Characterisation of Tertiary Lymphoid Organs in Explanted Rejected Donor Kidneys

References

• Aloisi F, Pujol-Borrell R. (2006). Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol, 6, 205–17.
   PubMed Web of Science ®Google Scholar
• Baddoura FK, Nasr IW, Wrobel B, et al. (2005). Lymphoid neogenesis in murine cardiac allografts undergoing chronic rejection. Am J Transplant, 5, 510–6.
   PubMed Web of Science ®Google Scholar
• Brown K, Sacks SH, Wong W. (2011). Tertiary lymphoid organs in renal allografts can be associated with donor-specific tolerance rather than rejection. Eur J Immunol, 41, 89–96.
   PubMed Web of Science ®Google Scholar
• Cowan ML, Sciammas R, Chong AS. (2012). Experimental models of B cell tolerance in transplantation. Semin Immunol, 24, 77–85.
   PubMed Web of Science ®Google Scholar
• DiLillo DJ, Matsushita T, Tedder TF. (2010). B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. Ann N Y Acad Sci, 1183, 38–57.
   PubMed Web of Science ®Google Scholar
• Einecke G, Reeve J, Mengel M, et al. (2008). Expression of B cell and immunoglobulin transcripts is a feature of inflammation in late allografts. Am J Transplant, 8, 1434–43.
   PubMed Web of Science ®Google Scholar
• Fillatreau S, Gray D, Anderton SM. (2008). Not always the bad guys: B cells as regulators of autoimmune pathology. Nat Rev Immunol, 8, 391–7.
   PubMed Web of Science ®Google Scholar
• Haas M, Sis B, Racusen LC, et al. (2014). Banff 2013 meeting report: Inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Am J Transplant, 14, 272–83.
   PubMed Web of Science ®Google Scholar
• Hu M, Wang C, Zhang GY, et al. (2013). Infiltrating Foxp3(+) regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. Am J Transplant, 13, 2819–30.
   PubMed Web of Science ®Google Scholar
• Hwang HS, Song JH, Hyoung BJ, et al. (2010). Clinical impacts of CD38+ B cells on acute cellular rejection with CD20+ B cells in renal allograft. Transplantation, 89, 1489–95.
   PubMed Web of Science ®Google Scholar
• Iwata Y, Matsushita T, Horikawa M, et al. (2011). Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood, 117, 530–41.
   PubMed Web of Science ®Google Scholar
• Josephson MA. (2014). Late kidney dysfunction in a kidney transplant recipient. Clin J Am Soc Nephrol, 9, 590–7.
   PubMed Web of Science ®Google Scholar
• Katakai T, Nomura T, Gonda H, et al. (2006). Spontaneous large-scale lymphoid neogenesis and balanced autoimmunity versus tolerance in the stomach of H+/K+-ATPase-reactive TCR transgenic mouse. J Immunol, 177, 7858–67.
   PubMed Web of Science ®Google Scholar
• Kerjaschki D, Regele HM, Moosberger I, et al. (2004). Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates. J Am Soc Nephrol, 15, 603–12.
   PubMed Web of Science ®Google Scholar
• Le TL, Thebault P, Carvalho-Gaspar M, et al. (2012). Immunoregulatory function of IL-27 and TGF-beta1 in cardiac allograft transplantation. Transplantation, 94, 226–33.
   PubMed Web of Science ®Google Scholar
• Montgomery RA, Lonze BE, King KE, et al. (2011). Desensitization in HLA-incompatible kidney recipients and survival. N Engl J Med, 365, 318–26.
   PubMed Web of Science ®Google Scholar
• Motallebzadeh R, Bolton EM, Pettigrew GJ. (2008). Lymphoid tissue formation in allografts: Innocent until proven guilty. Transplantation, 85, 309–11.
   PubMed Web of Science ®Google Scholar
• Nasr IW, Reel M, Oberbarnscheidt MH, et al. (2007). Tertiary lymphoid tissues generate effector and memory T cells that lead to allograft rejection. Am J Transplant, 7, 1071–9.
   PubMed Web of Science ®Google Scholar
• Newell KA, Asare A, Kirk AD, et al. (2010). Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest, 120, 1836–47.
