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Original Article

Vitamin a Deficiency: Consequences for Sight and Life

Pages 207-213 | Published online: 02 Jul 2009

References

  • Olson J A. Physiological and metabolic basis of major signs of vitamin A deficiency. Vitamin A Deficiency and Its Control, J C Bauernfeind. Academic, Orlando, FL 1986; 19–67
  • Humphrey J H, West K P, Jr, Sommer A. Vitamin A deficiency and attributable mortality among under-5-year-olds. Bull World Health Organ 1992; 70: 225–232
  • Sommer A. Nutritional Blindness. Oxford University, New York, NY 1982; 1–282
  • Oomen H APC, ten Doesschate J. The periodicity of xerophthalmia in South and East Asia. Ecol Food Nutr 1973; 2: 207–217
  • Tielsch J M, Sommer A. The epidemiology of vitamin A deficiency and xerophthalmia. Annu Rev Nutr 1984; 4: 183–205
  • Salus R. Ophthalmology in a concentration camp. Am J Ophthalmol 1957; 44: 12–17
  • Dushiminana A, Graham N MH, Humphrey J H, et al. Maternal vitamin A levels and HIV-related birth outcome in Rwanda. VIII International Conference on AIDS/III STD World Conference, Amsterdam, July, 1992, Abstract
  • Ward B J, Humphrey J H, Clement L, et al. Vitamin A status in HIV infection. Nutr Res 1993; 13: 157–166
  • Semba R D, Graham N MH, Caiaffa W T, et al. Increased mortality associated with vitamin A deficiency during HIV-1 infection. Archlnt Med, (In press.)
  • Thurnham D I. Vitamin A deficiency and its role in infection. Trans R Soc Trop Med Hyg 1989; 83: 721–723
  • Hirschberg J. Ueber die durch Encephalitis bedingte Hornhautverschwarung bei kleinen Kindern. Klin Wochen-schr 1868; 5: 324–326
  • Blegvad O. Xerophthalmia, keratomalacia, and xerosis conjunctivae. Am J Ophthalmol 1924; 7: 89–117
  • Sommer A, Hussaini G, Tarwotjo I, et al. Increased mortality in children with mild vitamin A deficiency. Lancet 1983; 2: 585–588
  • Sommer A, Katz J, Tarwotjo I. Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency. Am J Clin Nutr 1984; 40: 1090–1095
  • Sommer A, Tarwotjo I, Katz J. Increased risk of xerophthalmia following diarrhea and respiratory disease. Am J Clin Nutr 1987; 45: 977–980
  • Campos F ACS, Flores H, Underwood B A. Effect of an infection on vitamin A status of children as measured by the relative dose response (RDR). Am J Clin Nutr 1987; 46: 91–94
  • Sommer A, Tarwotjo I, Djunaedi E, et al. Impact of vitamin A supplementation on childhood mortality: a randomised community trial. Lancet 1986; 2: 585–588
  • Muhilal D, Permeisih Y, Idjradinata R, et al. Vitamin A-fortified monosodium glutamate and health, growth, and survival of children: a controlled field trial. Am J Clin Nutr 1988; 48: 1271–1276
  • Rahmathullah L, Underwood B A, Thulasiraj R D, et al. Reduced mortality among children in southern India receiving a small weekly dose of vitamin A. N Engl J Med 1990; 323: 929–935
  • Kothari G. The effect of vitamin A prophylaxis on morbidity and mortality among children in urban slums in Bombay. J Trop Pediatr 1991; 37: 141
  • West K P, Jr, Pokhrel R P, Katz J, et al. Efficacy of vitamin A in reducing preschool child mortality in Nepal. Lancet 1991; 338: 67–71
  • Daulaire N MP, Starbuck E S, Houston R M, Houston R M, Church M S, Stukel T A, Pandey M R. Childhood mortality after a high dose of vitamin A in a high risk population. BMJ 1992; 304: 207–210
  • Arthur P, Kirkwood B, Ross D, et al. Impact of vitamin A supplementation on childhood morbidity in northern Ghana. Lancet 1992; 339: 361–362
  • Barclay A JG, Foster A, Sommer A. Vitamin A supplements and mortality related to measles: a randomised clinical trial. BMJ 1987; 294: 294–296
  • Hussey G D, Klein M. A randomized, controlled trial of vitamin A in children with severe measles. N Engl J Med 1990; 323: 160–164
  • Fawzi W W, Chalmers T C, Herrera G, Mosteller F. Vitamin A supplementation and child mortality: a metaanalysis. JAMA 1993; 269: 898–903
  • Beaton G H, Martorell R, ĽAbbé K A, et al. Effectiveness of Vitamin A Supplementation in the Control of Young Child Morbidity and Mortality in Developing Countries. University of Toronto, Toronto, CA 1992; 1–108
  • Glasziou P P, Mackerras D EM. Vitamin A supplementation in infectious diseases: a meta-analysis. BMJ 1993; 306: 366–370
