Genetics of Systemic Autoimmunity in Mouse Models of Lupus

References

• Mongey A., Hess E. V. The role of environment in systemic lupus erythematosus and associated disorders. Dubois' Lupus Erythematosus, D. J. Wallace, B. H. Harm. Willaims & Wilkins, Baltimore 1977; 31
   Google Scholar
• Alarcon-Segovia D., Alarcon Riquelme M. E. Etiopathogenesis of systemic lupus erythmatosus: a tale of three troikas. Systemic Lupus Erythematosus, R. G. Lahita. Academic Press, San Diego 1999; 55
   Google Scholar
• Maldonado M. A., Kakkanaiah V., Mac G. C., Donald Chen F., Reap E. A., Balish E., Farkas W. R., Jennette J. C., Madaio M. P., Kotzin B. L., Cohen P. L., Eisenberg R. A. The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice [In Process Citation]. J. Immunol 1999; 162: 6322
   PubMed Web of Science ®Google Scholar
• Merino R., Iwamoto M., Gershwin M. E., Izui S. The Yaa gene abrogates the major histocompatibility complex association of murine lupus in (NZBxBXSB)F1 hybrid mice. J. Clin. Invest 1994; 94: 521
   PubMed Web of Science ®Google Scholar
• Vyse T. J., Halterman R. K., Rozzo S. J., Izui S., Kotzin B. L. Control of separate pathogenic autoantibody responses marks MHC gene contributions to murine lupus. Proc. Natl. Acad. Sci., USA 1999; 96: 8098
   PubMed Web of Science ®Google Scholar
• Fujimura T., Hirose S., Jiang Y., Kodera S., Ohmuro H., Zhang D., Hamano Y., Ishida H., Furukawa S., Shirai T. Dissection of the effects of tumor necrosis factor-alpha and class II gene polymorphisms within the MHC on murine systemic lupus erythematosus (SLE) [In Process Citation]. Int. Immunol 1998; 10: 1467
   PubMed Web of Science ®Google Scholar
• Ibnou N., ZekriIwamoto M., Fossati L., McConahey P., Izui S. Role of the major histocompatibility complex class II E‡ gene in lupus susceptibility in mice. Proc. Natl. Acad. Sci., USA 1997; 94: 14654
   PubMed Web of Science ®Google Scholar
• Jacob C. O., Lee S. K., Strassmann G. Mutational analysis of TNF-alpha gene reveals a regulatory role for the 3′-untranslated region in the genetic predisposition to lupus-like autoimmune disease. J. Immunol 1996; 156: 3043
   PubMed Web of Science ®Google Scholar
• Lander E. S., Schork N. J. Genetic dissection of complex traits. Science 1994; 265: 2037
   PubMed Web of Science ®Google Scholar
• Rikke B. A., Johnson T. E. Towards the cloning of genes underlying murine QTLs. Mamm. Genome 1998; 9: 963
   PubMed Web of Science ®Google Scholar
• Darvasi A. Experimental strategies for the genetic dissection of complex traits in animal models. Nat. Genet 1998; 18: 19
   PubMed Web of Science ®Google Scholar
• Hirose S., Ueda G., Noguchi K., Okada T., Sekigawa I., Sato H., Shirai T. Requirement of H-2 heterozygosity for autoimmunity in (NZBxNZW)F1 hybrid mice. Eur. J. Immunol 1986; 16: 1631
   PubMed Web of Science ®Google Scholar
• Kotzin B. L., Palmer E. The contribution of NZW genes to lupus-like disease in (NZB × NZW)F1 mice. J. Exp. Med 1987; 165: 1237
   PubMed Web of Science ®Google Scholar
• Smith L. R., Theofilopoulos A. N. Sequence of I-E genes from autoimmune New Zealand white mice. Arth. Rheum 1990; 33: 583
   PubMedGoogle Scholar
• Ogawa S., Nishimura H., Awaji M., Nozawa S., Hirose S., Shirai T. Nucleotide sequence analysis of MHC class II genes in autoimmune disease-prone (NZBxNZW)Fl mice. Immunogenetics 1990; 32: 295
   Web of Science ®Google Scholar
• Nygard N. R., Mc D. M., Carthy Schiffenbauer J., Schwartz B. D. Mixed haplotypes and autoimmunity. Immunol. Today 1993; 14: 53
   PubMedGoogle Scholar
