1,412
Views
58
CrossRef citations to date
0
Altmetric
Research Article

Uveitis in Mouse and Man

, MD, , MSc, , MD & , MD, PhD
Pages 76-96 | Accepted 31 Oct 2012, Published online: 29 Jan 2013

REFERENCES

  • Suttorp-Schulten MS, Rothova A. The possible impact of uveitis in blindness: a literature survey. Br J Ophthalmol 1996;80:844–848.
  • Forrester JV, Dick AD, Mcmenamin PG, Roberts F. The eye: basic science in practice. Edinburgh: Saunders Elsevier; 2008.
  • Xu H, Chen M, Reid DM, Forrester JV. LYVE-1-positive macrophages are present in normal murine eyes. Invest Ophthalmol Vis Sci 2007;48:2162–2171.
  • Schroedl F, Brehmer A, Neuhuber WL, The normal human choroid is endowed with a significant number of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1)-positive macrophages. Invest Ophthalmol Vis Sci 2008;49:5222–5229.
  • Yucel YH, Johnston MG, Ly T, Identification of lymphatics in the ciliary body of the human eye: a novel “uveolymphatic” outflow pathway. Exp Eye Res 2009;89:810–819.
  • Egan RM, Yorkey C, Black R, Peptide-specific T cell clonal expansion in vivo following immunization in the eye, an immune-privileged site. J Immunol 1996;157:2262–2271.
  • Camelo S, Kezic J, Shanley A, Antigen from the anterior chamber of the eye travels in a soluble form to secondary lymphoid organs via lymphatic and vascular routes. Invest Ophthalmol Vis Sci 2006;47:1039–1046.
  • Kuffova L, Netukova M, Duncan L, Cross presentation of antigen on MHC class II via the draining lymph node after corneal transplantation in mice. J Immunol 2008;180:1353–1361.
  • Tam AL, Gupta N, Zhang Z, Yucel YH. Quantum dots trace lymphatic drainage from the mouse eye. Nanotechnology 2011;22:425101.
  • Jabs DA, Nussenblatt RB, Rosenbaum JT, Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol 2005;140:509–516.
  • De Groot-Mijnes JD, De Visser L, Zuurveen S, Identification of new pathogens in the intraocular fluid of patients with uveitis. Am J Ophthalmol 2010;150:628–636.
  • Kongyai N, Sirirungsi W, Pathanapitoon K, Viral causes of unexplained anterior uveitis in Thailand. Eye (Lond) 2012;26:529–534.
  • Rothova A, Van Veenedaal WG, Linssen A, Clinical features of acute anterior uveitis. Am J Ophthalmol 1987;103:137–145.
  • Ormerod LD, Puklin JE, Giles CL. Chronic Propionibacterium acnes endophthalmitis as a cause of intermediate uveitis. Ocul Immunol Inflamm 1997;5:67–68.
  • Yasuhara T, Tada R, Nakano Y, The presence of Propionibacterium spp. in the vitreous fluid of uveitis patients with sarcoidosis. Acta Ophthalmol Scand 2005;83:364–369.
  • Liu DT, Li CL, Lee VY. The presence of Propionibacterium spp. in the vitreous fluid of uveitis patients with sarcoidosis. Acta Ophthalmol Scand 2006;84:152–153; author reply 153.
  • Ficker L, Meredith TA, Wilson LA, Chronic bacterial endophthalmitis. Am J Ophthalmol 1987;103:745–748.
  • Forrester JV, Borthwick GM. Clinical relevance of S-antigen induced experimental uveoretinitis. Trans Ophthalmol Soc UK 1983;103(Part 5):497–502.
  • Caspi RR, Chan CC, Wiggert B, Chader GJ. The mouse as a model of experimental autoimmune uveoretinitis (EAU). Curr Eye Res 1990;9(Suppl):169–174.
  • Forrester JV. Intermediate and posterior uveitis. Chem Immunol Allergy 2007;92:228–243.
  • Caspi RR, Silver PB, Luger D, Mouse models of experimental autoimmune uveitis. Ophthalmic Res 2008;40:169–174.
  • Caspi RR. Understanding autoimmune uveitis through animal models. The Friedenwald Lecture. Invest Ophthalmol Vis Sci 2011;52:1872–1879.
  • Rosenbaum JT, Rosenzweig HL, Smith JR, Uveitis secondary to bacterial products. Ophthalmic Res 2008;40:165–168.
  • Forrester JV, Worgul BV, Merriam GR, Jr. Endotoxin-induced uveitis in the rat. Albrecht Von Graefes Arch Klin Exp Ophthalmol 1980;213:221–233.
  • Kanda A, Noda K, Oike Y, Ishida S. Angiopoietin-like protein 2 mediates endotoxin-induced acute inflammation in the eye. Lab Invest 2012:92(11):1553–1563.
  • Almulki L, Noda K, Amini R, et al. Surprising up-regulation of P-selectin glycoprotein ligand-1 (PSGL-1) in endotoxin-induced uveitis. FASEB J 2009;23:929–939.
  • Wang J, Lu H, Hu X, Nuclear factor translocation and acute anterior uveitis. Mol Vis 2011a;17:170–176.
  • Rosenzweig HL, Woods A, Clowers JS, The NLRP3 inflammasome is active but not essential in endotoxin-induced uveitis. Inflamm Res 2012;61:225–231.
  • Bora NS, Kaplan HJ. Intraocular diseases –anterior uveitis. Chem Immunol Allergy 2007;92:213–220.
  • Bora NS, Woon MD, Tandhasetti MT, Induction of experimental autoimmune anterior uveitis by a self-antigen: melanin complex without adjuvant. Invest Ophthalmol Vis Sci 1997;38:2171–2175.
