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Research Article

Mechanisms of Immune Privilege in the Posterior Eye

Pages 42-56 | Accepted 11 Oct 2012, Published online: 29 Jan 2013

REFERENCES

  • Stein-Streilein J. Immune regulation and the eye. Trends Immunol 2008;29(11):503–586. Epub 2008/11/08.
  • Streilein JW. Ocular immune privilege: therapeutic opportunities from an experiment of nature. Nat Rev Immunol 2003;3:878–889.
  • van Dooremaal JC. Die Entwicklung der in fremden Grund versetzen lebenden Gewebe. Albrecht Von Graefes Arch Ophthalmol 1873;19:358–373.
  • Medawar PB. A second study of the behavior and fate of skin homografts in rabbits. (A report to the War Wounds Committee of the Medical Research Council). J Anat 1945;79:157–188.
  • Kaplan HJ, Streilein JW. Immune response to immunization via the anterior chamber of the eye. I. F1-lymphocyte-induced immune deviation. J Immunol 1977;118(3):809–814.
  • Wenkel HSJ. Analysis of immune deviation eleicited by antigens injected into the subretinal space. Invest Opthahalmol Vis Sci 1998;39(10):1823–1834.
  • Sonoda KH, Sakamoto T, Qiao H, The analysis of systemic tolerance elicited by antigen inoculation into the vitreous cavity: vitreous cavity-associated immune deviation. Immunology 2005;116(3):390–399.
  • Wenkel H, Streilein JW. Analysis of immune deviation elicited by antigens injected into the subretinal space. Invest Ophthalmol Vis Sci 1998;39(10):1823–1834.
  • Sugita S, Keino H, Futagami Y, B7+ iris pigment epithelial cells convert T cells into CTLA-4+, B7-expressing CD8+ regulatory T cells. Invest Ophthalmol Vis Sci 2006;47(12):5376–5384.
  • Sugita S, Futagami Y, Smith SB, Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta. Exp Eye Res 2006;83(6):1459–1471.
  • Cousins SW, McCabe MM, Danielpour D, Streilein JW. Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. Invest Ophthalmol Vis Sci 1991;32:2201–2211.
  • Taylor AW. Neuropeptides, aqueous humor, and ocular immune privilege. In: Troger J, Kieslbach G, Bechrakis N, editors. Neuropeptides in the eye. Kerala, India: Research Signpost; 2009. pp. 79–91.
  • Lin HH, Faunce DE, Stacey M, The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J Exp Med 2005;201(10):1615–1625.
  • McKnight AJ, Gordon S. The EGF-TM7 family: unusual structures at the leukocyte surface. J Leukoc Biol 1998;63(3):271–280.
  • Chen L, Yang P, Kijlstra A. Distribution, markers, and functions of retinal microglia. Ocul Immunol Inflamm 2002;10(1):27–39.
  • Morris L, Graham CF, Gordon S. Macrophages in haemopoietic and other tissues of the developing mouse detected by the monoclonal antibody F4/80. Development 1991;112(2):517–526.
  • Broderick C, Hoek RM, Forrester JV, et al. Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am J Pathol 2002;161(5):1669–1677. Epub 2002/11/05.
  • Dick AD, Carter D, Robertson M, Control of myeloid activity during retinal inflammation. J Leukoc Biol 2003;74(2):161–166. Epub 2003/07/30.
  • Chen L, Sham CW, Chan AM, Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells. Invest Ophthalmol Vis Sci 2009;50(10):4941–4948. Epub 2009/05/08.
  • Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 2010;236:219–242. Epub 2010/07/20.
  • Wenkel H, Streilein JW. Evidence that retinal pigment epithelium functions as an immune-privileged tissue. Invest Ophthalmol Vis Sci 2000;41(11):3467–3473.
  • Zamiri P, Sugita S, Streilein JW. Immunosuppressive properties of the pigmented epithelial cells and the subretinal space. Chem Immunol Allergy 2007;92:86–93. Epub 2007/02/01.
  • Ishida K, Panjwani N, Cao Z, Streilein JW. Participation of pigment epithelium in ocular immune privilege. 3. Epithelia cultured from iris, ciliary body, and retina suppress T-cell activation by partially non-overlapping mechanisms. Ocul Immunol Inflamm 2003;11(2):91–105.
