Testing for endothelial dysfunction

References

• Celermajer D S. Endothelial dysfunction: Does it matter? Is it reversible. J Am Coll Cardiol 1997; 30: 325–33
   PubMed Web of Science ®Google Scholar
• Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362: 801–9
   PubMed Web of Science ®Google Scholar
• Machovich R. Choices among the possible reaction routes catalyzed by thrombin. Ann N Y Acad Sci 1986; 485: 170–83
   PubMed Web of Science ®Google Scholar
• Moncada S. Biological importance of prostacyclin. Br J Pharmacol 1982; 76: 3–31
   PubMed Web of Science ®Google Scholar
• Jaffe E A. Cell biology of endothelial cells. Hum Pathol 1987; 18: 234–9
   PubMed Web of Science ®Google Scholar
• Vanhoutte P M. Endothelium and control of vascular function. Hypertension 1989; 13: 658–67
   PubMed Web of Science ®Google Scholar
• Furchgott R F, Zawadzki J V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373–6
   PubMed Web of Science ®Google Scholar
• Palmer R M, Ashton D S, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988; 333: 664–6
   PubMed Web of Science ®Google Scholar
• Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitrix oxide on peripheral arteriolar tone in man. Lancet 1989; 2: 997–1000
   PubMed Web of Science ®Google Scholar
• Celermajer D S, Dollery C, Burch M, Deanfield J E. Role of endothelium in the maintenance of low pulmonary vascular tone in normal children. Circulation 1994; 89: 2041–4
   PubMed Web of Science ®Google Scholar
• Pohl U, Hultz R, Busse R, Bassenge E. Crucial role of endothelium in the vasodilator response to increased flow in-vivo. Hypertension 1986; 8: 37–44
   PubMed Web of Science ®Google Scholar
• Collins P, Griffith T M, Henderson A H, Lewis M J. Endothelium-derived relaxing factor alters calcium fluxes in rabbit aorta: a cyclic guanosine monophosphate-mediated effect. J Physiol 1986; 381: 427–37
   PubMed Web of Science ®Google Scholar
• Rubanyi G M. The role of endothelium in cardiovascular homeostasis and diseases. J Cardiovasc Pharmacol 1993; 22(SUPPI 4)S1–14
   PubMedGoogle Scholar
• Moore S. Thromboatherosclerosis in normolipemic rabbits; a result of continued endothelial damage. Lab Invest 1973; 29: 478–87
   PubMed Web of Science ®Google Scholar
• Reidy M A, Scwartz S M. A technique to investigate surface morphology and endothelial cell replication of small arteries; a study in acute angiotensin-induced hypertension. Mircovasc Res 1982; 24: 158–67
   PubMed Web of Science ®Google Scholar
• Celermajer D S, Sorensen K E, Bull C, Robinson J, Deanfield J E. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 1994; 24: 1468–74
   PubMed Web of Science ®Google Scholar
• Raitakari O T, Adam M R, Celermajer D S. Effect of Ip(a) on the early functional and structural changes of atherosclerosis. Arterioscler Thromb Vasc Biol 1999; 19: 990–5
   PubMed Web of Science ®Google Scholar
• Celermajer D S, Sorensen K E, Georgakopoulos D, Bull C, Thomas O, Robinson J, et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation 1993; 88: 2149–55
   PubMed Web of Science ®Google Scholar
• Celermajer D S, Adam M R, Clarkson P, Robinson J, McCredie R, Donald A, et al. Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. N Engl J Med 1996; 334: 150–4
   PubMed Web of Science ®Google Scholar
• Clarkson P, Celermajer D S, Donald A E, Sampson M, Sorense K E, Adam M, et al. Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels. J Am Coll Cardiol 1996; 28: 573–9
   PubMed Web of Science ®Google Scholar
• Celermajer D S, Sorensen K E, Gooch V M, Spiegelhalter D J, Miller O I, Sullivan I D, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111–5
