Stimulation of B7-H1 in Hepatocarcinoma Cells by Hepatitis B virus X Antigen

REFERENCES

• Azuma, T., Yao, S., Zhu, G., Flies, A.S., Flies, S.J., Chen, L. (2008). B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 111:3635–3643.
   PubMed Web of Science ®Google Scholar
• Blank, C., Brown, I., Peterson, A.C., Spiotto, M., Iwai, Y. (2004). PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells. Cancer Res. 64:1140–1145.
   PubMed Web of Science ®Google Scholar
• Bouchard, M.J., Schneider, R.J. (2004). The enigmatic X gene of hepatitis B virus. J. Virol. 78:12725–12734.
   PubMed Web of Science ®Google Scholar
• Brown, J.A., Dorfman, D.M., Ma, F.R., Sullivan, E.L., Munoz, O. (2003). Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J. Immunol. 170:1257–1266.
   PubMed Web of Science ®Google Scholar
• Butte, M.J., Keir, M.E., Phamduy, T.B., Sharpe, A.H., Freeman, G.J. (2007). Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 27:111–122.
   PubMed Web of Science ®Google Scholar
• Chen, Y., Zhang, J., Guo, G., Ruan, Z., Jiang, M., Wu, S., Guo, S., Fei, L., Tang, Y., Yang, C., Jia, Z., Wu, Y. Induced B7-H1 expression on human renal tubular epithelial cells by the sublytic terminal complement complex C5b-9. Mol. Immunol. 46:375–383.
   Google Scholar
• Cougot, D., Neuveut, C., Buendia, M.A. (2005). HBV induced carcinogenesis. J. Clin. Virol. 34(Suppl 1): S75–S78.
   PubMedGoogle Scholar
• Dong, H., Chen, L. (2003). B7-H1 pathway and its role in the evasion of tumor immunity. J. Mol. Med. 81:281–287.
   PubMed Web of Science ®Google Scholar
• Dong, H., Strome, S.E., Salomao, D.R., Tamura, H., Hirano, F., Flies, D.B., Roche, P.C., Lu, J., Zhu, G., Tamada, K., Lennon, V.A., Celis, E., Chen, L. (2002). Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 8:793–800.
   PubMed Web of Science ®Google Scholar
• Dong, H., Zhu, G., Tamada, K., Chen, L. (1999). B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5:1365–1369.
   PubMed Web of Science ®Google Scholar
• Freeman, G.J., Long, A.J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L.J., Malenkovich, N., Okazaki, T., Byrne, M.C., Horton, H.F., Fouser, L., Carter, L., Ling, V., Bowman, M.R., Carreno, B.M., Collins, M., Wood, C.R., Honjo, T. (2000). Engagement of the PD-1 immunoinhibitory receptor by a novel B7 familymember leads to negative regulation of lymphocyte activation. J. Exp. Med. 192:1027–1034.
   PubMed Web of Science ®Google Scholar
• Gao, Q, Wang, X.Y., Qiu, S.J., Yamato, I., Sho, M., Nakajima, Y., Zhou, J., Li, B.Z., Shi, Y.H., Xiao, Y.S., Xu, Y., Fan, J. (2009). Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human. hepatocellular carcinoma. Clin. Cancer Res. 15:971–979.
   PubMed Web of Science ®Google Scholar
• Hirano, F., Kaneko, K., Tamura, H., Dong, H., Wang, S., Ichikawa, M., Rietz, C., Flies, D.B., Lau, J.S., Zhu, G., Tamada, K., Chen, L. (2005). Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 65:1089–1096.
   PubMed Web of Science ®Google Scholar
• Hsieh, J.L., Wu, C.L., Lee, C.H., Shiau, A.L. (2003) Hepatitis B virus X protein sensitizes hepatocellular carcinoma cells to cytolysis induced by E1B-deleted adenovirus through the disruption of p53 function. Clin. Cancer Res. 9:338–345.
   Google Scholar
• Iwai, Y., Ishida, M., Tanaka, Y., Okazaki, T., Honjo, T., Minato, N. (2002). Involvement of PDL1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl. Acad. Sci. USA 99:12293–12297.
   PubMed Web of Science ®Google Scholar
• Keir, M.E., Butte, M.J., Freeman, G.J., Sharpe, A.H. (2008). PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26:677–704.
