Regulation of T-cell Responses and Disease by Tec Kinase Itk

REFERENCES

• Smith C, Islam T, Mattsson P, Mohamed A, Nore B, Vihinen M. The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species. Bioessays. 2001;23:436–446.
   PubMed Web of Science ®Google Scholar
• Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL. Tec family kinases in T lymphocyte development and function. Annu Rev Immunol. 2005;23:549–600.
   Google Scholar
• Prince AL, Yin CC, Enos ME, Felices M, Berg LJ. The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development. Immunol Rev. 2009;228:115–131.
   Google Scholar
• Readinger JA, Mueller KL, Venegas AM, Horai R, Schwartzberg PL. 2009. Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk. Immunol Rev. 228:93–114.
   Google Scholar
• Felices M, Berg LJ. The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. J Immunol. 2008;180:3007–3018.
   Google Scholar
• Vetrie D, Vorechovský I, Sideras P, The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature. 1993;361:226–233. Erratum in: Nature. 1993 Jul 1922;1364(6435):1362.
   Google Scholar
• Smith CI, Islam TC, Mattsson PT, Mohamed AJ, Nore BF, Vihinen M. The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species. Bioessays. 2001;23:436–446.
   Google Scholar
• August A, Sadra A, Dupont B, Hanafusa H. Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase. Proc Natl Acad Sci U S A. 1997;94:11227–11232.
   Google Scholar
• Ching K, Kawakami Y, Kawakami T, Tsoukas C. Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain. J Immunol. 1999;163:6006–6013.
   Google Scholar
• Woods M, Kivens W, Adelsman M, Qiu Y, August A, Shimizu Y. A novel function for the Tec family tyrosine kinase Itk in activation of beta1 integrins by the T-cell receptor. EMBO J. 2001;20:1232–1244.
   Google Scholar
• Kawakami Y, Yao L, Tashiro M, Gibson S, Mills G, Kawakami T. Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on Fc epsilon RI cross-linking on mast cells. J Immunol. 1995;155:3556–3562.
   Google Scholar
• Bunnell S, Diehn M, Yaffe M, Findell P, Cantley L, Berg L. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. J Biol Chem. 2000;275:2219–2230.
   Google Scholar
• Su YW, Zhang Y, Schweikert J, Koretzky GA, Reth M, Wienands J. Interaction of SLP adaptors with the SH2 domain of Tec family kinases. Eur J Immunol. 1999;29:3702–3711.
   Google Scholar
• Alonzo E, Gottschalk R, Das J, Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. J Immunol. 2010;184:1268–1279. .
   Google Scholar
• Sicheri F, Moarefi I, Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck. Nature. 1997;385:602–609. PMID: 9024658.
   Google Scholar
• Xu W, Doshi A, Lei M, Eck M, Harrison S. Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Mol Cell. 1999;3:629–638.
   Google Scholar
• Nagar B, Hantschel O, Young M, Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell. 2003;112:859–871.
   Google Scholar
• Gonfloni S, Weijland A, Kretzschmar J, and Superti-Furga G. Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src. Nat Struct Biol. 2000; 281–286.
   Google Scholar
• Andreotti A, Bunnell S, Feng S, Berg L, Schreiber S. Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature. 1997;385:93–97.
   Google Scholar
• Qi Q, August A. The Tec family kinase Itk exists as a folded monomer in vivo. J Biol Chem. 2009;284:29882–29892. Epub 22009 Aug 29828.
   Google Scholar
• Brazin K, Fulton D, Andreotti A. A specific intermolecular association between the regulatory domains of a Tec family kinase. J Mol Biol. 2000;302:607–623.
   Google Scholar
• Andreotti A, Schwartzberg P, Joseph R, Berg L. T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harb Perspect Biol. 2010;2:a002287. Epub 002010 Jun 002282.
   Web of Science ®Google Scholar
• August A, Fischer A, Hao S, Mueller C, Ragin M. The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals. Int J Biochem Cell Biol. 2002;34:1184–1189.
   Google Scholar
• Grasis J, Tsoukas C. Itk: the rheostat of the T cell response. J Signal Transduct. 2011;297868. Epub 292011 Apr 297867.
   Google Scholar
• Shan X, Wange RL. Itk/Emt/Tsk Activation in Response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment. J Biol Chem. 1999;274: 29323–29330.
   Google Scholar
• Bogin Y, Ainey C, Beach D, Yablonski D. SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK. Proc Natl Acad Sci U S A. 2007;104:6638–6643. Epub 2007 Apr 6639.
   Google Scholar
• Qi Q, Sahu N, August A. Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors. J Biol Chem. 2006;281:38529–38534.