   PubMed Web of Science ®Google Scholar
• Pitkänen O. P, Nuutila P, Raitakari O T, Rönnemaa T, Koskinen P J, Iida H, et al. Coronary flow reserve is reduced in young men with insulin-dependent diabetes mellitus. Diabetes 1998; 47: 248–54
   PubMedGoogle Scholar
• Steinberg D S. Lipoproteins and the pathogenesis of atherosclerosis. Circulation 1987; 76: 508–14
   PubMed Web of Science ®Google Scholar
• Henderson A H. Endothelium in control. Br Heart J 1991; 65: 116–25
   PubMedGoogle Scholar
• Ohara Y, Peterson T E, Harrison D G. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993; 91: 2546–51
   PubMed Web of Science ®Google Scholar
• Zeiher A M, Krause T, Schachinger V, Minners J, Moser E. Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myo-cardial ischemia. Circulation 1995; 91: 2345–52
   PubMed Web of Science ®Google Scholar
• Andrews T C, Raby K, Barry J, Naimi C L, Alfred E, Ganz P, et al. Effect of cholesterol reduction on myocardial ischemia in patients with coronary disease. Circulation 1997; 95: 324–8
   PubMed Web of Science ®Google Scholar
• Van Bowen A J, Jukema J W, Zwinderman A H, Crijins H JGM, Lie K I, Bruschke A VG. Reduction of transient myocardial ischemia with pravastatin in addition to the conventional treatment in patients with angina pectoris. Circulation 1996; 94: 1503–5
   PubMed Web of Science ®Google Scholar
• Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4s). Lancet 1994; 344: 1383–9
   PubMed Web of Science ®Google Scholar
• Blankenhorn D H, Azen S P, Kramsch D M, Mack W J, Cashin-Hemphill L, Hodis H N, et al. Coronary angiographic changes with lovastatin therapy: the monitored atherosclerosis regression study (MARS). Ann Intern Med 1993; 119: 969–76
   PubMed Web of Science ®Google Scholar
• Cooke J P, Tsao P S. Is NO an endogenous antiatherogenic molecule. Arterioscler Thromb 1994; 14: 653–5
   PubMedGoogle Scholar
• Braman R S, Hendrix S A. Nanogram nitrate and nitrate determination in environmental and biological materials by vanadium (III) reduction with chemiluminescence detection. Anal Chem 1989; 61: 2715–8
   PubMed Web of Science ®Google Scholar
• Tsikas D, Boger R H, Bode-Boger S M, Frolich J C. Quantification of nitrite and nitrate in human urine and plasma as pentafluorobenzyl derivatives by gas chromatography-mass spectrometry using their 15N-labelled analogs. J Chromatogr B Biomed Appl 1994; 661: 185–91
   PubMedGoogle Scholar
• Viinikka L. Nitric oxide as a challenge for the clinical chemistry laboratory. Scand J Lab Invest 1996; 56: 577–81
   PubMed Web of Science ®Google Scholar
• Wennmalm A, Benthin G, Edlund A, Jungersten L, Kieler-Jensen N, Lundin S, et al. Metabolism and excretion of nitric oxide in humans: an experimental and clinical study. Circulation 1993; 73: 1121–7
   Web of Science ®Google Scholar
• Moncada S, Higgs E A. The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329: 2002–12
   PubMed Web of Science ®Google Scholar
• Ignarro L J. Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu Rev Pharmacol Toxicol 1990; 30: 535–60
   PubMed Web of Science ®Google Scholar
• Böger R H, Bode-Boger S M, Mügge A, Kienke S, Brandes R, Dwenger A, et al. Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production. Atherosclerosis 1995; 117: 273–84
   PubMed Web of Science ®Google Scholar
• Böger R H, Bode-Boger S M, Thiele W, Junker W, Alexander K, Frolich J C. Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial disease. Circulation 1997; 95: 2068–74
   PubMed Web of Science ®Google Scholar
