White matter hyperintensities – from medical comorbidities to bipolar disorders and back

References

• Hajek T, Slaney C, Garnham J, Ruzickova M, Passmore M, Alda M. Clinical correlates of current level of functioning in primary care-treated bipolar patients. Bipolar Disord. 2005;7:286–91.
   PubMed Web of Science ®Google Scholar
• Begley CE, Annegers JF, Swann AC, Lewis C, Coan S, Schnapp WB, . The lifetime cost of bipolar disorder in the US: an estimate for new cases in 1998. Pharmacoeconomics. 2001;19:483–95.
   PubMed Web of Science ®Google Scholar
• Hirschfeld RM, Lewis L, Vornik LA. Perceptions and impact of bipolar disorder: how far have we really come? Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorder. J Clin Psychiatry. 2003;64:161–74.
   PubMed Web of Science ®Google Scholar
• Ghaemi SN, Sachs GS, Chiou AM, Pandurangi AK, Goodwin K. Is bipolar disorder still underdiagnosed? Are antidepressants overutilized? J Affect Disord. 1999;52:135–44.
   PubMed Web of Science ®Google Scholar
• McDonald C, Zanelli J, Rabe-Hesketh S, Ellison-Wright I, Sham P, Kalidindi S, . Meta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorder. Biol Psychiatry. 2004;56:411–7.
   PubMed Web of Science ®Google Scholar
• Beyer JL, Young R, Kuchibhatla M, Krishnan KR. Hyperintense MRI lesions in bipolar disorder: A meta-analysis and review. Int Rev Psychiatry. 2009;21:394–409.
   PubMed Web of Science ®Google Scholar
• Thomas AJ, O'Brien JT, Barber R, McMeekin W, Perry R. A neuropathological study of periventricular white matter hyperintensities in major depression. J Affect Disord. 2003; 76:49–54.
   Web of Science ®Google Scholar
• Thomas AJ, Perry R, Barber R, Kalaria RN, O'Brien JT. Pathologies and pathological mechanisms for white matter hyperintensities in depression. Ann N Y Acad Sci. 2002;977:333–9.
   Google Scholar
• Manolio TA, Kronmal RA, Burke GL, Poirier V, O'Leary DH, Gardin JM, . Magnetic resonance abnormalities and cardiovascular disease in older adults. The Cardiovascular Health Study. Stroke. 1994;25:318–27.
   PubMed Web of Science ®Google Scholar
• Ahearn EP, Speer MC, Chen YT, Steffens DC, Cassidy F, Van Meter S, . Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype. Am J Med Genet. 2002;114:652–8.
   PubMedGoogle Scholar
• Hirono N, Yasuda M, Tanimukai S, Kitagaki H, Mori E. Effect of the apolipoprotein E {epsilon}4 allele on white matter hyperintensities in dementia. Stroke. 2000;31:1263–8.
   Google Scholar
• Ormerod IE, Miller DH, McDonald WI, du Boulay EP, Rudge P, Kendall BE, . The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions. A quantitative study. Brain. 1987;110(Pt 6):1579–616.
   Google Scholar
• Wong V. Occipital deep white matter hyperintensities in autism spectrum disorder. Pediatr Int. 2007;49:513–5.
   Google Scholar
• Lyoo IK, Lee HK, Jung JH, Noam GG, Renshaw PF. White matter hyperintensities on magnetic resonance imaging of the brain in children with psychiatric disorders. Compr Psychiatry. 2002;43:361–8.
   PubMed Web of Science ®Google Scholar
• Swartz RH, Kern RZ. Migraine is associated with magnetic resonance imaging white matter abnormalities: a meta-analysis. Arch Neurol. 2004;61:1366–8.
   PubMedGoogle Scholar
• Rocca MA, Colombo B, Pratesi A, Comi G, Filippi M. A magnetization transfer imaging study of the brain in patients with migraine. Neurology. 2000;54:507–9.