  • Sugita S, Usui Y, Horie S, T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions. Invest Ophthalmol Vis Sci 2009;50(6):2862–2870. Epub 2009/02/03.
  • Sugita S. Role of ocular pigment epithelial cells in immune privilege. Arch Immunol Ther Exp (Warsz) 2009;57(4):263–268. Epub 2009/07/02.
  • Usui Y, Okunuki Y, Hattori T, Functional expression of B7H1 on retinal pigment epithelial cells. Exp Eye Res 2008;86(1):52–59. Epub 2007/11/06.
  • Sugita S, Horie S, Nakamura O, Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells. J Immunol 2008;181(11):7525–7536.
  • Willermain F, Caspers-Velu L, Nowak B, Retinal pigment epithelial cells phagocytosis of T lymphocytes: possible implication in the immune privilege of the eye. Br J Ophthalmol 2002;86(12):1417–1421. Epub 2002/11/26.
  • Chen L, Pai V, Levinson R, Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis. Ocul Immunol Inflamm 2009;17(1):47–55. Epub 2009/03/19.
  • Kaplan HJ, Leibole MA, Tezel T, Ferguson TA. Fas ligand (CD95 ligand) controls angiogenesis beneath the retina. Nat Med 1999;5(3):292–297. Epub 1999/03/23.
  • Wahlsten JL, Gitchell HL, Chan CC, et al. Fas and Fas ligand expressed on cells of the immune system, not on the target tissue, control induction of experimental autoimmune uveitis. J Immunol 2000;165(10):5480–5486. Epub 2000/11/09.
  • Granstein RD, Staszewski R, Knisely TL, Aqueous humor contains transforming growth factor-β and a small (<3500 daltons) inhibitor of thymocyte proliferation. J Immunol 1990;144(10):3021–3027.
  • Streilein JW, Cousins SW. Aqueous humor factors and their effect on the immune response in the anterior chamber. Curr Eye Res 1990;9(Suppl):175–182.
  • Apte RS, Sinha D, Mayhew E, et al. Role of macrophage migration inhibitory factor in inhibiting NK cell activity and preserving immune privilege. J Immunol 1998;160(12):5693–5696.
  • Ferguson TA, Griffith TS. The role of Fas ligand and TNF-related apoptosis-inducing ligand (TRAIL) in the ocular immune response. Chem Immunol Allergy 2007;92:140–154.
  • Ferguson TA, Griffith TS. A vision of cell death: Fas ligand and immune privilege 10 years later. Immunol Rev 2006;213:228–238. Epub 2006/09/16.
  • Taylor AW. Ocular immunosuppressive microenvironment. Chem Immunol Allergy 2007;92:71–85.
  • Streilein JW, Stein-Streilein J. Does innate immune privilege exist? J Leukoc Biol 2000;67(4): 479–487.
  • Stein-Streilein J, Taylor AW. An eye's view of T regulatory cells. J Leukoc Biol 2007;81(3):593–598.
  • Streilein JW, Okamoto S, Sano Y, Taylor AW. Neural control of ocular immune privilege. Ann N Y Acad Sci 2000;917:297–306.
  • Ng TF, Kitaichi N, Taylor AW. In vitro generated autoimmune regulatory T cells enhance intravitreous allogeneic retinal graft survival. Invest Ophthalmol Vis Sci 2007;48(11):5112–5117. Epub 2007/10/27.
  • Taylor A. A review of the influence of aqueous humor on immunity. Ocul Immunol Inflamm 2003;11(4):231–241.
  • Zamiri P, Masli S, Streilein JW, Taylor AW. Pigment epithelial growth factor suppresses inflammation by modulating macrophage activation. Invest Ophthalmol Vis Sci 2006;47(9):3912–3918.
  • Streilein JW, Wilbanks GA, Taylor A, Cousins S. Eye-derived cytokines and the immunosuppressive intraocular microenvironment. Curr Eye Res 1992;11(Suppl):41–47.
  • Li MO, Wan YY, Sanjabi S, et al. Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 2006;24:99–146.
  • Kriegel MA, Li MO, Sanjabi S, et al. Transforming growth factor-beta: recent advances on its role in immune tolerance. Curr Rheumatol Rep 2006;8(2):138–144.
