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Original Article

Evaluation of Growth Hormone Secretion and Treatment

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Pages 237-247 | Published online: 08 Jul 2009

References

  • Hlndmarsh P, Smith P H, Brook C GD, et al. The relationship between height velocity, and growth hormone secretion in short prepubertal children. Clin Endocrinol 1967; 27: 581–91
  • Alien D B, Post N C. Growlh hormone therapy for short stature: panacea or Pandora's box?. J Pediatr 1990; 117: 16–21
  • Guillemin R, Brazeau P, Böhlen P, Esch F, Ling N, Wehrenberg W B. Growlh hormone‐releasing factor from a human pancreatic tumor that caused acromegaly. Science 1982; 218: 585–7
  • Rivier J, Spiess J, Thorner M, Vale W. Characterization of a growth hormone‐releasing factor from a human pancreatic islet tumor. Nature 1982; 300: 276–8
  • Ling N, Esch F, Böhlen P, Brazeau P, Wehrenberg W P, Guillemin R. Isolation, primary structure, and synthesis of human hypothalmic somatocrinin; growth hormone‐releasing factor. Proc Natl Acad Sci USA 1984; 81: 4302–6
  • Brazeau P, Ling N, Böhlen P, Esch F, Ylng S ‐Y., Guillemin R. Growth hormone‐releasing factor, somatocrinin, releases pituitary growth hormone in vitro. Proc Natl Acad Sci USA 1982; 79: 7909–13
  • Spless J, Rivler J, Vale W. Characterization of rat hypothalamic growth hormone‐releasing factor. Nature 1933; 303: 532–5
  • Frohman L A, Jansson J ‐O. Growth hormone‐releasing hormone. Endocrin Rev 1986; 7: 223–52
  • Thorner M O, Rivier J, Spiess J, et al. Human pancreatic growth hormone‐releasing faclor selectively stimulates growth hormone secretion in man. Lancet 1983; 1: 24–8
  • Rosenthal S M, Schriock E A, Kaplan S L, Guillemin R, Grumbach M M. Synthetic human pancreas growth hormone‐releasing factor (hpGRH 1–44‐NH2) stimulates growth hormone secretion in normal men. J Clin Endocrinol Metab 1983; 57: 677–9
  • Chlhara K, Kodama H, Kaji H, et al. Augmentation by propranol of growth hormone‐releasing hormone‐(1–44)‐NH 2‐induced growth hormone release in normal short and normal children. J Clin Endocrinol Metab 1985; 61: 229–33
  • Bloch B, Galllard R C, Brazeau P, Lin H D, Ling N. Topographical and ontogenetic study of the neurons producing growth hormone‐releasing factor in human hypothalamus. Regul Pept 1984; 8: 21–31
  • Frohman L A, Thominet J L, Webb C B, et al. Metabolic clearance and plasma disappearance rates of human pancreatic tumor growth hormone‐releasing factor in man. J Clin Invest 1984; 73: 1304–11
  • Thorner M O, Frohman L A, Leong O A, et al. Extrahypothalamic growth hormone‐releasing factor (GRF) secretion is a rare cause of acromegaly: plasma GRF levels in 177 acromegalic patients. J Clin Endocrinol Metab 1984; 59: 846–9
  • Donnadieu M, Evain‐Brion D, Tonon M C, Vaudry H, Job J ‐C. Variations of plasma growth hormone (GH)‐relaasing factor levels during GH stimulation tests in children. J Clin Endocrinol Metab 1984; 69: 1132–4
  • Penny E S, Patience R L, Sopwith A M, Wass J AH, Besser G M, Rees L H. Characterization by high performance liquid chromatography of circulating growth hormone‐releasing factors in a human plasma. J Endocrinol 1985; 105: R1–R4
  • Leppäluoto J, Tapanalnen P, Knip M. Heat exposure elevates plasma immunoreactive growth hormone‐releasing hormone levels in man. J Clin Endocrinol Metab 1987; 65: 1035–8
