13
Views
2
CrossRef citations to date
0
Altmetric
Original Article

The Alcohol Tolerant and Alcohol Nontolerant Rat Lines Selected for Differential Sensitivity to Ethanol: A Tool to Study Mechanisms of the Actions of Ethanol

&
Pages 283-287 | Published online: 08 Jul 2009

References

  • Sinclair J D., Lê A D., Kiianmaa K. Genetically-selected rat lines as models of alcoholism and alcohol intoxication. Genetically-defined animal models in neurobehavioral dysfunctions, P Driscoll. Birkhäuser Boston Inc., Cambridge, MA 1990, (in press)
  • Eriksson K, Rusi M. (1981) Finnish selection studies on alcoholrelated behaviors: General outline. Development of animal models as pharmacogenetic tools. 1981, G E. McClearn, R A. Deitrich, G Erwin. Government Printing Office, Rockville, 87–117, Proceedings of the Workshop Boulder. NIAAA Research Monograph, 6
  • Sinclair J D., Lê A D., Kiianmaa K. The AA and ANA rat lines, selected for differences in voluntary alcohol consumption. Experientia 1989; 45: 798–805
  • Goldstein D B. Animal models developed by selective out-breeding: some questions raised and few answered. Genetic aspects of alcoholism. The Finnish Foundation for Alcohol Studies, K Kiianmaa, B Tabakoff, T Saito. Painokaari, Helsinki 1989; Vol 37: 229–38
  • Phillips T J., Feller D J., Crabbe J C. Selected mouse lines, alcohol and behavior. Experientia 1989; 45: 805–27
  • Arvola A, Sammalisto L, Wallgren H. A test for level of alcohol intoxication in the rat. Q J Stud Alcohol 1958; 19: 563–72
  • Hellevuo K, Kiianmaa K, Korpi E R. Effect of GABAergic drugs on motor impairment from ethanol, barbital and lorazepam in rat lines selected for differential sensitivity to ethanol. Pharmacol Biochem Behav 1989; 34: 399–404
  • Eriksson C JP, Sarviharju M. Motor impairment, narcosis and hypothermia by ethanol: Separate genetic mechanisms. Alcohol 1984; 1: 59–62
  • Hellevuo K, Kiianmaa K. GABA turnover in the brain of rat lines developed for differential ethanol-induced motor impairment. Pharmacol Biochem Behav 1989; 34: 905–9
  • Hellevuo K, Korpi E R. Failure of Ro 15-4513 to antagonize ethanol in rat lines selected for differential sensitivity to ethanol and in Wistar rats. Pharmacol Biochem Behav 1988; 30: 183–8
  • Lê A D., Kiianmaa K. Initial sensitivity and the development of acute and rapid tolerance to ethanol in the AT and ANT rats. Genetic aspects of alcoholism, The Finnish Foundation for Alcohol Studies, K Kiianmaa, B Tabakoff, T Saito. Painokaari, Helsinki 1989; Vol 37: 147–55
  • Korpi E R., Tuominen K, Uusi-Oukari M, Saransaari P, Oja S S., Suzdak P D. Mechanisms of alcohol intoxication in a rodent model: Blunted alcohol-oposing reaction in “alcohol-sensitive” rats. Ann Med 1990; 22: 253–8
  • Lê A D., Kiianmaa K. Role of initial sensitivity and genetic factors in the development of tolerance to ethanol in the AT and ANT rats. Psychopharmacology 1990; 102: 11–6
  • Sinclair J D., Viitamaa T, Hyytiä P. Behavioral and color variations between rat lines developed for differential alcohol sensitivity. Alcohol Alcohol 1987; 449–53, Suppl 1
  • Tuominen K, Hellevuo K, Korpi E R. Plus-maze behavior and susceptibility to 3-mercaptopropionate-induced seizures in rat lines selected for high and low alcohol sensitivity. Pharmacol Biochem Behav 1990; 35: 721–5
  • Nutt D, Glue P. Monoamines and alcohol. Br J Addict 1986; 81: 327–38
  • Pohorecky L A., Brick J. Pharmacology of ethanol. Pharmacol Ther 1988; 36: 335–427
  • Kiianmaa K. Alcohol intake and ethanol intoxication in the rat: Effect of a 6-OHDA-induced lesion of the ascending noradrenaline pathways. Eur J Pharmacol 1980; 64: 9–19
  • Kiianmaa K, Andersson K, Fuxe K. On the role of ascending dopamine systems in the control of voluntary ethanol intake and ethanol intoxication. Pharmacol Biochem Behav 1979; 10: 603–8
