Differences in Intraepithelial Lymphocytes in the Proximal, Middle, Distal Parts of Small Intestine, Cecum, and Colon of Mice

REFERENCES

• Beagley, K.W., Fujihashi, K., Lagoo, A.S., Lagoo-Deenadaylan, S., Black, C.A., Murray, A.M., Sharmanov, A.T., Yamamoto, M., McGhee, J.R., Elson, C.O., Kiyono, H. (1995). Differences in intraepithelial lymphocytes T cell subsets isolated from murine small versus large intestine. J. Immunol. 154:5611–5619.
   PubMed Web of Science ®Google Scholar
• Boismenu, R., Havran, W.L. (1994). Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 266:1253–1255.
   PubMed Web of Science ®Google Scholar
• Boll, G., Rudolphi, A., Spieß, S., Reimann, J. (1995). Regional specialization of intraepithelial T cells in the murine small and large intestine. Scand. J. Immunol. 41:103–113.
   PubMed Web of Science ®Google Scholar
• Camerini, V., Panwala, C., Kronenberg, M. (1993). Regional specialization of the mucosal immune system. Intraepithelial lymphocytes of the large intestine have a different phenotype and function than those of the small intestine. J. Immunol. 151:1765–1776.
   PubMed Web of Science ®Google Scholar
• Chen, Y., Chou, K., Fuchs, E., Havran, W.L., Boismenu, R. (2002). Protection of the intestinal mucosa by intraepithelial γδ T cells. Proc. Natl. Acad. Sci. USA. 99:14338–14343.
   PubMed Web of Science ®Google Scholar
• Cuff, C.F., Cebra, C.K., Rubin, D.H., Cebra, J.J. (1993). Developmental relationship between cytotoxic α/β T cell receptor-positive intraepithelial lymphocytes and Peyer's patch lymphocytes. Eur. J. Immunol. 23:1333–1339.
   PubMed Web of Science ®Google Scholar
• Culshaw, R.J., Bancroft, G.J., McDonald, V. (1997). Gut intraepithelial lymphocytes induce immunity against Cryptosporidium infection through a mechanism involving gamma interferon production. Infect. Immun. 65:3074–3079.
   PubMed Web of Science ®Google Scholar
• Finamore, A., Roselli, M., Britti, S., Monastra, G., Ambra, R., Turrini, A., Mengheri, E. (2008). Intestinal and peripheral immune response to MON810 maize ingestion in weaning and old mice. J. Agric. Food Chem. 56:11533–11539.
   PubMed Web of Science ®Google Scholar
• Fujihashi, K., Taguchi, T., McGhee, J.R., Eldridge, J.H., Bruce, M.G., Green, D.R., Singh, B., Kiyono, H. (1990). Regulatory function for murine intraepithelial lymphocytes two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral tolerance. J. Immunol. 145:2010–2019.
   PubMed Web of Science ®Google Scholar
• Fujihashi, K., Yamamoto, M., McGhee, J.R., Beagley, K.W., Kiyono, H. (1993). Function of αβTCR+ intestinal intraepithelial lymphocytes: Th1- and Th2-type cytokine production by CD4+CD8- and CD4+CD8+ T cells for helper activity. Int. Immunol. 5:1473–1481.
   PubMed Web of Science ®Google Scholar
• Goodman, T., Lefrançois, L. (1988). Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes. Nature 333:855–858.
   PubMed Web of Science ®Google Scholar
• Guy-Grand, D., Azogui, O., Celli, S., Darche, S., Nussenzweig, M. C., Kourilsky, P., Vassalli, P. (2003). Extrathymic T cell lymphopoiesis: Ontogeny and contribution to gut intraepithelial lymphocyte in athymic and euthymic mice. J. Exp. Med. 197:333–341.
   PubMed Web of Science ®Google Scholar
• Guy-Grand, D., Malassis-Seris, M., Briottet, C., Vassalli, P. (1991). Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules. J. Exp. Med. 173:1549–1552.
   PubMed Web of Science ®Google Scholar
• Guy-Grand, D., Rocha, B., Mintz, P., Malassis-Seris, M., Selz, F., Malissen, B., Vassalli, P. (1994). Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation. J. Exp. Med. 180:673–679.
