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Original Article

Antiplatelet medications and their indications in preventing and treating coronary thrombosis

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Pages 561-571 | Published online: 08 Jul 2009

References

  • Wright I. Experience with anticoagulants. Circulation 1959; 19: 110–3
  • Craven L. Acetylsalicylic acid, possible preventive of coronary thrombosis. Ann West Med Surg 1950; 4: 95
  • Craven LL. Experiences with aspirin (acetylsalicylic acid) in the nonspecific prophylaxis of coronary thrombosis. Mississippi Valley Medical Journal 1953; 75: 38–44
  • Herrick J. Clinical features of sudden obstruction of the coronary arteries. JAMA 1912; 59: 2015–20
  • DeWood M. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med 1980; 303: 897–901
  • Davis M, Thomas A. Thrombosis and acute coronary artery lesions in sudden cardiac ischemic death. N Engl J Med 1984; 310: 1137–40
  • Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N Engl J Med 1992; 326: 242–50
  • Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med 1992; 326: 310–8
  • Wagner CL, Mascelli MA, Neblock DS, Weisman HF, Coller BS, Jordan RE. Analysis of GPIIb/IIIa receptor number by quantification of 7E3 binding to human platelets. Blood 1996; 88: 907–14
  • Lefkovits J, Plow EF, Topol EJ. Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine. N Engl J Med 1995; 332: 1553–9
  • Gifford R, Feinstein A. A critique of methodology in studies of anticoagulant therapy for acute myocardial infarction. N Engl J Med 1969; 280: 351–7
  • ISIS-2 Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 1988; 2: 349–60
  • Awtry E, Loscalzo J. Aspirin. Circulation 2000; 101: 1206–18
  • Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature 1971; 231: 231–5
  • Patrignani P, Filabozzi P, Patrono C. Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. J Clin Invest 1982; 69: 1366–72
  • Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy—I. Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 1994; 308: 81–106
  • Mills DCB, Puri R, Hu C-J, Minniti C, Grana G, Freedman MD. Clopidogrel inhibits the binding of ADP analogues to the receptor mediating inhibition of platelet adenylate cyclase. Arterioscler Thromb 1992; 12: 430–6
  • Herbert J-M, Dol F, Bernat A, Falotico R, Lale A, Savi P. The antiaggregating and antithrombotic activity of clopidogrel is potentiated by aspirin in several experimental models in the rabbit. Thromb Haemost 1998; 80: 512–8
  • Di Perri T, Pasini FL, Frigerio C, Blardi P, Centini F, Messa GL. Pharmacodynamics of ticlopidine in man in relation to plasma and blood cell concentration. Eur J Clin Pharmacol 1991; 41: 429–34
  • Bachman F, Savcic M, Hauert J, Geudelin B, Kieffer G, Cariou R. Rapid onset of inhibition of ADP-induced platelet aggregation by a loading dose of clopidogrel (abstract). Eur Heart J 1996; 17: 263
  • Bennett CL, Kiss JE, Weinberg PD, Pinevich AJ, Green D, Kwaan HC. Thrombotic thrombocytopenic purpura after stenting and ticlopidine. Lancet 1998; 352: 1036–7
  • Steinhubl SR, Tan WA, Foody JM, Topol EJ. Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting. EPISTENT Investigators. JAMA 1999; 281: 806–10
  • Bennett C, Connors J, Carwile J, Moake J, Bell W, Tarantolo S. Thrombotic thrombocytopenic purpura associated with clopidogrel. N Engl J Med 2000; 342: 1773–7
  • Gent M, Blakely JA, Easton JD, Ellis DJ, Hachinski VC, Harbison JW. The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. The CATS Group. Lancet 1989; 1: 1216–20
  • CAPRIE Steering Committee. A randomised, blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996; 348: 1329–39
  • Mascelli M, Lance E, Wagner C. Abciximab (7E3) pharmaco-dynamics demonstrates an extended and gradual recover from GPIIb/IIIa blockade. Circulation 1996; 95: 809–13
  • Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: a randomised trial. The SYMPHONY Investigators. Lancet 2000; 355: 337–45
  • O'Neill WW, Serruys P, Knudtson M, Van Es GA, Timmis GC, Van der Zwaan C. Long-term treatment with a platelet glycoprotein-receptor antagonist after percutaneous coronary revascularization. EXCITE Trial Investigators. N Engl J Med 2000; 342: 1316–24
  • Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A. European Stroke Prevention Study 2. Dipyrid-amole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 1996; 143: 1–13
  • Peto R, Gray R, Collins R, Wheatley K, Hennekens C, Jamrozik K. Randomised trial of prophylactic daily aspirin in British male doctors. BMJ 1988; 926: 313–6
