Novel Considerations on the Antibody/Autoantigen System in Type I (insulin-dependent) Diabetes Mellitus

References

• Eisenbarth G S. Type 1 diabetes mellitus: a chronic autoimmune disease. N Engl J Med 1986; 314: 1360–8
   PubMed Web of Science ®Google Scholar
• Bottazzo G F., Pujol-Borrell R, Gale E AM. Autoimmunity and Type I diabetes: bringing the story up to date. The Diabetes Annual/3, K GMM Alberti, L P. Krall. Elsevier Science Publ., Amsterdam 1987; 15–38
   Google Scholar
• Buschard K. The thymus-dependent immune system in the pathogenesis of Type 1 (insulin-dependent) diabetes mellitus. Dan Med Bull 1985; 32: 139–51
   PubMedGoogle Scholar
• Bach J F. Mechanisms of autoimmunity in insulin-dependent diabetes mellitus. Clin Exp Immunol 1988; 72: 1–8
   PubMed Web of Science ®Google Scholar
• Bottazzo G F., Dean B M., McNally J M., Mackay E H., Swift P GF, Gamble D R. In situ characterisation of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 1985; 313: 353–60
   PubMed Web of Science ®Google Scholar
• Bottazzo G F., Todd I, Mirakian R, Belfiore A, Pujol-Borrell R. Organ-specific autoimmunity: a 1986 overview. Immunol Rev 1986; 94: 137–69
   PubMed Web of Science ®Google Scholar
• Insulitis and Type I diabetes. Lessons from the NOD mouse, S Tarui, Y Tochino, K Nonaka. Academic Press, Tokyo 1986
   Google Scholar
• Mordes J P., Rossini A A. Keys to understanding autoimmune diabetes mellitus: the animal models of insulin-dependent diabetes mellitus. Endocrine and other organ–orientated autoimmune disorders. Clinical Immunology and Allergy, D Doniach, G F. Bottazzo. Bailliere Tindall, London 1987; 1: 29–52
   Google Scholar
• Frontiers in diabetes research. Lesson from animal diabetes, E Shafrin, A E. Renold. J. Libby & Col., London, II 1988
   Google Scholar
• Bottazzo G F., Florin-Christensen A, Doniach D. Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiency. Lancet 1974; II: 1279–83
   Google Scholar
• Lendrum R, Walker I G., Gamble D R. Islet cell antibodies in juvenile diabetes mellitus of recent onset. Lancet 1975; I: 880–2
   Google Scholar
• Lendrum R, Walker I G., Cudworth A G., et al. Islet cell antibodies in diabetes mellitus. Lancet 1976; II: 1273–6
   Google Scholar
• Dean B M., Bottazzo G F., Cudworth A G. IgG subclass distribution in organ-specific autoantibodies. Its relationship to complement-fixing ability. Clin Exp Immunol 1983; 52: 61–6
   PubMed Web of Science ®Google Scholar
• Millward B A., Hussain M J., Peakman M, Pyke D A., Leslie R DG, Vergani D. Characterisation of islet cell antibody in insulin dependent diabetes: evidence for lgG1 subclass restriction and polyclonality. Clin Exp Immunol 1988; 71: 353
   PubMed Web of Science ®Google Scholar
• Bottazzo G F., Doniach D. Autoimmunity in diabetes mellitus. Secondary Diabetes: the Spectrum of the Diabetes Syndrome, S Podolsky, M Kiswanathan. Raven Press, New York 1980; 391–408
   Google Scholar
• Bottazzo G F., Dean B M., Gorsuch A N., Cudworth A G., Doniach D. Complement-fixing islet-cell antibodies in Type I diabetes: possible monitors of active beta-cell damage. Lancet 1980; I: 668–72
   Google Scholar
• Bottazzo G F., Pujol-Borrell R, Gale E AM. Autoimmunity and diabetes: progress, consolidation and controversy. The Diabetes Annual/2, K GMM Alberti, L P. Krall. Elsevier Science Publishers, Amsterdam 1986; 13–29
   Google Scholar
• Immunotherapy of Type 1 diabetes, D Andreani, H Kolb, P Pozzilli. J. Wiley & Sons, Chichester 1989
   Google Scholar
• Gorsuch A N., Spencer K M., Lister J, et al. The natural history of Type I (insulin-dependent) diabetes mellitus: evidence for a long pre-diabetic period. Lancet 1981; II: 363–5
