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Original Article

Genetic risk factors and ischaemic cerebrovascular disease: role of common variation of the genes encoding apolipoproteins and angiotensin-converting enzyme

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Pages 224-233 | Received 21 Aug 1997, Accepted 09 Dec 1997, Published online: 08 Jul 2009

References

  • World Health Organization. Cerebrovascular Disease: Prevention, Treatment, and Rehabilitation. World Health Organization, Geneva 1971, WHO Technical Report Series No 469
  • Kjellin K G, Mettinger K L, Siden A. (1980) A study of stroke before age 55. International Conference on Atherosclerosis. 1980, L A Carlson. Raven Press, New York, 227–38
  • Chopra J S, Prabhakar A. Clinical features and risk factors in stroke in young. Acta Neurol Scand 1979; 60: 289–300
  • Aho K, Harmsen P, Hatano S, Marquardsen J, Smirnov V E, Strasser T. Cerebrovascular disease in the community: results of a WHO collaborative study. Bull World Health Organ 1980; 58: 113–30
  • Suzuki K, Sarti C, Tuomilehto J, et al. Stroke indicence and case fatality in Finland and in Akita, Japan: a comparative study. Neuroepidemiology 1994; 13: 236–44
  • Uemura K, Pisa Z. Trends in cardiovascular disease mortality in industrialized countries since 1950. World Health Stat Q 1988; 41: 155–78
  • Wolf P A, Cobb J L, ĎAgostino R B. Epidemiology of stroke. Stroke. Pathophysiology, Diagnosis, and Management, 2nd ed., H JM Barnett, J P Mohr, B M Stein, F M Yatsu. Churchill Livingstone, New York 1992; 3–27
  • Dyken M L, Wolf P A, Barnett H JM. Risk factors in stroke. A statement for physicians by the subcommittee on risk factors and stroke of the Stroke Council. Stroke 1984; 6: 1105–11
  • Tell G S, Crouse J R, Furberg C D. Relation between blood lipids, lipoproteins, and cerebrovascular atherosclerosis. Stroke 1988; 19: 423–30
  • Albers M J. Genetics of cerebrovascular disease. Stroke 1990; 21(Suppl 3)111–127, 30
  • Sing C F, Moll P P. Genetics of atherosclerosis. Annu Rev Genet 1990; 24: 171–87
  • Dammerman M, Breslow J L. Genetic basis of lipoprotein disorders. Circulation 1995; 91: 505–12
  • Gordon D J, Knoke J, Probstfield J L, Superko R, Tyroler H A. High density lipoprotein cholestrol and coronary heart disease in hypercholesterolemic men: the Lipid Research Clinics Coronary Primary Prevention trial. Circulation 1986; 74: 1217–25
  • Miller N E. Associations of high density lipoprotein subclasses and apolipoproteins with ischemic heart dissease and coronary atherosclerosis. Am Heart J 1987; 113: 589–97
  • Aalto-Setälä K, Fisher E A, Chen X, et al. Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles. J Clin Invest 1992; 90: 1889–900
  • Maeda N, Li H, Lee D, Oliver P, Quarfordt S H, Osaka J. Targeted distribution of the apolipoprotein C-III gene in mice results in hypertriglyceridemia and protection from postprandial hypertriglyceridemia. J Biol Chem 1994; 269: 23610–6
  • Rees A, Stocks J, Sharpe C R, et al. Deoxyribonucleic acid polymorphism in the apolipoprotein A-1-C-III gene cluster. Association with hypertriglyceridemia. J Clin Invest 1985; 76: 1090–5
  • Aalto-Setälä K, Kontula K, Sane T, Nieminen M, Nikkilä E. DNA polymorphism of apolipoprotein A-1/C-III and insulin genes in familial hypertriglyceridemia and coronary heart disease. Atherosclerosis 1987; 66: 145–52
  • Tas S. Strong association of a single nucleotide substitution in the 3' untranslated region of the apolipoprotein CHI gene with common hypertriglyceridemia in Arabs. Clin Chem 1989; 35: 256–9