   Google Scholar
• Schmidt R, Fazekas F, Kleinert G, Offenbacher H, Gindl K, Payer F, . Magnetic resonance imaging signal hyperintensities in the deep and subcortical white matter. A comparative study between stroke patients and normal volunteers. Arch Neurol. 1992;49:825–7.
   PubMed Web of Science ®Google Scholar
• Bokura H, Yamaguchi S, Iijima K, Nagai A, Oguro H. Metabolic syndrome is associated with silent ischemic brain lesions. Stroke. 2008;39:1607–9.
   Google Scholar
• Murray AD, Staff RT, Shenkin SD, Deary IJ, Starr JM, Whalley LJ. Brain white matter hyperintensities: relative importance of vascular risk factors in nondemented elderly people. Radiology. 2005;237:251–7.
   PubMed Web of Science ®Google Scholar
• Wardlaw JM, Sandercock PAG, Dennis MS, Starr J. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke. 2003;34:806–12.
   PubMed Web of Science ®Google Scholar
• Liao D, Higgins M, Bryan NR, Eigenbrodt ML, Chambless LE, Lamar V, . Lower pulmonary function and cerebral subclinical abnormalities detected by MRI: the Atherosclerosis Risk in Communities study. Chest. 1999;116:150–6.
   PubMed Web of Science ®Google Scholar
• Fiedorowicz JG, Palagummi NM, Forman-Hoffman VL, Miller DD, Haynes WG. Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder. Ann Clin Psychiatry. 2008;20:131–7.
   PubMed Web of Science ®Google Scholar
• Angst F, Stassen HH, Clayton PJ, Angst J. Mortality of patients with mood disorders: follow-up over 34–38 years. J Affect Disord. 2002;68:167–81.
   PubMed Web of Science ®Google Scholar
• Regenold WT, Thapar RK, Marano C, Gavirneni S, Kondapavuluru PV. Increased prevalence of type 2 diabetes mellitus among psychiatric inpatients with bipolar I affective and schizoaffective disorders independent of psychotropic drug use. J Affect Disord. 2002;70:19–26.
   PubMed Web of Science ®Google Scholar
• Taylor V, MacQueen G. Associations between bipolar disorder and metabolic syndrome: A review. J Clin Psychiatry. 2006;67:1034–41.
   PubMed Web of Science ®Google Scholar
• Meijer L, Flajolet M, Greengard P. Pharmacological inhibitors of glycogen synthase kinase 3. Trends Pharmacol Sci. 2004;25:471–80.
   PubMed Web of Science ®Google Scholar
• Krabbe KS, Nielsen AR, Krogh-Madsen R, Plomgaard P, Rasmussen P, Erikstrup C, . Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia. 2007;50:431–8.
   PubMed Web of Science ®Google Scholar
• Steffens DC, Krishnan KR. Structural neuroimaging and mood disorders: recent findings, implications for classification, and future directions. Biol Psychiatry. 1998;43:705–12.
   PubMed Web of Science ®Google Scholar
• Aylward EH, Roberts-Twillie JV, Barta PE, Kumar AJ, Harris GJ, Geer M, . Basal ganglia volumes and white matter hyperintensities in patients with bipolar disorder. Am J Psychiatry. 1994;151:687–93.
   PubMed Web of Science ®Google Scholar
• Kato T, Fujii K, Kamiya A, Kato N. White matter hyperintensity detected by magnetic resonance imaging and lithium response in bipolar disorder: a preliminary observation. Psychiatry Clin Neurosci. 2000;54:117–20.
   PubMedGoogle Scholar
• Sassi RB, Brambilla P, Nicoletti M, Mallinger AG, Frank E, Kupfer DJ, . White matter hyperintensities in bipolar and unipolar patients with relatively mild-to-moderate illness severity. J Affect Disord. 2003;77:237–45.
   PubMed Web of Science ®Google Scholar
• Gunde E, Novak T, Kopecek M, Schmidt M, Propper L, Stopkova P, . White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: A two-center high-risk study. J Psychiatr Res. 2011;45:76–82.