  • Final report on the aspirin component of the ongoing Physicians' Health Study. Steering Committee of the Physicians' Health Study Research Group. N Engl J Med 1989; 321: 129–35
  • Hansson L, Zanchetti A, Carruthers S, Dahiof B, Elmfeldt D, Julius S. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998; 351: 1755–62
  • Thrombosis prevention trial: randomized trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk. The Medical Research Council's General Practice Research Framework. Lancet 1998; 351: 233–41
  • Hass WK, Easton JD, Adams HP, Jr., Pryse-Phillips W, Molony BA, Anderson S. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high risk patients. Ticlopidine Aspirin Stroke Study Group. N Engl J Med 1989; 321: 501–7
  • Savonitto S, Ardissino D, Granger C, Morando G, Prando M, Mafrici A. Prognostic value of the admission electrocardiogram in acute coronary syndromes. JAMA 1999; 281: 707–13
  • Lewis H, Davis J, Archibald D, Steinke W, Smitherman T, Doherty J. Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. N Engl J Med 1983; 309: 396–403
  • Cairns J, Gent M, Singer J, Finnie K, Froggatt G, Holder D. Aspirin, sulfinpyrazone, or both in unstable angina: Results of a Canadian multicenter trial. N Engl J Med 1985; 313: 1369–75
  • Theroux P, Quimet H, McCans J, Latour J, Joly P, Levy G. Aspirin, heparin, or both to treat acute unstable angina. N Engl J Med 1988; 319: 1105–11
  • Wallentin LC. Aspirin (75 mg/day) after an episode of unstable coronary artery disease: long-term effects on the risk for myocardial infarction, occurrence of severe angina and the need for revascularization. Research Group on Instability in Coronary Artery Disease in Southeast Sweden. J Am Coll Cardiol 1991; 18: 1587–93
  • Balsano F, Rizzon P, Violi F, Scrutinio D, Cimminiello C, Aguglia F. Antiplatelet treatment with ticlopidine in unstable angina: a controlled multicenter clinical trial. The studio della Ticlopidina nell'Angina Instabile Group. Circulation 1990; 82: 17–26
  • Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction. PRISM-PLUS Study Investigators. N Engl J Med 1998; 338: 1488–97
  • Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromes. The PURSUIT Trial Investigators. Platelet Glycoprotein Ilb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy. N Engl J Med 1998; 339: 436–43
  • International, randomized, controlled trial of lamifiban (a platelet glycoprotein IIb/IIIa inhibitor), heparin, or both in unstable angina. The PARAGON Investigators. Platelet Antagonism for the Reduction of Acute coronary syndrome events in a Global Organization Network. Circulation 1998; 97: 2386–95
  • A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina. Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) Study Investigators. N Engl J Med 1998; 338: 1498–505
  • Lincoff A, Califf R, Topol E. Platelet glycoprotein IIb/IIIa receptor blockade in coronary artery disease. J Am Coll Cardiol 2000; 35: 1103–15
  • Randomised placebo-controlled trial of abciximab before and during coronary interventions in refractory unstable angina: the CAPTURE Study. Lancet 1997; 349: 1429–35
  • Ryan T, Anderson J, Antman E, Braniff B, Brooks N, Califf R. ACC/AHA guidelines for the management of patients with acute myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). J Am Coll Cardiol 1996; 28: 1328–428
  • Baigent C, Collins R, Appleby P, Parish S, Sleight P, Peto R. ISIS-2: 10 year survival among patients with suspected acute myocardial infarction in randomised comparison of intravenous streptokinase, oral aspirin, both, or neither. BMJ 1998; 316: 1337–43
  • Roux S, Christeller S, Luedin E. Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: a meta-analysis. J Am Coll Cardiol 1992; 19: 671–7
  • Simes R, Topol E, Holmes DJ, White H, Rutsch W, Vahanian A. Link between the angiographic substudy and mortality outcomes in a large randomized trial of myocardial reperfusion. Importance of early and complete infarct artery reperfusion. GUSTO-I Investigators. Circulation 1995; 91: 1923–8
  • Falk E. Thrombosis in unstable angina: pathologic aspects. Cardiovasc Clin 1987; 18: 137–49
  • Zhu Y, Carmeliet P, Fay W. Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance. Circulation 1999; 99: 3050–5
  • Antman EM, Giugliano RP, Gibson CM, McCabe CH, Coussement P, Kleiman NS. Abciximab facilitates the rate and extent of thrombolysis: results of the thrombolysis in myocardial infarction (TIMI) 14 Trial. The TIMI 14 Investigators. Circulation 1999; 99: 2720–32
  • Trial of abciximab with and without low-dose reteplase for acute myocardial infarction. Strategies for Patency Enhancement in the Emergency Department (SPEED) Group. Circulation 2000; 101: 2788–94