  • Tapanalnen P, Knip M, Lautala P, Leppäluoto J. Variable plasma growth hormone (GH)‐releasing hormone and GH response to clonidine, L‐dopa, and insulin in normal men. J Clin Endocrinol Metab 1988; 67: 845–9
  • Lina L, Carolto M C, Dall'Ara A, Cocchi D. Significance of circulating immunocreative growth hormone‐releasing hormone: CNS vs. peripheral source. 70th Annual Meeting of the Endocrine Society. June, 1988. New Orleans, LA, 8–11, abstract 261
  • Saito H, Saito S, Yamazaki R, Hosol E. Clinical value of radioimmunoassay of plasma growth hormone‐releasing factor. Lancet 1984; 2: 401–2
  • Smith P J, Pringle P J, Rafferty B, Brook C GD. The relationship between endogenous immunocreative GRH and GH secretion. J Endocrinol 1985; 104: 86, Suppl:
  • Tapanainen P, Rantala H, Leppäluoto J, Lautala P, Käär M L, Knip M. Nocturnal release of immunoreactive growth hormone (GH)‐releasing hormone and GH in normal children. Pediatr Res 1989; 26: 404–9
  • Brazeau P, Vale W, Burgus R, et al. Hypothalmic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 1973; 179: 77–9
  • Hall R, Besser G M, Schally A V, et al. Action of growth hormone‐release inhibitory hormone in healthy men and in acromegaly. Lancet 1973; 2: 581–4
  • Prange‐Hansen A P, Orskov H, Seyer‐Hansen K, Lund‐baek K. Some actions of growth hormone‐release inhibiting factor. Br Med J 1973; 3: 523–4
  • Mortimer C H, Tunbrldge W MB, Carr D, et al. Effects of growth hormone‐release‐inhibiting hormone on circulating glucagon, insulin, and growth hormone in normal, diabetic, acromegalic, and hypopituitary patients. Lancet 1974; 1: 697–701
  • Wehrenberg W B, Brazeau P, Luben R, Böhlen P, Guillemin R. Inhibition of the pulsatile secretion of growth hormone by monoclonal antibodies to the hypothalamic growth hormone releasing factor (GRF). Endocrinology 1982; 111: 2147–8
  • Llapl C, Evain‐Brlon O, Argente J, Vaudry H, Donnadieu M. Negative correlation between peripheral plasma somatostatin levels and GH responses to GHRH stimulation tests in children. Acta Endocrinol 1986; 113: 1–4
  • Rosskamp R, Becker M, Haverkamp F, et al. Plasma levels of growth hormone‐releasing hormone and somatostatin in response to a mixed meal and during sleep in children. Acta Endocrinol 1987; 116: 549–54
  • Frohman L A, Downs T R, Katakami H, Jansson J ‐O. The interaction of growth hormone‐releasing hormone and somatostatin in the regulation of growth hormone secretion. Growth hormone: basic and clinical aspects, O Isaksson, C Binder, K Hall, B Hökfelt. Excerpta Medica International Congress Series, Amsterdam 1987; 748: 63–77
  • Ferland L, Labrie F, Jobin M, Arimura A, Schally A V. Physiological role of somatostatin in the control of growth hormone and thyrotropin secretion. Biochem Biophys Res Commun 1976; 68: 149–56
  • Wehrenberg W B, Brazeau P, Ling N, Textor G, Guillemin R. Pituitary growth hormone response in rats during a 24‐hour infusion of growth hormone‐releasing factor. Endocrinology 1984; 114: 1613–6
  • Katakami H, Downs T R, Frohman L A. Inhibitory effect of hypothalamic medial preoptic area somatostatin (SRTIF) on GH‐releasing hormone (GRH) in the rat. 68th Annual Meeting of the Endocrine Society. June, 1986. Anaheim, CA, 26–27, abstract 65
  • Vance M L, Borges J LC, Kaiser D L, et al. Human pancreatic tumor growth hormone‐releasing factor: dose‐response relationships in normal man. J Clin Endocrinol Metab 1984; 58: 838–44