   Google Scholar
• Huang Y, Grasis J, Miller A, Positive regulation of Itk PH domain function by soluble IP4. Science. 2007;316:886–889. Epub 2007 Apr 2005.
   Google Scholar
• Qi Q, Sahu N, August A. Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors. J Biol Chem. 2006;281:38529–38534. .
   Google Scholar
• August A, Sadra A, Dupont B, Hanafusa H. Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase. Proc Natl Acad Sci U S A. 1997;94:11227–11232.
   Google Scholar
• Fowell D, Shinkai K, Liao X, Impaired NFATc Translocation and Failure of Th2 Development in Itk Deficient CD4 T Cells. Immunity. 1999;11:399–409.
   Google Scholar
• Schaeffer E, Debnath J, Yap G, Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science. 1999;284:638–641.
   Google Scholar
• Liu K, Bunnell S, Gurniak C, Berg L. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J Exp Med. 1998;187:1721–1727.
   Google Scholar
• Dolmetsch R, Lewis R, Goodnow C, Healy J. Differential activation of transcription factors induced by Ca2 +response amplitude and duration. Nature. 1997;386:855–858.
   Google Scholar
• Dolmetsch R, Xu K, Lewis R. Calcium oscillations increase the efficiency and specificity of gene expression. Nature. 1998;392:933–936.
   Google Scholar
• Schaeffer E, Yap G, Lewis C, Mutation of Tec family kinases alters T helper cell differentiation. Nat Immunol. 2001;2:1183–1188.
   Google Scholar
• Miller AT, Berg LJ. Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase. J Immunol. 2002;168:2163–2172.
   Google Scholar
• Min L, Joseph RE, Fulton DB, Andreotti AH. Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1. Proc Natl Acad Sci U S A. 2009;106:21143–21148.
   Google Scholar
• Dombroski D, Houghtling RA, Labno CM, Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. J Immunol. 2005;174:1385–1392.
   Google Scholar
• Reynolds L, Smyth L, Norton T, Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. J Exp Med. 2002;195:1103–1114.
   Google Scholar
• Qi Q, Xia M, Bai Y, Yu S, Cantorna M, August A. Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell. J Biol Chem. 2011;286:138–146. Epub 2010 Oct 2029.
   Google Scholar
• Grasis J, Browne C, Tsoukas C. Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor. J Immunol. 2003;170:3971–3976.
   Google Scholar
• Dombroski D, Houghtling R, Labno C, Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. J Immunol. 2005;174:1385–1392. .
   Google Scholar
• Hao S, Qi Q, Hu J, August A. A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activation. FEBS Lett. 2006;580:2691–2697. Epub 2006 Apr 2619.PMID: 16631752.
   Google Scholar
• Hao S, Qi Q, Hu J, August A. A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activation. FEBS Lett. 2006;580:2691–2697.
   Google Scholar
• Schaeffer EM, Broussard C, Debnath J, Anderson S, McVicar DW, Schwartzberg PL. Tec family kinases modulate thresholds for thymocyte development and selection. J Exp Med. 2000;192:987–1000.
   Google Scholar
• Liao X, Littman D. Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity. 1995;3:757–769.
   Google Scholar
• Berg, LJ. Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development. Nat Rev Immunol. 2007;7:479–485.
   Google Scholar
• Broussard C, Fleischacker C, Horai R, Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity. 2006;25:93–104.
   Google Scholar
• Dubois S, Waldmann TA, Muller JR. ITK and IL-15 support two distinct subsets of CD8+ T cells. Proc Natl Acad Sci U S A. 2006;103:12075–12080.
   Google Scholar
• Hu J, Sahu N, Walsh E, August A. Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk. Eur J Immunol. 2007;37:2892–2899.
   Google Scholar
• Horai R, Mueller KL, Handon RA, Requirements for selection of conventional and innate T lymphocyte lineages. Immunity. 2007;27:775–785.
   Google Scholar
• Hu J, August A. Naive and innate memory phenotype CD4 +T cells have different requirements for active Itk for their development. J Immunol. 2008;180:6544–6552.
   Google Scholar
• Huck K, Feyen O, Niehues T, Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. J Clin Invest. 2009;119:1350–1358.
   Google Scholar
• Weinreich M, Takada K, Skon C, Reiner S, Jameson S, Hogquist K. KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity. 2009;31:122–130.
   Google Scholar
• Weinreich M, Odumade O, Jameson S, Hogquist K. T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells. Nat Immunol. 2010;11:709–716. Epub 2010 Jul 2014.
   Google Scholar
• Lai D, Zhu J, Wang T, KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells. J Exp Med. 2011;1093–1103. Epub 2011 Apr 1011.
   Google Scholar
• Qi Q, Xia M, Hu J, Enhanced development of CD4 +gammadelta T cells in the absence of Itk results in elevated IgE production. Blood. 2009;114:564–571.
