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Original Article

Pathogenesis of Diabetic Retinopathy

Pages 4-11 | Published online: 02 Jul 2009

References

  • Sabour M S, MacDonald M K, Robson J S. An electron microscopic study of the human kidney in young diabetic patients with normal renal function. Diabetes 1962; 11: 291–295
  • Siperstein M D, Linger R H, Madison L L. Studies of muscle capillary basement membranes in normal subjects, diabetic and prediabetic patients. J Clin Invest 1968; 47: 1973–1999
  • Dornan T L, Ting A, McPherson C K. Genetic susceptibility to the development of retinopathy in insulin-dependent diabetics. Diabetes 1982; 31: 226–231
  • Barbosa J, Ramsay R C, Knobloch W H. Histocompatibility antigen frequences in diabetic retinopathy. Am J Opthalmol 1980; 90: 148–153
  • Cudworth A G, Bottazzo G F, Doniach D. Genetic and immunological factors in type 1 diabetes. Immunology of Diabetes, WJ Irvine. Teviot, Edinburgh 1980; 67–99
  • Leslie R DG, Pyke D A. Diabetic retinopathy in identical twins. Diabetes 1982; 31: 19–21
  • Sevel D, Bristow J H, Bank S. Diabetic retinopathy in chronic pancreatitis. Arch Ophthalmol 1971; 86: 245–250
  • Griffiths J D, Dymock I W, Davies E WG. Occurrence and prevalence of diabetic retinopathy in haemochromatosis. Diabetes 1971; 20: 766–770
  • Tiengo A, Segata T, Briani G. The presence of retinopathy in patients with secondary diabetes following pancreatectomy or chronic pancreatitis. Diabetes Care 1983; 6: 544–740
  • Mohan R, Rajendran B, Mohan V. Retinopathy in tropical pancreatic diabetes. Arch Ophthalmol 1985; 103: 1487–1489
  • Bloodworth J MB, Molitor D L. Ultrastructural aspects of human and canine diabetic retinopathy. Invest Ophthalmol 1965; 4: 1037–1048
  • Kernell A, Arnqvist H. Effect of insulin treatment on the blood-retinal barrier in rats with streptozotocin-induced diabetes. Arch Ophthalmol 1983; 101: 968–970
  • Frank R N. On the pathogenesis of diabetic retinopathy. Ophthalmology 1984; 91: 626–634
  • Barnes A J, Kohner E M, Johnston D G. Severe retinopathy and mild carbohydrate intolerance: Possible role of insulin deficiency and elevated circulating growth hormone. Lancet 1985; 1: 1465–1468
  • Grant M, Russell B, Fitzgerald C. Insulin-like growth factors in vitreous: Studies in control and diabetic subjects with neovascularization. Diabetes 1986; 35: 416–420
  • Merimee T J, Zapf J, Froesch E R. Insulin-like growth factors: Studies in diabetics with and without retinopathy. N Engl J Med 1983; 309: 527–530
  • Jerneld B, Algvere P. Relationship of duration and onset of diabetes to prevalence of diabetic retinopathy. Am J Ophthalmol 1986; 102: 431–437
  • Soler N G, Fitzgerald M G, Malins J M. Retinopathy at diagnosis of diabetes, with special reference to patients under 40 years of age. Br Med J 1969; 3: 567
  • Garner A, Ashton N. Ophthalmic artery stenosis and diabetic retinopathy. Trans Ophthalmol Soc UK 1972; 92: 101–110
  • Young R J, McCulloch D K, Prescott R J. Alcohol: Another risk factor for diabetic retinopathy. Br Med J 1984; 288: 1035–1037
  • Cunha-Vaz J G. Studies on the pathophysiology of diabetic retinopathy: The blood-retinal barrier in diabetes. Diabetes 1983; 32: 20–27, (suppl 2)
  • Cunha Vaz J G, Abren J R, Campos A J. Early breakdown of the blood-retinal barrier in diabetes. Br J Ophthalmol 1975; 89: 649–656
  • Tso M OM, Cunha-Vaz J G, Shih C-Y. Clinicopathologic study of blood-retinal barrier in experimental diabetes mellitus. Arch Ophthalmol 1980; 98: 2032–2040
  • Wallow I HL, Engerman R L. Permeability and potency of retinal blood vessels in experimental diabetes. Invest Ophthalmol Vis Sci 1977; 16: 447–461
  • Christacoupoulos P D, Soeldner J S, Gleason R F. Variations in retinal haemodynamics in different stages of diabetes. Excerpta Medica, International Congress Series 1972; 280: 180–181
