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Original Articles

Plasma Homocysteine is Associated with Retinopathy in Type 1 Diabetic Patients in the Absence of Nephropathy

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Pages 198-202 | Received 09 Jan 2014, Accepted 01 Apr 2014, Published online: 02 May 2014

References

  • Soedamah-Muthu SS, Chaturvedi N, Teerlink T, et al. Plasma homocysteine and microvascular and macrovascular complications in type 1 diabetes: A cross-sectional nested case-control study. J Intern Med 2005;258:450–459
  • Wotherspoon F, Laight DW, Shaw KM, Cummings MH. Homocysteine, endothelial dysfunction and oxidative stress in type 1 diabetes mellitus. Br J Diabetes Vasc Dis 2003;3:334–340
  • Hofmann MA, Kohl B, Zumbach MS, et al. Hyperhomocysteinemia and endothelial dysfunction in IDDM. Diabetes Care 1998;21:841–848
  • Vaccaro O, Perna AF, Mancini FP, et al. Plasma homocysteine and microvascular complications in type 1 diabetes. Nutr Metab Cardiovasc Dis 2000;10:297–304
  • Agardh E, Hultberg B, Agardh CD. Severe retinopathy in type 1 diabetic patients is not related to the level of plasma homocysteine. Scand J Clin Lab Invest 2000;60:169–174
  • Saeed BO, Nixon SJ, White AJ, et al. Fasting homocysteine levels in adults with type 1 diabetes and retinopathy. Clin Chim Acta 2004;341:27–32
  • Neugebauer S, Tarnow L, Stehouwer C, et al. Total plasma homocysteine is associated with hypertension in type 1 diabetic patients. Diabetologia 2002;45:1315–1324
  • Buysschaert M, Jamart J, Dramais AS, et al. Micro- and macrovascular complications and hyperhomocysteinaemia in type 1 diabetic patients. Diabetes Metab 2001;27:655–659
  • Veldman BAJ, Vervoort G, Blom H, Smits P. Reduced plasma total homocysteine concentrations in type 1 diabetes mellitus is determined by increased renal clearance. Diabet Med 2005;22:301–305
  • Chen YF, Li PL, Zou AP. Effect of hyperhomocysteinemia on plasma or tissue adenosine levels and renal function. Circulation 2002;106:1275–1281
  • Chico A, Perez A, Cordoba A, et al. Plasma homocysteine is related to albumin excretion rate in patients with diabetes mellitus: A new link between diabetic nephropathy and cardiovascular disease? Diabetologia 1998;41:684–693
  • Pavia C, Ferrer I, Valls C, et al. Total homocysteine in patients with type 1 diabetes. Diabetes Care 2000; 23:84–87
  • Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet 2010;376:124–136
  • Grunwald JE, Alexander J, Ying GS, et al. Retinopathy and chronic kidney disease in the Chronic Renal Insufficiency Cohort (CRIC) study. Arch Ophthalmol 2012;130:1136–1144
  • Brazionis L, Rowley K, Itsiopoulos C, et al. Homocysteine and diabetic retinopathy. Diabetes Care 2008;31:50–56
  • Cho HC. The relationship among homocysteine, bilirubin, and diabetic retinopathy. Diabetes Metab J 2011;35:595–601
  • Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009;150:604–612
  • Vučić LM, Radišić BV, Božičević S, et al. Estimating glomerular filtration rate (GFR) in diabetes: The performance of MDRD and CKD-EPI equations in patients with various degrees of albuminuria. Clin Biochem 2012;45:1694–1696
  • Aldington SJ, Kohner EM, Meuer S, et al. Methodology for retinal photography and assessment of diabetic retinopathy: The EURODIAB IDDM Complications Study. Diabetologia 1995;38:437–444
  • Hankey GJ, Eikelboom JW, Ho WK, van Bockxmeer FM. Clinical usefulness of plasma homocysteine in vascular disease. Med J Aust 2004;181:314–318
  • Lahiri KD, Dutta J, Datta H, Das HN. Hyperhomocysteinemia, as an independent risk factor for retinal venous occlusion in an Indian population. Indian J Clin Biochem 2013;28:61–64