   PubMed Web of Science ®Google Scholar
• Kekule, A., Lauer, U., Weiss, L., Luber, B., Hofsschneider, P. (1993). Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature 361:742–745.
   PubMed Web of Science ®Google Scholar
• Kim, C.M., Koike, K., Saito, I., Miyamura, T., Jay, G. (1991). HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351:317–320.
   PubMed Web of Science ®Google Scholar
• Lara-Pezzi, E., Majano, P.L., Gómez-Gonzalo, M., García-Monzón, C., Moreno-Otero, R., Levrero, M., López-Cabrera, M. (1998) The hepatitis B virus X protein up-regulates tumor necrosis factor alpha gene expression in hepatocytes. Hepatology 28:1013–1021.
   PubMed Web of Science ®Google Scholar
• Lee, S.H., Park, S.G., Lim, S.O., Jung, G. (2005). The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes. Biochem. Biophys. Acta 1741:75–84.
   Google Scholar
• Lee, S.K., Seo, S.H., Kim, B.S., Kim, C.D., Lee, J.H., Kang, J.S., Maeng, P.J., Lim, J.S. (2005). IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells. J. Dermatol. Sci. 40:95–103.
   PubMed Web of Science ®Google Scholar
• Lucito, R., Schneider, R.J. (1992). Hepatitis B virus protein activates transcription factor NF-κB without a requirement for protein kinase C. J. Virol. 66:983–991.
   PubMed Web of Science ®Google Scholar
• Lupberger, J., Hildt, E. (2007). Hepatitis B virus-induced oncogenesis. World J. Gastroenterol. 13:74–81.
   PubMed Web of Science ®Google Scholar
• Maguire, H.F., Hoeffler, J.P., Siddiqui, A. (1991). HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 252:842–844.
   PubMed Web of Science ®Google Scholar
• Mühlbauer, M., Fleck, M., Schütz, C., Weiss, T., Froh, M., Blank, C., Schölmerich, J., Hellerbrand, C. (2006). PD-L1 is induced in hepatocytes by viral infection and by interferon-a and -γ and mediates T cell apoptosis. J. Hepatol. 45:520–528.
   PubMed Web of Science ®Google Scholar
• Murakami, S. (2001). Hepatitis B virus X protein: a multifunctional viral regulator. J. Gastroenterol. 36:651–660.
   PubMed Web of Science ®Google Scholar
• Rodig N., Ryan T., Allen J.A., Pang H., Grabie N., Chernova T., Greenfield E.A., Liang S.C., Sharpe A.H., Lichtman A.H., Freeman G.J. (2003). Endothelial expression of PD-L1 and PD-L2 downregulates CD8+ T cell activation and cytolysis. Eur. J. Immunol. 33:3117– 3126.
   PubMed Web of Science ®Google Scholar
• Sharpe, A.H., Abbas, A.K. (2006). T-cell costimulation-biology, therapeutic potential, and challenges. N. Engl. J. Med. 355:973–975.
   PubMed Web of Science ®Google Scholar
• Yen, T.S. (1996). Hepadnaviral X protein: review of recent progress. J. Biomed. Sci. 3:20–30.
   PubMedGoogle Scholar
• Yoo, Y.D., Ueda, H., Park, K., Flanders, K.C., Lee, Y.I., Jay, G., Kim, S.J. (1996). Regulation of transforming growth factor-b1 expression by the hepatitis B virus (HBV) X transactivator. J. Clin. Invest. 97:388–395.
   PubMed Web of Science ®Google Scholar
• Yu, D.Y., Moon, H.B., Son, J.K., Jeong, S., Yu, S.L., Yoon, H., Han, Y.M., Lee, C.S., Park, J.S., Lee, C.H., Hyun, B.H., Murakami, S., Lee, K.K. (1999). Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X‐protein. J. Hepatol. 31:123–132.
   PubMed Web of Science ®Google Scholar
• Yun, C., Um, H.R., Jin, Y.H., Wang, J.H., Lee, M.O., Park S., Lee, J.H., Cho, H. (2002). NF-kappaB activation by hepatitis B virus X (HBx) protein shifts the cellular fate toward survival. Cancer Lett. 184:97–104.
   PubMed Web of Science ®Google Scholar
• Zhang, X., Zhang, H., Ye, L. (2006). Effects of hepatitis B virus X protein on the development of liver cancer. J. Lab. Clin. Med. 147:58–66.
   PubMed Web of Science ®Google Scholar