  • Frank R N. The mechanism of blood-retinal barrier breakdown in diabetes. Arch Ophthalmol 1985; 103: 1303–1304
  • Lorenzi M, Caglieco E, Toledo S. Glucose toxicity for human endothelial cells in culture: Delayed replication, disturbed cell cycle, and accelerated death. Diabetes 1985; 34: 621–627
  • Cunha-Vaz J G, Mota C C, Leite E C. Effect of sorbinil on blood-retinal barrier in early diabetic retinopathy. Diabetes 1986; 35: 574–578
  • Kohner E M, Hamilton A M, Saunders S J. The retinal blood flow in diabetes. Diabetologia 1975; 11: 27–33
  • Hill D W, Atherton H A. Experimental studies of the retinal circulation relating to diabetic retinopathy. Trans Ophthalmol Soc UK 1979; 99: 4–7
  • Little H L. Pathogenesis. Diabetic Retinopathy, Clinical Evaluation and Management, FA L'Esperance, Jr, WA James, Jr. Mosby, St Louis 1981; 58–88
  • Kohner E M, Dollery C T. Diabetic retinopathy. Complications of Diabetes, H Keen, J Jarrett. Edward Arnold, London 1975; 7–98
  • Cogan D G, Toussaint D, Kuwabara T. Retinal vascular patterns. IV. Diabetic retinopathy. Arch Ophthalmol 1961; 66: 366–378
  • Addison D J, Garner A, Ashton N. Degeneration of intramural pericytes in diabetic retinopathy. Br Med J 1970; 1: 264–266
  • Tilton R G, Hoffman P L, Kilo C. Pericyte degeneration and basement membrane thickening in skeletal muscle capillaries of human diabetes. Diabetes 1981; 30: 326–334
  • Sharma N K, Gardiner T A, Archer D B. A morphologic and autoradiographic study of cell death and regeneration in the retinal microvasculature of normal and diabetic rats. Am J Ophthalmol 1985; 100: 51–60
  • De Oliveira F. Pericytes in diabetic retinopathy. Br J Ophthalmol 1966; 50: 134–143
  • Ashton N. Diabetic micro-angiopathy. Adv Ophthalmol 1958; 8: 1–84, (Bibl Ophthalmol Fasc 22)
  • Larsen H W. Diabetic Retinopathy. Acta Ophthalmol 1960; 60: 1–89, (suppl)
  • Kohner E M. The evolution and natural history of diabetic retinopathy. Int Ophthalmol Clin 1978; 18: 1–215
  • Aiello L M, Rand L I, Briones J C. Diabetic retinopathy in Joslin clinic patients with adult-onset diabetes. Ophthalmology 1981; 88: 619–623
  • Fine B S, Brucker A J. Macular edema and cystoid macular edema. Am J Ophthalmol 1981; 92: 466–481
  • Gass J MD, Anderson D R, Davis E B. A clinical, fluorescein angiographic, and electron microscopic correlation of cystoid macular edema. Am J Ophthalmol 1985; 100: 82–86
  • Blair N P, Tso M OM, Dodge J T. Pathologic studies of the blood-retinal barrier in the spontaneously diabetic BB rat. Invest Ophthalmol Vis Sci 1984; 25: 302–311
  • Ishibashi T, Tanaka K, Taniguchi Y. Disruption of blood-retinal barrier in experimental diabetic rats: An electronmicroscopic study. Exp Eye Res 1980; 30: 401–410
  • Abrahamson D R. Recent studies on the structure and pathology of basement membranes. J Pathol 1986; 149: 257–278
  • Ashton N. Vascular basement membrane changes in diabetic retinopathy. Br J Ophthalmol 1974; 58: 344–366
  • Ishibashi T, Tanaka K, Taniguchi Y. An experimental study on the role of vascular permeability in the development and progression of diabetic retinopathy. Acta Soc Ophthal Jpn 1979; 83: 766–782
  • Kohner E M, Dollery C T, Paterson J W. Arterial fluorescein studies in diabetic retinopathy. Diabetes 1967; 16: 1–10
  • Dollery C T, Friedman L A, Hensby C N. Circulating prostacyclin may be reduced in diabetes. Lancet 1979; 2: 8156
  • Dobbie J G, Kwaan H C, Colwell J A. The role of platelets in the pathogenesis of diabetic retinopathy. Trans Am Acad Ophthalmol Otolaryngol 1973; 77: OP43–46
  • Porta M, Hilgard P, Kohner E M. Platelet shape change abnormalities in diabetic retinopathy. Diabetologia 1980; 18: 217–221
  • McMillan D E. Plasma protein changes, blood viscosity, and diabetic microangiopathy. Diabetes 1976; 25: 858–864, (suppl 2)
  • Alexander W D, Kearns M, Kohner E M. Trauma and severe proliferative retinopathy in diabetes mellitus. Br Med J 1979; 2: 831