   PubMed Web of Science ®Google Scholar
• Hummel, K.P., Richardson, F.L., Fekete, E. (1975). Anatomy. In: Green E.L. ( Ed.), Biology of the laboratory mouse (second edition). Dover Publications Inc., pp.247–307.
   Google Scholar
• Ishikawa, H., Naito, T., Iwanaga, T., Takahashi-Iwanaga, H., Suematu, M., Hibi, T., Nanno, M. (2007). Curriculum vitae of intestinal intraepithelial T cells: their development and behavioral characteristics. Immunol. Rev. 215:154–165.
   PubMed Web of Science ®Google Scholar
• Ishimoto, Y., Tomiyama-Miyaji, C., Watanabe, H., Yokoyama, H., Ebe, K., Tsubata, S., Aoyagi, Y., Abo T. (2004). Age-dependent variation in the proportion and number of intestinal lymphocyte subsets, especially natural killer T cells, double-positive CD4+ CD8+ cells and B220+ T cells, in mice. Immunology 113:371–377.
   PubMed Web of Science ®Google Scholar
• Ke, Y., Pearce, K., Lake, J.P., Ziegler, H.K., Kapp, J.A. (1997). Gamma delta T lymphocytes regulate the induction and maintenance of oral tolerance. J. Immunol. 158:3610–3618.
   PubMed Web of Science ®Google Scholar
• Kronenberg, M., Cheroutre, H. (2005). Development, Function, and Specificity of Intestinal Intraepithelial Lymphocytes. In: Mestecky, J., Lamm, M.E., Strober, W., Bienenstock, J., McGhee, J.R., Mayer, L. ( Eds.), Mucosal Immunology vol. 1 (third edition). Elsevier Academic Press, pp. 565–581.
   Google Scholar
• Kuo, S., El Guindy, A., Panwala, C.M., Hagan, P.M., Camerini, V. (2001). Differential appearance of T cell subsets in the large and small intestine of neonatal mice. Pediatr. Res. 49:543–551.
   PubMed Web of Science ®Google Scholar
• Lambolez, F., Kronenberg, M., Cheroutre, H. (2007). Thymic differentiation of TCRαβ+ CD8αα+ IELs. Immunol. Rev. 215:178–188.
   PubMed Web of Science ®Google Scholar
• Page, S.T., Bogatzki, L.Y., Hamerman, J.A., Sweenie, C.H., Hogarth, P.J., Malissen, M., Perlmutter, R.M., Pullen, A.M. (1998). Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor αβ lineage. Proc. Natl. Acad. Sci. USA 95:9459–9464.
   PubMed Web of Science ®Google Scholar
• Poussier, P., Ning, T., Banerjee, D., Julius, M. (2002). A unique subset of self-specific intraintestinal T cells maintains gut integrity. J. Exp. Med. 195:1491–1497.
   PubMed Web of Science ®Google Scholar
• Reséndiz-Albor, A.A., Esquivel, R., López-Revilla, R., Verdín, L., Moreno-Fierros, L. (2005). Striking phenotypic and functional differences in lamina propria lymphocytes from the large and small intestine of mice. Life Sci. 76:2783–2803.
   PubMed Web of Science ®Google Scholar
• Roberts, S.J., Smith, A.L., West, A.B., Wen, L., Findly, R.C., Owen, M.J., Hayday, A.C. (1996). T-cell αβ+ and γδ+ deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proc. Natl. Acad. Sci. USA 93:11774–11779.
   PubMed Web of Science ®Google Scholar
• Rocha, B., Vassalli, P., Guy-Grand, D. (1991). The Vβ repertoire of mouse gut homodimeric a CD8+ intraepithelial T cell receptor α/β+ lymphocytes reveals a major extrathymic pathway of T cell differentiation. J. Exp. Med. 173:483–486.
   PubMed Web of Science ®Google Scholar
• Rocha, B., Vassalli, P., Guy-Grand, D. (1994). Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice. J. Exp. Med. 180:681–686.
