The Immunological Basis of Degenerative Diseases of the Eye

REFERENCES

• Group A-REDSR. Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: age-related eye disease study report number 3. Ophthalmology. 2000;107:2224–2232.
   PubMed Web of Science ®Google Scholar
• Bressler NM, Silva JC, Bressler SB, et al. Clinicopathologic correlation of drusen and retinal pigment epithelial abnormalities in age-related macular degeneration. Retina. 1994;14:130–142.
   PubMed Web of Science ®Google Scholar
• Ferris FL, 3rd, Fine SL, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol. 1984;102:1640–1642.
   PubMed Web of Science ®Google Scholar
• Nussenblatt RB, Liu B, Li Z. Age-related macular degeneration: an immunologically driven disease. Curr Opin Investig Drugs. 2009;10:434–442.
   PubMedGoogle Scholar
• Patel M, Chan CC. Immunopathological aspects of age-related macular degeneration. Semin Immunopathol. 2008;30:97–110.
   PubMed Web of Science ®Google Scholar
• Sarks JP, Sarks SH, Killingsworth MC. Evolution of soft drusen in age-related macular degeneration. Eye (Lond). 1994;8 (Pt 3):269–283.
   PubMedGoogle Scholar
• Sarks SH, Arnold JJ, Killingsworth MC, Sarks JP. Early drusen formation in the normal and aging eye and their relation to age related maculopathy: a clinicopathological study. Br J Ophthalmol. 1999;83:358–368.
   PubMed Web of Science ®Google Scholar
• Hageman GS, Luthert PJ, Victor Chong NH, An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res. 2001;20:705–732.
   PubMed Web of Science ®Google Scholar
• Johnson LV, Ozaki S, Staples MK, A potential role for immune complex pathogenesis in drusen formation. Exp Eye Res. 2000;70:441–449.
   PubMed Web of Science ®Google Scholar
• Dastgheib K, Green WR. Granulomatous reaction to Bruch's membrane in age-related macular degeneration. Arch Ophthalmol. 1994;112:813–818.
   PubMedGoogle Scholar
• Grossniklaus HE, Ling JX, Wallace TM, Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization. Mol Vis. 2002;8:119–126.
   PubMed Web of Science ®Google Scholar
• Lopez PF, Grossniklaus HE, Lambert HM, Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration. Am J Ophthalmol. 1991;112:647–656.
   PubMed Web of Science ®Google Scholar
• Penfold PL, Madigan MC, Gillies MC, Provis JM. Immunological and aetiological aspects of macular degeneration. Prog Retin Eye Res. 2001;20:385–414.
   PubMed Web of Science ®Google Scholar
• Cherepanoff S, McMenamin P, Gillies MC, Kettle E, Sarks SH. Bruch's membrane and choroidal macrophages in early and advanced age-related macular degeneration. Br J Ophthalmol. 2010;94:918–925.
   PubMed Web of Science ®Google Scholar
• Grossniklaus HE, Cingle KA, Yoon YD, Correlation of histologic 2-dimensional reconstruction and confocal scanning laser microscopic imaging of choroidal neovascularization in eyes with age-related maculopathy. Arch Ophthalmol. 2000;118:625–629.
   PubMedGoogle Scholar
• Skeie JM, Mullins RF. Macrophages in neovascular age-related macular degeneration: friends or foes? Eye (Lond). 2009;23:747–755.
   PubMed Web of Science ®Google Scholar
• Grossniklaus HE, Miskala PH, Green WR, Histopathologic and ultrastructural features of surgically excised subfoveal choroidal neovascular lesions: submacular surgery trials report no. 7. Arch Ophthalmol. 2005;123:914–921.
   PubMedGoogle Scholar
• Ambati J, Anand A, Fernandez S, An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med. 2003;9:1390–1397.
   PubMed Web of Science ®Google Scholar
• Cao X, Shen D, Patel MM, Macrophage polarization in the maculae of age-related macular degeneration: a pilot study. Pathol Int. 2011;61:528–535.
   PubMed Web of Science ®Google Scholar
• Kaneko H, Dridi S, Tarallo V, DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011;471:325–330.
   PubMed Web of Science ®Google Scholar
• Tarallo V, Hirano Y, Gelfand BD, DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell. 2012;149:847–859.