  • Vance M L, Kaiser D L, Evans W S, et al. Evidence for a limited growth hormone (GH)‐releasing hormone (GHRH)‐releasable quantity of GH: effects of 6‐hour infusions of GHRH on GH secretion in normal man. J Clin Endocrinol Metab 1985; 60: 370–5
  • Webb C B, Vance M L, Thorner M O, et al. Plasma growth hormone responses to constant infusions of human pancreatic growth hormone releasing factor: intermittent secretion or response attenuation. J Clin Invest 1984; 74: 96–103
  • Camanni F, Ghigo E, Mazza E, . Aspects of neurotransmitter control of GH secretion: basic and clinical studies. Advances in growth hormone and growth factor research, E Müller, D Cocchi, V Locatelli, et al. Pythagora Press, Roma‐Milano 1989; 263–81
  • Müller E E. Neural control of somatotropic function. Physiol Rev 1987; 67: 962–1053
  • Froesch E R, Schmid C, Schwander J, Zapf J. Actions of insulin‐like growth factors. Ann Rev Physiol 1985; 47: 443–67
  • Casella S J, Han V K, D'Ercole A J, Svoboda M E, Van Wyk J J. Insulin‐like growth factor II binding to the type I somatomedin receptor: evidence for two high affinity binding sites. J Biol Chem 1986; 261: 9268–73
  • Rosenfeld R G, Lamson G, Pham H, et al. Insulin‐like growth factor binding proteins. Rec Progr Horm Res 1990; 46: 99–163
  • Rutanen E M, Pekonen F. Insulin‐like growth factors and their binding proteins. Acta Endocrinol 1990; 123: 7–13
  • Lamson G, Gludlce L C, Rosenfeld R G. Insulin‐like growth factor binding proteins: structural and molecular relationships. Growth Factors 1991; 5: 19–28
  • Clemmons D R, van Wyk J J. Factors controlling blood concentrations of somatomedin C. Clin Endocrinol Metab 1984; 13: 113–43
  • Isaksson O GP, Llndahl A, Nilsson A, Isgaard J. Mechanism of the stimulatory effect of growth hormone on longitudinal bone growth. Endocrine Rev 1987; 8: 426–38
  • Hirt H, Kimelman J, Birnbaum M J, et al. The human growth hormone gene locus: structure, evolution and allelic variations. DNA 1987; 6: 59–70
  • Baumann G, Stolar M W, Amburn K, et al. A specific growth hormone binding protein in human plasma: initial characterization. J Clin Endocrinol Metab 1986; 62: 134–41
  • Phillips J A. Regulation of and defects in expression of growth hormone genes, O Isaksson, C Binder, K Hall, B Hökfelt. Excerpta Medica International Congress Series, III, Amsterdam 1987; 748: 11–27
  • Honda Y, Takahashi K, Takahashi S, et al. Growth hormone secretion during nocturnal sleep in normal subjects. J Clin Endocrinol Metab 1969; 29: 20–9
  • Thorner M O, Rogol A D. Neuroendocrine regulation of growth hormone secretion. Human growth hormone, progress and challenges, L E Underwood. Marcel Dekker Inc., New York 1988; 113–30
  • Thompson R G, Rodriguez A, Kowarski A, Migeon C J, Blizzard R M. Integrated concentrations of growth hormone correlated with plasma testosterone and bone age in preadolescent and adolescent males. J Clin Endocrinol Metab 1972; 35: 334–7
  • Zadik Z, Chafew S A, McCarter J, Jr, Melstas M, Kowarski A A. The influence of age on the 24‐hour integrated concentration of growth hormone. J Clin Endocrinol Metab 1985; 60: 513–16
  • Albertsson‐Wikland K, Rosberg S. Analyses of 24‐hour growth hormone profiles in children: relation to growth. J Clin Endocrinol Metab 1988; 67: 493–500
  • Minuto F, Barreca A, Ferrini S, Mazzocchi G, Del Monte P, Giordano G. Growth hormone secretion in pubertal and adult subjects. Acta Endocrinol 1982; 99: 161–5