   Google Scholar
• Bingley P J., Gale E AM. The incidence of insulin-dependent diabetes in England: a study in the Oxford region 1985–1986. Brit Med J 1989; 289: 558–60
   Google Scholar
• Wolf E, Spencer K M., Cudworth A G. The genetic susceptibility to Type I (insulin-dependent) diabetes: analysis of the HLA-DR association. Diabetologia 1984; 24: 224–30
   Web of Science ®Google Scholar
• Tarn A C., Thomas J M., Dean B M., et al. Predicting insulin-dependent diabetes. Lancet 1988; I: 845–50
   Google Scholar
• Bonifacio E, Boitard C, Gleichmann H, et al. Assessment of precision, concordance, specificity, and sensitivity of islet cell antibody measurement in 41 assays. Diabetologia 1990; 33: 731–6
   PubMed Web of Science ®Google Scholar
• Gleichmann H, Bottazzo G F. Islet-cell and insulin autoantibodies in diabetes. Immunol Today 1987; 8: 167–8
   Google Scholar
• Bonifacio E, Bingley P, Shattock M, et al. Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet 1989; 335: 147–9
   Web of Science ®Google Scholar
• Riley W J., Maclaren N K., Krischer J, et al. A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N Engl J Med 1990; 323: 1167–72
   PubMed Web of Science ®Google Scholar
• Ziegler A G., Ziegler R, Vardi P, Jackson R A., Soeldner J S., Eisenbarth G S. Life-table analysis of progression to diabetes of anti-insulin autoantibody-positive relatives of individuals with Type I diabetes. Diabetes 1989; 38: 1320–5
   PubMed Web of Science ®Google Scholar
• Bruining G J., Molenaar J L., Grobee De, et al. Ten year follow up study of islet cell antibodies and childhood diabetes mellitus. Lancet 1989; I: 1100–3
   Google Scholar
• Landin-Olsson M, Karlsson A, Dahlquist G, Blom L, Lernmark A, Sundkvist G. Islet cell and other organ-specific autoantibodies in all children developing Type I (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children. Diabetologia 1989; 32: 387–95
   PubMed Web of Science ®Google Scholar
• Karjalainen J K. Islet cell antibodies as predictive markers for IDDM in children with high background incidence of disease. Diabetes 1990; 39: 1144–50
   PubMed Web of Science ®Google Scholar
• Bosi E, Becker F, Bonifacio E, et al. Progression to Type I (insulin-dependent) diabetes in autoimmune endocrine patients with islet cell antibodies. Diabetes 1991; 40: 977–84
   PubMed Web of Science ®Google Scholar
• Srikanta S, Ganda O P., Jackson R A., et al. Type I diabetes mellitus in monozygotic twins: chronic progressive beta cell dysfunction. Ann Intern Med 1983; 99: 320–6
   PubMed Web of Science ®Google Scholar
• Johnston C, Millward B A., Hoskins P, Leslie R DG, Bottazzo G F., Pyke D A. Islet-cell antibodies as predictors of the later development of Type I (insulin-dependent) diabetes. A study in identical twins. Diabetologia 1989; 32: 382–6
   PubMed Web of Science ®Google Scholar
• Genovese S, Bonifacio E, Dean B M., McNally J M., Bosi E, Bottazzo G F. Heterogeneous cell specific islet cell and glutamic acid decarboxylase antibodies. Diabetologia 1991; 34: A97
   Google Scholar
• Gianani R, Rabizadeh A, Jackson R, Schriffin A, Eisenbarth G S. Heterogeneity of cytoplasmic islet cell autoantibodies. Diabetes 1991; 40(Suppl 1)224A
   Google Scholar
• Nayak R C., Omar M AK, Rabizadeh A, Srikanta S, Eisenbarth G S. Cytoplasmic islet cell antibodies: evidence that the target antigen is a sialoglycoconjugate. Diabetes 1985; 34: 617–9
   PubMed Web of Science ®Google Scholar
• Colman P G., Eisenbarth G S. Immunology of Type I diabetes–1987. The Diabetes Annual/4, K GMM Alberti, L P. Krall. Elsevier Scientific Publishers, Amsterdam 1988; 17–45
   Google Scholar
