Checkpoint genes in cancer

References

• Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87: 159–70
   PubMed Web of Science ®Google Scholar
• Sherr CJ. Cancer cell cycles. Science 1996; 274: 1672–7
   PubMed Web of Science ®Google Scholar
• Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. Creation of human tumour cells with defined genetic elements. Nature 1999; 400: 464–8
   PubMed Web of Science ®Google Scholar
• McDonald ER, 3rd, El-Deiry WS. Cell cycle control as a basis for cancer drug development. Int J Oncol 2000; 16: 871–86
   PubMed Web of Science ®Google Scholar
• Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD. Mutations of mitotic checkpoint genes in human cancers. Nature 1998; 392: 300–3
   PubMed Web of Science ®Google Scholar
• Corn PG, Kuerbitz SJ, van Noesel MM, Esteller M, Compitello N, Baylin SB. Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation. Cancer Res 1999; 59: 3352–6
   PubMed Web of Science ®Google Scholar
• Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature 2000; 408: 433–9
   PubMed Web of Science ®Google Scholar
• Bell DW, Varley JM, Szydlo TE, Rang DH, Wahrer DC, Shannon KE. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 1999; 286: 2528–31
   PubMed Web of Science ®Google Scholar
• Harbour JW, Dean DC. The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev 2000; 14: 2393–409
   PubMed Web of Science ®Google Scholar
• Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B. 14–3–3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 1999; 401: 616–20
   PubMed Web of Science ®Google Scholar
• Sage J, Mulligan GJ, Attardi LD, Miller A, Chen S, Williams B. Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev 2000; 14: 3037–50
   PubMed Web of Science ®Google Scholar
• Dannenberg JH, van Rossum A, Schuijff L, te Riele H. Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev 2000; 14: 3051–64
   PubMed Web of Science ®Google Scholar
• Wohlschlegel JA, Dwyer BT, Dhar SK, Cvetic C, Walter JC, Dutta A. Inhibition of eukaryotic DNA replication by geminin binding to cdt1. Science 2000; 290: 2309–12
   PubMed Web of Science ®Google Scholar
• Shapiro GI, Harper JW. Anticancer drug targets: cell cycle and checkpoint control. J Clin Invest 1999; 104: 1645–53
   PubMed Web of Science ®Google Scholar
• Lohka MJ, Hayes MK, Mailer JL. Purification of maturation-promoting factor, an intracellular regulator of early mitotic events. Proc Natl Acad Sci U S A 1988; 85: 3009–13
   PubMed Web of Science ®Google Scholar
• Evans T, Rosenthal ET, Youngblom J, Distel D, Hunt T. Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell 1983; 33: 389–96
   PubMed Web of Science ®Google Scholar
• Morgan DO. Principles of CDK regulation. Nature 1995; 374: 131–4
   PubMed Web of Science ®Google Scholar
• Luo RX, Postigo AA, Dean DC. Rb interacts with histone deacetylase to repress transcription. Cell 1998; 92: 463–73
   PubMed Web of Science ®Google Scholar
• Strobeck MW, Knudsen KE, Fribourg AF, DeCristofaro MF, Weissman BE, Imbalzano AN. BRG-1 is required for RB-mediated cell cycle arrest. Proc Natl Acad Sa U S A 2000; 97: 7748–53
   PubMed Web of Science ®Google Scholar
• Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 1999; 98: 859–69
   PubMed Web of Science ®Google Scholar
• Zhang HS, Gavin M, Dahiya A, Postigo AA, Ma D, Luo RX. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell 2000; 101: 79–89
   PubMed Web of Science ®Google Scholar
• Dutta A, Bell SP. Initiation of DNA replication in eukaryotic cells. Annu Rev Cell Dev Biol 1997; 13: 293–332
   PubMed Web of Science ®Google Scholar
• Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J 1999; 18: 396–410
   PubMed Web of Science ®Google Scholar
• Hua XH, Yan H, Newport J. A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle. J Cell Biol 1997; 137: 183–92
   PubMedGoogle Scholar
• Cortez D, Elledge SJ. Conducting the mitotic symphony. Nature 2000; 406: 354–6
   PubMedGoogle Scholar
• Ookata K, Hisanaga S, Bulinski JC, Murofushi H, Aizawa H, Itoh TJ. Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics. J Cell Biol 1995; 128: 849–62
   PubMedGoogle Scholar
• Blangy A, Lane FLA, d'Herin P, Harper M, Kress M, Nigg EA. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 1995; 83: 1159–69
   PubMed Web of Science ®Google Scholar