   PubMed Web of Science ®Google Scholar
• Sasahara, T., Tamauchi, H., Ikewaki, N., Kubota, K. (1994). Unique properties of a cytotoxic CD4+CD8+ intraepithelial T-cell line established from the mouse intestinal epithelium. Microbiol. Immunol. 38:191–199.
   PubMed Web of Science ®Google Scholar
• Suzuki, H., Jeong, K.I., Doi, K. (2001a). Regional variations in the distributions of small intestinal intraepithelial lymphocytes (IELs) in BALB/c +/+, nu/+ and nu/nu mice. Comp. Med. 51:127–133.
   PubMed Web of Science ®Google Scholar
• Suzuki, H., Jeong, K.I., Doi, K. (2001b). Regional variations in the distribution of small intestinal intraepithelial lymphocytes in alymphoplasia (aly/aly) mice and heterozygous (aly/+) mice. Immunol. Invest. 30:315–324.
   Web of Science ®Google Scholar
• Suzuki, H., Jeong, K.I., Doi, K. (2002a). Age-related changes in the regional variations in the number and subsets of intraepithelial lymphocytes in mouse small intestine. Dev. Comp. Immunol. 26:589–595.
   PubMed Web of Science ®Google Scholar
• Suzuki, H., Jeong, K.I., Itoh, K., Doi, K. (2002b). Regional variations in the distributions of small intestinal intraepithelial lymphocytes in germ-free and specific pathogen-free mice. Exp. Mol. Pathol. 72:230–235.
   PubMed Web of Science ®Google Scholar
• Suzuki, H., Jeong, K.I., Okutani, T., Doi, K. (2000a). Regional variations in the number and subsets of intraepithelial lymphocytes in the mouse small intestine. Comp. Med. 50:39–42.
   PubMed Web of Science ®Google Scholar
• Suzuki, H., Jeong, K.I., Okutani, T., Doi, K. (2000b). Regional variations in the distributions of small intestinal intraepithelial lymphocytes (IELs) in three inbred strains of mice. J. Vet. Med. Sci. 62:881–887.
   PubMed Web of Science ®Google Scholar
• Suzuki, H., Shibata, S., Okutani, T., Suzuki, M., Nakayama, M., Nishimura, T., Doi, K. (1999). Diurnal changes in intraepithelial lymphocytes (IELs) in the small intestine of mice. Exp. Anim. 48:115–118.
   PubMed Web of Science ®Google Scholar
• Suzuki, H., Yamamoto, S. (2006). Regional variations in the distributions of small intestinal intraepithelial lymphocytes (IELs) in outbred laboratory mice (Mus musculus domesticus) and the inbred strain of mice established from Japanese fancy mice (Mus musculus molossinus). Dev. Comp. Immunol. 30:523–529.
   PubMed Web of Science ®Google Scholar
• Sydora, B.C., Jamieson, B.D., Ahmed, R., Kronenberg, M. (1996). Intestinal intraepithelial lymphocytes respond to systemic lymphocytic choriomeningitis virus infection. Cell. Immunol. 167:161–169.
   PubMed Web of Science ®Google Scholar
• Taguchi, T., Aicher, W.K., Fujihashi, K., Yamamoto, M., McGhee, J.R., Bluestone, J.A., Kiyono, H. (1991). Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, γ/δ TCR+ T cells produce IFN-g and IL-5. J. Immunol. 147:3736–3744.
   PubMed Web of Science ®Google Scholar
• Takeuchi, M., Miyazaki, H., Mirokawa, K., Yokokura, T., Yoshikai, Y. (1993). Age-related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice. Eur. J. Immunol. 23:1409–1411.
   PubMed Web of Science ®Google Scholar
• Umesaki, Y., Setoyama, H., Matsumoto, S., Okada, Y. (1993). Expansion of αβ T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus. Immunology 79:32–37.
   PubMed Web of Science ®Google Scholar
• Yamagiwa, S., Sugahara, S., Shimizu, T., Iwanaga, T., Yoshida, Y., Honda, S., Watanabe, H., Suzuki, K., Asakura, H., Abo, T. (1998). The primary site of CD4−8−B220+ αβ T cells in lpr mice: The appendix in normal mice. J. Immunol. 160:2665–2674.
   PubMed Web of Science ®Google Scholar