• Wang J, Brown M A, Tam S H, Chan M C, Whitworth J A. Effects of diet on measurements of nitric oxide metabolites. Clin Exp Pharmacol Physiol 1997; 24: 418–20
   PubMed Web of Science ®Google Scholar
• Ludmer P L, Selwyn A P, Shook T L, Wayne R R, Mudge G H, Alexander R W, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986; 315: 1046–51
   PubMed Web of Science ®Google Scholar
• Drexler H, Zeiher A M. Endothelial function in human coronary arteries in vivo. Hypertension 1991; 18: 90–9
   Web of Science ®Google Scholar
• Vita J A, Treasure C B, Nabel E G, McLenachan J M, Fish R D, Yeung A C, et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 1990; 81: 491–7
   PubMed Web of Science ®Google Scholar
• Reddy K G, Nair N R, Sheehan H M, Hodgson J M. Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis. J Am Coll Cardiol 1994; 23: 83343
   Web of Science ®Google Scholar
• Gordon J B, Ganz P, Nabel E G, Fish R D, Zebede J, Mudge G H, et al. Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise. J Clin Invest 1989; 83: 1946–52
   PubMed Web of Science ®Google Scholar
• Nabel E G, Selwyn A P, Ganz P. Large coronary arteries in humans are responsive to changing blood flow: an endothelium-dependent mechanism that fails in patients with atherosclerosis. J Am Coll Cardiol 1990; 16: 349–56
   PubMed Web of Science ®Google Scholar
• Suwaidi J A, Hamasaki S, Higano S T, Nishimura R A, Holmes D RJ, Lerman A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 2000; 101: 948–54
   PubMed Web of Science ®Google Scholar
• Schächinger V, Britten M B, Zeiher A M. Prognostic impact of coronary vasodilator function on adverse long-term outcome of coronary heart disease. Circulation 2000; 101: 1899–906
   PubMed Web of Science ®Google Scholar
• Anderson T J, Meredith I T, Yeung A C, Frei B, Selwyn A P, Ganz P. The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med 1995; 332: 488–93
   PubMed Web of Science ®Google Scholar
• Creager M A, Cooke J P, Mendelsohn M E, Gallagher S J, Coleman S M, Loscalzo J, et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 1990; 86: 228–34
   PubMed Web of Science ®Google Scholar
• Panza J A, Quyyumi A A, Brush J EJ, Epstein S E. Abnormal endothelium-dependent vascular reaction in patients with essential hypertension. N Engl J Med 1990; 323: 22–7
   PubMed Web of Science ®Google Scholar
• Webb D J. The pharmacology of human blood vessels in vivo. J Vasc Res 1995; 32: 2–15
   PubMed Web of Science ®Google Scholar
• Mäkmattila S, Virkamäki A, Groop P -H, Cockcroft J, Utriainen T, Fagerudd J, et al. Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus. Circulation 1996; 94: 1276–82
   PubMed Web of Science ®Google Scholar
• Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 1998; 97: 2222–9
   PubMed Web of Science ®Google Scholar
• Stefan J, Schlaich M, Langenfeld M, Weihprecht H, Schmitz G, Weidinger G, et al. Increased bioavailability of nitric oxide after lipid-lowering therapy in hypercholesterolemic patients. A randomized, placebo-controlled, double-blind study. Circulation 1998; 98: 211–6
   PubMed Web of Science ®Google Scholar
• Yokoyama I, Ohtake T, Momomura S, Nishikawa J, Sasaki Y, Omata M. Reduced coronary flow reserve in hypercholesterolemic patients without overt coronary stenosis. Circulation 1996; 94: 3232–8
   PubMed Web of Science ®Google Scholar
• Pitkanen O -P, Raitakari O T, Niinikoski H, Nuutila P, Iida H, Voipio-Pulkki L -M, et al. Coronary flow reserve is impaired in young men with hypercholesterolemia. J Am Coll Cardiol 1996; 28: 1705–11
   PubMed Web of Science ®Google Scholar