• Vyse T. J., Rozzo S. J., Drake C. G., Appel V. B., Lemeur M., Izui S., Palmer E., Kotzin B. L. Contributions of Ea(z) and Eb(z) MHC genes to lupus susceptibility in New Zealand mice. J. Immunol 1998; 160: 2757
   PubMed Web of Science ®Google Scholar
• Rozzo S. J., Vyse T. J., David C. S., Palmer E., Izui S., Kotzin B. L. Analysis of MHC class II genes in the susceptibility to lupus in New Zealand mice. J. Immunol 1999; 162: 2623
   PubMed Web of Science ®Google Scholar
• Bazzoni F., Beutler B. Comparative expression of TNF-alpha alleles from normal and autoimmune-prone MHC haplotypes. J. Inflanan 1995; 45: 106
   PubMedGoogle Scholar
• Morel L., Tian X. H., Croker B. P., Wakeland E. K. Epistatic modifiers of autoimmunity in a murine model of lupus nephritis [In Process Citation]. Immunity 1999; 11: 131
   PubMed Web of Science ®Google Scholar
• Gotoh Y., Takashima H., Noguchi K., Nishimura H., Tokushima M., Shirai T., Kimoto M. Mixed haplotype A beta z/A alpha d class II molecule in (NZB × NZW)F1 mice detected by T cell clones. J. Immunol 1993; 150: 4777
   PubMed Web of Science ®Google Scholar
• Hirose S., Nagasawa R., Sekikawa I., Hamaoka M., Ishida Y., Sata H., Shirai T. Enhancing effect of H-2 linked NZW genes on the autoimmune traits of (NZB × NZW)F1 mice. J. Exp. Med 1983; 158: 228
   PubMed Web of Science ®Google Scholar
• Kawano H., Abe M., Zhang D., Saikawa T., Fujimori M., Hirose S., Shirai T. Heterozygosity of the major histocompatibility complex controls the autoimmune disease in (NZW × BXSB)F1 mice. Clin. Immunol. Immunopathol 1992; 65: 308
   PubMedGoogle Scholar
• Drake C. G., Rozzo S. J., Hirschfeld H. F., Smamworawong N. P., Palmer E., Kotzin B. L. Analysis of the New Zealand Black contribution to lupus-like renal disease. Multiple genes that operate in a threshold manner. J. Immunol 1995; 154: 2441
   PubMed Web of Science ®Google Scholar
• Kono D. H., Burlingame R. W., Owens D. G., Kuramochi A., Balderas R. S., Balomenos D., Theofilopoulos A. N. Lupus susceptibility loci in New Zealand mice. Proc. Natl. Acad. Sci. USA 1994; 91: 10168
   PubMed Web of Science ®Google Scholar
• Drake C. G., Babcock S. K., Palmer E., Kotzin B. L. Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB × NZW)F1 mice. Proc. Natl. Acad. Sci. USA 1994; 91: 4062
   PubMed Web of Science ®Google Scholar
• Morel L., Rudofsky U. H., Longmate J. A., Schiffenbauer J., Wakeland E. K. Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity 1994; 1: 219
   PubMed Web of Science ®Google Scholar
• Hirose S., Tsurui H., Nishimura H., Jiang Y., Shirai T. Mapping of a gene for hypergammaglobulinemia to the distal region on chromosome 4 in NZB mice and its contribution to systemic lupus erythematosus in (NZB × NZW)F1 mice. Int. Immunol 1994; 6: 1857
   PubMed Web of Science ®Google Scholar
• Mohan C., Morel L., Yang P., Wakeland E. K. Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity. J. Immunol 1997; 159: 454
   PubMed Web of Science ®Google Scholar
• Mohan C., Morel L., Yang P., Wakeland E. K. Accumulation of splenic B1a cells with potent antigen-presenting capability in NZM2410 lupus-prone mice. Arthritis Rheum 1998; 41: 1652
   PubMed Web of Science ®Google Scholar
• Jiang Y., Hirose S., Hamano Y., Kodera S., Tsurui H., Abe M., Terashima K., Ishikawa S., Shirai T. Mapping of a gene for the increased susceptibility of B1 cells to Mott cell formation in murine autoimmune disease. J. Immunol 1997; 158: 992
   PubMed Web of Science ®Google Scholar
• Santiago M. L., Mary C., Parzy D., Jacquet C., Montagutelli X., Parkhouse R. M., Lemoine R., Izui S., Reininger L. Linkage of a major quantitative trait locus to Yaa gene-induced lupus-like nephritis in (NZW × C57BL/6)F1 mice. Eur. J. Immunol 1998; 28: 4257
