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Original Article

The C3H/HeJBir Mouse Model: A High Susceptibility Phenotype for Colitis

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Pages 63-75 | Published online: 10 Jul 2009

References

  • Sundberg J. P., Elson C. O., Bedigian H., Birkenmeier E. H. Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice. Gastroenterology 1994; 107: 1726–1735
  • McCabe R. P., Sharmanov A., Birkenmeier E., Sundberg J., Elson C. O. Mucosal immune abnormalities in C3H/HeJBir mice with susceptibility to colitis. Gastroenterology 1994; 106: A731
  • Ni J., Chen S. F., Hollander D. Immunological abnormality in C3H/HeJ mice with heritable inflammatory bowel disease. Cellular Immunology 1996; 169: 7–15
  • Brandwein S. L., McCabe R. P., Cong Y., Waites K. B., Ridwan B. U., Dean P. A., Ohkusa T., Birkenmeier E. H., Sundberg J. P., Elson C. O. Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. Journal of Immunology 1997; 159: 44–52
  • Cong Y., Brandwein S. L., McCabe R. P., Lazenby A., Birkenmeier E. H., Sundberg J. P., Elson C. O. CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice. Increased Th1 response and ability to transfer disease. J. Exp. Med. 1998; 187: 855–864
  • Powrie F., Leach M. W., Mauze S., Caddie L. B., Coffman R. L. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 1993; 5: 1461–1471
  • Tokonogy S. L., Sartor R. B. Immune system activation in C3H/HeJBir mice exhibiting spontaneous perianal ulceration. Inflammatory Bowel Diseases 1997; 3: 10–19
  • Groux H., O'Garra A., Bigler M., Rouloux M., Antonenko S., deVries J. E., Roncarolo M. G. A CD4+ T cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389: 737–742
  • Fox J. G., Dewhirst F. E., Tully J. G., Paster B. J., Yan L., Taylor N. S., Collins M. J., Jr., Gorelick P. L., Ward J. M. Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice. J. Clin. Microbiol. 1994; 32: 1238–1245
  • Ward J. M., Anver M. R., Raines D. C., Melhorn J. M., Gorelick P., Yan L., Fox J. G. Inflammatory large bowel disease in immunodeficient mice naturally infected with Helicobacter hepaticus. Laboratory Animal Science 1996; 46: 15–20
  • Mahler M., Bristol I. J., Leiter E. H., Birkenmeier E. H., Elson C. O., Sundberg J. P. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am. J. Physiol. 1998; 274: G544–G551
  • Bristol I. J., Mahler M., Sundberg J. P., Leiter E. H., Cong Y., Elson C. O. Severe, early colitis in C3H/HeJBir-IL-10 deficient mice. Gastroenterology 1998; 114: A943
  • Ehrhardt R. O., Ludviksson B. R., Gray B., Neurath M., Strober W. Induction and prevention of colonic inflammation in IL-2-deficient mice. Journal of Immunology 1997; 158: 566–573
  • Mahler M., Bristol I. J., Sundberg J. P., Churchill G. A., Birkenmeier E. H., Elson C. O., Leiter E. H. Genetic analysis of susceptibility to dextran sodium sulfate-induced colitis in mice. Genomics 1999; 55: 147–156

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