  • Ashton N. Diabetic retinopathy, a new approach. Lancet 1959; 2: 628–630
  • Cogan D G, Kuwabara T. Capillary shunts in the pathogenesis of diabetic retinopathy. Diabetes 1963; 12: 293–300
  • Ashton N, Dollery C T, Henkind P. Focal retinal ischaemia: Ophthalmoscopic, circulatory and ultrastructural changes. Br J Ophthalmol 1966; 50: 281–384
  • Lawson P M, Champion P C, Canny C. Continuous subcutaneous insulin infusion (CSII) does not prevent progression of proliferative and preproliferative retinopathy. Br J Ophthalmol 1982; 66: 762–766
  • Mohan R, Kohner E M. Retinal revascularisation in diabetic retinopathy. Br J Ophthalmol 1986; 70: 114–117
  • Vracko R, Benditt E P. Capillary basal lamina thickening: Its relationship to endothelial cell death and replacement. J Cell Biol 1970; 47: 281–285
  • Taniguchi Y. Ultrastructure of newly formed blood vessels in diabetic retinopathy. Jpn J Ophthalmol 1976; 20: 19–31
  • Wallow I HL, Geldner P S. Endothelial fenestrae in proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 1980; 19: 1176–1183
  • Miller H, Miller B, Zonis S. Diabetic neovascularization: Permeability and ultrastructure. Invest Ophthalmol Vis Sci 1984; 25: 1338–1342
  • Constable I J. Pathology of vitreous membranes and the effect of haemorrhage and new vessels on the vitreous. Trans Ophthalmol Soc UK 1975; 95: 382–386
  • Weiss J B, Hill C R, Davis R J. Activation of a procollagenase by low molecular weight angiogenesis factor. Biosci Rep 1983; 3: 171–177
  • Hiscott P S, Grierson I, Hitchins C A. Epiretinal membranes in vitro. Trans Ophthalmol Soc UK 1983; 103: 89–102
  • Bloom G, Balazs F. An electron microscopic study of hyalocytes. Exp Eye Res 1965; 4: 249–265
  • Machemer R, Horn D, Aaberg T M. Pigment epithelial proliferation in human retinal detachment with massive periretinal proliferation. Am J Ophthalmol 1978; 85: 181–191
  • Cohen M P, Frank R N, Khalifa A A. Collagen production by cultured retinal capillary pericytes. Invest Ophthalmol Vis Sci 1980; 19: 90–94
  • Li W, Shen S, Khatami M. Stimulation of retinal capillary pericyte protein and collagen synthesis in culture by high glucose concentration. Diabetes 1984; 33: 785–789
  • Garner A. Ocular angiogenesis. Int Rev Exp Pathol 1986; 28: 249–306
  • Glaser B M, D'Amore P A, Michels R G. Demonstration of vasoproliferative activity from mammalian retina. J Cell Biol 1980; 84: 298–304
  • Federman J L, Brown G C, Felberg N T. Experimental ocular angiogenesis. Am J Ophthalmol 1980; 89: 231–237
  • Glaser B M, D'Amore P A, Michels R G. The demonstration of angiogenic activity from ocular tissues. Ophthalmology 1980; 87: 440–446
  • Hill C R, Kissun R D, Weiss J B. Angiogenic factor in vitreous from diabetic retinopathy. Experientia 1983; 39: 583–585
  • D'Amore P A, Glaser B M, Branson S K. Studies on the nature of an angiogenic factor derived from retina. Invest Ophthalmol Vis Sci 1980; 20: 142, (suppl)
  • D'Amore P A. Purification of a retina-derived endothelial cell mitogen/angiogenic factor. J Cell Biol 1982; 95: 9055, (abstr)
  • Elstow S F, Schor A M, Weiss J B. Bovine retinal angiogenesis factor in a low molecule (molecular mass <600). Invest Ophthalmol Vis Sci 1985; 26: 74–79
  • Ashton N. Retinal vascularization in health and disease. Am J Ophthalmol 1957; 44: 7–17
  • Weiss J B, Brown R A, Kumar S. Tumour angiogenesis factor: A potent low molecular weight compound. Br J Cancer 1979; 40: 493–496
  • Taylor C M, Weiss J B, Kissun R D. Effect of oxygen tension on the quantities of procollagenase-activating angiogenic factor present in the developing kitten retina. Br J Ophthalmol 1986; 70: 162–165
  • Taylor C M, Weiss J B, Kissun R D. Increased procollagenase-activating angiogenic factor in the vitreous humour of oxygen treated kittens. Br J Ophthalmol, (in press)

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