• Pitkanen O -P, Nuutila P, Raitakari O T, Porkka K VK, Iida H, Nuotio I, et al. Coronary flow reserve in young men with familial combined hypercholesterolemia. Circulation 1999; 99: 1678–84
   PubMed Web of Science ®Google Scholar
• Laine H, Raitakari O T, Niinikoski H, Pitkänen O -P, Iida H, Viikari J SA, et al. Early impairment of coronary flow reserve in young men with borderline hypertension. J Am Coll Cardiol 1998; 32: 147–53
   PubMed Web of Science ®Google Scholar
• Raitakari O T, Pitkanen O -P, Lehtimäki T, Lahdenperä S, Iida H, Ylä-Herttuala S, et al. In vivo LDL oxidation relates to coronary reactivity in young men. J Am Coll Cardiol 1997; 30: 97–102
   PubMed Web of Science ®Google Scholar
• Pitkänen O -P, Raitakari O T, Rönnemaa T, Niinikoski H, Nuutila P, Iida H, et al. Influence of cardiovascular risk profile on coronary flow reserve in healthy young men. Am J Cardiol 1997; 79: 1690–2
   PubMed Web of Science ®Google Scholar
• Raitakari O T, Toikka J, Pitkanen O -P, Laine H, Viikari J SA, Knuuti J. Influence of subclinical atherosclerosis on coronary flow reserve in young men (abstract). Circulation 1998; 98: 1–94
   PubMed Web of Science ®Google Scholar
• Czernin J, Barnard J, Sun K T, Krivokapich J, Nitzsche E, Dorsey D, et al. Effect of short-term cardiovascular conditioning and low-fat diet on myocardial blood flow and flow reserve. Circulation 1995; 92: 197–204
   PubMed Web of Science ®Google Scholar
• Huggins G S, Pasternak R C, Alpert N M, Fischman A J, Gewirtz H. Effect of short term treatment of hyperlipidemia on coronary vasodilator function and myocardial perfusion in regions having substantial impairment of baseline dilator reserve. Circulation 1998; 98: 1291–6
   PubMed Web of Science ®Google Scholar
• Leipert B, Becker B F, Gerlach E. Different endothelial mechanisms involved in coronary responses to known vasodilators. Am J Physiol 1992; 262: H1676–83
   Google Scholar
• Mayhan W G. Endothelium-dependent responses of cerebral arterioles to adenosine 5′-diphosphate. J Vasc Res 1992; 29: 353–8
   PubMed Web of Science ®Google Scholar
• Rubanyi G, Romero J, Vanhoutte P. Flow-induced release of endothelium-derived relaxing factor. Am J Physiol 1986; 240: H1145–9
   Google Scholar
• Adams M R, Robinson J, McCredie R, Seale P J, Sorensen K E, Deanfield J E, et al. Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilatation in adults at risk of atherosclerosis. J Am Coll Cardiol 1998; 32: 123–7
   PubMed Web of Science ®Google Scholar
• Campisi R, Czernin J, Schoder H, Sayre J W, Schelbert H R. L-arginine normalizes coronary vasomotion in long-term smokers. Circulation 1999; 99: 491–7
   PubMed Web of Science ®Google Scholar
• Hozumi T, Yoshida K, Ogata Y, Akasaka T, Asami Y, Takagi T, et al. Noninvasive assessment of significant left anterior descending coronary artery stenosis by coronary flow velocity reserve with transthoracic color Doppler. Circulation 1998; 97: 1557–62
   PubMed Web of Science ®Google Scholar
• Broillet A, Puginier J, Ventrone R, Schneider M. Assessment of myocardial perfusion by intermittent harmonic power Doppler using SonoVue, a new ultrasound contrast agent. Invest Radiol 1998; 33: 209–15
   PubMed Web of Science ®Google Scholar
• Joannides R, Haefeli W E, Linder L, Richard V, Bakkali E H, Thuillez C, et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 1995; 91: 1314–9
   PubMed Web of Science ®Google Scholar
• Anderson T J, Uehata A, Gerhard M D, Meredith I T, Knab S, Delagrange D, et al. Close relationship of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 1995; 26: 1235–41
   PubMed Web of Science ®Google Scholar
