Publication Cover
Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 44, 2015 - Issue 6
298
Views
24
CrossRef citations to date
0
Altmetric
Original Articles

Protective Effects of Total Glucosides of Paeony on N-nitrosodiethylamine-induced Hepatocellular Carcinoma in Rats via Down-regulation of Regulatory B Cells

, , , , , & show all

References

  • Aravalli RN, Cressman EN, Steer CJ. (2013). Cellular and molecular mechanisms of hepatocellular carcinoma: An update. Arch Toxicol, 87, 227–47
  • Cao W, Bouaziz JD, Matsushita T, et al. (2011). Paeoniflorin improves survival in LPS-challenged mice through the suppression of TNF-alpha and IL-1beta release and augmentation of IL-10 production. Int Immunopharmacol, 11, 172–8
  • Casper M, Weber SN, Kloor M, et al. (2013). Hepatocellular carcinoma as extracolonic manifestation of Lynch syndrome indicates SEC63 as potential target gene in hepatocarcinogenesis. Scand J Gastroenterol, 48, 344–51
  • Chen G, Deng XH, Guo LX, et al. (2008). Effect of total glucosides of paeony on nuclear factor-kappa B activation in rat peritoneal macrophages. Zhongguo Zhong Yao Za Zhi, 33, 669–71
  • Cheung F, Wang X, Wang N, et al. (2013). Chinese medicines as an adjuvant therapy for unresectable hepatocellular carcinoma during transarterial chemoembolization: A meta-analysis of randomized controlled trials. Evid Based Complement Alternat Med, 2013, 487919
  • Choi EM, Suh KS, Rhee SY, et al. (2014). Inhibitory effect of paeoniflorin on methylglyoxal-mediated oxidative stress in osteoblastic MC3T3-E1 cells. Phytomedicine, 21, 1170–7
  • Dhanasekaran R, Limaye A, Cabrera R. (2012). Hepatocellular carcinoma: Current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics. Hepat Med, 4, 19–37
  • Flores A, Marrero JA. (2014). Emerging trends in hepatocellular carcinoma: Focus on diagnosis and therapeutics. Clin Med Insights Oncol, 8, 71–6
  • Gahr S, Wissniowski T, Zopf S, et al. (2012). Combination of the deacetylase inhibitor panobinostat and the multi-kinase inhibitor sorafenib for the treatment of metastatic hepatocellular carcinoma-review of the underlying molecular mechanisms and first case report. J Cancer, 3, 158–65
  • Hameed B, Mehta N, Sapisochin G, et al. (2014). Alpha-fetoprotein level  > 1000 ng/mL as an exclusion criterion for liver transplantation in patients with hepatocellular carcinoma meeting the Milan criteria. Liver Transpl, 20, 945–51
  • Inoue S, Leitner WW, Golding B, et al. (2006). Inhibitory effects of B cells on antitumor immunity. Cancer Res, 66, 7741–7
  • Iwasa J, Shimizu M, Shiraki M, et al. (2010). Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice. Cancer Sci, 101, 460–7
  • Jiang WL, Chen XG, Zhu HB, et al. (2009). Paeoniflorin inhibits systemic inflammation and improves survival in experimental sepsis. Basic Clin Pharmacol Toxicol, 105, 64–71
  • Kim S, Fridlender ZG, Dunn R, et al. (2008). B-cell depletion using an anti-CD20 antibody augments antitumor immune responses and immunotherapy in nonhematopoetic murine tumor models. J Immunother, 31, 446–57
  • Liao YH, Lin CC, Li TC, et al. (2012). Utilization pattern of traditional Chinese medicine for liver cancer patients in Taiwan. BMC Complement Altern Med, 12, 146
  • Liu DF, Wei W, Song LH. (2006). Protective effect of paeoniflorin on immunological liver injury induced by Bacillus calmette-guerin plus lipopolysaccharide: Modulation of tumour necrosis factor-alpha and interleukin-6 MRNA. Clin Exp Pharmacol Physiol, 33, 332–9
