The brain-heart axis in the perception of cardiac Pain: the elusive link between ischaemia and pain

References

• Opie L H. The heart. Physiology and metabolism. Raven Press, New York, NY 1991; 52–66
   Google Scholar
• Hoffman J IE. Transmural myocardial perfusion. Prog Cardiovasc Dis 1987; 29: 429–64
   PubMed Web of Science ®Google Scholar
• Malliani A. The conceptualisation of cardiac pain as a nonspecific and unreliable alarm system. Visceral pain, progress in pain research and management, Vol 5, G F Gebhart. IASP Press, Seattle, WA 1995; 63–74
   Google Scholar
• Cechetto D F. Supraspinal mechanisms of visceral representation. Visceral pain, progress in pain research and management, Vol 5, G F Gebhart. ASP Press, Seattle, WA 1995; 261–90
   Google Scholar
• Keay K A, Clement C I, Bandler R. The neuroanatomy of cardiac nociceptive pathways. The nervous system and the heart, ter Horst. Humana Press, New Jersey 2000; 303–42
   Google Scholar
• Meller S T, Gebhart G F. Visceral pain: a review of experimental studies. Neuroscience 1992; 48: 501–24
   PubMedGoogle Scholar
• Dampney R AL. Functional organization of central pathways regulating the cardiovascular system. Physiol Rev 1994; 74: 323–64
   PubMed Web of Science ®Google Scholar
• White J C. Cardiac Pain. Anatomic pathways and physiologic mechanisms. Circulation 1957; 16: 644–55
   PubMed Web of Science ®Google Scholar
• Françis-Franck C A. Physiological significance of sympathetic resection in Basedow's disease, epilepsy, idiotism and glaucoma (in French). Bull Acad Méd Paris 1899; 41: 565–74
   Google Scholar
• Mannheimer C, Augustinsson L E, Carlsson C A, Manhem K, Wilhelmsson C. Epidural spinal electrical stimulation in severe angina pectoris. Br Heart J 1988; 59: 56–61
   PubMedGoogle Scholar
• Hill J A, Pepine C J. Myocardial ischaemia and chest pain: a misunderstood and oversimplified relationship. Cardiol Clin 1986; 4: 621–5
   PubMedGoogle Scholar
• Warren J. Remarks on angina pectoris. N Engl J Med Surg 1812; 1: 1–11
   Google Scholar
• Babey A M. Painless acute infarction of the heart. N. Engl J Med 1939; 220: 410–2
   Google Scholar
• Kannel W B, Abbott R D. Incidence and prognosis of unrecognised myocardial infarction: an update on the Framingham study. N Engl J Med 1984; 311: 114–7
   Web of Science ®Google Scholar
• Schang S J, Pepine C J. Transient asymptomatic ST segment depression during daily activity. Am J Cardiol 1977; 39: 396–402
   PubMed Web of Science ®Google Scholar
• Deanfield J E, Maseri A, Selwyn A P, Ribeiro P, Chierchia S, Krikler S, et al. Myocardial ischaemia during daily life in patients with stable angina: its relation to symptoms and heart rate changes. Lancet 1983; 2: 753–8
   PubMed Web of Science ®Google Scholar
• Epstein S E, Quyyumi A A, Bonow R O. Current concepts, myocardial ischemia: silent or symptomatic. N Engl J Med 1988; 318: 1038–43
   PubMed Web of Science ®Google Scholar
• Gottlieb S O, Weisfeldt M L, Ouyang P, Mellits E D, Gerstenblith G. Silent ischemia as a marker for early unfavorable outcome in patients with unstable angina. N Engl J Med 1986; 314: 1214–9
   PubMed Web of Science ®Google Scholar
• Tzivoni D, Gavish A, Zin D, Gottlieb S, Moriel M, Keren A, et al. Prognostic significance of ischemic episodes in patients with previous myocardial infarction. Am J Cardiol 1988; 62: 661–4
   PubMed Web of Science ®Google Scholar
• Gottlieb S O, Gottlieb S H, Achuff S C, Baumgardner R, Mellits E D, Weisfeldt M L, et al. Silent ischemia on Holter monitoring predicts mortality in high risk post infarction patients. JAMA 1988; 259: 1030–5
   PubMed Web of Science ®Google Scholar
• Hong R A, Bhandari A K, McKay C R, Au P K, Rahimtoola S H. Life threatening ventricular tachycardia and fibrillation induced by painless myocardial ischemia during exercise testing. JAMA 1987; 257: 1937–40
   PubMed Web of Science ®Google Scholar
• Klein J, Chao S Y, Berman D S, Rozanski A. Is ‘silent’ myocardial ischemia really as severe as symptomatic ischemia? The analytical effect of patient selection biases. Circulation 1994; 89: 1958–66
   PubMed Web of Science ®Google Scholar