• Neunteufl T, Katzenschlager R, Hassan A, Klaar U, Schwarzacher S, Glogar D, et al. Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease. Atherosclerosis 1997; 129: 111–8
   PubMed Web of Science ®Google Scholar
• Sorensen K E, Celermajer D S, Spiegelhalter D J, Georgakopoulos D, Robinson J, Thomas O, et al. Non-invasive measurement of endothelium-dependent arterial responses in man: accuracy and reproducibility. Br Heart J 1995; 74: 247–53
   PubMedGoogle Scholar
• Raitakari O T, Celermajer D S. Endothelial function of peripheral arteries: A window for presymptomatic detection of atherosclerosis. J Card Dis Prev 1998; 1: 2–6
   Google Scholar
• Raitakari O T, Adams M R, McCredie R J, Griffiths K A, Celermajer D S. Passive-smoke related arterial endothelial dysfunction is potentially reversible in healthy young adults. Ann Intern Med 1999; 130: 578–81
   PubMed Web of Science ®Google Scholar
• Li J, Zhao S P, Li X P, Zhuo Q C, Gao M, Lu S K. Non-invasive detection of endothelial dysfunction in patients with essential hypertension. Int J Cardiol 1997; 19: 165–9
   Google Scholar
• Iiyama K, Nagano M, Yo Y, Nagano N, Kamide K, Higaki J, et al. Impaired endothelial with essential hypertension assessed by ultrasonography. Am Heart J 1996; 132: 779–82
   PubMed Web of Science ®Google Scholar
• Celermajer D S, Sorensen K E, Spiegelhalter D J, Georgakopoulos D, Robinson J, Deanfield J E. Aging is related with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 1994; 24: 471–6
   PubMed Web of Science ®Google Scholar
• Clarkson P, Celermajer D S, Donald A E, Sampson M, Sorensen K, Adam M R, et al. Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and LDL-cholesterol levels. J Am Coll Cardiol 1996; 28: 573–9
   PubMed Web of Science ®Google Scholar
• Woo K S, Chook P, Lolin Y I, Cheung A SP, Chan L T, Sun Y Y, et al. Hyperhomocysteinemia is a risk factor for arterial dysfunction in humans. Circulation 1997; 96: 2642–4
   Web of Science ®Google Scholar
• Leiper J, Vallance P. Biological significance of endogenous methylargines that inhibit nitric oxide synthase. Cardiovasc Res 1999; 43: 542–8
   PubMed Web of Science ®Google Scholar
• Bode-Böger S M, Boger R H, Kienke S, Junker W, Frölich J C. Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits. Biochem Biophys Res Commun 1996; 219: 598–603
   PubMed Web of Science ®Google Scholar
• Miyazaki H, Matsuoka H, Cooke J P, Usui M, Ueda S, Okuda S, et al. Endogenous nitric oxide synthase inhibitor. A novel marker of atherosclerosis. Circulation 1999; 99: 1141–6
   PubMed Web of Science ®Google Scholar
• Böger R H, Bode-Böger S M, Szuba A, Tsao P S, Chan J R, Tangphao O, et al. Asymmetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction. Its role in hypercholesterolemia. Circulation 1998; 98: 1842–7
   PubMed Web of Science ®Google Scholar
• Ito A, Tsao P S, Adimoolam S, Kimoto M, Ogawa T, Cooke J P. Novel mechanism for endothelial dysfunćtion. Dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999; 99: 3092–5
   PubMed Web of Science ®Google Scholar
• Mathew V, Hasdai D, Lerman A. The role of endothelin in coronary atherosclerosis. Mayo Clin Proc 1996; 71: 769–77
   PubMed Web of Science ®Google Scholar
• Lerman A, Edwards B S, Hallett J W, Heublein D M, Sandberg S M, Burnett J CJ. Circulation and tissue endothelin immuno-reactivity in advanced atherosclerosis. N. Engl J Med 1991; 325: 997–1001
   PubMed Web of Science ®Google Scholar
• Haak T, Marz W, Jungmann E, Hausser S, Siekmeier R, Gross W, et al. Elevated endothelin levels in patients with hyperlipoproteinemia. Clin Investig 1994; 72: 580–4
   PubMedGoogle Scholar