  • Kezuka T, Streilein JW. In vitro generation of regulatory CD8+ T cells similar to those found in mice with anterior chamber associated immune deviation. Invest Ophthalmol Vis Sci 2000;41: 1803–1811.
  • Kezuka T, Streilein JW (editors). Analysis of in vivo regulatory properties of T cells activated in vitro by TGFbeta2-treated antigen presenting cells. Invest Ophthalmol Vis Sci 2000;41(6):1410–1421.
  • Taylor AW, Streilein JW, Cousins SW. Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor. Curr Eye Res 1992;11:1199–1206.
  • Taylor AW, Kitaichi N, Taylor AW. Melanocortin 5 receptor and ocular immunity. Cell Mol Biol 2006;52:141–147.
  • Taylor AW. Ocular immune privilege. Eye 2009;23:1885–1889. Epub 2009/01/13.
  • Taylor AW, Lee DJ. The alpha-melanocyte stimulating hormone induces conversion of effector T cells into treg cells. J Transplant 2011;2011:246856. Epub 2011/09/24.
  • Luttrull JK, Dorin G. Subthreshold diode micropulse laser photocoagulation (SDM) as invisible retinal phototherapy for diabetic macular edema: a review. Curr Diabetes Rev 2012;8(4):274–284. Epub 2012/05/17.
  • Lee DJ, Taylor AW. Following EAU recovery there is an associated MC5r-dependent APC induction of regulatory immunity in the spleen. Invest Ophthalmol Vis Sci 2011;52(12):8862–8867. Epub 2011/10/13.
  • Szliter EA, Lighvani S, Barrett RP, Hazlett LD. Vasoactive intestinal peptide balances pro- and anti-inflammatory cytokines in the Pseudomonas aeruginosa-infected cornea and protects against corneal perforation. J Immunol 2007;178(2):1105–1114. Epub 2007/01/05.
  • Delgado M, Pozo D, Ganea D. The significance of vasoactive intestinal peptide in immunomodulation. Pharmacol Rev 2004;56(2):249–290.
  • Delgado M, Munoz-Elias EJ, Gomariz RP, Ganea D. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide enhance IL-10 production by murine macrophages: in vitro and in vivo studies. J Immunol 1999;162(3):1707–1716. Epub 1999/02/11.
  • Martinez C, Delgado M, Pozo D, et al. VIP and PACAP enhance IL-6 release and mRNA levels in resting peritoneal macrophages: in vitro and in vivo studies. J Neuroimmunol 1998;85(2):155–167. Epub 1998/06/18.
  • Delgado M, Munoz-Elias EJ, Gomariz RP, Ganea D. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide prevent inducible nitric oxide synthase transcription in macrophages by inhibiting NF-kappa B and IFN regulatory factor 1 activation. J Immunol 1999;162(8):4685–4696. Epub 1999/04/14.
  • Catalani E, Gangitano C, Bosco L, Casini G. Expression of the neurokinin 1 receptor in the mouse retina. Neuroscience 2004;128(3):519–530. Epub 2004/09/24.
  • Marriott I, Bost KL. Expression of authentic substance P receptors in murine and human dendritic cells. J Neuroimmunol 2001;114(1–2):131–141. Epub 2001/03/10.
  • Holzer P, Holzer-Petsche U. Tachykinins in the gut. Part II. Roles in neural excitation, secretion and inflammation. Pharmacol Ther 1997;73(3):219–263. Epub 1997/01/01.
  • Qiao H, Lucas K, Stein-Streilein J. Retinal laser burn disrupts immune privilege in the eye. Am J Pathol 2009;174(2):414–422. Epub 2009/01/17.
  • Masli S, Turpie B, Hecker KH, Streilein JW. Expression of thrombospondin in TGFbeta-treated APCs and its relevance to their immune deviation-promoting properties. J Immunol 2002;168(5):2264–2273. Epub 2002/02/23.
  • Masli S, Turpie B, Streilein JW. Thrombospondin orchestrates the tolerance-promoting properties of TGF{beta}-treated antigen-presenting cells. Int Immunol 2006;18(5):689–699.
  • Streilein JW. Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation. J Leukoc Biol 2003;74(2):179–185.
  • Streit M, Velasco P, Brown LF, Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas. Am J Pathol 1999;155(2):441–452.