   Google Scholar
• Felices M, Yin CC, Kosaka Y, Kang J, Berg LJ. Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo. Proc Natl Acad Sci U S A. 2009;106:8308–8313.
   Google Scholar
• Gordon S, Carty S, Kim J, Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells. J Immunol. 2011;186:4573–4578. Epub 2011 Mar 4577.
   Google Scholar
• Lauritsen J, Wong G, Lee S, Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. Immunity. 2009;31:565–575.
   Google Scholar
• Xia M, Qi Q, Jin Y, Wiest D, August A, Xiong N. Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells. J Immunol. 2010;184:6807–6814.
   Google Scholar
• Au-Yeung B, Fowell D. A key role for Itk in both IFN gamma and IL-4 production by NKT cells. J Immunol. 2007;179:111–119.
   Google Scholar
• Felices M, Berg L. The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. J Immunol. 2008;180:3007–3018.
   Google Scholar
• Zhu J, Paul WE. Peripheral CD4 +T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev. 2010;238:247–262.
   Google Scholar
• Au-Yeung B, Katzman S, Fowell D. Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function. J Immunol. 2006;176:3895–3899.
   Google Scholar
• Gomez-Rodriguez J, Sahu N, Handon R, Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity. 2009;31:587–597.
   Google Scholar
• Miller A, Wilcox H, Lai Z, Berg L. 2004. Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. Immunity. 2004;21:67–80.
   Google Scholar
• Chang J, Ciocca M, Kinjyo I, Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity. 2011;34:492–504. Epub 2011 Apr 2014.
   Google Scholar
• Bachmann M, Littman D, Liao X. Antiviral immune responses in Itk-deficient mice. J Virol. 1997;71:7253–7257.
   Google Scholar
• Atherly L, Brehm M, Welsh R, Berg L. Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help. J Immunol. 2006;176:1571–1581.
   Google Scholar
• Sahu N, Venegas A, Jankovic D, Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses. J Immunol. 2008;181:6125–6131.
   Google Scholar
• Readinger J, Schiralli G, Jiang J, Selective targeting of ITK blocks multiple steps of HIV replication. Proc Natl Acad Sci U S A. 2008;105:6684–6689.
   Google Scholar
• Mueller C, August A. Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK. J Immunol. 2003;170:5056–5063.
   Google Scholar
• Ferrara T, Mueller C, Sahu N, Ben-Jebria, A, and AA. Reduced airway hyperresponsiveness and tracheal responses during allergic asthma in mice lacking tyrosine kinase inducible T-cell kinase. J Allergy Clin Immunol. 2006;117:780–786. Epub 2006 Feb 2007.
   Google Scholar
• Sahu N, Morales JL, Fowell D, August A. Modeling susceptibility versus resistance in allergic airway disease reveals regulation by Tec kinase Itk. PLoS ONE. 2010;5:e11348.
   PubMedGoogle Scholar
• Sahu N, Mueller C, Fischer A, August A. Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migration. J Immunol. 2008;180:3833–3838. Erratum in: J Immunol. 2008 May 3815;3180(3810):7047–3838.
   Google Scholar
• Lin T, McIntyre K, Das J, Selective itk inhibitors block T-cell activation and murine lung inflammation. Biochemistry. 2004;43:11056–11062.
   Google Scholar
• Matsumoto Y, Oshida T, A, et al. Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis. Int Arch Allergy Immunol. 2002;129:327–340.
   Google Scholar
• von Bonin A, Rausch A, Mengel A, Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases. Exp Dermatol. 2011;20:41–47. doi: 10.1111/j.1600-0625.2010.01198.x.
   Google Scholar
• Benson M, Mobini R, Barrenas F, A haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis. Allergy. 2009;64:1286–1291.
   Google Scholar
• Lee S, Chang H, Jang A, The association of a single-nucleotide polymorphism of the IL-2 inducible T-cell kinase gene with asthma. Ann Hum Genet. 2011;75:359–369. doi: 310.1111/j.1469-1809.2010.00637.x. Epub 02011 Feb 00615.
   Google Scholar
• Graves P, Siroux V, Guerra S, Klimecki W, Martinez F. Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33. J Allergy Clin Immunol. 2005;116:650–656.
   Google Scholar
• Iyer A, August A. The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses. J Immunol. 2008;180:7869–7877.
   Google Scholar
• Iyer A, Morales J, Huang W, Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses. J Biol Chem. 2011;286:9503–9513. Epub 2011 Jan 9506.
   Google Scholar
• Sahu N, August A. ITK inhibitors in inflammation and immune-mediated disorders. Curr Top Med Chem. 2009;9:690–703.
   Google Scholar