  • Argente J, Evain‐Brion D, Munoz‐Villa A, Gamier P, Hernandez M, Donnadieu M. Relationship of plasma growth hormone‐releasing hormone levels to pubertal changes. J Clin Endocrinol Metab 1986; 63: 680–2
  • Kostyo J L. The growth‐promoting activity of growth hormone. Human growth hormone, progress and challenges, L E Underwood. Marcel Dekker Inc., New York 1988; 63–73
  • Schoenle E, Zapf J, Froesch E R. Insulin‐like growth factors I and II stimulate growth of hypophysectomized rats. Diabetologia 1982; 23: 199
  • Schoenle E, Zapf J, Humbel R E, Froesch E R. Insulin‐like growth factor I stimulates growth in hypophysectomized rats. Nature 1982; 296: 252–3
  • Rose S R, Ross J L, Uriarte M, et al. The advantage of measuring stimulated as compared with spontaneous growth hormone levels in the diagnosis of growth hormone deficiency. N Engl J Med 1988; 319: 201–7
  • Roth J, Glick S M, Yalow R S, Berson S A. Hypoglycemia: a potent stimulus to secretion of growth hormone. Science 1963; 140: 987–8
  • The Health Services Human Growth Hormone Committee. Comparison of the intravenous insulin and oral clonidine tolerance tests for growth hormone secretion. Arch Dis Child 1981; 56: 852–4
  • Boyd A E, Lebovitz H E, Pfeiffer J B. Stimulation of human growth hormone secretion by L‐dopa. N Engl J Med 1970; 283: 1425–9
  • Vanderschueren‐Lodeweyckx M, Wolter R, Malvaux P, et al. The glucagon stimulation test: effect on plasma growth hormone and on immunocreative insulin, Cortisol and glucose in children. J Pediatr 1974; 85: 182–7
  • Merimee T J, Lillicrap D A, Rabinovitz D. Effect of arginine on serum levels of human growth hormone. Lancet 1965; 2: 668–70
  • Hamilton W, Hussein D M. Growth hormone response to prostaglandin E 2. Acta Pediatr Scand 1979; 68: 251–6
  • Frasier S D. A review of growth hormone stimulation tests in children. Pediatrics 1974; 53: 929–37
  • Brook C GD, Hindmarsh P C, Smith P J, Stanhope R. Clinical features and investigation of growth hormone deficiency. Clin Endocrinol Metab 1986; 15: 479–93
  • Takahashi Y, Kipnis D M, Daughaday W H. Growth hormone secretion during sleep. J Clin Invest 1968; 47: 2079–90
  • Lacey K A, Hewison A, Parkin J M. Exercise as a screening test for growth hormone deficiency in children. Arch Dis Child 1973; 48: 508–12
  • Hindmarsh P C, Smith P J, Taylor B J, et al. Comparison between a physiological and a pharmacological stimulus of growth hormone secretion: response to stage IV sleep and insulin‐induced hypoglycaemia. Lancet 1985; 2: 1033–5
  • Geisen K, Meder R. The effect of heat on the level of human growth hormone in the serum. Z Kinderheilkd 1969; 106: 308–13
  • Dacou‐Voutetakis C, Drakopoulou M, Maniati M. Growth hormone levels during sleep in children. Pediatr Adolesc Endocrinol 1983; 12: 44–52
  • Bercu B B, Shulman D, Root A W, Spiliots B E. Growth hormone (GH) provocative testing frequently does not reflect endogenous GH secretion. J Clin Endocrinol Metab 1986; 63: 709–16
  • Albertsson‐Wikland K, Westphal O, Westgren U. Daily subcutaneous administration of human growth hormone in growth hormone deficient children. Acta Paediatr Scand 1986; 75: 89–97
  • Schulman D I, Bercu B B. Evaluation of growth hormone secretion: provocative testing vs. endogenous 24‐hour growth hormone profile. Acta Paediatr Scand 1987, Suppl. 337: 61–71
  • Sukegawa I, Hizuka N, Takano K, et al. Urinary growth hormone (GH) measurements are useful for evaluating endogenous GH secretion. J Clin Endocrinol Metab 1988; 66: 1119–23