• Yamishiro Y, Taniguchi H, Morimoto Y, Kodama S, Baba S. Target antigen of islet cell antibody in Japanese insulin-dependent diabetes mellitus. Diabetes 1989; 6: 161–5
   Web of Science ®Google Scholar
• Colman P G., Nayak R C., Campbell I L., Eisenbarth G S. Binding of cytoplasmic islet cell antibodies is blocked by human pancreatic glycolipid extracts. Diabetes 1988; 37: 645–52
   PubMed Web of Science ®Google Scholar
• Giilard B K., Thomas J W., Nell L J., Marcu D M. Antibodies against ganglioside G(T3) in the sera of patients with Type I diabetes mellitus. J Immunol 1989; 142: 3826–32
   PubMed Web of Science ®Google Scholar
• Baekkeskov S, Aanstoot H J., Christgau S, et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990; 347: 151–6
   PubMed Web of Science ®Google Scholar
• Baekkeskov S, Nielsen J H., Marner B, Bilde T, Ludvigsson J, Lernmark A. Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature 1982; 298: 167–9
   PubMed Web of Science ®Google Scholar
• Baekkeskov S, Landin M, Kristensen J K., et al. Antibodies to a 64 000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest 1987; 79: 926–34
   PubMed Web of Science ®Google Scholar
• Atkinson M A., Maclaren N K., Scharp D W., Lacy P E., Riley W J. 64 000 Mr autoantibodies as predictors of insulin-dependent diabetes. Lancet 1990; 335: 1357–60
   PubMed Web of Science ®Google Scholar
• Christie M R., Daneman D, Champagne P, Delovitch T L. Persistence of serum antibodies to 64 000–Mr islet cell protein after onset of Type I diabetes. Diabetes 1990; 39: 653–6
   PubMed Web of Science ®Google Scholar
• Christie M R., Pipeleers D G., Lernmark A, Baekkeskov S. Cellular and subcellular localization of an M(r) 64,000 protein autoantigen in insulin-dependent diabetes. J Biol Chem 1990; 265: 376–81
   PubMed Web of Science ®Google Scholar
• Baekkeskov S, Warnock G, Christie M, Rajotte R V., Larsen P M., Fey S. Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2–D gel electrophoresis: unambiguous identification of 64K target antigen. Diabetes 1989; 38: 1133–41
   PubMed Web of Science ®Google Scholar
• Kampe O, Andersson A, Bjork E, Hallberg A, Karlsson F A. High-glucose stimulation of 64,000-Mr islet cell autoantigen expression. Diabetes 1989; 38: 1326–8
   PubMed Web of Science ®Google Scholar
• Solimena M, Folli F, Denis-Donini S, et al. Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy and Type I diabetes mellitus. N Engl J Med 1988; 318: 1012–20
   PubMed Web of Science ®Google Scholar
• Bosi E, Vicari A, Comi G, et al. Association of stiff-man syndrome and type I diabetes with islet cell and other autoantibodies. Arch Neurol 1988; 45: 246–7
   PubMedGoogle Scholar
• Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P. Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N Engl J Med 1990; 322: 1555–60
   PubMed Web of Science ®Google Scholar
• Vincent S R., Hokfelt T, Wu J Y., Elde R P., Morgan L M., Kimmel J R. Immunohistochemical studies of the GABA system in the pancreas. Neuroendocrinology 1983; 36: 197–204
   PubMed Web of Science ®Google Scholar
• Martino G V., Tappaz M, Braghi S, et al. Autoantibodies to glutamic acid decarboxylase in insulin-dependent diabetes mellitus. J Autoimmunity, in press
   Google Scholar
• Christie M R., Vohra G, Champagne P, Daneman D, Delovitch T L. Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. J Exp Med 1990; 172: 789–95
   PubMed Web of Science ®Google Scholar
• Christie M R., Hollands J, Delovitch T L. Differential expression of components of the islet 64kD antigen after heat shock. Diabetes 1991; 40(Suppl 1)2A
   Google Scholar
