237
Views
9
CrossRef citations to date
0
Altmetric
Review Article

Strategies to Identify Genes for Complex Diseases

, &
Pages 493-498 | Published online: 20 Nov 2010

References

  • Stern C. Principles of Human Genetics3rd edn. W. H. Freeman and Company, San Francisco 1973
  • Kerem B, Rommens J M, Buchanan J A, et al. Identification of the cystic fibrosis gene: genetic analysis. Science 1989; 245: 1073–80
  • Gusella J F, Wexler N S, Conneally P M, et al. A polymorphic DNA marker genetically linked to Huntington's disease. Nature 1983; 306: 234–8
  • The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993; 72: 971–83
  • Davies K, White M. Breakthrough: The Race to Find the Breast Cancer Gene. Wiley, New York 1996
  • Ottman R, Pike M C, King M C, Casagrande J T, Henderson B E. Familial breast cancer in a population-based series. Am J Epidemiol 1986; 123: 15–21
  • Slattery M L, Kerber R A. A comprehensive evaluation of family history and breast cancer risk: the Utah Population Database. JAMA 1993; 270: 1563–8
  • King M C, Go R CP, Lynch H T, et al. Genetic epidemiology of breast cancer and associated cancers in high-risk families. II. Linkage analysis. J Natl Cancer Inst 1983; 71: 463–7
  • Hall J M, Lee M K, Newman B, et al. Linkage of early-onset familial breast cancer to chromosome 17q21. Science 1990; 250: 1684–9
  • Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994; 266: 66–71
  • Ford D, Easton D F. Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence. Am J Hum Genet 1995; 57: 1457–62
  • Thomson G, Robinson W P, Kuhner M K, et al. Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus. Am J Hum Genet 1988; 43: 799–816
  • Barnett A H, Eff C, Leslie R DG, Pyke D A. Diabetes in identical twins. A study of 200 pairs. Diabetologia 1981; 20: 87–93
  • Morton N E, Green A, Dunsworth T, et al. Heterozygous expression of insulin-dependent diabetes mellitus (IDDM) determinants in the HLA system. Am J Hum Genet 1983; 35: 201–13
  • Bell G L, Horita S, Karam J H. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 1984; 33: 176–83
  • Spielman R S, McGinnis R E, Ewens W J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993; 52: 506–16
  • Davies J L, Kawaguchi Y, Bennett S T, et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 1994; 371: 130–6
  • Hashimoto L, Habita C, Beressi J P, et al. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11 q. Nature 1994; 371: 161–4
  • Bennett S T, Lucassen A M, Gough S C, et al. Susceptibility of human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat Genet 1995; 9: 283–92
  • Pugliese A, Zeller M, Fernandez A, Jr, et al. The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. War Genef 1997; 15: 293–7
  • Robertson N P, Fraser M, Deans J, Clayton D, Walker N, Compston D A. Age-adjusted recurrence risks for relatives of patients with multiple sclerosis. Brain 1996; 119: 449–55
  • Farrall M. Mapping genetic susceptibility to multiple sclerosis. Lancet 1996; 348: 1674–5
  • Ebers G C, Bulman D E, Sadovnick A D, et al. A population-based study of multiple sclerosis in twins. N Engl J Med 1986; 315: 1638–42
  • Sawcer S, Jones H B, Feakes R, et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet 1996; 13: 464–8
  • The Multiple Sclerosis Genetics Group. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. Nat Genet 1996; 13: 469–71
  • Ebers G, Kukay K, Bulman D E, et al. A full genome search in multiple sclerosis. Nat Genet 1996; 13: 472–6
  • Williams W R, Anderson D E. Genetic epidemiology of breast cancer: segregation analysis of 200 Danish pedigrees. Genet Epidemiol 1984; 1: 7–20
  • Colins F S. BRCA1 - lots of mutations, lots of dilemmas. N Engl J Med 1996; 334: 186–8
  • Stunkard A J, Sorensen T IA, Hanis C, et al. An adoption study of human obesity. N Engl J Med 1986; 314: 193–8
  • Risch N. Genetic linkage and complex diseases, with special reference to psychiatric disorders. Genef Epidemiol 1990; 7: 3–16
  • Lander E S, Schork N J. Genetic dissection of complex traits. Science 1994; 265: 2037–48
  • Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996; 273: 1516–7
  • Risch N, Zhang H. Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 1995; 268: 1584–9
  • Haseman J K, Elston R C. The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 1972; 2: 3–19
  • Carey G, Williamson J. Linkage analysis of quantitative traits: increased power by using selected samples. Am J Hum Genet 1991; 49: 786–96
  • Eaves L, Meyer J. Locating human quantitative trait loci: guidelines for the selection of sibling pairs for genotyping. Behav Genet 1994; 24: 443–55
  • Risch N, Zhang H. Mapping quantitative trait loci with extreme discordant sib pairs: sample size considerations. Am J Hum Genet 1996; 58: 836–42
  • Zhang H, Risch N. Mapping quantitative trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes. Am J Hum Genet 1996; 59: 951–7
  • Zhao H, Zhang H, Rotter J I. Cost-effective sib-pair designs in the mapping of quantitative-trait loci. Am J Hum Genet 1997; 60: 1211–21
  • Gu C, Todorov A, Rao D C. Combining extremely concordant sibpairs with extremely discordant sibpairs provides a cost effective way to linkage analysis of quantitative trait loci. Genet Epidemiol 1996; 13: 513–33
  • Ziegler A, Hebebrand J, Schafer H. A clinically orientated approach for combining discordant and concordant sib pairs. Biom J

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.