A proposal of three distinct subtypes of type 1 diabetes mellitus based on clinical and pathological evidence

References

• Eisenbarth GS. Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med 1986; 314: 1360–8
   PubMed Web of Science ®Google Scholar
• Bach JF. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev 1994; 15: 516–42
   PubMed Web of Science ®Google Scholar
• Bottazzo GF, Dean JM, McNally JM, MacKay EH, Swift PGF, Gamble DR. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 1985; 313: 353–60
   PubMed Web of Science ®Google Scholar
• Foulis AK, Liddle CN, Farquharson MA, Richmond JA, Weir RS. The histopathology of the pancreas in Type I (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 1986; 29: 267–74
   PubMed Web of Science ®Google Scholar
• Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997; 20: 1183–97
   PubMed Web of Science ®Google Scholar
• Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15: 539–53
   PubMed Web of Science ®Google Scholar
• Hanafusa T, Miyazaki A, Miyagawa J, Tamura S, Inada M, Yamada K. Examination of islets in the pancreas biopsy specimens from newly diagnosed type I (insulin-dependent) diabetic patients. Diabetologia 1990; 33: 105–11
   PubMed Web of Science ®Google Scholar
• Itoh N, Hanafusa T, Miyazaki A, Miyagawa J, Yamagata K, Yamamoto K. Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest 1993; 92: 2313–22
   PubMed Web of Science ®Google Scholar
• Imagawa A, Hanafusa T, Itoh N, Waguri M, Yamamoto K, Miyagawa J. Immunological abnormalities in islets at diagnosis paralleled further deterioration of glycaemic control in patients with recent-onset Type I (insulin-dependent) diabetes mellitus. Diabetologia 1999; 42: 574–8
   PubMedGoogle Scholar
• Moriwaki M, Itoh N, Miyagawa J, Yamamoto K, Imagawa A, Yamagata K. Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recentonset Type I diabetes mellitus. Diabetologia 1999; 42: 1332–40
   PubMed Web of Science ®Google Scholar
• Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y. A. novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group. N Engl J Med 2000; 342: 301–7
   PubMedGoogle Scholar
• Kagi D, Vignaux F, Ledermann B, Burki K, Depraetere V, Nagata S. Fas and perform pathways as major mechanisms of T cell-mediated cytotoxicity. Science 1994; 265: 528–30
   PubMed Web of Science ®Google Scholar
• Lowin B, Hahne M, Mattmann C, Tschopp J. Cytolytic T cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 1994; 370: 650–2
   PubMed Web of Science ®Google Scholar
• Todd JA, Bell JI, McDevitt HO. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 1987; 329: 599–604
   PubMed Web of Science ®Google Scholar
• Tiberti C, Buzzetti R, Anastasi E, Dotta F, Vasta M, Petrone A. Autoantibody negative new onset type 1 diabetic patients lacking high risk HLA alleles in a Caucasian population: are these type 1b diabetes cases. Diabet Metab Res Rev 2000; 16: 8–14
   PubMedGoogle Scholar
• Yoshiuchi I, Yamagata K, Yang Q, Iwahashi H, Okita K, Yamamoto K. Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes meliitus: clinical features and functional characterization. Diabetologia 1999; 42: 621–6
   PubMedGoogle Scholar
• Gaines KL, Kayes SG, Wilson GL. Altered pathogenesis in encephalomyocarditis virus (D variant)-infected diabetes-susceptible and resistant strains of mice. Diabetologia 1986; 29: 313–20
   PubMedGoogle Scholar
• Hartig PC, Webb SR. Heterogeneity of a human isolate of coxsackie B4: biological differences. J Infect 1983; 6: 43–8
   PubMedGoogle Scholar
• Roivainen M, Rasilainen S, Ylipaasto P, Nissinen R, Ustinov J, Bouwens L. Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells. J Clin Endocrinol Metab 2000; 85: 432–40
   PubMedGoogle Scholar
• Itoh N, Hanafusa T, Yamagata K, Nakajima H, Tomita K, Tamura S. No detectable cytomegalovirus and Epstein-Barr virus genomes in the pancreas of recent-onset IDDM patients. Diabetologia 1995; 38: 667–71
   PubMedGoogle Scholar
• Panicot L, Mas E, Thivolet C, Lombardo D. Circulating antibodies against an exocrine pancreatic enzyme in type 1 diabetes. Diabetes 1999; 48: 2316–23
   PubMed Web of Science ®Google Scholar