• Bottazzo G F., Bonifacio E, Genovese S, Leslie R DG, Christie M R. New insights into islet autoantigens in insulin-dependent diabetes: the expanding concept of heterogeneity. Congress Series, Proceedings of the 14th International Diabetes Federation Congress, Washington, D.C., 23–28 June, 1991. Elsevier Science Publisher B.V., Amsterdam, (in press)
   Google Scholar
• Palmer J P., Asplin C M., Clemons P, et al. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 1983; 222: 1337–9
   PubMed Web of Science ®Google Scholar
• Srikanta S, Ricker A T., McCulloch D K., Soeldner J S., Eisenbarth G S., Palmer S P. Autoimmunity to insulin, beta cell dysfunction and development of insulin-dependent diabetes mellitus. Diabetes 1986; 39: 139–42
   Google Scholar
• Dean B M., Becker F, McNally J M., et al. Insulin autoantibodies in the pre-diabetic period: correlation with islet cell antibodies and the development of diabetes. Diabetologia 1986; 29: 339–42
   PubMed Web of Science ®Google Scholar
• Betterle C, Presotto F, Pedini B, et al. Islet cell and insulin autoantibodies in organ-specific autoimmune patients. Their behaviour and predictive value for the development of Type I (insulin-dependent) diabetes mellitus. A 10 year follow-up study. Diabetologia 1987; 30: 292–7
   PubMed Web of Science ®Google Scholar
• Vardi P, Dib S A., Tuttleman M, et al. Competitive insulin autoantibody assay. Prospective evaluation of subjects at high risk for development of Type I diabetes mellitus. Diabetes 1987; 36: 1286–91
   PubMed Web of Science ®Google Scholar
• Palmer J P. Insulin autoantibodies: their role in the pathogenesis of IDDM. Diabetes Metab Rev 1987; 3: 1005–15
   PubMedGoogle Scholar
• Ziegler A G., Eisenbarth G S. Immunology of IDDM (Type I diabetes)– 1989. The Diabetes Annual/5, K GMM Alberti, L P. Krall. Elsevier Scientific Publishers, Amsterdam 1990; 22–50
   Google Scholar
• Wilkin T, Palmer J, Kurtz A, Bonifacio E, Diaz J L. The second international workshop on the standardisation of insulin autoantibody (IAA) measurement. Diabetologia 1988; 31: 449–50
   PubMed Web of Science ®Google Scholar
• Wilkin T J., Schoenfeld S L., Diaz J L., et al. Systematic variations and differences in insulin-autoantibody measurements. Diabetes 1989; 38: 172–81
   PubMed Web of Science ®Google Scholar
• Kuglin B, Kolb H, Greenbaum C, Maclaren N K., Lernmark A, Palmer J P. The Fourth International Workshop on standardisation of insulin autoantibody measurement. Diabetologia 1990; 33: 638–9
   PubMedGoogle Scholar
• Koch M, Sodoyez J C., Sodoyez-Goffaux F, Dozio N, Di Silvio L S., Kurtz A B. Is quantitative assessment of insulin-antibodies and autoantibodies feasible?. Diabetologia 1989; 32: 774–8
   PubMed Web of Science ®Google Scholar
• Dean B M., McNally J M., Bonifacio E, et al. Comparison of insulin autoantibodies in diabetes-related and normal populations by precise displacement ELISA. Diabetes 1989; 38: 1275–81
   PubMed Web of Science ®Google Scholar
• Kuglin B, Rjasanowski I, Bertrams J, Gries F A., Kolb, Michaelis D. Antibodies to pro-insulin and insulin as predictive markers of Type I diabetes. Diabetic Med 1990; 7: 310–4
   PubMed Web of Science ®Google Scholar
• Dean B M., McNally J M., Bonifacio E, Bingley P J., Gale E AM, Bottazzo G F. Autoantibodies to human pro-insulin in first degree relatives of Type I (insulin dependent) diabetic probands. Diab Nutr Metab, (in press)
   Google Scholar
• Hartling S G., Lindgren F, Dahlqvist G, Persson B, Binder C. Elevated pro-insulin in healthy siblings of IDDM patients independent of HLA identity. Diabetes 1989; 38: 1271–4
   PubMed Web of Science ®Google Scholar
• Elias D, Markovits D, Reshef D, et al. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci U.S.A. 1990; 87: 1576–80
