insulin resistance. Circ Res 2008;102:401–14
  • Morino K, Petersen KF, Shulman GI. Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes 2006;55:S9–15
  • Lindinger A, Peterli R, Peters T, et al. Mitochondrial DNA content in human omental adipose tissue. Obes Surg 2010;20:84–92
  • Cormio A, Milella F, Marra M,et al. Variations at the H-strand replication origins of mitochondrial DNA and mitochondrial DNA content in the blood of type 2 diabetes patients. Biochim Biophys Acta 2009;1787:547–52
  • Stump CS, Short KR, Bigelow ML, et al. Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts. Proc Natl Acad Sci USA 2003;100:7996–8001
  • Boirie Y, Short KR, Ahlman B, et al. Tissue-specific regulation of mitochondrial and cytoplasmic protein synthesis rates by insulin. Diabetes 2001;50:2652–8
  • Han DH, Hancock CR, Jung SR, et al. Deficiency of the mitochondrial electron transport chain in muscle does not cause insulin resistance. PLoS One 2011;6:e19739
  • Sleigh A, Raymond-Barker P, Thackray K,et al. Mitochondrial dysfunction in patients with primary congenital insulin resistance. J Clin Invest 2011;121:2457–61
  • Larsen S, Stride N, Hey-Mogensen M, et al. Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes. Diabetologia 2011;54:1427–36
  • Capková M, Houstek J, Hansíková H, et al. Activities of cytochrome c oxidase and citrate synthase in lymphocytes of obese and normal-weight subjects. Int J Obes Relat Metab Disord 2002;26:1110–17
  • Hoeks J, Wilde JD, Hulshof MF, et al. High fat diet-induced changes in mouse muscle mitochondrial phospholipids do not impair mitochondrial respiration despite insulin resistance. PLoS One 2011;6:e27274
  • Liu CS, Tsai CS, Kuo CL,et al. Oxidative stress-related alteration of the copy number of mitochondrial DNA in human leukocytes. Free Radic Res 2003;37:1307–17
  • Holmström MH, Iglesias-Gutierrez E, Zierath JR. Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab 2012;302:E731–9
  • Nadal-Casellas A, Bauzá-Thorbrügge M, Proenza AM,et al. Sex-dependent differences in rat brown adipose tissue mitochondrial biogenesis and insulin signaling parameters in response to an obesogenic diet. Mol Cell Biochem 2013 Jan;373:125–35
  • Barbalat R, Ewald SE, Mouchess ML, et al. Nucleic acid recognition by the innate immune system. Annu Rev Immunol 2011;29:185–214
  • Collins LV, Hajizadeh S, Holme E, et al. Mitochondrial DNA content in human omental adipose tissue. Obes Surg 2010;20:84–92
  • Zhang Y, Lee AS, Shameli A, et al. TLR9 blockade inhibits activation of diabetogenic CD8+ T cells and delays autoimmune diabetes. J Immunol 2010;184:5645–53
  • Bournat JC, Brown CW. Mitochondrial dysfunction in obesity. Curr Opin Endocrinol Diabetes Obes 2010;17:446–52
  • Oka T, Hikoso S, Yamaguchi O, et al. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 2012;485:251–5
  • Bondia-Pons I, Ryan L, Martinez JA. Oxidative stress and inflammation interactions in human obesity. J Physiol Biochem 2012 Dec;68:701–11
  • Martínez JA. Mitochondrial oxidative stress and inflammation: an slalom to obesity and insulin resistance. J Physiol Biochem 2006;62:303–6

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