  • Mauri C, Ehrenstein MR. (2008). The ‘short' history of regulatory B cells. Trends Immunol, 29, 34–40
  • Monu NR, Frey AB. (2012). Myeloid-derived suppressor cells and anti-tumor T cells: A complex relationship. Immunol Invest, 41, 595–613
  • Najafi S, Firooze Moqadam I, Mohammadzadeh M, et al. (2014). Interleukin-10 gene polymorphisms in recurrent aphthous stomatitis. Immunol Invest, 43, 405–9
  • Oka A, Ishihara S, Mishima Y, et al. (2014). Role of regulatory B cells in chronic intestinal inflammation: Association with pathogenesis of Crohn's disease. Inflamm Bowel Dis, 20, 315–28
  • Oquinena S, Guillen-Grima F, Iñarrairaegui M, et al. (2009). Spontaneous regression of hepatocellular carcinoma: A systematic review. Eur J Gastroenterol Hepatol, 21, 254–7
  • Shah S, Divekar AA, Hilchey SP, et al. (2005). Increased rejection of primary tumors in mice lacking B cells: Inhibition of anti-tumor CTL and TH1 cytokine responses by B cells. Int J Cancer, 117, 574–86
  • Song SS, Yuan PF, Li PP, et al. (2014). Dynamic analysis of tumor-associated immune cells in DEN-induced rat hepatocellular carcinoma. Int Immunopharmacol, 22, 392–9
  • Wang C, Yuan J, Wu HX, et al. (2015). Total glucosides of paeony inhibit the inflammatory responses of mice with allergic contact dermatitis by restoring the balanced secretion of pro-/anti-inflammatory cytokines. Int Immunopharmacol, 24, 325–34
  • Wang H, Wei W, Wang NP, et al. (2005). Effects of total glucosides of peony on immunological hepatic fibrosis in rats. World J Gastroenterol, 11, 2124–9
  • Wang X. (1992). The effects of total glucosides of paeony on T lymphocyte subsets. Chin Pharmacol Bull, 27, 119–30
  • Xu XX, Qi XM, Zhang W, et al. (2014). Effects of total glucosides of paeony on immune regulatory toll-like receptors TLR2 and 4 in the kidney from diabetic rats. Phytomedicine, 21, 815–23
  • Yanaba K, Bouaziz JD, Haas KM, et al. (2008). A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity, 28, 639–50
  • Yanaba K, Bouaziz JD, Matsushita T, et al. (2009). The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol, 182, 7459–72
  • Yang M, Sun L, Wang S, et al. (2010). Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells. J Immunol, 184, 3321–5
  • Yi X, Long L, Yang C, et al. (2014). Maotai ameliorates diethylnitrosamine-initiated hepatocellular carcinoma formation in mice. PLoS One, 9, e93599
  • Yim SH, Chung YJ. (2010). An overview of biomarkers and molecular signatures in HCC. Cancers (Basel), 2, 809–23
  • Zhang LL, Wei W, Wang NP, et al. (2008). Paeoniflorin suppresses inflammatory mediator production and regulates G protein-coupled signaling in fibroblast-like synoviocytes of collagen induced arthritic rats. Inflamm Res, 57, 388–95
  • Zhang W, Dai SM. (2012). Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis. Int Immunopharmacol, 14, 27–31
  • Zheng MK, Xing C, Xiao H, et al. (2014a). Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis. Immunol Invest, 43, 705–16
  • Zheng SG, Xu HX, Liu LN. (2014b). Management of hepatocellular carcinoma: The role of contrast-enhanced ultrasound. World J Radiol, 6, 7–14
  • Zhou WP. (2005). Immunosuppresive networks in the tumor environment and their therapeutic relevance. Nat Rev Cancer, 5, 263–74

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.