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Original Article

Calcium — a Neglected Key Factor in Arteriosclerosis. The Pathogenetic Role of Arterial Calcium Overload and Its Prevention by Calcium Antagonists

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Pages 589-599 | Published online: 08 Jul 2009

References

  • Long E R. Development of our knowledge of arteriosclerosis. Cowdy's arteriosclerosis. A survey of the problem. First Edition, H T Blumenthal. Charles C Thomas Publ, Springfiedl/III USA 1933
  • Anitschkow N, Chalatow S. Über experimented cholesterinsteatose und ihre Bedeutung für die Entstehung einiger pathologischer prozesse. Zentralbl f Allgemeine Pathol u Anat 1913; 14: 1–9
  • Henry D P. Calcium channel blockers and atherosclerosis. J Cardiovasc Pharmacol 1990; 16((Suppl 1))S12–5
  • Janke J, Hein B, Pachinger O, Leder O, Fleckenstein A. (1972) Hemmung arteriosklerotischer Gefässprozesse durch prophylaktische Behandlung mit MgCI2, KCI und organischen Ca++-Antagonisten (quantitative Studien mit 45Ca bei ratten). ascular Smooth Muscle, Verh Satel Symp XXV Internat Congr Physiol Wissenschatten, Tubingen, Juli, 1971, E Betz. Springer Verlag, Berlin-Heidelberg-New York, 71–2, V
  • Fleckenstein A, Fleckenstein-Grün G. Cardiovascular protection by Ca antagonists. Eur Heart J 1980; 1: 15–21
  • Fleckenstein A, Frey M, Leder O. (1983) Prevention by calcium antagonists of arterial calcinosis. Drug Development and Evaluation - New Calcium Antagonists - Recent Developments and Prospects, Diltiazem Workshop, Freiburg/Germany, May, 1982, A Fleckenstein, K Hashimoto, M Herrmann, A Schwartz, L Seipel. Gustav FischerVerlag, Stuttgart-New York, 15–31
  • Fleckenstein A. Calcium Antagonism in Heart and Smooth Muscle - Experimental Facts and Therapeutic Prospects. John Wiley Publishing Company, New York-Chichester-Brisbane-Toronto-Singapore 1983
  • Fleckenstein A, Frey M, Zorn J, Fleckenstein-Grün G. Calcium, a neglected key factor in hypertension and arteriosclerosis. Experimental vasoprotection with calcium antagonists or ACE inhibitors. Hypertension: Pathophysiology, Diagnosis, and Management, J H Laragh, B M Brenner. Raven Press, New York 1990; 471–509
  • Van Breemen C, Saida K. Cellular mechanisms regulating (Ca2+)i smooth muscle. Ann Rev Physiol 1989; 51: 315–9
  • Fleckenstein A. (1971) Specific inhibitors and promoters of calcium action in the excitation-contraction coupling of heart muscle and their role in the prevention or production of myocardial lesions. Calcium and the Heart. Proceed of the Meeting of the Europ Section of the Internat Study Group for Research in Cardiac Metabolism, London, Sept, 1970, P Harris, L Opie. Academic Press, London-New York, 135–88
  • Fleckenstein A. Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. Ann Rev Pharmacol Toxicol 1977; 17: 149–66
  • Fleckenstein A. History of calcium antagonists. Calcium Channel Blocking Drugs: A Novel Intervention for the Treatment of Cardiac Disease, Monograph Nr 95 of the Amer Heart Association, A Schwartz, N Taira. Circ Res Part II, 1983; Vol 52: 3–16, Nr2
  • Fleckenstein A, Kammermeier H, Döring H J, Freund H J, Grün G, Kienle A. Zum Wirkungsmechanismus neuartiger Koronardilatatoren mit Gleichzeitig Sauerstoff-einsparenden Myokard-Effekten, Prenylamin und Iproveratril. Z f Kreislaufforsch 1967; 56: 716–44, 839–58