   Google Scholar
• Persaud R, Russow H, Harvey I, Lewis SW, Ron M, Murray RM, . Focal signal hyperintensities in schizophrenia. Schizophr Res. 1997;27:55–64.
   PubMedGoogle Scholar
• Takahashi K, Oshima A, Ida I, Kumano H, Yuuki N, Fukuda M, . Relationship between age at onset and magnetic resonance image-defined hyperintensities in mood disorders. J Psychiatr Res. 2008;42:443–50.
   Google Scholar
• Deicken RF, Reus VI, Manfredi L, Wolkowitz OM. MRI deep white matter hyperintensity in a psychiatric population. Biol Psychiatry. 1991;29:918–22.
   PubMed Web of Science ®Google Scholar
• Hickie I, Scott E, Mitchell P, Wilhelm K, Austin MP, Bennett B. Subcortical hyperintensities on magnetic resonance imaging: Clinical correlates and prognostic significance in patients with severe depression. Biol Psychiatry. 1995;37:151–60.
   PubMed Web of Science ®Google Scholar
• Tamashiro JH, Zung S, Zanetti MV, de Castro CC, Vallada H, Busatto GF, . Increased rates of white matter hyperintensities in late-onset bipolar disorder. Bipolar Disord. 2008;10:765–75.
   PubMed Web of Science ®Google Scholar
• Zanetti MV, Cordeiro Q, Busatto GF. Late onset bipolar disorder associated with white matter hyperintensities: a pathophysiological hypothesis. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:551–6.
   PubMed Web of Science ®Google Scholar
• Swayze VW, Andreasen NC, Alliger RJ, Ehrhardt JC, Yuh WT. Structural brain abnormalities in bipolar affective disorder. Ventricular enlargement and focal signal hyperintensities. Arch Gen Psychiatry. 1990;47:1054–9.
   PubMedGoogle Scholar
• Pillai JJ, Friedman L, Stuve TA, Trinidad S, Jesberger JA, Lewin JS, . Increased presence of white matter hyperintensities in adolescent patients with bipolar disorder. Psychiatry Res. 2002;114:51–6.
   PubMed Web of Science ®Google Scholar
• Figiel GS, Krishnan KR, Rao VP, Doraiswamy M, Ellinwood EH Jr, Nemeroff CB, . Subcortical hyperintensities on brain magnetic resonance imaging: a comparison of normal and bipolar subjects. J Neuropsychiatry Clin Neurosci. 1991;3:18–22.
   PubMedGoogle Scholar
• Gulseren S, Gurcan M, Gulseren L, Gelal F, Erol A. T2 hyperintensities in bipolar patients and their healthy siblings. Arch Med Res. 2006;37:79–85.
   PubMed Web of Science ®Google Scholar
• McDonald WM, Tupler LA, Marsteller FA, Figiel GS, DiSouza S, Nemeroff CB, . Hyperintense lesions on magnetic resonance images in bipolar disorder. Biol Psychiatry. 1999;45:965–71.
   Google Scholar
• Schurhoff F, Bellivier F, Jouvent R, Mouren-Siméoni MC, Bouvard M, Allilaire JF, . Early and late onset bipolar disorders: two different forms of manic-depressive illness? J Affect Disord. 2000;58:215–21.
   PubMed Web of Science ®Google Scholar
• Atwood LD, Wolf PA, Heard-Costa NL, . Genetic variation in white matter hyperintensity volume in the Framingham Study. Stroke. 2004;35:1609–13.
   PubMed Web of Science ®Google Scholar
• de Leeuw FE, Richard F, de Groot JC, van Duijn CM, Hofman A, Van Gijn J, . Interaction between hypertension, apoE, and cerebral white matter lesions. Stroke. 2004;35:1057–60.