  • Sarici AM, Yetik H, Akar S, Arvas S. The association between serum homocysteine levels and retinopathy of prematurity. J Int Med Res 2012;40:1912–1918
  • Gopinath B, Flood VM, Rochtchina E, et al. Homocysteine, folate, vitamin B-12, and 10-y incidence of age-related macular degeneration. Am J Clin Nutr 2013;98:129–135
  • Aydin E, Demir HD, Ozyurt H, Etikan I. Association of plasma homocysteine and macular edema in type 2 diabetes mellitus. Eur J Ophthalmol 2008;18:226–232
  • Lim CP, Loo AV, Khaw KW, et al. Plasma, aqueous and vitreous homocysteine levels in proliferative diabetic retinopathy. Br J Ophthalmol 2012;96:704–707
  • Omae T, Nagaoka T, Tanano I, Yoshida A. Homocysteine inhibition of endothelium-dependent nitric oxide-mediated dilation of porcine retinal arterioles via enhanced superoxide production. Invest Ophthalmol Vis Sci 2013;54:2288–2295
  • Chow K, Cheung F, Lao TT, O K. Effect of homocysteine on the production of nitric oxide in endothelial cells. Clin Exp Pharmacol Physiol 1999;26:817–818
  • Bellamy MF, McDowell IF, Ramsey MW, et al. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation 1998;98:1848–1852
  • Weiss N. Mechanisms of increased vascular oxidant stress in hyperhomocysteinemia and its impact on endothelial function. Curr Drug Metab 2005;6:27–36
  • Maeda M, Fujio Y, Azuma J. MTHFR gene polymorphism and diabetic retinopathy. Curr Diabetes Rev 2006;2:467–476
  • Poddar R, Sivasubramanian N, DiBello PM, et al. Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells. Circulation 2001;103:2717–2723
  • Berg K, Malinow MR, Kierulf P, Upson B. Population variation and genetic of plasma homocyst(e)ine level. Clin Genet 1992;41:315–321
  • Hoffman MA, Kohl B, Zumbach MS, et al. Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM. Diabetes Care 1998;21:841–848
  • Norlund L, Grubb A, Fex G, et al. The increase of plasma homocysteine concentrations with age is partly due to the deterioration of renal function as determined by plasma cystatin C. Clin Chem Lab Med 1998;36:175–178
  • Macisaac RJ, Premaratne E, Jerums G. Estimating glomerular filtration rate in diabetes using serum cystatin C. Clin Biochem Rev 2011;32:61–67
  • Wiesli P, Schwegler B, Spinas GA, Schmid C. Serum cystatin C is sensitive to small changes in thyroid function. Clin Chem Acta 2003;338:87–90
  • Wollesen F, Brattstrom L, Refsum H, et al. Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus. Kidney Int 1999;55:1028–1035
  • Ubbink JB. Vitamin nutrition status and homocysteine: An atherogenic risk factor. Nutr Rev 1994;52:383–393
  • Kaye J, Stanton K, McCann V, Vasikaran S. Homocysteine, folate, MTHFR genotype and vascular morbidity in diabetic subjects. Clin Sci 2002;102:631–637
  • Shcherbak N, Shutsleaya Z, Sheridina A, et al. MTHFR gene polymorphism as a risk factor for diabetic nephropathy in IDDM patients. Mol Genet Metab 1999;68:375–378
  • Ukinc K, Ersoz HO, Karahan C, et al. Methyltetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy. Endocrine 2009;36:255–261
  • McGimpsey SJ, Woodside JV, Cardwell C, et al. Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism, and risk of retinal vein occlusion: A meta-analysis. Ophthalmology 2009;116:1778–1787
  • Rowley KG, Lee AJ, Yarmirr D, O’Dea K. Homocysteine concentrations lowered following dietary intervention in an aboriginal community. Asia Pac J Clin Nutr 2003;12:92–95
  • Smolek MK, Notaroberto NF, Jaramillo AG, Pradillo LR. Intervention with vitamins in patients with nonproliferative diabetic retinopathy: A pilot study. Clin Ophthalmol 2013;7:1451–1458

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