  • Kiianmaa K, Attila L MJ. Alcohol intake, ethanol-induced narcosis and intoxication in rats following neonatal 6-hydroxydopamine or 5,7-dihydroxytryptamine treatment. Naunyn Schmiedebergs Arch Pharmacol 1979; 308: 165–70
  • Kiianmaa K, Tabakoff B. Neurochemical correlates of tolerance and strain differences in the neurochemical effects of ethanol. Pharmacol Biochem Behav 1983; 18(suppl 1)383–8
  • Kiianmaa K, Tabakoff B. Catecholaminergic correlates of genetic differences in ethanol sensitivity. Catecholamines: Neuropharmacology and central nervous system - theoretical aspects, E Usdin, A Carlsson, A Dahlström, J Engel. Alan R. Liss, New York 1984; 145–51
  • Kiianmaa K, Hellevuo K, Korpi E R. The AT (Alcohol Tolerant) and ANT (Alcohol Nontolerant) rat lines selected for differences in sensitivity to ethanol: an overview. Biomedical and social aspects of alcohol and alcoholism, K Kuriyama, A Takada, H Ishii. Elsevier Science Publishers B.V., Amsterdam 1988; 415–8
  • Ahtee L, Attila L MJ, Kiianmaa K. Brain catecholamines in rats selected for their alcohol behaviour. Animal models in alcohol research, K Eriksson, J D. Sinclair, K Kiianmaa. Academic Press, London 1980; 51–5
  • Hellevuo K, Kiianmaa K, Kim C. Effect of ethanol on brain catecholamines in rat lines developed for differential ethanol-induced motor impairment. Alcohol 1990; 7: 159–63
  • Pispa J P., Huttunen M O., Sarviharju M, Ylikahri R. Enzymes of catecholamine metabolism in the brains of rat strains differing in their preference for or tolerance of ethanol. Alcohol Alcohol 1986; 21: 181–4
  • Korpi E R., Sinclair J D., Malminen O. Dopamine D2 receptor binding in striatal membranes of rat lines selected for differences in alcohol-related behaviours. Pharmacol Toxicol 1987; 61: 94–7
  • Hellevuo K, Kiianmaa K, Juhakoski A, Kim C. Intoxicating effects of lorazepam and barbital in rat lines selected for differential sensitivity to ethanol. Psychopharmacology 1987; 91: 263–7
  • Sinclair J D., Rusi M, Airaksinen M M., Altshuler H L. Relating TIQ's opiates, and ethanol. Beta-carbolines and tetrahydro-isoquinolines, F E. Bloom, J Barchas, M Sandier, E Usdin. Alan R. Liss, New York 1982; 265–376
  • Olsen R W. GABA-benzodiazepine-barbiturate receptor interactions. J Neurochem 1981; 37: 1–13
  • Ticku M K., Kulkarni S K. Molecular interactions of ethanol with GABAergic system and potential of Ro 15-4513 as an ethanol antagonist. Pharmacol Biochem Behav 1988; 30: 501–10
  • Harris R A., Allan A M. Alcohol intoxication: ion channels and genetics. FASEB J 1989; 3: 1689–95
  • Hellevuo K, Kiianmaa K. Effects of ethanol, barbital and lorazepam on brain monoamines in rat lines selectively outbred for differential sensitivity to ethanol. Pharmacol Biochem Behav 1988; 29: 183–8
  • Frye G D., Fincher A S. Effect of ethanol on gamma-vinyl-GABA-induced GABA accumulation in the substan-tia nigra and on synaptosomal GABA content in six rat brain regions. Brain Res 1988; 449: 71–9
  • Suzdak P D., Paul S M., Crawley J N. Effects of Ro 15-4513 and other benzodiazepine receptor inverse agonists on alcohol-induced intoxication in the rat. J Pharmacol Exp Ther 1988; 245: 880–6
  • Malminen O, Korpi E R. GABA/benzodiazepine receptor/chloride ionophore complex in brains of rat lines selectively bred for differences in ethanol-induced motor impairment. Alcohol 1988; 5: 239–49
  • Uusi-Oukari M, Korpi E R. Cerebellar GABAA receptor binding and function in vitro, in two rat lines developed for high and low alcohol sensitivity. Neurochem Res 1989; 14: 733–9
  • Korpi E R., Uusi-Oukari M. GABAA receptor mediated chloride flux in brain homogenates from rat lines with differing innate alcohol sensitivities. Neuroscience 1989; 32: 387–92

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.