   PubMed Web of Science ®Google Scholar
• Dichgans M, Mayer M, Uttner I, Brüning R, Müller-Höcker J, Rungger G, . The phenotypic spectrum of CADASIL: clinical findings in 102 cases. Ann Neurol. 1998;44:731–9.
   PubMed Web of Science ®Google Scholar
• Bellivier F, Laplanche JL, Schürhoff F, Feingold J, Féline A, Jouvent R, . Apolipoprotein E gene polymorphism in early and late onset bipolar patients. Neurosci Lett. 1997;233:45–8.
   Google Scholar
• Corbo RM, Scacchi R. Apolipoprotein E (APOE) allele distribution in the world. Is APOE *4 a ‘thrifty’ allele? Ann Hum Genet. 1999;63:301–10.
   PubMed Web of Science ®Google Scholar
• Ahearn EP, Steffens DC, Cassidy F, Van Meter SA, Provenzale JM, Seldin MF, . Familial leukoencephalopathy in bipolar disorder. Am J Psychiatry. 1998;155:1605–7.
   PubMedGoogle Scholar
• Barkovich AJ. Concepts of myelin and myelination in neuroradiology. AJNR Am J Neuroradiol. 2000;21:1099–109.
   PubMed Web of Science ®Google Scholar
• Whitlock FA, Siskind MM. Depression as a major symptom of multiple sclerosis. J Neurol Neurosurg Psychiatry. 1980;43:861–5.
   PubMed Web of Science ®Google Scholar
• Bozikas VP, Anagnostouli MC, Petrikis P, Sitzoglou C, Phokas C, Tsakanikas C, . Familial bipolar disorder and multiple sclerosis: a three-generation HLA family study. Prog Neuropsychopharmacol Biol Psychiatry. 2003; 27:835–9.
   PubMed Web of Science ®Google Scholar
• Edwards LJ, Constantinescu CS. A prospective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic. Mult Scler. 2004;10:575–81.
   PubMed Web of Science ®Google Scholar
• Fisk JD, Morehouse SA, Brown MG, Skedgel C, Murray TJ. Hospital-based psychiatric service utilization and morbidity in multiple sclerosis. Can J Neurol Sci. 1998;25:230–5.
   PubMed Web of Science ®Google Scholar
• Asghar-Ali AA, Taber KH, Hurley RA, Hayman LA. Pure neuropsychiatric presentation of multiple sclerosis. Am J Psychiatry. 2004;161:226–31.
   PubMed Web of Science ®Google Scholar
• Clarke T, Wadhwa U, Leroi I. Psychotic depression: an atypical initial presentation of multiple sclerosis. Psychosomatics. 1998;39:72–5.
   PubMedGoogle Scholar
• Schiffer RB, Babigian HM. Behavioral disorders in multiple sclerosis, temporal lobe epilepsy, and amyotrophic lateral sclerosis. An epidemiologic study. Arch Neurol. 1984; 41:1067–9.
   PubMed Web of Science ®Google Scholar
• Rabins PV, Brooks BR, O'Donnell P, Pearlson GD, Moberg P, Jubelt B, . Structural brain correlates of emotional disorder in multiple sclerosis. Brain. 1986;109(Pt 4): 585–97.
   Google Scholar
• Minden SL, Orav J, Schildkraut JJ. Hypomanic reactions to ACTH and prednisone treatment for multiple sclerosis. Neurology. 1988;38:1631–4.
   PubMed Web of Science ®Google Scholar
• Feinstein A, du Boulay G, Ron MA. Psychotic illness in multiple sclerosis. A clinical and magnetic resonance imaging study. Br J Psychiatry. 1992;161:680–5.
   PubMed Web of Science ®Google Scholar
• Berg D, Supprian T, Thomae J, Warmuth-Metz M, Horowski A, Zeiler B, . Lesion pattern in patients with multiple sclerosis and depression. Mult Scler. 2000;6:156–62.
   PubMed Web of Science ®Google Scholar
• Honer WG, Hurwitz T, Li DK, Palmer M, Paty DW. Temporal lobe involvement in multiple sclerosis patients with psychiatric disorders. Arch Neurol. 1987;44:187–90.