• Heald R, McKeon F. Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis. Cell 1990; 61: 579–89
   PubMed Web of Science ®Google Scholar
• Foisner R, Gerace L. Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation. Cell 1993; 73: 1267–79
   PubMed Web of Science ®Google Scholar
• Lew DJ, Kornbluth S. Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. Curr Opin Cell Biol 1996; 8: 795–804
   PubMed Web of Science ®Google Scholar
• Russo AA, Jeffrey PD, Pavletich NP. Structural basis of cyclin-dependent kinase activation by phosphorylation. Nat Struct Biol 1996; 3: 696–700
   PubMedGoogle Scholar
• Fisher RP, Morgan DO. A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase. Cell 1994; 78: 713–24
   PubMed Web of Science ®Google Scholar
• Hunter T. Oncoprotein networks. Cell 1997; 88: 333–46
   PubMed Web of Science ®Google Scholar
• Cheng M, Olivier P, Diehl JA, Fero M, Roussel MF, Roberts JM. The p21(Cip1) and p27(Kip1) CDK ‘inhibitors’ are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 1999; 18: 1571–83
   PubMed Web of Science ®Google Scholar
• Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993; 75: 805–16
   PubMed Web of Science ®Google Scholar
• el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM. WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75: 817–25
   PubMed Web of Science ®Google Scholar
• Orr-Weaver TL, Weinberg RA. A checkpoint on the road to cancer. Nature 1998; 392: 223–4
   PubMedGoogle Scholar
• King RW, Peters JM, Tugendreich S, Rolfe M, Hieter P, Kirschner MW. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 1995; 81: 279–88
   PubMed Web of Science ®Google Scholar
• Zou H, McGarry TJ, Bernal T, Kirschner MW. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science 1999; 285: 418–22
   PubMed Web of Science ®Google Scholar
• Scolnick DM, Halazonetis TD. Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature 2000; 406: 430–5
   PubMed Web of Science ®Google Scholar
• Painter RB, Young BR. Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc Natl Acad Sci U S A 1980; 77: 7315–7
   PubMed Web of Science ®Google Scholar
• Elledge SJ. Cell cycle checkpoints: preventing an identity crisis. Science 1996; 274: 1664–72
   PubMed Web of Science ®Google Scholar
• Weinert T. A DNA damage checkpoint meets the cell cycle engine. Science 1997; 277: 1450–1
   PubMedGoogle Scholar
• Lopez-Girona A, Furnari B, Mondesert O, Russell P. Nuclear localization of Cdc25 is regulated by DNA damage and a 14–3–3 protein. Nature 1999; 397: 172–5
   PubMedGoogle Scholar
• Mailand N, Falck J, Lukas C, Syljuasen RG, Welcker M, Bartek J. Rapid destruction of human Cdc25A in response to DNA damage. Science 2000; 288: 1425–9
   PubMed Web of Science ®Google Scholar
• Chehab NH, Malikzay A, Appel M, Halazonetis TD. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev 2000; 14: 278–88
   PubMed Web of Science ®Google Scholar
• Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 2000; 287: 1824–7
   PubMed Web of Science ®Google Scholar
• Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 1998; 281: 1677–9
   PubMed Web of Science ®Google Scholar
• Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998; 281: 1674–7
   PubMed Web of Science ®Google Scholar
• Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000; 408: 307–10
   PubMed Web of Science ®Google Scholar
• Matsuoka S, Huang M, Elledge SJ. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 1998; 282: 1893–7
   PubMed Web of Science ®Google Scholar
• Gong JG, Costanzo A, Yang HQ, Melino G, Kaelin WG, Jr, Levrero M. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 1999; 399: 806–9
   PubMed Web of Science ®Google Scholar
• Hermeking H, Lengauer C, Polyak K, He TC, Zhang L, Thiagalingam S. 14–3–3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell 1997; 1: 3–11
   PubMed Web of Science ®Google Scholar
• Ohki R, Nemoto J, Murasawa H, Oda E, Inazawa J, Tanaka N. Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. J Biol Chem 2000; 275: 22627–30
   PubMed Web of Science ®Google Scholar
• Cortez D, Wang Y, Qin J, Elledge SJ. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 1999; 286: 1162–6
   PubMed Web of Science ®Google Scholar
• Lim DS, Kim ST, Xu B, Maser RS, Lin J, Petrini JH. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 2000; 404: 613–7