  • Ordovas J M, Civeira F, Genets J, Jr, et al. Restriction fragment length polymorphism of the apolipoproteins A-I, C-III, A-IV gene locus: relationships with lipids, apolipoproteins, and premature coronary artery disease. Atherosclerosis 1991; 87: 75–86
  • Ahn Y I, Valdez R, Reddy A P, Cole S A, Weiss K M, Ferrell R E. DNA polymorphisms of the apolipoprotein AI/CIII/AIV gene cluster influence plasma cholesterol and triglyceride levels in the Mayans of the Yucatan Peninsula, Mexico. Hum Hered 1991; 41: 281–9
  • Zeng Q, Dammerman M, Takada Y, Matsunage A, Breslow J L, Sasaki J. An apolipoprotein CM marker associated with hypertriglyceridemia in Caucasians also confers increased risk in a west Japanese population. Hum Genet 1995; 95: 371–5
  • Ordovas J M, Schaefer E J, Salem D, et al. Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia. N Engl J Med 1986; 314: 671–7
  • Ferns G AA, Stocks J, Richie C, Galton D J. Genetic polymorphism of apolipoprotein C-III and insulin in survivors of myocardial infarction. Lancet 1985; 2: 300–3
  • Berg K. DNA polymorphism at the apolipoprotein B locus is associated with lipoprotein level. Clin Genet 1986; 30: 515–20
  • Talmud P J, Barni N, Kessling A M, et al. Apolipoprotein B gene variants are involved in the determination of serum cholesterol levels: a study in normo- and hyperlipidaemic individuals. Atherosclerosis 1987; 67: 81–9
  • Aalto-Setälä K, Tikkanen M J, Taskinen M-R, Nieminen M, Holmberg P, Kontula K. Xbal and c/g polymorphisms of the apolipoprotein B gene locus are associated with serum cholesterol and LDL-cholesterol levels in Finland. Atherosclerosis 1988; 74: 47–54
  • Aalto-Setälä K, Gylling H, Helve E, et al. Genetic polymorphism of the apolipoprotein B gene locus influences serum LDL cholesterol level. Hum Genet 1989; 82: 305–7
  • Hegele R A, Huang L-S, Herbert P H, et al. Apolipoprotein B-gene polymorphisms associated with myocardial infarction. N Engl J Med 1986; 315: 1509–15
  • Ehnholm C, Lukka M, Kuusi T, Nikkilä E, Utermann G. Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations. J Lipid Res 1986; 27: 227–35
  • Eto M, Watanabe K, Ishii K. Reciprocal effects of apolipoprotein E alleles (ε2 and ε4) on plasma lipid levels in normolipidemic subjects. Clin Genet 1986; 29: 477–84
  • Sing C F, Davignon J. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet 1985; 37: 268–85
  • Davignon J, Gregg R E, Sing C F. Apolipoprotein E polymorphism and atherosclerosis. Atherosclerosis 1988; 8: 1–21
  • Gregg R E, Lech L A, Gabelli C, Brewer H B. Apolipoprotein modulates the metabolism of apolipoprotein B containing lipoproteins by multiple mechanisms. Cholesterol Transport Systems and Their Relation to Atherosclerosis, A Steinmetz, H Kaffarnik, J Schneider. Springer-Verlag, Berlin 1989; 11–21
  • Zee R YL, Lou Y K, Griffiths L R, Morris J M. Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension. Biochem Biophys Res Commun 1992; 184: 9–15
  • Palomaki H, Kaste M, Raininko R, Salonen O, Juvele S, Sarna S. Risk factors for cervical atherosclerosis in patients with transient ischemic attack or minor ischemic stroke. Stroke 1993; 24: 970–5
  • Chikos P M, Fisher V, Hirsch J H, Harley J D, Thiele B L, Strandness D E. Observer variability in evaluating extracranial carotid artery stenosis. Stroke 1983; 14: 885–92
  • Mendez I, Hachinski P B, Wolfe B. Serum lipids after stroke. Neurology 1987; 37: 507–11
  • Havel R J, Eder H A, Bragdon J H. The distribution and chemical composition of ulrxacenrrifugally separated lipoproteins in human serum. J Clin Invest 1955; 34: 1345–53
  • Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343–6