   PubMedGoogle Scholar
• Reischies FM, Baum K, Nehrig C, Schörner W. Psychopathological symptoms and magnetic resonance imaging findings in multiple sclerosis. Biol Psychiatry. 1993; 33:676–8.
   Google Scholar
• Zorzon M, de Masi R, Nasuelli D, Ukmar M, Mucelli RP, Cazzato G, . Depression and anxiety in multiple sclerosis. A clinical and MRI study in 95 subjects. J Neurol. 2001;248:416–21.
   PubMed Web of Science ®Google Scholar
• Pujol J, Bello J, Deus J, Martí-Vilalta JL, Capdevila A. Lesions in the left arcuate fasciculus region and depressive symptoms in multiple sclerosis. Neurology. 1997;49: 1105–10.
   PubMed Web of Science ®Google Scholar
• Moller A, Wiedemann G, Rohde U, Backmund H, Sonntag A. Correlates of cognitive impairment and depressive mood disorder in multiple sclerosis. Acta Psychiatr Scand. 1994;89:117–21.
   PubMed Web of Science ®Google Scholar
• Sabatini U, Pozzilli C, Pantano P, Koudriavtseva T, Padovani A, Millefiorini E, . Involvement of the limbic system in multiple sclerosis patients with depressive disorders. Biol Psychiatry. 1996;39:970–5.
   PubMed Web of Science ®Google Scholar
• Hirtz D, Thurman DJ, Gwinn-Hardy K, Mohamed M, Chaudhuri AR, Zalutsky R. How common are the ‘common’ neurologic disorders? Neurology. 2007;68:326–37.
   PubMed Web of Science ®Google Scholar
• Stahlberg O, Soderstrom H, Rastam M, Gillberg C. Bipolar disorder, schizophrenia, and other psychotic disorders in adults with childhood onset AD/HD and/or autism spectrum disorders. J Neural Transm. 2004;111:891–902.
   PubMed Web of Science ®Google Scholar
• Wozniak J, Biederman J, Faraone SV, Frazier J, Kim J, Millstein R, . Mania in children with pervasive developmental disorder revisited. J Am Acad Child Adolesc Psychiatry. 1997;36:1552–9.
   PubMed Web of Science ®Google Scholar
• Biederman J, Faraone S, Wozniak J, Mick E, Kwon A, Aleardi M. Further evidence of unique developmental phenotypic correlates of pediatric bipolar disorder: findings from a large sample of clinically referred preadolescent children assessed over the last 7 years. J Affect Disord. 2004;82:S45–58.
   PubMedGoogle Scholar
• Jerrell JM, McIntyre RS, Tripathi A. A cohort study of the prevalence and impact of comorbid medical conditions in pediatric bipolar disorder. J Clin Psychiatry. 2010;71:1518–25.
   PubMed Web of Science ®Google Scholar
• Krabbendam L, Honig A, Wiersma J, Vuurman EF, Hofman PA, Derix MM, . Cognitive dysfunctions and white matter lesions in patients with bipolar disorder in remission. Acta Psychiatr Scand. 2000;101:274–80.
   PubMed Web of Science ®Google Scholar
• Silverstone T, McPherson H, Li Q, Doyle T. Deep white matter hyperintensities in patients with bipolar depression, unipolar depression and age-matched control subjects. Bipolar Disord. 2003;5:53–7.
   PubMed Web of Science ®Google Scholar
• Zanetti MV, Schaufelberger MS, de Castro CC, Menezes PR, Scazufca M, McGuire PK, . White-matter hyperintensities in first-episode psychosis. Br J Psychiatry. 2008; 193:25–30.
   Google Scholar
• Botteron KN, Vannier MW, Geller B, Todd RD, Lee BCP. Preliminary study of magnetic resonance imaging characteristics in 8- to 16-year-olds with mania. J Am Acad Child Adolesc Psychiatry. 1995;34:742–9.