• Langer A, Freeman M, Josse R, Steiner G, Armstrong P. Detection of silent myocardial ischemia in diabetes mellitus. Am J Cardiol 1991; 67: 1073–8
   PubMed Web of Science ®Google Scholar
• Shakespeare C F, Katritsis D, Crowther A, Cooper I C, Coltart J C, Webb-Peploe M M. Differences in autonomic function in patients with silent and symptomatic myocardial ischaemia. Br Heart J 1994; 71: 22–9
   PubMedGoogle Scholar
• Woolf C J, Wall P D. Endogenous opioid peptides and pain mechanisms: a complex relationship. Nature 1983; 306: 739–40
   PubMed Web of Science ®Google Scholar
• Sheps D S, Maixner W, Hinderliter A L. Mechanisms of pain perception in patients with silent myocardial ischemia. Am Heart J 1989; 119: 983–7
   Web of Science ®Google Scholar
• Droste C, Roskamm H. Pain perception and endogenous pain modulation in angina pectoris. Silent mvocardial ischemia: A critical appraisal, J J Kellerman, E. Braunwald. Karger, BaselSwitzerland 1990; 37: 142–64
   Google Scholar
• Heller G V, Garber C E, Connolly M J, Allen-Rowlands C F, Siconolfi S F, Gann D S, et al. Plasma beta-endorphin levels in silent myocardial ischemia induced by exercise. Am J Cardiol 1987; 59: 735–9
   PubMed Web of Science ®Google Scholar
• Falcone C, Specchia G, Rondanelli R, Guasti L, Corsico G, Codega S, et al. Correlation between beta-endorphin plasma levels and anginal symptoms in patients with coronary artery disease. J Am Coll Cardiol 1988; 11: 719–23
   PubMed Web of Science ®Google Scholar
• Barsky A J, Hochstrasser B, Coles A, Zisfein J, O'Donnell C, Eagle K A. Silent myocardial ischemia: Is the person or the event silent. JAMA 1990; 264: 1132–5
   PubMed Web of Science ®Google Scholar
• Friston K J, Frackowiak R SJ. Imaging functional anatomy. Brain work and mental activity, Alfred Benzon symposium vol 31, N A Lassen, D H Ingvar, M E Raichle, L Friberg. Munksgaard, CopenhagenDenmark 1991; 267–79
   Google Scholar
• Fox P T, Raichle M E, Mintun M A, Dence C. Nonoxidative glucose consumption during focal physiologic neural activity. Science 1988; 241: 462–4
   PubMed Web of Science ®Google Scholar
• Raichle M. Circulatory and metabolic correlates of brain function in normal humans. Handbook of Physiology. Section 1: The nervous system. Vol V Higher functions of the brain, V B Mountcastle, F Plum, S R Geiger. American Physiological Society, Bethesda, MD 1987; 643–74
   Google Scholar
• Mata M, Fink D G, Ganier H, Smith C B, Davidsen L, Sawaki H, et al. Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity. J Neurochem 1980; 34: 213–5
   PubMed Web of Science ®Google Scholar
• Rosen S D, Paulesu E, Frith C D, Jones T, Davies G J, Frackowiak R SJ, et al. Central neural correlates of angina pectoris as a model of visceral pain. Lancet 1994; 344: 147–50
   PubMed Web of Science ®Google Scholar
• Takao Y, Kamisaki Y, Itoh T. Beta adrenergic regulation of amine precursor amino-acid transport across the blood-brain barrier. Eur J Pharmacol 1992; 215: 245–51
   PubMed Web of Science ®Google Scholar
• Opie L H. Drugs and the heart. Saunders, Philadelphia, PA 1991; 143
   Google Scholar
• Spinks T J, Jones T, Bailey D L, Townsend D W, Grootoonk S, Bloomfield P M, et al. Physical performance of a positron tomograph for brain imaging with retractable septa. Phys Med Biol 1992; 37: 1637–55
   PubMed Web of Science ®Google Scholar
• Talairach J, Tournoux P. A co-planar stereotactic atlas of the human brain. Thieme, StuttgartGermany 1988
   Google Scholar
• Friston K J, Frith C D, Liddle P F, Lammertsma A A, Dolan R D, Frackowiak R SJ. The relationship between local and global changes in PET scans. J Cereb Blood Flow Metab 1990; 10: 458–66
   PubMed Web of Science ®Google Scholar
• Friston K J, Frith C D, Liddle P F, Frackowiak R SJ. Comparing functional (PET) images: assessment of significant change. J Cereb Blood Flow Metab 1991; 11: 690–9
   PubMed Web of Science ®Google Scholar
• Friston K J, Passingham R E, Nutt J G, Heather J D, Sawle C V, Frackowiak R SJ. Localisation in PET images: direct fitting of the intercommissural (AC-PC) line. J Cereb Blood Flow Metab 1989; 9: 690–5
   PubMed Web of Science ®Google Scholar
