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Original Article

An Academic Centre for Gene Therapy Research with Clinical Grade Manufacturing Capability

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Pages 579-583 | Published online: 20 Nov 2010

References

  • Medicines Control Agency. Rules and Guidance for Pharmaceutical Manufacturers. Her Majesty's Stationery Office, London 1993
  • Bjorkstrand B, Gahrton G, Dilber M S, Ljungman P, Smith C IE, Xauthopoulos K G. Retroviral-mediated gene transfer of CD34-enriched bone marrow and peripheral blood cells during autologous stem cell transplantation for multiple myetoma. Hum Gene Ther 1994; 5: 1279–86
  • Oilber M S, Abedi M R, Björkstrand B, et al. Suicide gene therapy for plasma cell tumors. Blood 1996; 88: 2192–200
  • Oilber M S, Smith C IE. Suicide genes and bystander killing: local and distant effects. Gene Ther 1997; 4: 273–4
  • Wilson K M, Stambrook P J, Bi W L, Pavelic Z P, Pavelic L, Gluckmann J L. HSV-tk gene therapy in head and neck squamous cell carcinoma. Enhancement by the local and distant bystander effect. Arch Otolaryngol Head Neck Surg 1996; 122: 746–9
  • Dilber M S, Abedi M R, Christensson B, et al. Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo. Cancer Res 1997; 57: 1523–8
  • Vetrie D, Vorechovsky I, Sideras R, et al. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature 1993; 361: 226–33
  • Thomas J D, Sideras P, Smith C IE, Vorechovosky I, Chapman V, Paul W E. Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science 1993; 261: 355–8
  • Ferrara N, Henzel W J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989; 161: 851–8
  • Ferrara N. The role of vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Res Treat 1995; 36: 127–37
  • Isner J M, Pieczek A, Schainfeld R, et al. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet 1996; 348: 370–4
  • Isner J M, Walsh K, Rosenfield K, et al. Arterial gene therapy for restenosis. Hum Gene Ther 1996; 7: 989–1011
  • Ulmer J B, Donnelly J J, Parker S E, et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993; 259: 1745–9
  • Yew N S, Wysokenski D M, Wang K X, et al. Optimization of plasmid vectors for high-level expression in lung epithelial cells. Hum Gene Ther 1997; 8: 575–84
  • Wahren B. Gene vaccines. Immune-technology 1996; 2: 77–83
  • Fynan E F, Webster R G, Fuller D H, Haynes J R, Santoro J C, Robinson H L. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc Natl Acad Sci USA 1993; 90: 11478–82
  • Hinkula J, Svanholm C, Schwartz S, et al. Recognition of prominent viral epitopes induced by immunization with human immunodeficiency virus type 1 regulatory genes. JWro 1997; 71: 5528–39
  • Wang B, Ugen K E, Srikantan V, et al. Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1993; 90: 4156–60
  • Boyer J D, Ugen K E, Wang B, et al. Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nat Med 1997; 3: 526–32
  • Ugen K E, Boyer J D, Wang B, et al. Facilitated nucleic acid vaccinations of humans with a HIV-1 expressing DNA plasmid boosts immune responses against viral proteins. Abstracts of the Molecular Approaches to the Control of Infectious Diseases Meeting. Cold Spring Harbor Laboratory. Cold Spring Harbour Laboratory Press, Cold Spring Harbour, NY 1996; 92
  • Wahren B, Hinkula J, Lundholm P, et al. Nucleic acid vaccination with HIV regulatory genes. Genes that induce immunity. Nobel Symposium, Abstract. Karolinska Institute, Stockholm 1996; 30
  • Rossi J J. Controlled, targeted, intracellular expression of ribozymes: progress and problems. Trends Biotechnol 1995; 13: 301–6
  • Thompson J D, Macejak D, Couture L, Stinchcomb D T. Ribozymes in gene therapy. Nat Med 1995; 1: 277–8
  • Kashani-Sabet M, Scanlon K J. Application of ribozymes to cancer gene therapy. Cancer Gene Ther 1995; 2: 213–23
  • Larsson S, Hotchkiss G, Su J, et al. A novel ribozyme target site located in the HIV-1 nef open reading frame. Virology 1996; 219: 161–9
  • Riordan J R, Rommens J M, Kerem B, et al. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA (published erratum appears in Science 1989, 245, 1437). Science 1989; 245: 1066–73
  • Rommens J M, Lannuzzi M C, Kerem B, et al. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 1989; 245: 1059–65
  • Riordan J R. The cystic fibrosis transmembrane conductance regulator. Annu Rev Physiol 1993; 55: 609–30
  • Collins F S. Cystic fibrosis: molecular biology and therapeutic implications. Science 1992; 256: 774–9
  • Zabner J, Couture L A, Gregory R J, Graham S M, Smith A E, Welsh M J. Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 1993; 75: 207–16
  • Knowles M R, Hohneker K W, Zhou Z, et al. A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N Engl J Med 1995; 333: 823–31
  • Hay J G, McElvaney N G, Herena J, Crystal R G. Modification of nasal epithelial potential differences of individuals with cystic fibrosis consequent to local administration of a normal CFTR cDNA adenovirus gene transfer vector. Hum Gene Ther 1995; 6: 1487–96
  • Zabner J, Ramsey B W, Meeker D P, et al. Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis. J Clin Invest 1996; 97: 1504–11
  • Mittereder N, Yei S, Bachurski C, et al. Evaluation of the efficacy and safety of in vitro adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA. Hum Gene Ther 1994; 5: 717–29
  • Rosenfeld M A, Yoshimura K, Trapnell B C, et al. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 1992; 68: 143–55
  • Engelhardt J F, Simon R H, Yang Y, et al. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: biological efficacy study. Hum Gene Ther 1993; 4: 759–69
  • Bout A, Imler J L, Schultz H, et al. In vivo adenovirus-mediated transfer of human CFTR cDNA to rhesus monkey airway epithelium: efficacy, toxicity and safety. Gene Ther 1994; 1: 385–94
  • Caplen N J, Alton E W, Middleton P G, et al. Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis (published erratum appears in Nat Med 1995, 1, 272). Nat Med 1995; 1: 39–46
  • Gill D R, Southern K W, Mofford K A, et al. A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis. Gene Ther 1997; 4: 199–209
  • Porteous D J, Dorin J R, McLachlan G, et al. Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Gene Ther 1997; 4: 210–8
  • Miller A D. Retroviral vectors. Curr Top Microbiol Immunol 1992; 158: 1–24
  • Anderson W F. End-of-the-year potpourri-1996. Hum Gene Ther 1996; 7: 2201–2
  • Landau N R, Littman D R. Packaging system for rapid production of murine leukemia virus vectors with variable tropism. J Virol 1992; 66: 5110–3
  • Naviaux R K, Costanzi E, Haas M, Verma I M. The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J Virol 1996; 70: 5701–5
  • Liljestrdm P, Garoff H. A new generation of animal cell expression vectors based on the Semliki Forest virus replicon. Biotechnology 1991; 9: 1356–61
  • Li K J, Garoff H. Production of infectious recombinant Moloney murine leukemia virus particles in BHK cells using Semliki Forest virus-derived RNA expression vectors. Proc Natl Acad Sci USA 1996; 93: 11658–63

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