   PubMed Web of Science ®Google Scholar
• Pallier A, Hillion S, Danger R, et al. (2010). Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype. Kidney Int, 78, 503–13.
   PubMed Web of Science ®Google Scholar
• Pitzalis C, Jones GW, Bombardieri M, Jones SA. (2014). Ectopic lymphoid-like structures in infection, cancer and autoimmunity. Nat Rev Immunol, 14, 447–62.
   PubMed Web of Science ®Google Scholar
• Racusen LC, Colvin RB, Solez K, et al. (2003). Antibody-mediated rejection criteria – An addition to the Banff 97 classification of renal allograft rejection. Am J Transplant, 3, 708–14.
   PubMed Web of Science ®Google Scholar
• Ruddle NH. (2014). Lymphatic vessels and tertiary lymphoid organs. J Clin Invest, 124, 953–9.
   PubMed Web of Science ®Google Scholar
• Sagoo P, Perucha E, Sawitzki B, et al. (2010). Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest, 120, 1848–61.
   PubMed Web of Science ®Google Scholar
• Sayegh MH, Carpenter CB. (2004). Transplantation 50 years later – Progress, challenges, and promises. N Engl J Med, 351, 2761–6.
   PubMed Web of Science ®Google Scholar
• Solez K, Colvin RB, Racusen LC, et al. (2008). Banff 07 classification of renal allograft pathology: Updates and future directions. Am J Transplant, 8, 753–60.
   PubMed Web of Science ®Google Scholar
• Terasaki PI. (2003). Humoral theory of transplantation. Am J Transplant, 3, 665–73.
   PubMed Web of Science ®Google Scholar
• Thaunat O. (2011). Pathophysiologic significance of B-cell clusters in chronically rejected grafts. Transplantation, 92, 121–6.
   PubMed Web of Science ®Google Scholar
• Thaunat O. (2012a). Humoral immunity in chronic allograft rejection: Puzzle pieces come together. Transpl Immunol, 26, 101–6.
   PubMed Web of Science ®Google Scholar
• Thaunat O, Field AC, Dai J, et al. (2005). Lymphoid neogenesis in chronic rejection: Evidence for a local humoral alloimmune response. Proc Natl Acad Sci USA, 102, 14723–8.
   PubMed Web of Science ®Google Scholar
• Thaunat O, Graff-Dubois S, Fabien N, et al. (2012b). A stepwise breakdown of B-cell tolerance occurs within renal allografts during chronic rejection. Kidney Int, 81, 207–19.
   PubMed Web of Science ®Google Scholar
• Thaunat O, Morelon E, Defrance T. (2010a). Am”B”valent: Anti-CD20 antibodies unravel the dual role of B cells in immunopathogenesis. Blood, 116, 515–21.
   PubMed Web of Science ®Google Scholar
• Thaunat O, Patey N, Caligiuri G, et al. (2010b). Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis. J Immunol, 185, 717–28.
   PubMed Web of Science ®Google Scholar
• Waldmann H, Adams E, Fairchild P, Cobbold S. (2006). Infectious tolerance and the long-term acceptance of transplanted tissue. Immunol Rev, 212, 301–13.
   PubMed Web of Science ®Google Scholar
• Wing JB, Sakaguchi S. (2014). Foxp3(+) T(reg) cells in humoral immunity. Int Immunol, 26, 61–69.
   PubMed Web of Science ®Google Scholar
• Xu Q, Lee J, Jankowska-Gan E, et al. (2007). Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance. J Immunol, 178, 3983–95.
   PubMed Web of Science ®Google Scholar
• Xu X, Huang H, Cai M, et al. (2011). Serum hematopoietic growth factors as diagnostic and prognostic markers of acute renal allograft rejection: A potential role for serum stem cell factor. Cytokine, 56, 779–85.
   PubMed Web of Science ®Google Scholar
• Zarkhin V, Kambham N, Li L, et al. (2008). Characterization of intra-graft B cells during renal allograft rejection. Kidney Int, 74, 664–73.
   PubMed Web of Science ®Google Scholar