  • Serruys PW, Strauss BH, Beatt KJ, Bertrand ME, Puel J, Rickards AF. Angiographic follow-up after placement of a self-expanding coronary artery stent. N Engl J Med 1991; 324: 13–7
  • Schwartz L, Bourassa MG, Lesperance J, Aldridge HE, Kazim F, Salvatori VA. Aspirin and dipyridamole in the prevention of restenosis after percutaneous transluminal coronary angioplasty. N Engl J Med 1988; 318: 1714–9
  • Lembo N, Black A, Roubin G, Wilentz J, Mufson L, Douglas JJ. Effect of pretreatment with aspirin versus aspirin plus dipyridamole on frequency and type of acute complications of percutaneous transluminal coronary angioplasty. Am J Cardiol 1990; 65: 422–6
  • Barnathan ES, Schwartz JS, Taylor L, Lasky W, Kleaveland JP, Kussmaul WG. Aspirin and dipyridamole in the prevention of acute coronary thrombosis complicating coronary angioplasty. Circulation 1987; 76: 125–34
  • Rupprecht H-J, Darius H, Borkowski U, Voigtlander T, Nowak B, Genth S. Comparison of antiplatelet effects of aspirin, ticlopidine, or their combination after stent implantation. Circulation 1998; 97: 1046–52
  • Quinn M, Fitzgerald D. Ticlopidine and clopidogrel. Circulation 1999; 100: 1667–72
  • Urban P, Macaya C, Rupprecht HJ, Kiemeneij F, Emanuelsson H, Fontanelli A. Randomized evaluation of anticoaguiation versus antiplatelet therapy after coronary stent implantation in high-risk patients: the multicenter aspirin and ticlopidine trial after intracoronary stenting (MATTIS). Circulation 1998; 98: 2126–32
  • Bertrand ME, Legrand V, Boland J, Fleck E, Bonnier J, Emmanuelson H. Randomized multicenter comparison of conventional anticoaguiation versus antiplatelet therapy in unplanned and elective coronary stenting. The Full Anticoaguiation Versus Aspirin and Ticlopidine (FANTASTIC) Study. Circulation 1998; 98: 1597–603
  • Leon MB, Baim DS, Popma JJ, Gordon PC, Cutlip DE, Ho KKL. A clinical trial comparing three anti-thrombotic regimens following coronary-artery stenting. Stent Anti-coagulation Restenosis Study Investigators. N Eng J Med 1998; 339: 1665–71
  • Schomig A, Neumann F-J, Kastrati A, Schuhlen H, Blasini R, Hadamitzky M. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Eng J Med 1996; 334: 1084–9
  • Cadroy Y, Bossavy J, Thalamas C, Sagnard L, Sakariassen K, Boneu B. Early potent antithrombotic effect with combined aspirin and a loading dose of clopidogrel on experimental arterial thrombogenesis in humans. Circulation 2000; 101: 2823–8
  • Mueller C, Buettner H, Petersen J, Roskamm H. A randomized comparison of clopidogrel and aspirin versus ticlopidine and aspirin after the placement of coronary-artery stents. Circulation 2000; 101: 590–3
  • Taniuchi M, Kurz H, Smith S, Lasala J. Ticlid or plavix post-stent (TOPPS): randomization to 2 weeks of treatment. Am J Cardiol 1999; 84: 68P–9P, (Suppl 6A)
  • Morris D. Results from late-breaking clinical trials sessions at ACCIS 99 and ACC 99. J Am Coll Cardiol 1999; 34: 1–8
  • Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization. The EPILOG Investigators. N Engl J Med 1997; 336: 1689–96
  • Randomised placebo-controlled and balloon-angioplasty-controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade. The EPISTENT Investigators. Evaluation of Platelet IIb/IIIa Inhibitor for Stenting. Lancet 1998; 352: 87–92
  • Randomised placebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention. IMPACT-II. Integrilin to Minimise Platelet Aggregation and Coronary Thrombosis-II. Lancet 1997; 349: 1422–8
  • Brener SJ, Barr LA, Burchenal E, Katz S, George BS, Jones AA. Randomized, placebo-controlled trial of platelet glycoprotein IIb/IIIa blockade with primary angioplasty for acute myocardial infarction. ReoPro and Primary PTCA Organization and Randomized Trial (RAPPORT) Investigators. Circulation 1998; 98: 734–41
  • Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. The EPIC Investigation. N Engl J Med 1994; 330: 956–61
  • Effects of platelet glycoprotein IIb/IIIa blockade with tirofiban on adverse cardiac events in patients with unstable angina or acute myocardial infarction undergoing coronary angioplasty. The RESTORE Investigators. Randomized Efficacy Study of Tirofiban for Outcomes and Restenosis. Circulation 1997; 96: 1445–53
  • Bach R, Jung F, Kohsiek I, Ozbek C, Spitzer S, Scheller B. Factors affecting the restenosis rate after percutaneous translumina… coronary angioplasty. Thromb Res 1994; 74: S55–67
  • Acute platelet inhibition with abciximab does not reduce instent restenosis (ERASER Study). The Eraser Investigators. Circulation 1999; 100: 799–806

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