   PubMedGoogle Scholar
• Chang K, Barnea-Goraly N, Karchemskiy A, Simeonova DI, Barnes P, Ketter T, . Cortical magnetic resonance imaging findings in familial pediatric bipolar disorder. Biol Psychiatry. 2005;58:197–203.
   PubMed Web of Science ®Google Scholar
• Kruit MC, van Buchem MA, Hofman PAM, Bakkers JT, Terwindt GM, Ferrari MD, . Migraine as a risk factor for subclinical brain lesions. JAMA. 2004;291:427–34.
   PubMed Web of Science ®Google Scholar
• Kruit MC, Launer LJ, Ferrari MD, van Buchem MA. Brain stem and cerebellar hyperintense lesions in migraine. Stroke. 2006;37:1109–12.
   PubMed Web of Science ®Google Scholar
• Kruit MC, van Buchem MA, Launer LJ, Terwindt GM, Ferrari MD. Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: the population-based MRI CAMERA study. Cephalalgia. 2009;30:129–36.
   Google Scholar
• Fasmer OB. The prevalence of migraine in patients with bipolar and unipolar affective disorders. Cephalalgia. 2001; 21:894–9.
   PubMedGoogle Scholar
• Silberstein SD, Young WB. Migraine aura and prodrome. Semin Neurol. 1995;15:175–82.
   PubMed Web of Science ®Google Scholar
• Oedegaard KJ, Fasmer OB. Is migraine in unipolar depressed patients a bipolar spectrum trait? J Affect Disord. 2005;84: 233–42.
   PubMed Web of Science ®Google Scholar
• Low NCP, Du Fort GG, Cervantes P. Prevalence, clinical correlates, and treatment of migraine in bipolar disorder. Headache. 2003;43:940–9.
   PubMed Web of Science ®Google Scholar
• McIntyre RS, Konarski JZ, Wilkins K, Bouffard B, Soczynska JK, Kennedy SH. The prevalence and impact of migraine headache in bipolar disorder: results from the Canadian Community Health Survey. Headache. 2006; 46:973–82.
   Google Scholar
• Merikangas KR, Angst J, Isler H. Migraine and psychopathology. Results of the Zurich cohort study of young adults. Arch Gen Psychiatry. 1990;47:849–53.
   PubMed Web of Science ®Google Scholar
• Lipton RB, Bigal ME. Migraine: epidemiology, impact, and risk factors for progression. Headache. 2005;45 Suppl 1:S3–13.
   PubMed Web of Science ®Google Scholar
• Ortiz A, Cervantes P, Zlotnik G, van de Velde C, Slaney C, Garnham J, . Cross-prevalence of migraine and bipolar disorder. Bipolar Disord. 2010;12:397–403.
   Google Scholar
• Dilsaver SC, Benazzi F, Oedegaard KJ, Fasmer OB, Akiskal HS. Is a family history of bipolar disorder a risk factor for migraine among affectively ill patients? Psychopathology. 2009;42:119–23.
   Google Scholar
• Oedegaard KJ, Greenwood TA, Lunde A, Fasmer OB, Akiskal HS, Kelsoe JR. A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11. J Affect Disord. 2010;122:14–26.
   Google Scholar
• Kato T. Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder. Cell Calcium. 2008;44:92–102.
   PubMed Web of Science ®Google Scholar
• Moskowitz MA, Bolay H, Dalkara T. Deciphering migraine mechanisms: clues from familial hemiplegic migraine genotypes. Ann Neurol. 2004;55:276–80.
   PubMed Web of Science ®Google Scholar
• Hamel E. Serotonin and migraine: biology and clinical implications. Cephalalgia. 2007;27:1293–300.
   PubMed Web of Science ®Google Scholar
• Peroutka SJ. Dopamine and migraine. Neurology. 1997; 49:650–6.