• Haak T, Jungmann E, Raab C, Usadel K H. Elevated endothelin-1 levels after cigarette smoking. Metabolism 1994; 43: 267–9
   PubMed Web of Science ®Google Scholar
• Boulanger C M, Tanner F C, Bea M -L, Hahn A WA, Werner A, Luscher T F. Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium. Circ Res 1992; 70: 1191–7
   PubMed Web of Science ®Google Scholar
• Lerman A, Holmes D RJ, Bell M R, Garratt K N, Nishimura R A, Burnett J CJ. Endothelin in coronary endothelial dysfunction and early atherosclerosis in humans. Circulation 1995; 92: 2426–31
   PubMed Web of Science ®Google Scholar
• Mannucci P M. von Willebrand Factor. A marker of endothelial damage. Arterioscler Thromb Vasc Biol 1998; 18: 1359–62
   PubMed Web of Science ®Google Scholar
• Jansson J H, Nilsson T K, Johnson O. Von Willebrand factor in plasma: a novel risk factor for recurrent myocardial infarction and death. Br Heart J 1991; 1991: 351–5
   Google Scholar
• Cortellaro M, Boschetti C, Cofrancesco E, Zanussi C, Catalano M, deGaetano G, et al. The PLAT Study: hemostatic function in relation to atherothrombotic ischemic events in vascular disease patients: principal results. Arterioscler Thromb 1992; 12: 1063–70
   PubMedGoogle Scholar
• Thompson S G, Kienast J, Pyke S DM, Haverkate F, van de Loo J CW. Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. European Concerted Action on Thrombosis, and Disabilities Angina Pectoris Study Group. N Engl J Med 1995; 332: 635–41
   PubMed Web of Science ®Google Scholar
• Blann A D, Davies A, Miller J P, McCollum C N. Reduction in cholesterol is associated with reduction in von Willebrand factor. Atherosclerosis 1993; 103: 299–304
   Google Scholar
• Geppert A, Graf S, Beckmann R, Hornykewycz S, Schuster E, Binder B R, et al. Concentration of endogenous tPA antigen in coronary artery disease. Relation to thrombotic events, aspirin treatment, hyperlipidemia, and multivessel disease. Arterioscler Thromb Vasc Biol 1998; 18: 1634–42
   PubMed Web of Science ®Google Scholar
• Ridker P M, Vaughan D E, Stampfer M J, Manson J E, Hennekens C H. Endogenous tissue-type plasminogen activator and risk of myocardial infarction. Lancet 1993; 341: 1165–8
   PubMed Web of Science ®Google Scholar
• Ridker P M, Hennekens C H, Stampfer M J, Manson A E, Vaughan D E. Prospective study of endogenous tissue plasminogen activator and risk of stroke. Lancet 1994; 343: 940–3
   PubMed Web of Science ®Google Scholar
• Salomaa V, Stinson V, Kark J D, Folsom A R, Davis C E, Wu K K. Association of fibrinolytic parameters with early atherosclerosis. The ARIC Study. Circulation 1995; 91: 284–90
   PubMed Web of Science ®Google Scholar
• Underwood M J, DeBono D P. Increased fibrinolytic activity in the intima of atheromatous coronary arteries: protection at a price. Cardiovasc Res 1993; 27: 882–5
   PubMed Web of Science ®Google Scholar
• Smokovitis A, Kokolis N, Alexaki-Tzivanidou E. Fatty streaks and fibrous plaques in human aorta show increased plasminogen activator activity. Haemostasis 1988; 18: 146–53
   PubMedGoogle Scholar
• Stein C M, Brown N, Vaughan D E, Lang C C, Wood A J. Regulation of local tissue-type plasminogen activator release by endothelium-dependent and endothelium-independent agonists in human vasculature. J Am Coll Cardiol 1998; 32: 117–22
   PubMed Web of Science ®Google Scholar
• Newby D E, Wright R A, Labinloh C, Ludlam C A, Fox K A, Boon N A, et al. Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction. Circulation 1999; 99: 1411–5
   PubMed Web of Science ®Google Scholar