  • Lawler J. The functions of thrombospondin-1 and-2. Curr Opin Cell Biol 2000;12(5):634–640. Epub 2000/09/09.
  • Sheibani N, Sorenson CM, Cornelius LA, Frazier WA. Thrombospondin-1, a natural inhibitor of angiogenesis, is present in vitreous and aqueous humor and is modulated by hyperglycemia. Biochem Biophys Res Commun 2000;267(1):257–261.
  • Hall JA, Grainger JR, Spencer SP, Belkaid Y. The role of retinoic acid in tolerance and immunity. Immunity 2011;35(1):13–22. Epub 2011/07/23.
  • Doyle JW, Dowgiert RK, Buzney SM. Retinoic acid metabolism in cultured retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 1995;36(3):708–717. Epub 1995/03/01.
  • Lee SA, Belyaeva OV, Popov IK, Kedishvili NY. Overproduction of bioactive retinoic acid in cells expressing disease-associated mutants of retinol dehydrogenase 12. J Biol Chem 2007;282(49):35621–35628. Epub 2007/10/11.
  • Zhou R, Horai R, Mattapallil MJ, Caspi RR. A new look at immune privilege of the eye: dual role for the vision-related molecule retinoic acid. J Immunol 2011;187(8):4170–4177. Epub 2011/ 09/16.
  • Mucida D, Cheroutre H. TGF beta and retinoic acid intersect in immune-regulation. Cell Adh Migr 2007;1(3):142–144. Epub 2007/07/01.
  • Kawazoe Y, Sugita S, Keino H, Retinoic acid from retinal pigment epithelium induces T regulatory cells. Exp Eye Res 2012;94(1):32–40. Epub 2011/11/26.
  • Anderson DH, Mullins RF, Hageman GS, Johnson LV. A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 2002;134(3):411–431.
  • Coleman HR, Chan CC, Ferris FL, 3rd, Chew EY. Age-related macular degeneration. Lancet 2008;372(9652):1835–1845. Epub 2008/11/26.
  • Sohn JH, Bora PS, Jha P, et al. Complement, innate immunity and ocular disease. Chem Immunol Allergy 2007;92:105–114.
  • Goslings WRO, Prodeus AP, Streilein JW, et al. A small molecular weight factor in aqueous humor acts on C1q to prevent antibody-dependent complement activation. Invest Ophthalmol Visual Sci 1998;39:989–995.
  • Chang JH, McCluskey PJ, Wakefield D. Recent advances in Toll-like receptors (TLRs) and anterior uveitis. Clin Experiment Ophthalmol 2012. Epub 2012/03/21.
  • Chang JH, McCluskey PJ, Wakefield D. Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease. Br J Ophthalmol 2006;90(1):103–108. Epub 2005/12/20.
  • Jha P, Bora PS, Sohn JH, et al. Complement system and the eye. Adv Exp Med Biol 2006;586:53–62.
  • Sohn JH, Bora PS, Suk HJ, et al. Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Nat Med 2003;9(2):206–212.
  • Copland DA, Calder CJ, Raveney BJ, Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis. Am J Pathol 2007;171(2):580–588. Epub 2007/06/30.
  • Warfvinge K, Kamme C, Englund U, Wictorin K. Retinal integration of grafts of brain-derived precursor cell lines implanted subretinally into adult, normal rats. Exp Neurol 2001;169(1):1–12. Epub 2001/04/21.
  • Robertson MJ, Erwig LP, Liversidge J, et al. Retinal microenvironment controls resident and infiltrating macrophage function during uveoretinitis. Invest Ophthalmol Vis Sci 2002;43(7):2250–2257.
  • Minas K, Liversidge J. Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Crit Rev Immunol 2006;26(3):213–230. Epub 2006/08/25.
  • Chacko DM, Rogers JA, Turner JE, Ahmad I. Survival and differentiation of cultured retinal progenitors transplanted in the subretinal space of the rat. Biochem Biophys Res Commun 2000;268(3):842–846. Epub 2000/02/19.
  • Kiilgaard JF, Scherfig E, Prause JU, la Cour M. Transplantation of amniotic membrane to the subretinal space in pigs. Stem Cells Int 2012;2012:716968. Epub 2012/05/03.