   PubMed Web of Science ®Google Scholar
• Doyle SL, Campbell M, Ozaki E, NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat Med. 2012;18:791–798.
   PubMed Web of Science ®Google Scholar
• Scholl HP, Charbel Issa P, Walier M, Systemic complement activation in age-related macular degeneration. PLoS One. 2008;3:e2593.
   PubMed Web of Science ®Google Scholar
• Nitsch D, Douglas I, Smeeth L, Fletcher A. Age-related macular degeneration and complement activation-related diseases: a population-based case-control study. Ophthalmology. 2008;115:1904–1910.
   PubMed Web of Science ®Google Scholar
• Reynolds R, Hartnett ME, Atkinson JP, et al. Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Invest Ophthalmol Vis Sci. 2009;50:5818–5827.
   PubMed Web of Science ®Google Scholar
• Penfold PL, Provis JM, Furby JH, et al. Autoantibodies to retinal astrocytes associated with age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 1990;228:270–274.
   PubMed Web of Science ®Google Scholar
• Patel N, Ohbayashi M, Nugent AK, Circulating anti-retinal antibodies as immune markers in age-related macular degeneration. Immunology. 2005;115:422–430.
   PubMedGoogle Scholar
• Gu J, Pauer GJ, Yue X, Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers. Mol Cell Proteomics. 2009;8:1338–1349.
   PubMed Web of Science ®Google Scholar
• Hollyfield JG, Bonilha VL, Rayborn ME, Oxidative damage-induced inflammation initiates age-related macular degeneration. Nat Med. 2008;14:194–198.
   PubMed Web of Science ®Google Scholar
• Swaroop A, Chew EY, Rickman CB, Abecasis GR. Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. Annu Rev Genomics Hum Genet. 2009;10:19–43.
   PubMed Web of Science ®Google Scholar
• Edwards AO, Ritter R, 3rd, Abel KJ, Complement factor H polymorphism and age-related macular degeneration. Science. 2005;308:421–424.
   PubMed Web of Science ®Google Scholar
• Haines JL, Hauser MA, Schmidt S, Complement factor H variant increases the risk of age-related macular degeneration. Science. 2005;308:419–421.
   PubMed Web of Science ®Google Scholar
• Klein RJ, Zeiss C, Chew EY, Complement factor H polymorphism in age-related macular degeneration. Science. 2005;308:385–389.
   PubMed Web of Science ®Google Scholar
• Hageman GS, Anderson DH, Johnson LV, A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA. 2005;102:7227–7232.
   PubMed Web of Science ®Google Scholar
• Maller J, George S, Purcell S, Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat Genet. 2006;38:1055–1059.
   PubMed Web of Science ®Google Scholar
• Gold B, Merriam JE, Zernant J, Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet. 2006;38:458–462.
   PubMed Web of Science ®Google Scholar
• Yates JR, Sepp T, Matharu BK, Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med. 2007;357:553–561.
   PubMed Web of Science ®Google Scholar
• Fagerness JA, Maller JB, Neale BM, et al. Variation near complement factor I is associated with risk of advanced AMD. Eur J Hum Genet. 2009;17:100–104.
   PubMed Web of Science ®Google Scholar
• Dewan A, Liu M, Hartman S, HTRA1 promoter polymorphism in wet age-related macular degeneration. Science. 2006;314:989–992.
   PubMed Web of Science ®Google Scholar
• Yang Z, Camp NJ, Sun H, A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science. 2006;314:992–993.
   PubMed Web of Science ®Google Scholar
• Fritsche LG, Loenhardt T, Janssen A, Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA. Nat Genet. 2008;40:892–896.
   PubMed Web of Science ®Google Scholar
• Kanda A, Chen W, Othman M, A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci USA. 2007;104:16227–16232.
   PubMed Web of Science ®Google Scholar
• Jakobsdottir J, Conley YP, Weeks DE,et al. Susceptibility genes for age-related maculopathy on chromosome 10q26. Am J Hum Genet. 2005;77:389–407.
   PubMed Web of Science ®Google Scholar
• Rivera A, Fisher SA, Fritsche LG, Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. Hum Mol Genet. 2005;14:3227–3236.
   PubMed Web of Science ®Google Scholar
• Klaver CC, Kliffen M, van Duijn CM, Genetic association of apolipoprotein E with age-related macular degeneration. Am J Hum Genet. 1998;63:200–206.