   PubMed Web of Science ®Google Scholar
• Rozzo S. J., Vyse T. J., Drake C. G., Kotzin B. L. Effect of genetic background on the contribution of New Zealand black loci to autoimmune lupus nephritis. Proc. Natl. Acad. Sci. USA 1996; 93: 15164
   PubMed Web of Science ®Google Scholar
• Vyse T. J., Rozzo S. J., Drake C. G., Izui S., Kotzin B. L. Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice. J. Immunol 1997; 158: 5566
   PubMed Web of Science ®Google Scholar
• Morel L., Mohan C., Yu Y., Croker B. P., Tian N., Deng A., Wakeland E. K. Functional dissection of systemic lupus erythematosus using congenic mouse strains. J. Immunol 1997; 158: 6019
   PubMed Web of Science ®Google Scholar
• Clynes R., Dumitru C., Ravetch J. V. Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science 1998; 279: 1052
   PubMed Web of Science ®Google Scholar
• Park S. Y., Ueda S., Ohno H., Hamano Y., Tanaka M., Shiratori T., Yamazaki T., Arase H., Arase N., Karasawa A., Sato S., Ledermann B., Kondo Y., Okumura K., Ra C., Saito T. Resistance of Fc receptor-deficient mice to fatal glomerulonephritis. J. Clin. Invest 1998; 102: 1229
   PubMed Web of Science ®Google Scholar
• Balomenos D., Rumold R., Theofilopoulos A. N. Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J. Clin. Invest 1998; 101: 364
   PubMed Web of Science ®Google Scholar
• Tesch G. H., Maifert S., Schwarting A., Rollins B. J., Kelley V. R. Monocyte Chemoattractant Protein 1-dependent Leukocytic Infiltrates Are Responsible for Autoimmune Disease in MRL-Fas(lpr) Mice. J. Exp. Med 1999; 190: 1813
   PubMed Web of Science ®Google Scholar
• Knight J. G., Adams D. D. Genes determining autoimmune disease in New Zealand mice. J. Clin. Lab. Immunol 1981; 5: 165
   PubMedGoogle Scholar
• Nagata S., Suda T. Fas and Fas ligand: Ipr and gld mutations. [Review]. Immunol. Today 1995; 16: 39
   PubMedGoogle Scholar
• Theofilopoulos A. N., Kono D. H. The genes of systemic autoimmunity. Proc. Assoc. Am. Phys 1999; 111: 228
   PubMedGoogle Scholar
• Jackson C. E., Puck J. M. Autoimmune lymphoproliferative syndrome, a disorder of apoptosis. Curr. Opin. Pediatr 1999; 11: 521
   PubMedGoogle Scholar
• Balomenos D., Rumold R., Theofilopoulos A. N. The proliferative in vivo activities of Ipr double-negative T cells and the primary role of p59fyn in their activation and expansion. J. Immunol 1997; 159: 2265
   PubMed Web of Science ®Google Scholar
• Christiansen G. J., Blankenburg R. L., Duffy T. M., Panka D., Roths J. B., Marshak-Rothstein A., Roopenian D. C. beta2-microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice. J. Immunol 1996; 156: 4932
   PubMed Web of Science ®Google Scholar
• Koh D. R., Ho A., Rahemtulla A., Fung W. P., LeungGriesser H. and T.W. Mak, Murine lupus in MRL/lpr mice lacking CD4 or CDS T cells. Eur J. Immunol 1995; 25: 2558
   PubMed Web of Science ®Google Scholar
• Jevnikar A. M., Grusby M. J., Glimcher L. H. Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. J. Exp. Med 1994; 179: 1137
   PubMed Web of Science ®Google Scholar
• Chan O. T., Madaio M. P., Shlomchik M. J. B cells are required for lupus nephritis in the polygenicFas-intact MRL model of systemic autoimmunity. J. Immunol 1999; 163: 3592
   PubMed Web of Science ®Google Scholar
• Fukuyama H., Adachi M., Suematsu S., Miwa K., Suda T., Yoshida N., Nagata S. Transgenic expression of Fas in T cells blocks lymphoproliferation but not autoimmune disease in MRL-lpr mice. J. Immunol 1998; 160: 3805
   PubMed Web of Science ®Google Scholar