   PubMed Web of Science ®Google Scholar
• Jones D B., Hunter R N., Duff G W. Heat-shock protein 65Kd as a β-cell antigen of insulin-dependent diabetes. Lancet 1990; 336: 583–5
   PubMed Web of Science ®Google Scholar
• Kampe O, Velloso L, Andersson A, Karlsson A. No role for 65 Kd heat-shock protein in diabetes. Lancet 1990; 336: 1250
   PubMedGoogle Scholar
• Atkinson M, Maclaren N K., Scharp D W. No role for 65 Kd heat-shock protein in diabetes. Lancet 1990; 336: 1250–1
   PubMedGoogle Scholar
• Latchman D S. Heat-shock proteins. Lancet 1991; 337: 424
   PubMed Web of Science ®Google Scholar
• Jones D B., Duff G. Is there no role for heat-shock protein in diabetes?. Lancet 1991; 337: 115
   PubMed Web of Science ®Google Scholar
• Karounos D G., Thomas J W. Recognition of common islet antigen by autoantibodies from NOD mice and humans with IDDM. Diabetes 1990; 39: 1085–90
   PubMed Web of Science ®Google Scholar
• Karounos D G., Neil L J., Thomas J W. Autoantibodies present at onset of Type I diabetes recognize multiple islet cell antigens. Autoimmunity 1990; 6: 79–91
   PubMed Web of Science ®Google Scholar
• Castano L, Russo E, Zhou L, Lipes M A., Eisenbarth G S. Identification and cloning of a granule autoantigen (carboxy-peptide H) associated with Type I diabetes. J Clin Endocrinol Metab, (in press)
   Google Scholar
• Johnson J H., Crider B P., McCorki K, Alford M, Unger R H. Inhibition of glucose transport into rat islet cells by immunoglobulins from patients with new-onset insulin-dependent diabetes mellitus. N Engl J Med 1990; 322: 653–9
   PubMed Web of Science ®Google Scholar
• Lernmark A, Freedman Z R., Hofman C, et al. Islet cell surface antibodies in juvenile diabetes mellitus. N Engl J Med 1978; 299: 375–80
   PubMed Web of Science ®Google Scholar
• Pujol-Borrell R, Khoury E L., Bottazzo G F. Islet cell surface antibodies in Type I (insulin-dependent) diabetes mellitus: use of human fetal pancreas cultures as substrate. Diabetologia 1982; 22: 89–95
   PubMed Web of Science ®Google Scholar
• Van de Winkel M, Smets G, Gepts W, Pipeleers D G. Islet cell surface antibodies from insulin-dependent diabetics bind specifically to pancreatic B cells. J Clin Invest 1982; 70: 41–9
   PubMed Web of Science ®Google Scholar
• Ricordi C, Lacy P E., Finke E H., Olack B J., Sharp D W. Automated method for human pancreatic islets. Diabetes 1988; 137: 413–20
   Google Scholar
• Khoury E L., Bottazzo G F., Roitt I M. The thyroid 'microsomal' antibody revisited: its paradoxical binding in vivo to the apical surface of the follicular epithelium. J Exp Med, 159: 577–91
   PubMed Web of Science ®Google Scholar
• Boitard C, Sai P, Debray-Sachs M, Assan R, Hamburger J. Anti-pancreatic immunity. In vitro studies of cellular and humoral immune reactions directed towards pancreatic islets. Clin Exp Immunol 1984; 55: 571–80
   PubMed Web of Science ®Google Scholar
• Bottazzo G F., Lendrum R. Separate autoantibodies to human prancreatic glucagon and somatostatin cells. Lancet 1976; II: 873–6
   Google Scholar
• Papadopoulos G K., Lernmark A. The spectrum of islet cell antibodies. Autoimmune Endocrine Disease, T F. Davies. John Wiley & Sons, New York 1983; 176–80
   Google Scholar
• Bottazzo G F. Beta-cell damage in diabetic insulitis: are we approaching the solution?. Diabetologia 1984; 26: 241–50
   PubMed Web of Science ®Google Scholar
• Drell D W., Notkins A L. Multiple immunological abnormalities in patients with Type I (insulin-dependent) diabetes mellitus. Diabetologia 1987; 30: 132–43
   PubMed Web of Science ®Google Scholar