   PubMed Web of Science ®Google Scholar
• Baird PN, Richardson AJ, Robman LD, Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD). Hum Mutat. 2006;27:337–342.
   PubMed Web of Science ®Google Scholar
• Chen W, Stambolian D, Edwards AO, Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci USA. 2010;107:7401–7406.
   PubMed Web of Science ®Google Scholar
• Goverdhan SV, Howell MW, Mullins RF, Association of HLA class I and class II polymorphisms with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2005;46:1726–1734.
   PubMedGoogle Scholar
• Goverdhan SV, Ennis S, Hannan SR, Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration. Br J Ophthalmol. 2008;92:537–540.
   PubMed Web of Science ®Google Scholar
• Combadiere C, Feumi C, Raoul W, CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Invest. 2007;117:2920–2928.
   PubMed Web of Science ®Google Scholar
• Yang Z, Stratton C, Francis PJ, Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med. 2008;359:1456–163.
   PubMed Web of Science ®Google Scholar
• Zareparsi S, Buraczynska M, Branham KE, Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. Hum Mol Genet. 2005;14:1449–1455.
   PubMed Web of Science ®Google Scholar
• Yu Y, Bhangale TR, Fagerness J, Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet. 2011;20:3699–3709.
   PubMed Web of Science ®Google Scholar
• Arakawa S, Takahashi A, Ashikawa K, Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population. Nat Genet. 2011;43:1001–1004.
   PubMedGoogle Scholar
• Tuo J, Ning B, Bojanowski CM, Synergic effect of polymorphisms in ERCC6 5’ flanking region and complement factor H on age-related macular degeneration predisposition. Proc Natl Acad Sci USA. 2006;103:9256–9261.
   PubMed Web of Science ®Google Scholar
• Neale BM, Fagerness J, Reynolds R, Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci USA. 2010;107:7395–7400.
   PubMed Web of Science ®Google Scholar
• Seddon JM, Cote J, Page WF, The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences. Arch Ophthalmol. 2005;123:321–327.
   PubMed Web of Science ®Google Scholar
• de Jong PT. Age-related macular degeneration. N Engl J Med. 2006;355:1474–1485.
   PubMed Web of Science ®Google Scholar
• Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells. Annu Rev Immunol. 2009;27:485–517.
   PubMed Web of Science ®Google Scholar
• Liu B, Wei L, Meyerle C, Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration. J Transl Med. 2011;9:1–12.
   PubMed Web of Science ®Google Scholar
• Weinstein JM, Kelman SE, Bresnick GH, Kornguth SE. Paraneoplastic retinopathy associated with antiretinal bipolar cell antibodies in cutaneous malignant melanoma. Ophthalmology. 1994;101:1236–1243.
   PubMedGoogle Scholar
• Jacobson DM, Thirkill CE, Tipping SJ. A clinical triad to diagnose paraneoplastic retinopathy. Ann Neurol. 1990;28:162–167.
   PubMed Web of Science ®Google Scholar
• Sawyer RA, Selhorst JB, Zimmerman LE, Hoyt WF. Blindness caused by photoreceptor degeneration as a remote effect of cancer. Am J Ophthalmol. 1976;81:606–613.
   PubMed Web of Science ®Google Scholar
• Klingele TG, Burde RM, Rappazzo JA, et al. Paraneoplastic retinopathy. J Clin Neuroophthalmol. 1984;4:239–245.
   PubMedGoogle Scholar
• Jacobson DMMN, Newman NJ. Paraneoplastic diseases of neuro-ophthalmologic interest. In: Jacobson DM MN, Newman NJ, editors. Walsh & Hoyt's clinical neuro-ophthalmology. 5th ed. Baltimore, MD: Williams & Wilkins; 2008. pp 2497–551.
   Google Scholar
• Thirkill CE, Roth AM, Keltner JL. Cancer-associated retinopathy. Arch Ophthalmol. 1987;105:372–375.
   PubMedGoogle Scholar
• Keltner JL, Thirkill CE. Cancer-associated retinopathy vs recoverin-associated retinopathy. Am J Ophthalmol. 1998;126:296–302.
   PubMed Web of Science ®Google Scholar
• Vaphiades MS, Brown H, Whitcup SM. Node way out. Surv Ophthalmol. 2000;45:77–83.