  • Tanaka T, Yoshizawa A, Miki Y, Ito J. Clinical usefulness of urinary growth hormone measurement in short children. Acta Paediatr Scand 1990; 366: 155–8, (Suppl)
  • Schriock E A, Hulse J A, Harris D A, Kaplan S L, Grumbach M M. Evaluation of hypothalamic dysfunction in growth hormone (GH)‐deficient patients using single versus multiple doses of GH‐releasing hormone (GHRH‐44) and evidence for diurnal variation in somatotroph responsiveness to GHRH in GH‐deficient patients. J Clin Endocrinol Metab 1987; 65: 1177–82
  • Kajiwara S, Igarashi N, Imura E, Sato T. Correlation between pituitary growth hormone reserve and degree of growth failure in children with short stature. Eur J Pediatr 1988; 147: 584–87
  • Ranke M B, Gruhier M, Rosskamp R, et al. Testing with growth hormone‐releasing factor (GRH 1–29) NH2) and somatomedin C measurements for the evaluation of growth hormone deficiency. Eur J Pediatr 1986; 145: 485–92
  • Chatelain P. European collaborative study on the effect of synthetic 1–44 growth‐hormone‐releasing factor (GRF) on plasma growth hormone (GH) in prepubertal children with growth failure. Pediatr Res 1985; 19: 610
  • Borges J LC, Blizzard R M, Gelato M C, et al. Effects of human pancreatic tumour growth hormone releasing factor on growth hormone and somatomedin C levels in patients with idiopathic growth hormone deficiency. Lancet 1983; 1: 119–24
  • Schriock E A, Lustig R H, Rosenthal S M, Kaplan S L, Grumbach M M. Effect of growth hormone (GH)‐releasing hormone (GRH) on plasma GH in relation to magnitude and duration of GH deficiency in 26 children and adults with isolated GH deficiency or multiple pituitary hormone deficiencies: evidence for hypothalamic GRH deficiency. J Clin Endocrinol Metab 1984; 58: 1043–49
  • Schriock E A, Rosenthal S M, Egli C A, . Studies with growth hormone‐releasing factor (GRF) in the human: effect of a single pulse, or multiple pulses of GRF on growth hormone (GH) release in normal and GH‐deficient children and adults. Human growth hormone, S Raiti, R A Tolman, et al. Plenum Publishing Corp., New York 1986; 387–403
  • Furlanetto R W, Underwood L, Van Wyk J J, D'Ercole A J. Estimation of somatomedin‐C levels in normals and patients with pituitary disease by radioimmunoassay. J Clin Invest 1977; 60: 648–657
  • Zapf J, Walter H, Froesch E R. Radioimmunological determination of insulin‐like growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia. J Clin Invest 1981; 68: 1321–1330
  • Furlanetto R W. Insulin‐like growth factor measurements in the evaluation of growth hormone secretion. Horm Res 1990; 33(Suppl 4)25–30
  • Furlanetto R W, Marino J M. Radioimmunoassays of somatomedin C/insulin‐like growth factor I. Methods Enzymol 1985; 146: 216
  • Merimee T J, Zapf J, Froesch E R. Insulin‐like growth factors in the fed and fasted states. J Clin Endocrinol Metab 1982; 55: 999–1002
  • Rosenfeld R G, Wilson G M, Lee P OK, Hintz R L. Insulinlike‐growth factors I and II in evaluation of growth retardation. J Pediatr 1986; 109: 428–33
  • Blum W F, Ranke M B, Kletzmann K, Ganggel E, Zeisel H J, Bierich J R. A specific radioimmunoassay for the growth hormone (GH)‐dependent somatomedin‐binding protein: it's use for diagnosis of GH deficiency. J Clin Endocrinol Metab 1990; 70: 1292–8
  • Blum W F, Ranke M B. Use of insulin‐like growth factor‐binding protein 3 for evaluation of growth disorders. Horm Res 1990; 33(Suppl 4)31–7