  • Grün G, Fleckenstein A. Die elektro-mechanische Entkoppelung der glatten Gefäßmuskulatur als Grundprinzip der Coronardilatation durch 4-(2′-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsäure-dimethylester (Bay a 1040, Nifedipin). Arzneim Forsch (Drug Res) 1972; 22: 334–44
  • Fleckenstein-Grün G, Fleckenstein A. Calcium antagonism, a basic principle in vasodilation. Calcium Antagonism in Cardiovascular Therapy: Experience with Verapamil, Internat Symp in Florence/Italy, Oct 1980, A Zanchetti, D M Krikler. Excerpta Medica, Amsterdam-Oxford-Princeton 1981; 30–8
  • Fleckenstein A, Frey M, Fleckenstein-Grün G. Antihypertensive and arterial anticalcinotic effects of calcium antagonists. Am J Cardioi 1986; 57: 1D–10D
  • Fleckenstein A, Frey M, Zorn J, Fleckenstein-Grün G. Experimental basis of the long-term therapy of arterial hypertension with calcium antagonists. Am J Cardioi 1985; 56: 3H–14H
  • Fleckenstein A, Fleckenstein-Grün G, Frey M, Zorn J. Future directions in the use of calcium antagonists. Am J Cardioi 1987; 59: 177B–87B
  • Glossmann H, Ferry D R, Rombusch M. Molecular pharmacology of the calcium channel: evidence for subtypes, multiple drug receptor sites, channel subunits, and the development of radioiodinated 1,4-dihydropyridine calcium channel label, (125l) iodipine. J Cardiovasc Pharmacol 1984; 6: S608–21
  • Ferrante J, Triggle D J. Drug- and disease-induced regulation of voltage-dependent calcium channels. Pharmacol Rev 1990; 42: 29–44
  • Fleckenstein-Grün G, Frey M, Fleckenstein A. Calcium antagonists: Mechanisms and therapeutic uses. Trends in Pharmacological Sciences 1984; 5: 283–6
  • Fleckenstein A, Frey M, Zorn J, Fleckenstein-Grün G. The role of calcium in the pathogenesis of experimental arteriosclerosis. Trends in Pharmacological Sciences 1987; 8: 496–501
  • Fleckenstein A, Janke J, Döring H J, Pachinger O. Ca overload as the determinant factor in the production of catecholamine-induced myocardial lesions. Cardiomyopathies, Vol 2 of Recent Advances in Studies on Cardiac Structure and Metabolism, E Bajusz, G Rona. University Park Press, Baltimore 1973; 455–66
  • Fleckenstein A, Janke J, Döring H J, Leder O. Myocardial fibre necrosis due to intracellular Ca overload - A new principle in cardiac pathophysiology. Myocardial Biology, Vol 4 of “Recent Advances in Studies on Cardiac Structure and Metabolism”, N S Dhalla. University Park Press, Baltimore 1974; 563–79
  • Fleckenstein A, Janke J, Döring H J, Leder O. The key role of Ca in the production of noncoronarogenic myocardial necroses. Pathophysiology and Morphology of Myocardial Cell Alterations, Vol 6 of “Recent Advances in Studies on Cardiac Structure and Metabolism”, A Fleckenstein, G Rona. University Park Press, Baltimore-London-Tokyo 1975; 21–32
  • Hansen Fischer J. Effects of verapamil on mortality and major events after acute myocardial infarction (The Danish Verapamil Infarction Trial II - DAVIT II). Am J Cardioi 1990; 66: 779–85
  • Kazda S. The calcium channel and vascular injury. The Calcium Channel; Structure, Functional Implications, M Morad, W Nayler, S Kazda, M Schramm. Springer Verlag, Berlin-Heidelberg-New York-London-Paris-Tokyo 1988; 11–4, Stresa/I, May 1988
  • Dreyer E B, Kaiser P K, Offermann J T, Lipton S A. HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 1990; 248: 364–7