  • Shanmugan V, Sell K W, Saha B K. Mistyping ACE heterozygotes. PCR Methods Appl 1993; 3: 120–1
  • Kontula K, Aalto-Setälä K, Kuusi T, Hämäläinen L, Syvänen A-C. Apolipoprotein E polymorphism determined by restriction enzyme analysis of DNA amplified by polymerase chain reaction: convenient alternative to phenotyping by isoelectric focusing. Clin Chem 1990; 36: 2087–92
  • Gambien F, Poirier O, Lecerf L, et al. Deletion polymorphism in the gene for angiotensin converting enzyme is a potent risk for myocardial infarction. Nature 1992; 359: 641–4
  • Zhao Y, Higashimori K, Higaki J. Significance of the deletion polymorphism of the angitensin converting enzyme gene as a risk factor for myocardial infarction in Japanese. Hypertens Res 1994; 17: 55–7
  • Leatham E, Barley J, Redwood S, et al. Angiotensin-converting enzyme polymorphism in patients presenting with myocardial infarction or unstable angina. J Hum Hypertens 1994; 8: 635–8
  • Genton E, Barnett H JM, Fiels W S, Gent M, Hoak J C. Cerebral ischemia: the role of thrombosis and of antithrombotic therapy. Study group on antithrombotic therapy. Stroke 1977; 8: 150–75
  • Fisher M. Atherosclerosis: cellular aspects and potential interventions. Cerebrovasc Brain Metab Rev 1991; 3: 114–33
  • Kiwak K J, Caughlin S R, Moskowitz M A. Arachidonic acid metabolism in brain blood vessels: implications for the pathogenesis and treatment of cerebrovascular diseases. Stroke. Pathophysiology, Diagnosis, and Management.2nd ed., H JM Barnett, J P Mohr, B M Stein, F M Yatsu. Churchill Livingstone, New York 1992; 141–63
  • Pedro-Botet J, Senti M, Nogues X, et al. Lipoprotein and apolipoprotein profile in men with ischemic stroke: role of lipoprotein (a), triglyceride-rich lipoproteins, and apolipoprotein E polymorphism. Stroke 1992; 23: 1556–62
  • Courec R, Mahieux F, Bailleul S, Fenelon G, Mary R, Fermanian J. Prevalence of apolipoprotein E phenotypes in ischemic cerabrovascular disease: a case-control study. Stroke 1993; 24: 661–4
  • de Andrade M, Thandi I, Brown S, Gotto A, Jr, Patsch W, Boerwinkle E. Relationship of the apolipoprotein E polymorphism with carotid artery atherosclerosis. Am J Hum Genet 1995; 56: 1379–90
  • Kuusisto J, Mykkänen L, Kervinen K, Kesäniemi Y A, Laakso M. Apolipoprotein E4 phenotype is not an important risk factor for coronary heart disease or stroke in elderly subjects. Arterioscler Thromb Vase Biol 1995; 15: 1280–6
  • Nieminen M S, Manila K J, Aalto-Setälä K, et al. Lipoproteins and their genetic variation in subjects with and without angiographically verified coronary artery disease. Arteroscler Thromb 1992; 12: 58–69
  • Davignon J, Gregg R E, Sing C F. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 1988; 8: 1–21
  • Strittmatter W J, Roses A D. Apolipoprotein E and Alzheimer disease. Proc Natl Acad Sci USA 1995; 92: 4725–7
  • Henderson A S, Easteal S, Form A F, et al. Apolipoprotein E allele e4, dementia, and cognitive decline in a population sample. Lancet 1995; 346: 1387–90
  • Nicoll J AR, Roberts G W, Graham D I. Apolipoprotein E e4 allele is associated with deposition of amyloid p-protein following head injury. Nat Med 1995; 1: 135–7
  • Mahley R W, Nathan B P, Bellosta S, Pitas R. Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease. Curr Opin Lipidol 1995; 6: 86–91
  • Monsalva M V, Young R, Jobsis J, et al. DNA polymorphism of the gene for apolipoprotein B in patients with peripheral arterial disease. Atherosclerosis 1988; 70: 123–9
  • Aburatani H, Murase T, Takaku F, Itoh H, Matsumoto A, Itakura H. Apolipoprotein B-gene polymorphism and myocardial infarction. N Engl J Med 1987; 317: 52
