The Role of the Immune System in Glaucoma: Bridging the Divide Between Immune Mechanisms in Experimental Glaucoma and the Human Disease

REFERENCES

• Kass MA, Heuer DK, Higginbotham EJ, et al. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol 2002;120(6):701–713
   PubMed Web of Science ®Google Scholar
• Anderson DR. Collaborative normal tension glaucoma study. Curr Opin Ophthalmol 2003;14(2):86–90
   PubMedGoogle Scholar
• Leske MC, Heijl A, Hyman L, Bengtsson B. Early Manifest Glaucoma Trial: design and baseline data. Ophthalmology 1999;106(11):2144–2153
   PubMed Web of Science ®Google Scholar
• Garway-Heath DF1, Lascaratos G, Bunce C, et al. The United Kingdom Glaucoma Treatment Study: a multicenter, randomized, placebo-controlled clinical trial: design and methodology. Ophthalmology 2013;120(1):68–76
   PubMed Web of Science ®Google Scholar
• Cartwright MJ, Anderson DR. Correlation of asymmetric intraocular pressure in normal tension glaucoma. Arch Ophthalmol 1988;106:898–900
   PubMedGoogle Scholar
• Cherecheanu AP, Garhofer G, Schmidl D, et al. Ocular perfusion pressure and ocular blood flow in glaucoma. Curr Opin Pharmacol 2013;13:36–42
   PubMed Web of Science ®Google Scholar
• Cartwright MJ, Grajewski AL, Friedberg ML, et al. Immune-related disease and normal tension glaucoma. A case-control study. Arch Ophthalmol 1992;110:500–502
   PubMedGoogle Scholar
• Wax MB, Barrett DA, Pestronk A. Increased incidence of paraproteinemia and autoantibodies in patients with normal-pressure glaucoma. Am J Ophthalmol 1994;117:561–568
   PubMed Web of Science ®Google Scholar
• Abbas AK, Lichtman AH, Pillai S. Properties and overview of immune responses. In: Abbas AK (ed.) Cellular and Molecular Immunology. 7th ed. Philadelphia, PA: Elsevier, 2012, pp 1–27
   Google Scholar
• Alberts B, Johnson A, Lewis J, et al. The adaptive immune system. In: Alberts B (ed.) Molecular Biology of the Cell. 4th ed., chap. 24. New York, NY: Garland Science, 2002
   Google Scholar
• Stevens B, Allen NJ, Vasquez LE, et al. The classical complement cascade mediates CNS synapse elimination. Cell 2007;131:1164–1178
   PubMed Web of Science ®Google Scholar
• Howell GR, Soto I, Ryan M, et al. Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice. J Neuroinflammation 2013;10:76
   PubMedGoogle Scholar
• Alvarado JA, Murphy CG. Outflow obstruction in pigmentary and primary open-angle glaucoma. Arch Ophthalmol 1992;110:1769–1778
   PubMedGoogle Scholar
• Howell GR, Macalinao DG, Sousa GL, et al. Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J Clin Invest 2011;121:1429–1444
   PubMed Web of Science ®Google Scholar
• Howell GR, Soto J, Zhu X, et al. Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma. J Clin Invest 2012;122:1246–1261
   PubMed Web of Science ®Google Scholar
• Lee EJ, Kim JW, Kim M, Choi YJ. Peripapillary retinoschisis in glaucomatous eyes. PLoS One 2014;9:e90129
   PubMedGoogle Scholar
• Farjad H, Besada E, Frauens BJ. Peripapillary schisis with serous detachment in advanced glaucoma. Optom Vis Sci 2010;87:E205–217
   PubMed Web of Science ®Google Scholar
• Kizhatil K, Ryan M, Marchant J, et al. Schlemm’s canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process. PloS Biol 2014;12(7):e1001912
   PubMed Web of Science ®Google Scholar
• Yucel Y, Johnston M, Ly T, et al. Identification of lymphatics in the ciliary body of the human eye: A novel “uveolymphatic” outflow pathway. Exp Eye Res 2009;89(5):810–819.
   PubMed Web of Science ®Google Scholar
• Nakazawa T, Nakazawa C, Matsubara A, et al. Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma. J Neurosci 2006;26:12633–12641
   PubMed Web of Science ®Google Scholar
• Roh M, Zhang Y, Murakami Y, et al. Etanercept, a widely used inhibitor of tumor necrosis factor-alpha (TNF-alpha), prevents retinal ganglion cell loss in a rat model of glaucoma. PLoS One 2012;7:e40065
   PubMed Web of Science ®Google Scholar
• Tezel G, Li LY, Patil RV, Wax MB. TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes. Invest Ophthalmol Vis Sci 2001;42:1787–1794
   PubMed Web of Science ®Google Scholar
• Stein J, Talwar N, Kang J, et al. Bupropion use and risk of open angle glaucoma among enrollees in a large US managed care network. PLoS One 2015;10(4):e0123682
   Google Scholar
• Wax MB, Tezel G, Yang J, et al. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J Neurosci 2008;28:12085–12096
   PubMed Web of Science ®Google Scholar
• Joachim SC, Pfeiffer N, Grus FH. Autoantibodies in patients with glaucoma: a comparison of IgG serum antibodies against retinal, optic nerve, and optic nerve head antigens. Graefes Arch Clin Exp Ophthalmol 2005;243:817–823
   PubMed Web of Science ®Google Scholar
• Cohen LP, Wong J, Jiwani AZ, et al. A survey of pre-operative blood tests in primary open-angle glaucoma patients versus cataract surgery patients. Digital J Ophthalmol 2014;14:20–28
   Google Scholar
• Tezel G, Wax MB. The mechanism of hsp27 antibody-mediated apoptosis in retinal neuronal cells. J Neurosci 2000;20:3552–3562
   PubMed Web of Science ®Google Scholar
• Gramlich OW, et al. Enhanced insight into the autoimmune component of glaucoma: IgG autoantibody accumulation and proinflammatory conditions in human glaucomatous retina. PLoS One 2013;8(2):e57557
   PubMed Web of Science ®Google Scholar
• Fellman RL, Tezel G, Wax MB. Effects of methotrexate treatment on serum immunoreactivity of a patient with normal-pressure glaucoma. Am J Ophthalmol 1999;127:724–725
   PubMed Web of Science ®Google Scholar
• Lye-Barthel M, Sun D, Jakobs TC. Morphology of astrocytes in a glaucomatous optic nerve. Invest Ophthalmol Vis Sci 2013;54: 909–917
   PubMed Web of Science ®Google Scholar
• Tezel G, Yang J, Wax MB. Heat shock proteins, immunity, and glaucoma. Brain Res Bull 2004;2:473–480
   Google Scholar
• Yang X, Luo C, Cai J, et al. Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina. Invest Ophthalmol Vis Sci 2011;52:8442–8454
   PubMed Web of Science ®Google Scholar
• Yuan L, Neufeld AH. Tumor necrosis factor-α: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head. Glia 2000;32:42–50
   PubMed Web of Science ®Google Scholar