  • Young MJ, Ray J, Whiteley SJ, et al. Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats. Mol Cell Neurosci 2000;16(3):197–205. Epub 2000/09/21.
  • Takahashi M, Palmer TD, Takahashi J, Gage FH. Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. Mol Cell Neurosci 1998;12(6):340–348. Epub 1999/01/16.
  • Jiang LQ, Jorquera M, Streilein JW, Ishioka M. Unconventional rejection of neural retinal allografts implanted into the immunologically privileged site of the eye. Transplantation 1995;59(8):1201–1207. Epub 1995/04/27.
  • Jiang LQ, Jorquera M, Streilein JW. Immunologic consequences of intraocular implantation of retinal pigment epithelial allografts. Exp Eye Res 1994;58(6):719–728. Epub 1994/06/01.
  • Taylor AW, Yee DG, Nishida T, Namba K. Neuropeptide regulation of immunity. The immunosuppressive activity of alpha-melanocyte-stimulating hormone (alpha-MSH). Ann N Y Acad Sci 2000;917:239–247. Epub 2001/03/28.
  • Green DR, Ferguson T, Zitvogel L, Kroemer G. Immunogenic and tolerogenic cell death. Nat Rev Immunol 2009;9(5):353–363. Epub 2009/04/15.
  • Green DR. Apoptotic pathways: ten minutes to dead. Cell 2005;121(5):671–674. Epub 2005/06/07.
  • Sugita S, Usui Y, Horie S, Human corneal endothelial cells expressing programmed death-ligand 1 (PD-L1) suppress PD-1+ T helper 1 cells by a contact-dependent mechanism. Invest Ophthalmol Vis Sci 2009;50(1):263–272. Epub 2008/09/09.
  • Hori J, Wang M, Miyashita M, B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts. J Immunol 2006;177(9):5928–5935.
  • El Annan J, Goyal S, Zhang Q, et al. Programmed death-ligand 1 (PD-L1) regulates T cell chemotaxis in dry eye-associated corneal inflammation. Invest Ophthalmol Vis Sci 2010;51(7):3418–3423. Epub 2009/12/19.
  • Griffith TS, Yu X, Herndon JM, et al. CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity 1996;5(1):7–16. Epub 1996/07/01.
  • Müller G, Müller A, Tüting T, Interleukin-10-treated dendritic cells modulate immune responses of naive and sensitized T cells in vivo. J Invest Dermatol 2002;119:836–841.
  • Ferguson TA, Choi J, Green DR. Armed response: how dying cells influence T-cell functions. Immunol Rev 2011;241(1):77–88. Epub 2011/04/15.
  • Medawar PB. Immunity to homologous grafted skin. The fate of skin homografts transplanted to the brain, to subcutaneous tissue and to the anterior chamber of the eye. Br J Exp Pathol 1948;29(1):58–69.
  • Kelly TL, Williams KA, Coster DJ. Corneal transplantation for keratoconus: a registry study. Arch Ophthalmol 2011;129(6):691–697. Epub 2011/02/16.
  • Jiang LQ, Jorquera M, Streilein JW. Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts. Invest Ophthalmol Vis Sci 1993;34(12):3347–3354. Epub 1993/ 11/01.
  • Jiang LQ, Jorquera M, Streilein JW. Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts. Invest Ophthalmol Vis Sci 1993;34:3347–3354.
  • Jiang LQ, Streilein JW. Immune privilege extended to allogeneic tumor cells in the vitreous cavity. Invest Ophthalmol Vis Sci 1991;32:224–228.
  • Jiang LQ, Streilein JW, McKinney C. Immune privilege in the eye: an evolutionary adaptation. Dev Comp Immunol 1994;18(5):421–431. Epub 1994/09/01.
  • Klassen H, Kiilgaard JF, Warfvinge K, Photoreceptor differentiation following transplantation of allogeneic retinal progenitor cells to the dystrophic rhodopsin Pro347Leu transgenic pig. Stem Cells Int 2012;2012:939801. Epub 2012/05/09.
  • Klassen H, Ziaeian B, Kirov II, et al. Isolation of retinal progenitor cells from post-mortem human tissue and comparison with autologous brain progenitors. J Neurosci Res 2004;77(3):334–343. Epub 2004/07/13.