  • Ferns G AA, Robinson D, Gallon D J. DNA haplotypes of the human apolipoprotein B gene in coronary atherosclerosis. Hum Genet 1988; 81: 76–80
  • Tybjaerg-Hansen A, Nordestgaard B G, Gerdes L U, Faergeman O, Humpries S E. Genetic markers in the apoAI-CIII-AIV gene cluster for combined hyperlipidemia, hypertriglyceridemia, and predisposition to atherosclerosis. Atherosclerosis 1993; 100: 157–69
  • Kasturi R, Yatsu F M, Alam R, Rogers S. Restriction fragment length polymorphism of the apoprotein A-I-C-III gene cluster in control and stroke-prone white and black subjects: racial differences. Stroke 1992; 23: 1257–64
  • Patsch W, Sharrett A R, Chen I Y, et al. Associations of allelic differences at the A-I/C-III/A-IV gene cluster with carotid artery intima-media thickness and plasma lipid transport in hypercholesterolemic-hypertriglyceridemic humans. Arterioscler Thromb 1994; 14: 874–83
  • Schonfeld G, George P K, Miller J, Reilly P, Witztum J. Apolipoprotein C-II and C-III levels in hyperlipoproteinemia. Metabolism 1979; 28: 1001–10
  • Le N A, Gibson J C, Ginsberg H N. Independent regulation of plasma apolipoprotein C-II and C-III concentrations in very low density and high density lipoproteins: implications for the regulation of the catabolism of these lipoproteins. J Lipid Res 1988; 29: 669–77
  • Holmes D R, Elveback L R, Frye R L, Kottke B A, Ellefson R D. Association of risk factor variables and coronary artery disease documented with angiography. Circulation 1981; 63: 293–9
  • Randup A, Pakkenberg H. Plasma triglyceride and cholesterol levels in cerebrovascular disease. Sex and angiographic differences. J Atheroscler Res 1967; 7: 17–24
  • Terrence C F, Rao G R. Triglycerides as a risk factor in extracranial atherosclerotic cerebrovascular disease. Angiology 1983; 34: 452–60
  • Miettinen H E, Korpela K, Uinen L, Kontula K. Polymorphism of the apolipoprotein and angiotensin converting enzyme genes in young North Karelian patients with coronary heart disease. Hum Genet 1994; 94: 189–92
  • Duru K, Farrow S, Wang J M, Lockette W, Kurtz T. Frequency of a deletion polymorphism in the gene for angiotensin converting enzyme is increased in African-Americans with hypertension. Am J Hypertens 1994; 7: 759–62
  • Pujia A, Gnasso A, Irace C, et al. Association between ACE-D/D polymorphism and hypertension in type II diabetic subjects. J Hum Hypertens 1994; 8: 687–91
  • Jeunemaitre X, Lifton R P, Hunt S C, Williams R R, Lalouel J M. Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nat Genet 1992; 1: 72–5
  • Harrap S B, Davidson H R, Connor J M, et al. The angiotensin I converting enzyme gene and predisposition to high blood pressure. Hypertension 1993; 21: 455–60
  • Schmidt S, van Hooft I M, Grobbee D E, Ganten D, Ritz E. Polymorphism of the angiotensin I converting enzyme gene is apparently not related to high blood pressure: Dutch Hypertension and Offspring Study. J Hypertens 1993; 11: 345–8
  • West M J, Summers K M, Burstow D J, Wong K K, Huggard P R. Renin and angiotensin-converting enzyme genotypes in patients with essential hypertension and left ventricular hypertrophy. Clin Exp Pharmacol Physiol 1994; 21: 207–10
  • Gu X X, Spaepen M, Guo C, et al. Lack of association between the I/D polymorphism of the angiotensin-converting enzyme gene and essential hypertension in a Belgian population. J Hum Hypertens 1994; 8: 683–5
  • Markus H S, Barley J, Lunt R, et al. Angiotensin-converting enzyme gene deletion polymorphism. A new risk factor for lacunar stroke but not carotid atheroma. Stroke 1995; 26: 1329–33

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