  • Aaby P, Clements C J. Measles immunization research: a review. Bull World Health Organ 1989; 67: 443–448
  • Kiepela P, Coovadia H M, Coward P. T helper cell defect related to severity in measles. Scand J Infect Dis 1987; 19: 185–192
  • Griffin D E, Ward B J. Differential CD4 T cell activation in measles. J Inf Dis, (In press)
  • Tamashiro V G, Perez H H, Griffin D E. Prospective study of the magnitude and duration of changes in tuberculin reactivity during complicated and uncomplicated measles virus infections of man. Clin Immunol Immunopathol 1984; 31: 1–12
  • Hull H F, Williams P J, Oldfield F. Measles mortality and vaccine efficacy in rural West Africa. Lancet 1983; 1: 972–975
  • Dekker N WHM. The cornea in measles. Monogr Ophthalmol 1983; 3: 1–119
  • Coutsoudis A, Broughton M, Coovadia H M. Vitamin A supplementation reduces measles morbidity in young African children: a randomized, placebo-controlled, double-blind trial. Am J Clin Nutr 1991; 54: 890–895
  • Ong D E. Retinoid metabolism during intestinal absorption. J Nutr 1993; 123: 351–355
  • Goodman D S. Biosynthesis, absorption, and hepatic metabolism of retinol. The Retinoids, M B Sporn, A B Roberts, D S Goodman. Academic, New York, NY 1984; 2: 1–39
  • Olson J A, Gunning D B, Tilton R A. Liver concentrations of vitamin A and carotenoids, as a function of age and other parameters, of American children who died of various causes. Am J Clin Nutr 1984; 39: 903–910
  • Kanai M, Raz A, Goodman D S. Retinol-binding protein: the transport protein for vitamin A in human plasma. J Clin Invest 1968; 47: 658–667
  • McGuire B W, Orgebin-Crist M C, Chytil F. Autoradiographic localization of serum retinol-binding in rat testis. Endocrinology 1981; 108: 658–667
  • Napoli J L. Biosynthesis and metabolism of retinoic acid: Roles of CRBP and CRABP in retinoic acid homeostasis. J Nutr 1993; 123: 362–366
  • Petkovich M, Brand N J, Krust A, et al. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 1987; 330: 444–450
  • Giguere V, Ong E S, Segui P, et al. Identification of a receptor for the morphogen retinoic acid. Nature 1987; 330: 624–629
  • Brand N, Petkovich M, Krust A, et al. Identification of a second human retinoic acid receptor. Nature 1988; 332: 850–853
  • Zelent A, Krust A, Petkovich M, et al. Cloning of murine α and β retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature 1989; 339: 714–717
  • Evan R M. The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889–895
  • De Luca L M. Retinoids and their receptors in differentiation, embryogenesis, and neoplasia. FASEB J 1991; 5: 2924–2933
  • Mangelsdorf D J, Ong E S, Dyck J A, et al. A nuclear receptor that identifies a novel retinoic acid response pathway. Nature 1990; 345: 224–229
  • Heyman R A, Mangelsdorf E J, Dyck J A, et al. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 1992; 68: 397–406
  • Levin A A, Sturzenbecker L J, Kazmer S, et al. 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRa. Nature 1992; 355: 359–361
  • Zhang X, Hoffmann B, Tran P BV, et al. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature 1992; 355: 441–445
  • Leid M, Kastner P, Lyons R, et al. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or RT heterodimerizes to bind target sequences efficiently. Cell 1992; 68: 377–395
  • Kliewer S A, Umesono K, Mangelsdorf D J, et al. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone, and vitamin D3 signalling. Nature 1992; 355: 446–449
  • Mahalanabis D, Simpson T W, Chakraborty M L, Ganguli C, Bhattacharjee A K, Mukherjee K L. Malabsorption of water miscible vitamin A in children with giardiasis and ascariasis. Am J Clin Nutr 1979; 32: 313–318
  • Semba R D, Wirasasmita S, Natadisastra G, et al. Response of Bitot's spots in preschool children to vitamin A treatment. Am J Ophthalmol 1990; 110: 416–420
  • Sommer A. Field Guide to the Detection and Control of Xerophthalmia. World Health Organization, Geneva 1982; 1–58
  • Semba R D, Muhilal B, Ward J, et al. Abnormal T-cell subset proportions in vitamin A-deficient children. Lancet 1993; 341: 5–8
  • Semba R D, Muhilal A, Scott L, et al. Depressed immune response to tetanus in children with vitamin A deficiency. J Nutr 1992; 122: 101–107