   PubMed Web of Science ®Google Scholar
• Vaccaro M, Riva C, Tremolizzo L, Longoni M, Aliprandi A, Agostoni E, . Platelet glutamate uptake and release in migraine with and without aura. Cephalalgia. 2007;27:35–40.
   PubMed Web of Science ®Google Scholar
• Frazier JA, Breeze JL, Papadimitriou G, Kennedy DN, Hodge SM, Moore CM, . White matter abnormalities in children with and at risk for bipolar disorder. Bipolar Disord. 2007;9:799–809.
   PubMed Web of Science ®Google Scholar
• Wang F, Jackowski M, Kalmar JH, Chepenik LG, Tie K, Qiu M, . Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging. Br J Psychiatry. 2008;193:126–9.
   PubMed Web of Science ®Google Scholar
• Versace A, Almeida JR, Hassel S, Walsh ND, Novelli M, Klein CR, . Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics. Arch Gen Psychiatry. 2008;65:1041–52.
   PubMed Web of Science ®Google Scholar
• Neale MC, Kendler KS. Models of comorbidity for multifactorial disorders. Am J Hum Genet. 1995;57:935–53.
   PubMed Web of Science ®Google Scholar
• Moore PB, Shepherd DJ, Eccleston D, Macmillan IC, Goswami U, McAllister VL, . Cerebral white matter lesions in bipolar affective disorder: relationship to outcome. Br J Psychiatry. 2001;178:172–6.
   PubMed Web of Science ®Google Scholar
• Grangeon M, Seixas C, Quarantini LC, Miranda-Scippa A, Pompili M, Steffens DC, . White matter hyperintensities and their association with suicidality in major affective disorders: a meta-analysis of magnetic resonance imaging studies. CNS Spectr. 2010;15:375–81.
   PubMed Web of Science ®Google Scholar
• Altshuler LL, Curran JG, Hauser P, Mintz J, Denicoff K, Post R. T2 hyperintensities in bipolar disorder: magnetic resonance imaging comparison and literature meta-analysis. Am J Psychiatry. 1995;152:1139–44.
   PubMed Web of Science ®Google Scholar
• Rasgon NL, Kenna HA, Williams KE, Powers B, Wroolie T, Schatzberg AF. Rosiglitazone add-on in treatment of depressed patients with insulin resistance: a pilot study. ScientificWorldJournal. 2010;10:321–8.
   PubMedGoogle Scholar
• McIntyre RS, Soczynska JK, Lewis GF, MacQueen GM, Konarski JZ, Kennedy SH. Managing psychiatric disorders with antidiabetic agents: translational research and treatment opportunities. Expert Opin Pharmacother. 2006;7: 1305–21.
   PubMedGoogle Scholar
• Rayasam GV, Tulasi VK, Sodhi R, Davis JA, Ray A. Glycogen synthase kinase 3: more than a namesake. Br J Pharmacol. 2009;156:885–98.
   PubMed Web of Science ®Google Scholar
• Tkachev D, Mimmack ML, Ryan MM, Wayland M, Freeman T, Jones PB, . Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet. 2003;362: 798–805.
   PubMed Web of Science ®Google Scholar
• Le Niculescu H, Kurian SM, Yehyawi N, Dike C, Patel SD, Edenberg HJ, . Identifying blood biomarkers for mood disorders using convergent functional genomics. Mol Psychiatry. 2009;14:156–74.
   Google Scholar
• Chanraud S, Zahr N, Sullivan EV, Pfefferbaum A. MR diffusion tensor imaging: a window into white matter integrity of the working brain. Neuropsychol Rev. 2010;20: 209–25.
   PubMed Web of Science ®Google Scholar
• McIntosh AM, Hall J, Lymer GKS, Sussmann JED, Lawrie SM. Genetic risk for white matter abnormalities in bipolar disorder. Int Rev Psychiatry. 2009;21:387–93.
   PubMed Web of Science ®Google Scholar
• Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biol Psychiatry. 2003;54:515–28.
   PubMed Web of Science ®Google Scholar