  • Brook C GD, Hindmarsh P C, Smith P J. Is growth hormone deficiency a useful diagnosis?. Acta Paediatr Scand 1987, Suppl 33: 70–5
  • Vanderschuerer‐Lodeweyck Z. The establishment of growth hormone deficiency in children. International Growth Monitor 1990; 1: 3–9
  • Zadik Z, Chalew S A, Raiti S, Kowarski A A. Do short children secrete insufficient growth hormone?. Pediatrics 1985; 76: 355–60
  • Illig R, Prader A, Fernandez A, Zachmann M. Hereditary prenatal growth hormone deficiency with increased growth hormone antibody formation. Symposium der Deutschen Gesellschaft für Endokrinologie 1970; 16: 246–7
  • Hindmarsh P C, Brook C GD. Auxological and biochemical assessment of short stature. Acta Paediatr Scand 1988, Suppl 343: 73–6
  • Raben M S. Treatment of a pituitary dwarf with human growth hormone. J Clin Endocrinol Metab 1958; 18: 901–3
  • Powell‐Jackson, Weller J, Kennedy P, Preece M A, Whitcombe E M, Newson‐Davis J. Creutzfeldt‐Jakob disease after administration of human growth hormone. Lancet 1985; 2: 244–6
  • Gibbs C J, Jr, Joy A, Heffner R, Franko M, et al. Clinical and pathological features and laboratory confirmation of Creutzfeldt‐Jakob disease in a recipient of pituitary‐derived human growth hormone. N Engl J Med 1985; 313: 734–8
  • Fryklund L. Production of authentic recombinant somatropin. Acta Paediatr Scand 1987, Suppl 331: 5–8
  • Kaplan S L, Underwood L E, August G P, et al. Clinical studies with recombinant‐DNA‐derived methionyl human growth hormone in growth hormone‐deficient children. Lancet 1986; 1: 697–700
  • Hindmarsh P C, Brook C GD. Effect of growth hormone on short normal children. Br Med J 1987; 295: 573–7
  • Albertsson‐Wlkland K, Aronson S, Nilsson K O, et al. Recombinant somatotropin in treatment of growth hormone deficient children in Sweden and Finland. Acta Paediatr Scand 1980, Suppl 347: 176–80
  • Prader A, Zachmann M, Poley J R, Illig R, Szeky J. Longterm treatment with human growth hormone (Raben) in small doses. Evaluation of 18 hypopituitary patients. Helv Paediatr Acta 1967; 22: 423–40
  • Milner R DG, Russell‐Fraser T, Brook C GD, et al. Experience with human growth hormone in Great Britain: the report of the MRC working party. Clin Endocrinol 1979; 11: 15–38
  • Ranke M B, Blerich J R. Treatment of growth hormone deficiency. Clin Endocrinol Metab 1986; 15: 495–510
  • Zuppinger K, Joss E, Roten A, Schwartz H P, Aebl C. Endresultate bei hypophyzären Kleinwuchs nach Wachstumshormontherapie. Med Praxis 1980; 34: 1197–204
  • Lenko H L, Leisti S, Perheentupa J. The efficiency of growth hormone in different types of growth failure. An analysis of 101 cases. Eur J Pediatr 1982; 138: 241–9
  • Ad Hoc Committee on Growth Hormone Usage, The Lawson Wilkins Pediatric Endocrine Society, and Committee on Drugs. Growth hormone in the treatment of short stature. Pediatrics 1983; 72: 891–4
  • Bierich J R. Multicentre clinical trial of authentic recombinant somatropin in growth hormone deficiency. Acta Paediatr Scand 1987, Suppl 337: 135–40
  • Van Vliet G, Styne D M, Kaplan S L, Grumbach M M. Growth hormone treatment for short stature. N Engl J Med 1983; 309: 1016–22
  • Genentech Collaborative Study Group. Idiopathic short stature; results of nine 1‐year controlled study of human growth hormone treatment. J Pediatr 1989; 115: 713–9