• Camici P G, Araujo L I, Spinks T, et al. Increased uptake of 18F-fluorodeoxyglucose in postischemic myocardium of patients with exercise-induced angina. Circulation 1986; 74: 81–8
   PubMed Web of Science ®Google Scholar
• Rosen S D, Paulesu E, Nihoyannopoulos P, Tousoulis D, Frackowiak R SJ, Frith C D, et al. Silent ischaemia as a central problem: regional brain activation compared in silent and painful myocardial ischaemia. Ann Intern Med 1996; 124: 939–49
   PubMed Web of Science ®Google Scholar
• Wall P D. The gate control theory of pain mechanisms. A re-examination and a re-statement. Brain 1978; 101: 1–18
   PubMed Web of Science ®Google Scholar
• Neafsey E J, Terreberry R R, Hurley K M, Ruit K G, Frysztak R J. Anterior cingulate cortex in rodents: connections, visceral control functions and implications for emotion. Neurobiology of cingulate cortex and limbic thalamus: a comprehensive handbook, B A Vogt, M Gabriel. Birkhäuser, Boston, MA 1993; 206–23
   Google Scholar
• Terreberry R R, Neafsey E J. Rat medial frontal cortex: a visceral motor region with a direct projection to the solitary nucleus. Brain Res 1983; 278: 245–9
   PubMed Web of Science ®Google Scholar
• Hurley K M, Herbert H, Moga M M, Saper C B. Efferent projections of the inferolimbic cortex of the rat. J Comp Neurol 1991; 308: 249–76
   PubMed Web of Science ®Google Scholar
• Vogt B A, Pandya D N. Cingulate cortex of the rhesus monkey: 11. cortical afferents. J Comp Neurol 1987; 262: 271–89
   PubMed Web of Science ®Google Scholar
• Van Hoesen G W, Morecraft R J, Vogt B A. Connections of the monkey cingulate cortex. Neurobiology of cingulate cortex and limbic thalamus: a comprehensive handbook, B A Vogt, M Gabriel. Birkhauser, Boston, MA 1993; 249–84
   Google Scholar
• Jones A KP, Brown W D, Friston K J, Qi L Y, Frackowiak R SJ. Cortical and subcortical localization of response to pain in man using positron emission tomography. Proc R Soc Lond B 1991; 244: 39–44
   PubMed Web of Science ®Google Scholar
• Talbot J D, Marrett S, Evans A C, Meyer E, Bushnell M C, Duncan G H. Multiple representations of pain in human cerebral cortex. Science 1991; 251: 1355–8
   PubMed Web of Science ®Google Scholar
• Keefer C S, Resnik W H. Angina pectoris: a syndrome caused by anoxemia of the myocardium. Arch Intern Med 1928; 41: 769–807
   Google Scholar
• Rosen S D, Camici P G. Insights into the pathophysiology of syndrome X obtained using positron emission tomography (PET). Chest pain with normal coronary angiograms: Pathogenesis, diagnosis and management, J -C Kaski. Kluwer, Dordrechtthe Netherlands 1999; 69–80
   Google Scholar
• Cannon R O, Camici P G, Epstein S E. Pathophysiological dilemma of syndrome X. Circulation 1992; 85: 883–92
   PubMed Web of Science ®Google Scholar
• Shapiro L M, Crake T, Poole-Wilson P A. Is altered cardiac sensation responsible for chest pain in patients with normal coronary arteries? Clinical observation during cardiac catheterisation. Br Med J 1988; 296: 170–1
   PubMedGoogle Scholar
• Cannon R O, Quyyumi A A, Schenke W H, Fananapazir L, Tucker E E, Gaughan A M, et al. Abnormal cardiac sensitivity in patients with chest pain and normal coronary arteries. J Am Coll Cardiol 1990; 16: 1359–66
   PubMed Web of Science ®Google Scholar
• Lagerqvist B, Sylvin C, Beerman B, Helmius G, Walden-mom A. Intracoronary adenosine causes angina pectoris like pain - an inquiry into the nature of visceral pain. Cardiovasc Res 1990; 24: 609–13
   PubMed Web of Science ®Google Scholar
• Lagerqvist B, Sylvin C, Waldenstrom A. Lower threshold for adenosine-induced chest pain in patients with angina and normal coronary angiograms. Br Heart J 1992; 68: 282–5
   PubMedGoogle Scholar
• Nihoyannopoulos P, Kaski J -C, Crake T, Maseri A. Absence of myocardial dysfunction during pacing stress in patients with syndrome X. J Am Coll Cardiol 1991; 18: 1463–70
   PubMed Web of Science ®Google Scholar
• Panza J A, Laurienzo J M, Curiel R V, Unger E F, Quyyumi A A, Dilsizian V, et al. Investigation of the mechanism of chest pain in patients with angiographically normal coronary arteries using transesophageal dobutamine stress echo-cardiography. J Am Coll Cardiol 1997; 29: 293–301
   PubMed Web of Science ®Google Scholar