  • Fleckenstein A, Frey M, Fleckenstein-Grün G. (1983) Protection by calcium antagonists against experimental arterial calcinosis. Secondary Prevention of Coronary Heart Disease, Workshop of the Internat Soc and Federation of Cardiology, Titisee, Oct, 1983, K Pyörälä, E Rapaport, K König, G Schettler, C Diehm G. Thieme Verlag, Stuttgart-New York, 109–22
  • Fleckenstein A, Frey M v., Witzleben H. (1983) Vascular calcium overload - a pathogenetic factor in arteriosclerosis and its neutralization by calcium antagonists. New Therapy of Ischemic Heart Disease and Hypertension, Proceed of the 5th Internat Adalat Symp, Berlin, May, 1982, M Kaltenbach, H N Neufeld. Excerpta Medica, Amsterdam-Oxford-Princeton, 36–52
  • Lichtlen P R, Hugenholtz P G, Rafflenbeul W, Hecker H, Jost S, Nikutta P, Deckers J W. Retardation of coronary artery disease in humans by the calcium-channel blocker nifedipine: Results of the INTACT Study (International Nifedipine Trial on Antiatherosclerotic Therapy). Cardiovasc Drugs and Therapy 1990; 4: 1047–68
  • Brown M S, Goldstein J L. How LDL receptors influence cholesterol and atherosclerosis. Sci Am 1984; 251(5)58–66
  • Fleckenstein A, Frey M, Thimm F, Fleckenstein-Grün G. Excessive mural calcium overload - A predominant causal factor in the development of stenosing coronary plaques in humans. Cardiovasc Drugs and Therapy 1990; 4: 1005–14
  • Fleckenstein-Grün G. Hypertension and arteriosclerosis: The role of calcium. Annals of Intern Med, (in press)
  • Fleckenstein-Grün G, Frey M, Thimm F, Fleckenstein A. Differentiation between calcium-and cholesterol-dominated types of arteriosclerotic lesions. Antiarteriosclerotic aspects of calcium antagonists. J Cardiovasc Pharmacol, (in press)
  • Moon J Y. Factors affecting arterial calcification associated with atherosclerosis. Atherosclerosis 1972; 16: 119–26
  • Blumenthal H T, Larving A J, Wheeler P A. Calcification of the media of the human aorta and its relation to intimal arteriosclerosis, ageing and disease. Am J Pathol 1944; 20: 655
  • Weinstein D B, Heider J G. Antiatherogenic properties of calcium antagonists. Am J Cardioi 1987; 59: 163B–72B
  • Kramsch D M, Aspen A J, Rozlek J. Atherosclerosis: prevention by agents not affecting abnormal levels of blood lipids. Science 1981; 213: 1511–2
  • Herzenberg H. Studien über die Wirkungs weise des bestrahlten Ergosterins (Vigantol) und die Beziehungen der von ihm gesetzten Veränderungen zur Arteriosklerose. Beitr Path Anat 1929; 82: 27–56
  • Eisenstein R, Zeruolis L. Vitamin-D-induced aortic calcification. Arch Path 1964; 77: 27–35
  • Hass G M, Trueheart R E, Hemmens A. Experimental arteriosclerosis due to hypervitaminosis D. Am J Path 1960; 37: 521–39
  • Seydewitz V, Staubesand J. Calcifizierung der Arterienwand als Alternsprozess. Elektronenmikroskopische und biochemische Untersuchung am Modell der Vitamin D3-Überdosierung. Akt Gerontol 1983; 13: 114–8
  • Triggle D J. Ca antagonists in atherosclerosis: a review and commentary. Cardiovasc Drug Res 1989; 6: 320–35
  • Galle J, Bassenge E, Busse R. Oxidised low density lipoproteins potentiate vasoconstrictions to various agonists by direct interaction with vascular smooth muscle. Circ Res 1990; 66: 1287–1293

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