   PubMedGoogle Scholar
• Potter MJ, Thirkill CE, Dam OM, et al. Clinical and immunocytochemical findings in a case of melanoma-associated retinopathy. Ophthalmology. 1999;106:2121–2125.
   PubMedGoogle Scholar
• Mizener JB, Kimura AE, Adamus G, Autoimmune retinopathy in the absence of cancer. Am J Ophthalmol. 1997;123:607–618.
   PubMed Web of Science ®Google Scholar
• Ferreyra HA, Jayasundera T, Khan NW, Management of autoimmune retinopathies with immunosuppression. Arch Ophthalmol. 2009;127:390–397.
   PubMed Web of Science ®Google Scholar
• Larson TA, Gottlieb GC, Zein WM, Autoimmune retinopathy: prognosis and treatment. In: Invest Ophthalmol Vis Sci. 2010: E-Abstract 6375.
   Google Scholar
• Chan JW. Paraneoplastic retinopathies and optic neuropathies. Surv Ophthalmol. 2003;48:12–38.
   PubMed Web of Science ®Google Scholar
• Adamus G. Autoantibody-induced apoptosis as a possible mechanism of autoimmune retinopathy. Autoimmun Rev. 2003;2:63–68.
   PubMed Web of Science ®Google Scholar
• Weleber RG, Watzke RC, Shults WT, Clinical and electrophysiologic characterization of paraneoplastic and autoimmune retinopathies associated with antienolase antibodies. Am J Ophthalmol. 2005;139:780–794.
   PubMed Web of Science ®Google Scholar
• Polans AS, Witkowska D, Haley TL, Recoverin, a photoreceptor-specific calcium-binding protein, is expressed by the tumor of a patient with cancer-associated retinopathy. Proc Natl Acad Sci USA. 1995;92:9176–9180.
   PubMed Web of Science ®Google Scholar
• Matsubara S, Yamaji Y, Sato M, Fujita J, Takahara J. Expression of a photoreceptor protein, recoverin, as a cancer-associated retinopathy autoantigen in human lung cancer cell lines. Br J Cancer. 1996;74:1419–1422.
   PubMedGoogle Scholar
• Forooghian F, Macdonald IM, Heckenlively JR, The need for standardization of antiretinal antibody detection and measurement. Am J Ophthalmol. 2008;146:489–495.
   PubMed Web of Science ®Google Scholar
• Kondo M, Sanuki R, Ueno S, Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction. PLoS One. 2011;6:e19911.
   PubMed Web of Science ®Google Scholar
• Thirkill CE, Tait RC, Tyler NK, Intraperitoneal cultivation of small-cell carcinoma induces expression of the retinal cancer-associated retinopathy antigen. Arch Ophthalmol. 1993;111:974–978.
   PubMedGoogle Scholar
• Williams RC, Jr., Peen E. Apoptosis and cell penetration by autoantibody may represent linked processes. Clin Exp Rheumatol. 1999;17:643–647.
   PubMedGoogle Scholar
• Adamus G, Webb S, Shiraga S, Duvoisin RM. Anti-recoverin antibodies induce an increase in intracellular calcium, leading to apoptosis in retinal cells. J Autoimmun. 2006;26:146–153.
   PubMed Web of Science ®Google Scholar
• Adamus G, Machnicki M, Elerding H, Antibodies to recoverin induce apoptosis of photoreceptor and bipolar cells in vivo. J Autoimmun. 1998;11:523–533.
   PubMed Web of Science ®Google Scholar
• Ohguro H, Ogawa K, Nakagawa T. Recoverin and Hsc 70 are found as autoantigens in patients with cancer-associated retinopathy. Invest Ophthalmol Vis Sci. 1999;40:82–89.
   PubMed Web of Science ®Google Scholar
• Whitcup SM, Vistica BP, Milam AH, Recoverin-associated retinopathy: a clinically and immunologically distinctive disease. Am J Ophthalmol. 1998;126:230–237.
   PubMed Web of Science ®Google Scholar
• Heckenlively JR, Fawzi AA, Oversier J, Autoimmune retinopathy: patients with antirecoverin immunoreactivity and panretinal degeneration. Arch Ophthalmol. 2000;118:1525–1533.