  • Albertsson‐Wlkland K, Hall K. Growth hormone treatment in short children: relationship between growth and serum insulin‐like growth factor I and II levels. J Clin Endocrinol Metab 1987; 65: 671–8
  • Butenandt O. Die konstitutionelle entwicklungsverzögerung—untersuchungen zur therapie mit wachstumshormon. Klin Pediatr 1984; 196: 69–72
  • Tanner J M, Whltehouse R H, Hughes P CR, Vlnce F P. Effect of human growth hormone treatment for 1 to 7 years on growth of 100 children, with hormone deficiency, low birth‐weight, inherited smallness, Turner's syndrome, and other complaints. Arch Dis Child 1971; 46: 745–82
  • Rüdman D, Goldsmith M, Kutner M, Blackston D. Effect of growth hormone and oxandrolone singly and together on growth rate in girls with X chromosome abnormalities. J Pediatr 1980; 96: 132–5
  • Raiti S, Moore W V, Van Vliet G, Kaplan S L, The National Hormone and Pituitary Program. Growth‐stimulating effects of human growth hormone therapy in patients with Turner's syndrome. J Pediatr 1986; 109: 944–9
  • Rosenfeld R G, Hintz R L, Johanson A J, et al. Three year results of a randomized prospective trial of methionyl human growth hormone and oxandrolone in Turner syndrome. J Pediatr 1988; 113: 393–400
  • Ross R JM, Grossman A, Smith B, et al. Evidence that growth hormone inhibits the GH response to growth hormone‐releasing factor in man. J. Endocrinol 1985; 107(Suppl 28)
  • Thorner M O, Reschke J, Chitwood J, et al. Acceleration of growth in two children treated with human growth hormone‐releasing factor. N Engl J Med 1985; 312: 4–9
  • Rochlccloll P E, Tauber M T, Coude F X, et al. Results of 1‐year growth hormone (GH)‐releasing hormone (1–44) treatment on growth, somatomedin‐C, and 24‐hour GH secretion in six children with partial GH‐deficiency. J Clin Endocrinol Metab 1987; 65: 268–74
  • Ross R J, Rodda C, Tsagarakls S, et al. Treatment of growth hormone deficiency with growth hormone‐releasing hormone. Lancet 1987; 1: 5–8
  • Smith P J, Brook C G, Rivier J, Vale W, Thorner M O. Nocturnal pulsatile growth hormone releasing hormone treatment in growth hormone deficiency. Clin Endocrinol 1986; 25: 35–44
  • Low L CK, Wang C, Cheung P T, et al. Long term pulsatile growth hormone (GH)‐releasing hormone therapy in children with GH deficiency. J Clin Endocrinol Metab 1988; 66: 611–7
  • Plntor C, Cella S G, Loche S, et al. Clonidine treatment for short stature. Lancet 1987; 1: 1226–30
  • Loche S, Puggloni R, Fannl T, Ceila S G, Müller E E, Plntor C. Augmentation of growth hormone secretion in children with constitutional growth delay by short term clonidine administration: a pulse amplitude‐modulated phenomenon. J Clin Endocrinol Metab 1989; 68: 426–30
  • Pescovitz H, Tan E. Lack of benefit of clonidine treatment for short stature using double‐blind, placebo‐controlled trial. Lancet 1988; 2: 874–7
  • Laron Z, Klinger B, Erster B, Anln S. Effect of acute administration of insulin‐like growth factor I in patients with Laron‐type dwarfism. Lancet 1988; 2: 1170–2
  • Walker J L, Gfnalska‐Malinovska M, Romer T E, Pucilowska J B, Underwood L E. Effects of the infusion of insulin‐like growth factor 1 in a child with growth hormone insensitivity syndrome (Laron dwarfism). N Engl J Med 1991; 324: 1483–8
  • Hermanussen M, Geiger‐Benoit K, Burmeister J, Slppell W G. Can the knemometer shorten the time for growth rate assessment?. Acta Paediatr Scand 1987, Suppl 337: 30–6