• Ito M. R., Terasaki S., Itoh J., Katoh H., Yonehara S., Nose M. Rheumatic diseases in an MRL strain of mice with a deficit in the functional Fas ligand. Arthritis Rheum 1997; 40: 1054
   PubMed Web of Science ®Google Scholar
• Theofilopoulos A. N., Kono D. H. Murine lupus models: gene-specific and genome-wide studies. Systemic Lupus Erythematosus, R. G. Lahita. Academic Press, San Diego 1999; 145
   Google Scholar
• Vidal S., Kono D. H., Theofilopoulos A. N. Loci predisposing to autoimmunity in MRL-Faslpr, and C57BL/6-Faslpr mice. J. Clin. Invest 1998; 101: 696
   PubMed Web of Science ®Google Scholar
• Burlingame R. W., Rubin R. L., Balderas R. S., Theofilopoulos A. N. The genesis and evolution of anti-chromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen. J. Clin. Invest 1993; 91: 1687
   PubMed Web of Science ®Google Scholar
• Casciola L. A., RosenAnhalt G., Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes [see comments]. J. Exp. Med 1994; 179: 1317
   PubMed Web of Science ®Google Scholar
• Botto M., Dell Agnola C., Bygrave A. E., Thompson E. M., Cook H. T., Petry F., Loos M., Pandolfi P. P., Walport M. J. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat. Genet 1998; 19: 56
   PubMed Web of Science ®Google Scholar
• Eisenberg R. A., Craven S. Y., Warren R. W., Cohen P. L. Stochastic control of anti-Sm autoantibodies in MRL/Mp-lpr/lpr mice. J. din. Invest 1987; 80: 691
   PubMed Web of Science ®Google Scholar
• Watson M. L., Rao J. K., Gilfceson G. S., Ruiz P., Eicher E. M., Pisetsky D. S., Matsuzawa A., Rochelle J. M., Seldin M. F. Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J. Exp. Med 1992; 176: 1645
   PubMed Web of Science ®Google Scholar
• Wang Y., Nose M., Kamoto T., Nishimura M., Hiai H. Host modifier genes affect mouse autoimmunity induced by the Ipr gene. Am. J. Pathol 1997; 151: 1791
   PubMed Web of Science ®Google Scholar
• Gu L., Weinreb A., Wang X. P., Zack D. J., Qiao J. H., Weisbart R., Lusis A. J. Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-ipr/lpr mouse model of systemic lupus erythematosus. J. Immnnol 1998; 161: 6999
   PubMed Web of Science ®Google Scholar
• Theofilopoulos A. N., Dixon F. J. M urine models of systemic lupus erythematosus. Adv. Immunol 1985; 37: 269
   PubMed Web of Science ®Google Scholar
• Hogarth M. B., Slingsby J. H., Allen P. J., Thompson E. M., Chandler P., Davies K. A., Simpson E., Morley B. J., Walport M. J. Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice. J. Immunol 1998; 161: 2753
   PubMed Web of Science ®Google Scholar
• Ida A., Hirose S., Hamano Y., Kodera S., Jiang Y., Abe M., Zhang D., Nishimura H., Shirai T. Multigenic control of lupus-associated antiphospholipid syndrome in a model of (NZW × BXSB) Fl mice. Eur J. Immunol 1998; 28: 2694
   PubMed Web of Science ®Google Scholar
• Chiang B., Bearer E., Ansari A., Dorshkind K., Gershwin M. E. The BM12 mutation and autoantibodies to dsDNA in NZB.H-2bml2 mice. J. Immunol 1990; 145: 94
   PubMed Web of Science ®Google Scholar
• Kono D. H., Balomenos D., Pearson D. L., Park M. S., Hildebrandt B., Hultman P., Pollard K. M. The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Thl/Th2 imbalance. J. Immunol 1998; 161: 234
   PubMed Web of Science ®Google Scholar
• Kono D. H., Balomenos D., Park M. S., Theofilopoulos A. N. Lupus-like disease in BXSB mice is not dependent on IL-4. J. Immunol 2000; 164: 38
   PubMed Web of Science ®Google Scholar
• Mosmann T. R., Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more [see comments]. Immunol. Today 1996; 17: 138
   PubMedGoogle Scholar
• Romagnani S. The Thl/Th2 paradigm. Immunol Today 1997; 18: 263