• Alessi M C, Juhan-Vague I, Declerck P J, Anfosso F, Gueunoun E, Collen D. Correlations between t-PA and PAI-1 antigen and activity and t-PAPAI-1 complexes in plasma of control subjects and patients with increased t-PA and PAL1 levels. Thromb Res 1990; 60: 509–16
   PubMed Web of Science ®Google Scholar
• Pigott R, Dillon L P, Hemingway I, Gearing A JH. Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cell. Biochem Biophys Res Commun 1992; 187: 584–9
   PubMed Web of Science ®Google Scholar
• Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999; 340: 115–26
   PubMed Web of Science ®Google Scholar
• Li H, Cybulski M I, Gimbrone M AJ, Libby P. An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mono-nuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb 1993; 13: 197–204
   PubMed Web of Science ®Google Scholar
• Leeuwenberg J FM, Smeets E F, Neefjes J J, Shaffer M A, Cinek T, Jeunhomme T MAA, et al. E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro. Immunology 1992; 77: 543–9
   PubMed Web of Science ®Google Scholar
• Pigott R, Dillon L P, Hemingway I H, Gearing A J. Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells. Biochem Biophys Res Commun 1992; 187: 584–9
   PubMed Web of Science ®Google Scholar
• Kume N, Cybulski M I, Gimbrone M AJ. Lysophosphatidyl-choline, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured endothelial cells. J Clin Invest 1992; 90: 1138–44
   PubMed Web of Science ®Google Scholar
• Hwang S J, Ballantyne C M, Sharrett A R, Smith L C, Davis C E, Gotto A MJ, et al. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk in Communities (ARIC) Study. Circulation 1997; 96: 4219–25
   PubMed Web of Science ®Google Scholar
• Squadrito F, Saitta A, Altavilla D, Ioculano M, Canale P, Campo G M, et al. Thrombolytic therapy with urokinase reduces increased circulating endothelial adhesion molecules in acute myocardial infarction. Inflamm Res 1996; 45: 14–9
   PubMed Web of Science ®Google Scholar
• Ikeda H, Takajo Y, Ichiki K, Ueno T, Maki S, Noda T, et al. Increased soluble form P-selectin in patients with unstable angina. Circulation 1995; 92: 1693–6
   PubMed Web of Science ®Google Scholar
• Ikeda H, Nakayarna H, Oda T, Kuwano K, Muraishi A, Sugi K, et al. Soluble form of P-selectin in patients with acute myocardial infarction. Coron Artery Dis 1994; 5: 515–8
   PubMed Web of Science ®Google Scholar
• Kaikita K, Ogawa H, Yasue H, Sakamoto T, Suefuji H, Sumida H, et al. Soluble P-selectin is released into the coronary circulation after coronary spasm. Circulation 1995; 92: 1726–30
   PubMed Web of Science ®Google Scholar
• Davi G, Romano M, Mezzetti A, Priocopio A, Iacobelli S, Antidormi T, et al. Increased levels of soluble P-selectin in hypercholesterolemic patients. Circulation 1998; 97: 953–7
   PubMed Web of Science ®Google Scholar
• Blann A D, McCollum C N. Circulating endothelial cell/leukocyte adhesion molecules in atherosclerosis. Thromb Haemost 1994; 72: 151–4
   PubMed Web of Science ®Google Scholar
• Ridker P M, Hennekens C H, Roitman-Johnson B, Stampfer M J, Allen J. Plasma concentrations of soluble intercellular adhesion molecule 1 and risk of future myocardial infarction in apparently healthy men. Lancet 1998; 351: 88–92
   PubMed Web of Science ®Google Scholar
• Hackman A, Abe Y, Insull W J, Pownall H, Smith L, Dunn K, et al. Levels of soluble cell adhesion molecules in patients with dyslipidemia. circulation 1996; 93: 1334–8
   PubMed Web of Science ®Google Scholar
• Sampietro T, Tuoni M, Ferdeghini M, Ciardi A, Marraccini P, Prontera C, et al. Plasma cholesterol regulates soluble cell adhesion molecule expression in familial hypercholesterolemia. Circulation 1997; 96: 1381–5
   PubMed Web of Science ®Google Scholar