   PubMedGoogle Scholar
• Bazhin AV, Shifrina ON, Savchenko MS, Low titre autoantibodies against recoverin in sera of patients with small cell lung cancer but without a loss of vision. Lung Cancer. 2001;34:99–104.
   PubMed Web of Science ®Google Scholar
• Lei B, Bush RA, Milam AH, Sieving PA. Human melanoma-associated retinopathy (MAR) antibodies alter the retinal ON-response of the monkey ERG in vivo. Invest Ophthalmol Vis Sci. 2000;41:262–266.
   PubMed Web of Science ®Google Scholar
• Dhingra A, Fina ME, Neinstein A, Autoantibodies in melanoma-associated retinopathy target TRPM1 cation channels of retinal ON bipolar cells. J Neurosci. 2011;31:3962–3967.
   PubMed Web of Science ®Google Scholar
• Heckenlively JR, Ferreyra HA. Autoimmune retinopathy: a review and summary. Semin Immunopathol. 2008;30:127–134.
   PubMed Web of Science ®Google Scholar
• Adamus G, Ren G, Weleber RG. Autoantibodies against retinal proteins in paraneoplastic and autoimmune retinopathy. BMC Ophthalmol. 2004;4:5.
   PubMedGoogle Scholar
• Shin SJ, Kim BC, Kim TI, Anti-alpha-enolase antibody as a serologic marker and its correlation with disease severity in intestinal Behcet's disease. Dig Dis Sci. 2011;56:812–818.
   PubMedGoogle Scholar
• Adamus G, Chan CC. Experimental autoimmune uveitides: multiple antigens, diverse diseases. Int Rev Immunol. 2002;21:209–229.
   PubMedGoogle Scholar
• Heckenlively JR, Aptsiauri N, Nusinowitz S, Investigations of antiretinal antibodies in pigmentary retinopathy and other retinal degenerations. Trans Am Ophthalmol Soc. 1996;94:179–200; discussion -6.
   PubMedGoogle Scholar
• Guy J, Aptsiauri N. Treatment of paraneoplastic visual loss with intravenous immunoglobulin: report of 3 cases. Arch Ophthalmol. 1999;117:471–477.
   PubMed Web of Science ®Google Scholar
• Tezel G, Hernandez MR, Wax MB. In vitro evaluation of reactive astrocyte migration, a component of tissue remodeling in glaucomatous optic nerve head. Glia. 2001;34:178–189.
   PubMedGoogle Scholar
• Tezel G, Edward DP, Wax MB. Serum autoantibodies to optic nerve head glycosaminoglycans in patients with glaucoma. Arch Ophthalmol. 1999;117:917–924.
   PubMed Web of Science ®Google Scholar
• Adamis AP, Berman AJ. Immunological mechanisms in the pathogenesis of diabetic retinopathy. Semin Immunopathol. 2008;30:65–84.
   PubMed Web of Science ®Google Scholar
• Tezel G, Kolker AE, Kass MA, Wax MB. Comparative results of combined procedures for glaucoma and cataract: II. Limbus-based versus fornix-based conjunctival flaps. Ophthalmic Surg Lasers. 1997;28:551–557.
   PubMedGoogle Scholar
• Tezel G, Kass MA, Kolker AE, Wax MB. Comparative optic disc analysis in normal pressure glaucoma, primary open-angle glaucoma, and ocular hypertension. Ophthalmology. 1996;103:2105–2113.
   PubMed Web of Science ®Google Scholar
• Funatsu H, Yamashita H, Noma H, Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients. Graefes Arch Clin Exp Ophthalmol. 2005;243:3–8.
   PubMed Web of Science ®Google Scholar
• Leibovitch I, Loewenstein A, Alster Y, Interferon alpha-2a for proliferative diabetic retinopathy after complete laser panretinal photocoagulation treatment. Ophthalmic Surg Lasers Imaging. 2004;35:16–22.
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Nakazawa M, Suzuki K, Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion. Jpn J Ophthalmol. 2011;55: 256–263.
   PubMed Web of Science ®Google Scholar
• Abu El-Asrar AM, Missotten L, Geboes K. Expression of advanced glycation end products and related molecules in diabetic fibrovascular epiretinal membranes. Clin Experiment Ophthalmol. 2010;38:57–64; quiz 87.
   PubMedGoogle Scholar
• Sainson RC, Johnston DA, Chu HC, TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. Blood. 2008;111:4997–5007.