   PubMed Web of Science ®Google Scholar
• Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev 2000; 14: 927–39
   PubMed Web of Science ®Google Scholar
• Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell 1999; 3: 389–95
   PubMed Web of Science ®Google Scholar
• Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM. A novel cyclin encoded by a bell-linked candidate oncogene. Nature 1991; 350: 512–5
   PubMed Web of Science ®Google Scholar
• Welcker M, Lukas J, Strauss M, Bartek J. Enhanced protein stability: a novel mechanism of D-type cyclin over-abundance identified in human sarcoma cells. Oncogene 1996; 13: 419–25
   PubMedGoogle Scholar
• Bartkova J, Lukas J, Strauss M, Bartek J. Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene 1995; 10: 775–8
   PubMed Web of Science ®Google Scholar
• Keyomarsi K, O'Leary N, Molnar G, Lees E, Fingert HJ, Pardee AB. Cyclin E, a potential prognostic marker for breast cancer. Cancer Res 1994; 54: 380–5
   PubMed Web of Science ®Google Scholar
• Leach FS, Elledge SJ, Sherr CJ, Willson JK, Markowitz S, Kinzler KW. Amplification of cyclin genes in colorectal carcinomas. Cancer Res 1993; 53: 1986–9
   PubMed Web of Science ®Google Scholar
• Wolfel T, Hauer M, Schneider J, Serrano M, Wolfel C, Klehmann-Hieb E. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 1995; 269: 1281–4
   PubMed Web of Science ®Google Scholar
• Hall M, Peters G. Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Adv Cancer Res 1996; 68: 67–108
   PubMed Web of Science ®Google Scholar
• Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995; 1: 686–92
   PubMed Web of Science ®Google Scholar
• Tan P, Cady B, Wanner M, Worland P, Cukor B, Magi-Galluzzi C. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. Cancer Res 1997; 57: 1259–63
   PubMed Web of Science ®Google Scholar
• Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med 1997; 3: 231–4
   PubMed Web of Science ®Google Scholar
• Singh SP, Lipman J, Goldman H, Ellis FH, Jr, Aizenman L, Cangi MG. Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma. Cancer Res 1998; 58: 1730–5
   PubMed Web of Science ®Google Scholar
• Galaktionov K, Lee AK, Eckstein J, Draetta G, Meckler J, Loda M. CDC25 phosphatases as potential human oncogenes. Science 1995; 269: 1575–7
   PubMed Web of Science ®Google Scholar
• Gemma A, Seike M, Seike Y, Uematsu K, Hibino S, Kurimoto F. Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer. Genes Chromosomes Cancer 2000; 29: 213–8
   PubMed Web of Science ®Google Scholar
• Jaffrey RG, Pritchard SC, Clark C, Murray GI, Cassidy J, Kerr KM. Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancer. Cancer Res 2000; 60: 4349–52
   Google Scholar
• Yamaguchi K, Okami K, Hibi K, Wehage SL, Jen J, Sidransky D. Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines. Cancer Lett 1999; 139: 183–7
   PubMedGoogle Scholar
• Jin DY, Spencer F, Jeang KT. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell 1998; 93: 81–91
   PubMed Web of Science ®Google Scholar
• Brown EJ, Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 2000; 14: 397–402
   PubMed Web of Science ®Google Scholar
• Burns TF, El-Deiry WS. The p53 pathway and apoptosis. J Cell Physiol 1999; 181: 231–9
   PubMed Web of Science ®Google Scholar
• Fang S, Jensen JE, Ludwig RL, Vousden KH, Weissman AM. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem 2000; 275: 8945–51
   PubMed Web of Science ®Google Scholar
• Weber JD, Taylor LJ, Roussel MF, Sherr CJ, Bar-Sagi D. Nucleolar Arf sequesters Mdm2 and activates p53. Nat Cell Biol 1999; 1: 20–6
   PubMed Web of Science ®Google Scholar
• Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 1992; 358: 80–3
   PubMed Web of Science ®Google Scholar
• Leach FS, Tokino T, Meltzer P, Burrell M, Oliner JD, Smith S. p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res 1993; 53(10 Suppl)2231–4
   PubMedGoogle Scholar
• Quelle DE, Zindy F, Ashmun RA, Sherr CJ. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 1995; 83: 993–1000
   PubMed Web of Science ®Google Scholar
• Tirkkonen M, Johannsson O, Agnarsson BA, Olsson H, Ingvarsson S, Karhu R. Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations. Cancer Res 1997; 57: 1222–7
   PubMed Web of Science ®Google Scholar