  • Blackfan K D, Wolbach S B. Vitami A deficiency in infants: a clinical and pathological study. J Pediatr 1933; 3: 679–706
  • Nauss K M. Influence of vitamin A status on the immune system. Vitamin A Deficiency and Its Control, J C Bauernfeind. Academic, Orlando, FL 1986; 207–243
  • Ross A C. Vitamin A status: relationship to immunity and the antibody response. Proc Soc Exp Biol Med 1992; 200: 303–320
  • Douer D, Koeffler H P. Retinoic acid enhances colony-stimulating factor-induced clonal growth of normal human myeloid progenitor cells in vitro. ExpCellRes 1982; 138: 193–198
  • Douer D, Koeffler H P. Retinoic acid enhances growth of human early erythroid progenitor cells in vitro. J Clin Invest 1982; 69: 1039–1041
  • Mejia L A, Hodges R E, Arroyave G, et al. Vitamin A deficiency and anemia in Central American children. Am J Clin Nutr 1977; 30: 1175–1184
  • Hodges R E, Sauberlich H E, Canham J E, et al. Hematopoietic studies in vitamin A deficiency. Am J Clin Nutr 1978; 31: 876–885
  • Mejia L A, Arroyave G. The effect of vitamin A fortification of sugar on iron metabolism in preschool children in Guatemala. Am J Clin Nutr 1982; 36: 87–93
  • Mejia L A, Chew F. Hematological effect of supplementing anemic children with vitamin A alone and in combination with iron. Am J Clin Nutr 1988; 48: 595–600
  • Bloem M W, Wedel M, Egger R J, et al. Iron metabolism and vitamin A deficiency in children in northeastern Thailand. Am J Clin Nutr 1989; 50: 332–338
  • Bloem M W, Wedel M, van Agtmaal E J, et al. Vitamin A intervention: short-term effects of a single, oral, massive dose on iron metabolism. Am J Clin Nutr 1990; 51: 76–79
  • Semba R D, Muhilal West K P, Jr, et al. Impact of vitamin A supplementation on hematological indicators of iron metabolism and protein status in children. Nutr Res 1992; 12: 469–478
  • West K P, Jr. Dietary vitamin A deficiency: effects of growth, infection, and mortality. Bull Food Nutr 1991; 13: 119–131
  • Lloyd-Puryear M, Humphrey J H, West K P, Jr, et al. Vitamin A deficiency and anemia among Micronesian children. Nutr Res 1989; 9: 1007–1016
  • Bedo G, Santisteban P, Aranda A. Retinoic acid regulates growth hormone expression. Nature 1989; 339: 231–234
  • Sommer A, Hussaini G, Muhilal, et al. History of nightblindness: a simple tool for xerophthalmia screening. AmJClinNutr 1980; 33: 887–891
  • Natadisastra G, Wittpenn J R, West K P, Jr, et al. Impression cytology for detection of vitamin A deficiency. Arch Ophthalmol 1987; 105: 1224–1228
  • Keenum D G, Semba R D, Wirasasmita S, et al. Assessment of vitamin A status by a disk applicator for conjunctival impression cytology. Arch Ophthalmol 1990; 108: 1436–1441
  • Amédée-Manesme O, Luzeau R, Carlier C, et al. Simple impression cytology method for detecting vitamin A deficiency. Lancet 1987; 1: 1263
  • Underwood B A. Methods for assessment of vitamin A status. JNutr 1990; 120: 1459–1463
  • Pilch S M. Analysis of vitamin A data from the health and nutrition examination surveys. J Nutr 1987; 117: 636–640
  • Sommer A. Vitamin A deficiency and childhood mortality. Lancet 1992; 339: 864
  • Flores H, Azevedo M NA, Campos F ACS, et al. Serum vitamin A distribution curve for children aged 2–6 y known to have adequate vitamin A status: a reference population. Am J Clin Nutr 1991; 54: 707–711
  • Flores H, Campos F, Araujo C RC, et al. Assessment of marginal vitamin A deficiency in Brazilian children using the relative dose response procedure. Am J Clin Nutr 1984; 40: 1281–1289
  • Tanumihardjo S A, Olson J A. A modified relative dose-response assay employing 3.4-didehydroretinol (vitamin A2) in rats. J Nutr 1988; 118: 598–603
  • Olson J A. Liver vitamin A reserves of neonates, preschool children and adults dying of various causes in Salvador, Brazil. Arch Latinoam Nutr 1979; 29: 521–545
  • WHO/UNICEF/IVACG Task Force. Vitamin A Supplements. A Guide to Their Use in the Treatment and Prevention of Vitamin A Deficiency and Xerophthalmia. World Health Organization, Geneva 1988; 1–24
  • Rankins D, Hopkinson S, Diop M. Palatability and nutritional significance of solar dried mangoes for Senegal. Ecol Food Nutr 1989; 23: 131–140

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