   PubMedGoogle Scholar
• Baudouin C, Fredj-Reygrobellet D, Brignole F, MHC class II antigen expression by ocular cells in proliferative diabetic retinopathy. Fundam Clin Pharmacol. 1993;7:523–530.
   PubMedGoogle Scholar
• McLeod DS, Lefer DJ, Merges C, Lutty GA. Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. Am J Pathol. 1995;147:642–653.
   PubMed Web of Science ®Google Scholar
• Long SA, Rieck M, Sanda S, Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs beta-Cell Function. Diabetes. 2012;61:2340–2348.
   PubMed Web of Science ®Google Scholar
• Wax MB, Tezel G, Yang J, Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J Neurosci. 2008;28:12085–12096.
   PubMed Web of Science ®Google Scholar
• Howell GR, Soto I, Zhu X, Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma. J Clin Invest. 2012;122:1246–1261.
   PubMed Web of Science ®Google Scholar
• Cartwright MJ, Grajewski AL, Friedberg ML, Immune-related disease and normal-tension glaucoma. A case-control study. Arch Ophthalmol. 1992;110:500–502.
   PubMedGoogle Scholar
• Wax MB, Tezel G, Saito I, Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma. Am J Ophthalmol. 1998;125:145–157.
   PubMed Web of Science ®Google Scholar
• Tezel G, Hernandez R, Wax MB. Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes. Arch Ophthalmol. 2000;118:511–518.
   PubMedGoogle Scholar
• Grus F, Sun D. Immunological mechanisms in glaucoma. Semin Immunopathol. 2008;30:121–126.
   PubMedGoogle Scholar
• Grus FH, Joachim SC, Wuenschig D, Autoimmunity and glaucoma. J Glaucoma. 2008;17:79–84.
   PubMed Web of Science ®Google Scholar
• Schwartz M. Lessons for glaucoma from other neurodegenerative diseases: can one treatment suit them all? J Glaucoma. 2005;14:321–323.
   PubMed Web of Science ®Google Scholar
• Schwartz M. Modulating the immune system: a vaccine for glaucoma? Can J Ophthalmol. 2007;42:439–441.
   PubMed Web of Science ®Google Scholar
• Schwartz M, London A. Glaucoma as a neuropathy amenable to neuroprotection and immune manipulation. Prog Brain Res. 2008;173:375–384.
   PubMed Web of Science ®Google Scholar
• Bakalash S, Kessler A, Mizrahi T, Antigenic specificity of immunoprotective therapeutic vaccination for glaucoma. Invest Ophthalmol Vis Sci. 2003;44:3374–3381.
   PubMed Web of Science ®Google Scholar
• Bakalash S, Shlomo GB, Aloni E, T-cell-based vaccination for morphological and functional neuroprotection in a rat model of chronically elevated intraocular pressure. J Mol Med. 2005;83:904–916.
   PubMed Web of Science ®Google Scholar
• Karlstetter M, Ebert S, Langmann T. Microglia in the healthy and degenerating retina: insights from novel mouse models. Immunobiology. 2010;215:685–691.
   PubMed Web of Science ®Google Scholar
• Gehrig A, Langmann T, Horling F, Genome-wide expression profiling of the retinoschisin-deficient retina in early postnatal mouse development. Invest Ophthalmol Vis Sci. 2007;48:891–900.
   PubMedGoogle Scholar
• Sasahara M, Otani A, Oishi A, Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration. Am J Pathol. 2008;172:1693–1703.
   PubMed Web of Science ®Google Scholar
• Tamm SA, Whitcup SM, Gery I, Immune response to retinal antigens in patients with gyrate atrophy and other hereditary retinal dystrophies. Ocul Immunol Inflamm. 2001;9:75–84.
   PubMed Web of Science ®Google Scholar
• Newsome DA, Nussenblatt RB. Retinal S antigen reactivity in patients with retinitis pigmentosa and Usher's syndrome. Retina. 1984;4:195–199.
   PubMed Web of Science ®Google Scholar
• Strunnikova NV, Barb J, Sergeev YV, Loss-of-function mutations in Rab escort protein 1 (REP-1) affect intracellular transport in fibroblasts and monocytes of choroideremia patients. PLoS One. 2009;4:e8402.
   PubMed Web of Science ®Google Scholar