• Mirakian R, Cudworth A G., Bottazzo G F., Richardson C A., Doniach D. Autoimmunity to anterior pituitary cells and the pathogenesis of Type I (insulin-dependent) diabetes mellitus. Lancet 1982; I: 755–9
   Google Scholar
• Vercammen M, Gorus F, Foriers A, et al. Cell surface antibodies in Type I (insulin-dependent) diabetic patients. I. Presence of immunoglobulins M which bind to rat pituitary cells. Diabetologia 1989; 32: 611–7
   PubMed Web of Science ®Google Scholar
• Serjeantson S, Theophilus J, Zimmet P, Court J, Crossley J R., Elliott R B. Lymphocytotoxic antibodies and histo-compatibility antigens in juvenile-onset diabetes mellitus. Diabetes 1981; 30: 26–9
   PubMed Web of Science ®Google Scholar
• Segers O, Gorus F, Somers G, Van de Winkel M, Vercammen M, Pipeleers D. Cell surface antibodies in Type I (insulin-dependent) diabetic patients. II. Presence of immunoglobulins M which bind lymphocytes. Diabetologia 1989; 32: 618–23
   PubMed Web of Science ®Google Scholar
• Libert F, Ruel J, Ludgate M, et al. Thyroperoxidase, an auto-antigen with a mosaic structure made of nuclear and mitochondrial gene modules. EMBO J 1987; 6: 4193–6
   PubMed Web of Science ®Google Scholar
• Karlsson F A., Burman P, Lööf L, Mardh S. Major parietal cell antigen in autoimmune gastritis with pernicious anemia is the acid-producing H+, K+-Adenosine triphosphatase of the stomach. J Clin Invest 1988; 81: 475–9
   PubMed Web of Science ®Google Scholar
• Libert F, Lefort A, Gerard C, et al. Cloning sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. Biochem Biophys Res Comm 1989; 165: 1250–5
   PubMed Web of Science ®Google Scholar
• Nagayama Y, Kaufman K D., Seto P, Rapoport B. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem Biophys Res Comm 1989; 165: 1187–90
   Web of Science ®Google Scholar
• Banga J P., McGregor A M. Enzymes as targets for autoantibodies in human autoimmune disease: relevance to pathogenesis?. Autoimmunity 1991; 9: 177–82
   PubMed Web of Science ®Google Scholar
• De Berardinis P, Londei M, James R FL, Lake S P., Wise P H., Feldmann M. Do CD4-positive cytotoxic T cells damage islet b cells in Type I diabetes?. Lancet 1988; II: 823–4
   Google Scholar
• Van Vliet E, Roep B, Meulenbrock L, Bruining G J., De Vries R RP. Human T cell clones with specificities for insulinoma cell antigens. Eur J Immunol 1989; 19: 213–6
   PubMed Web of Science ®Google Scholar
• Roep B O., Arden S D., de Vries R P., Hutton J C. T-cell clones from a Type-1 diabetes patient respond to insulin secretory granule proteins. Nature 1990; 345: 632–4
   PubMed Web of Science ®Google Scholar
• Bottazzo G F., Pujol-Borrell R, Gale E. Etiology of diabetes: the role of autoimmune mechanisms. ‘Diabetes Annual/1’, K GMM Alberti, L P. Krall. Elsevier Science Publishers, Amsterdam 1985; 16–52
   Google Scholar
• Bosi E, Todd I, Pujol-Borrell R, Bottazzo G F. Mechanisms of autoimmunity: relevance to the pathogenesis of Type 1 (insulin-dependent) diabetes mellitus. Diabetes Metab Rev 1987; 3: 893–924
   PubMedGoogle Scholar
• Rossini A A., Handlez E S., Greiner D L., Mozoles J P. Insulin dependent diabetes mellitus hypothesis of autoimmunity. Autoimmunity 1991; 8: 221–35
   PubMed Web of Science ®Google Scholar
• Bonifacio E, Bottazzo G F. Immunology of IDDM (Type I diabetes). Entering the '90s. ‘Diabetes annual/6’, K GMM Alberti, L P. Krall. Elsevier Science Publishers, Amsterdam 1991; 20–47
   Google Scholar
• Bottazzo G F., Todd I, Belfiore A, Mirakian R, Pujol-Borrel R. Thyroid and related autoimmune disorders: challenging dogmas. Thyroid Autoimmunity, A Pinchera, S H. Ingbar, J M. McKenzie, G F. Fenzi. Plenum Press, New York and London 1987; 159–73
   Google Scholar