   PubMedGoogle Scholar
• Wofsy D. Administration of monoclonal anti-T cell antibodies retards murin lupus in BXSB mice. J. Immunol 1986; 136: 4554
   PubMed Web of Science ®Google Scholar
• Ray S. K., Putterman C., Diamond B. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. Proc. Natl. Acad. Sci. USA 1996; 93: 2019
   PubMed Web of Science ®Google Scholar
• Tillman D. M., Jou N. T., Hill R. J., Marion T. N. Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB × NZW)F1 mice. J. Exp. Med 1992; 176: 761
   PubMed Web of Science ®Google Scholar
• Chu E. B., Ernst D. N., Hobbs M. V., Weigle W. O. Maturational changes in CD4+ cell subsets and lymphokine production in BXSB mice. J. Immunol 1994; 152: 4129
   PubMed Web of Science ®Google Scholar
• Luzina I. G., Knitzer R. H., Atamas S. P., Gause W. C., Papadimitriou J. C., Sztein M. B., Starrer C. E., Handwerger B. S. Vasculitis in the Palmerston North mouse model of lupus: phenotype and cytokine production profile of infiltrating cells. Arthritis Rheum 1999; 42: 561
   PubMedGoogle Scholar
• Nakajima A., Hirose S., Yagita H., Okumura K. Role of IL-4 and IL-12 in the development of lupus in NZB/W F1 mice. J. Immunol 1997; 158: 1466
   PubMed Web of Science ®Google Scholar
• Schorlemmer H. U., Dickneite G., Kanzy E. J., Enssle K. H. Modulation of the imrnunoglobulin dysregulation in GvH-and SLE-like diseases by the murine IL-4 receptor (IL-4-R). Inflamm. Res 1995; 44(Suppl 2)S194
   Google Scholar
• Peng S. L., Moslehi J., Craft J. Roles of interferon-gamma and interleukin-4 in murine lupus. J. din. Invest 1997; 99: 1936
   PubMed Web of Science ®Google Scholar
• Goldman M., Druet P., Gleichmann E. TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. Immunol. Today 1991; 12: 223
   PubMedGoogle Scholar
• Biancone L., Andres G., Ahn H., Lim A., Dai C., Noelle R., Yagita H., De Martino C., Stamenkovic I. Distinct regulatory roles of lymphocyte costimulatory pathways on T helper type 2-mediated autoimmune disease. J. Exp. Med 1996; 183: 1473
   PubMed Web of Science ®Google Scholar
• Ochel M., Vohr H. W., Pfeiffer C., Gleichmann E. IL-4 is required for the IgE and IgGl increase and IgGl autoantibody formation in mice treated with mercuric chloride. J. Immunol 1991; 146: 3006
   PubMed Web of Science ®Google Scholar
• Prigent P., Saoudi A., Pannetier C., Graber P., Bonnefoy J. Y., Druet P., Hirsch F. Mercuric chloride, a chemical responsible for T helper cell (Th)2-mediated autoimmunity in brown Norway rats, directly triggers T cells to produce interleukin-4. J. Clin. Invest 1995; 96: 1484
   PubMed Web of Science ®Google Scholar
• Haas C., Ryffel B., Le H. M. IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice. J. Immunol 1997; 158: 5484
   PubMed Web of Science ®Google Scholar
• Haas C., Ryffel B., Le Hir M. IFN-gamma receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB × NZW)F1 mice. J. Immunol 1998; 160: 3713
   PubMed Web of Science ®Google Scholar
• Boehm U., Klamp T., Groot M., Howard J. C. Cellular responses to interferon-gamma. Anna. Rev. Immunol 1997; 15: 749
   PubMed Web of Science ®Google Scholar
• Wuthrich R. P., Yui M. A., Mazoujian G., Nabavi N., Glimcher L. H., Kelley V. E. Enhanced MHC class II expression in renal proximal tubules precedes loss of renal function in MRL/lpr mice with lupus nephritis. Am. J. Pathol 1989; 134: 45
   PubMed Web of Science ®Google Scholar
• Ring G. H., Dai Z., Saleem S., Baddoura F. K., Lakkis F. G. Increased susceptibility to immunologically mediated glomerulonephritis in IFN-gamma-deficient mice. J. Immunol 1999; 163: 2243
   PubMed Web of Science ®Google Scholar