  • Albertsson‐Wikland K, Isaksson O, Rosberg S, Westgren U, Westphal O. Frequency and mode of growth hormone administration: relationship to growth in prepubertal children. Acta Endocrinol 1983, Suppl 256: 215
  • Hermanussen M, Sippell W G, Valk I M. Knemometric monitoring of early effects of human growth hormone on leg length in children with growth hormone deficiency. Lancet 1985; 1069–71
  • D'Ercole A J, Underwood L E, Van Wyk J J. Serum somatomedin‐C in hypopituitarism and in other disorders of growth. J Pediatr 1977; 90: 375–81
  • Rosenfeld R G, Kemp S F, Hintz R L. Constancy of somatomedin response to growth hormone treatment of hypopituitary dwarfism, and lack of correlation with growth rate. J Clin Endocrinol Metab 1981; 53: 611–17
  • Blethen S L, Daughaday W H, Weldon W. Kinetics of the somatomedin C/insulin‐like growth factor I: Response to exogenous growth hormone (GH) in GH‐deficient children. J Clin Endocrinol Metab 1982; 54: 986–90
  • Lodeweyckx M, Wolter R. Effect of growth hormone‐releasing factor on plasma growth hormone, prolactin and somatomedin C in hypopituitary and short normal children. Horm Res 1985; 22: 32–45
  • Hlntz R, Frane J, Sherman B, The Genentech Collaborative Group. Pretreatment IGF‐I correlates with growth response to GH in hypopituitarism: the importance of acid separation. Pediatr Res 1988; 24: 522
  • Ristell J, Nlemi S, Trlvedl P, Mäentausta O, Mowat A P, Risteli L. Rapid equilibrium radioimmunoassay for the amino‐terminal propeptide of human type III procollagen. Clin Chem 1988; 34: 715–8
  • Tapanainen P, Risteli L, Knip M, Käär M ‐L., Risteli J. Serum aminoterminal propeptide of type III procollagen: a potential predictor of the response to growth hormone therapy. J Clin Endocrinol Metab 1988; 67: 1244–9
  • Trivedi P, Hindmarsh P, Risteli J, Risteli L, Mowat A, Brook C. Growth velocity, growth hormone therapy and serum concentrations of the aminoterminal propeptide of type III procollagen. J Pediatr 1989; 114: 225–30
  • Danne T, Grüters A, Schuppan D, Quantas N, Enders I, Weber B. Relationship of procollagen type III propeptide—related antigen in serum to somatic growth in healthy children and patients with growth disorders. J Pediatr 1989; 114: 257–60
  • Carey D E, Goldberg B, Ratzan S K, Rubin K R, Rowe D W. Radioimmunoassay for type I procollagen in growth hormone‐deficient children before and during treatment with growth hormone. Ped Res 1985; 19: 8–11
  • Hyams J S, Carey D E, Lelchtner A M, Goldberg B D. Type I procollagen as a biochemical marker of growth in children with inflammatory bowel disease. J Pediatr 1986; 109: 619–24
  • Tapanainen P, Risteli L, Knip M, Kemppainen L, Käär M ‐L., Risteli J. Collagen metabolities in prediction of response to growth hormone (GH) therapy in short children. Horm Pes 1990; 33(Suppl 3)20
  • Delmas P D, Malaval L, Arcot M E, Meunier P J. Serum bone Gla‐protein compared to bone histomorphometry in endocrine diseases. Bone 1985; 6: 339–41
  • Johansen J S, Giwercman A, Hartwell D, et al. Serum bone Gla‐protein as a marker of bone growth in children and adolescents: correlation with age, height, serum insulin‐like growth factor I and serum testosterone. J Clin Endocrinol 1988; 67: 273–8
  • Johansen J S, Jensen S B, Rüs B J, Rasmussen L, Zachmann M, Christiansen C. Serum bone Gla‐protein: a potential marker of growth hormone (GH) deficiency and the response to GH‐therapy. J Clin Endocrinol Metab 1990; 71: 122–6

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