  • Klassen HJ, Ng TF, Kurimoto Y, Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior. Invest Ophthalmol Vis Sci 2004;45(11):4167–4173. Epub 2004/10/27.
  • Ohta K, Wiggert B, Taylor AW, Streilein JW. Effects of experimental ocular inflammation on ocular immune privilege. Invest Ophthalmol Vis Sci 1999;40(9):2010–2018.
  • Mo JS, Streilein JW. Immune privilege persists in eyes with extreme inflammation induced by intravitreal LPS. Eur J Immunol 2001;31(12):3806–3815.
  • Lucas K, Karamichos D, Mathew R, et al. Retinal laser burn-induced neuropathy leads to substance p-dependent loss of ocular immune privilege. J Immunol 2012;189(3):1237–1242. Epub 2012/06/30.
  • Ferguson TA, Fletcher S, Herndon J, Griffith TS. Neuropeptides modulate immune deviation induced via the anterior chamber of the eye. J Immunol 1995;155:1746–1756.
  • Grossniklaus HE, Kang SJ, Berglin L. Animal models of choroidal and retinal neovascularization. Prog Retin Eye Res 2010;29(6):500–519. Epub 2010/05/22.
  • Grossniklaus HE, Green WR. Choroidal neovascularization. Am J Ophthalmol 2004;137(3):496–503. Epub 2004/03/12.
  • Hageman GS, Luthert PJ, Victor Chong NH, et al. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res 2001;20(6):705–732. Epub 2001/10/06.
  • Mullins RF, Russell SR, Anderson DH, Hageman GS. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J: official publication of the Federation of American Societies for Experimental Biology 2000;14(7):835–846. Epub 2000/04/27.
  • Penfold PL, Madigan MC, Gillies MC, Provis JM. Immunological and aetiological aspects of macular degeneration. Prog Retin Eye Res 2001;20(3):385–414. Epub 2001/04/05.
  • Ueta M, Hamuro J, Kiyono H, Kinoshita S. Triggering of TLR3 by poly I: C in human corneal epithelial cells to induce inflammatory cytokines. Biochem Biophys Res Commun 2005;331(1):285–294.
  • Ueta M, Nochi T, Jang MH, Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J Immunol 2004;173(5):3337–3347. Epub 2004/08/24.
  • Zhang J, Xu K, Ambati B, Yu FS. Toll-like receptor 5-mediated corneal epithelial inflammatory responses to Pseudomonas aeruginosa flagellin. Invest Ophthalmol Vis Sci 2003;44(10):4247–4254. Epub 2003/09/26.
  • Song PI, Abraham TA, Park Y, The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cells. Invest Ophthalmol Vis Sci 2001;42(12):2867–2877. Epub 2001/11/01.
  • Kumar A, Zhang J, Yu FS. Innate immune response of corneal epithelial cells to Staphylococcus aureus infection: role of peptidoglycan in stimulating proinflammatory cytokine secretion. Invest Ophthalmol Vis Sci 2004;45(10):3513–3522. Epub 2004/09/29.
  • Kumagai N, Fukuda K, Fujitsu Y, et al. Lipopolysaccharide-induced expression of intercellular adhesion molecule-1 and chemokines in cultured human corneal fibroblasts. Invest Ophthalmol Vis Sci 2005;46(1):114–1120. Epub 2004/12/30.
  • Chang JH, McCluskey P, Wakefield D. Expression of toll-like receptor 4 and its associated lipopolysaccharide receptor complex by resident antigen-presenting cells in the human uvea. Invest Ophthalmol Vis Sci 2004;45(6):1871–1878.
  • Brito BE, Zamora DO, Bonnah RA, et al. Toll-like receptor 4 and CD14 expression in human ciliary body and TLR-4 in human iris endothelial cells. Exp Eye Res 2004;79(2):203–208. Epub 2004/08/25.
  • Kumar MV, Nagineni CN, Chin MS, et al. Innate immunity in the retina: toll-like receptor (TLR) signaling in human retinal pigment epithelial cells. J Neuroimmunol 2004;153(1–2):7–15. Epub 2004/07/22.
  • Kindzelskii AL, Elner VM, Elner SG, et al. Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments. J Gen Physiol 2004;124(2):139–149. Epub 2004/07/28.

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