  • Sharp FA, Ruane D, Claass B, Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome. Proc Natl Acad Sci USA 2009;106:870–875.
  • Kerrigan AM, Brown GD. Phagocytes: fussy about carbs. Curr Biol 2011;21:R500–502.
  • Jha P, Manickam B, Matta B, Proteolytic cleavage of type I collagen generates an autoantigen in autoimmune uveitis. J Biol Chem 2009;284:31401–31411.
  • Wacker WB, Donoso LA, Kalsow CM, Experimental allergic uveitis. Isolation, characterization, and localization of a soluble uveitopathogenic antigen from bovine retina. J Immunol 1977;119:1949–1958.
  • Wacker WB, Lipton MM. Experimental allergic uveitis: homologous retina as uveitogenic antigen. Nature 1965;206:253–254.
  • Gery I, Wiggert B, Redmond TM, Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein. Invest Ophthalmol Vis Sci 1986;27:1296–1300.
  • Dua HS, Abrams M, Barrett JA, Epitopes and idiotypes in experimental autoimmune uveitis: a review. Curr Eye Res 1992;11(Suppl):59–65.
  • Forrester JV, Liversidge J, Dua HS, Experimental autoimmune uveoretinitis: a model system for immunointervention: a review. Curr Eye Res 1992;11(Suppl):33–40.
  • Yamaki K, Ohono S. Animal models of Vogt-Koyanagi-Harada disease (sympathetic ophthalmia). Ophthalmic Res 2008;40:129–135.
  • Caspi RR, Grubbs BG, Chan CC, Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model. Concomitant regulation by MHC and non-MHC genes. J Immunol 1992;148:2384–2389.
  • Sun B, Rizzo LV, Sun SH, Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response. J Immunol 1997;159:1004–1011.
  • Chen M, Copland DA, Zhao J, Persistent inflammation subverts thrombospondin-1-induced regulation of retinal angiogenesis and is driven by CCR2 ligation. Am J Pathol 2012;180:235–245.
  • Namba K, Ogasawara K, Kitaichi N, Identification of a peptide inducing experimental autoimmune uveoretinitis (EAU) in H-2Ak-carrying mice. Clin Exp Immunol 1998;111:442–449.
  • Cortes LM, Mattapallil MJ, Silver PB, Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10. RIII (H-2r) mice. Invest Ophthalmol Vis Sci 2008;49:1946–1956.
  • Pennesi G, Mattapallil MJ, Sun SH, A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice. J Clin Invest 2003;111:1171–1180.
  • Mattapallil MJ, Silver PB, Mattapallil JJ, Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells. J Immunol 2011;187:1977–1985.
  • Szpak Y, Vieville JC, Tabary T, Spontaneous retinopathy in HLA-A29 transgenic mice. Proc Natl Acad Sci USA 2001;98:2572–2576.
  • Mattapallil MJ, Wawrousek EF, Chan CC, The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci 2012;53:2921–2927.
  • Wisard J, Faulkner A, Chrenek MA, Exaggerated eye growth in IRBP-deficient mice in early development. Invest Ophthalmol Vis Sci 2011;52:5804–5811.
  • Avichezer D, Liou GI, Chan CC, et al. Interphotoreceptor retinoid-binding protein (IRBP)-deficient C57BL/6 mice have enhanced immunological and immunopathogenic responses to IRBP and an altered recognition of IRBP epitopes. J Autoimmun 2003:21:185–194.
  • Xu H, Wawrousek EF, Redmond TM, Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis. Eur J Immunol 2000;30:272–278.
  • Devoss J, Hou Y, Johannes K, Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med 2006;203:2727–2735.
  • Tykocinski LO, Sinemus A, Kyewski B. The thymus medulla slowly yields its secrets. Ann NY Acad Sci 2008;1143:105–122.
  • Taniguchi RT, Devoss JJ, Moon JJ, Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci USA 2012;109:7847–7852.
  • Gregerson DS, Dou C. Spontaneous induction of immunoregulation by an endogenous retinal antigen. Invest Ophthalmol Vis Sci 2002;43:2984–2991.
  • Lai JC, Lobanoff MC, Fukushima A, Uveitis induced by lymphocytes sensitized against a transgenically expressed lens protein. Invest Ophthalmol Vis Sci 1999;40:2735–2739.
  • Lambe T, Leung JC, Ferry H, Limited peripheral T cell anergy predisposes to retinal autoimmunity. J Immunol 2007;178:4276–4283.
  • Tan LT, Isa H, Lightman S, Rj Taylor S. Prevalence and causes of phthisis bulbi in a uveitis clinic. Acta Ophthalmol 2011;90:e417–e418.
  • Khera TK, Copland DA, Boldison J, Tumour necrosis factor-mediated macrophage activation in the target organ is critical for clinical manifestation of uveitis. Clin Exp Immunol 2012;168:165–177.
  • Wang L, Yu CR, Kim HP, Key role for IL-21 in experimental autoimmune uveitis. Proc Natl Acad Sci USA 2011b;108:9542–9547.
  • Saraswathy S, Rao NA. Photoreceptor mitochondrial oxidative stress in experimental autoimmune uveitis. Ophthalmic Res 2008;40:160–164.
  • Yu CR, Lee YS, Mahdi RM, Therapeutic targeting of STAT3 (signal transducers and activators of transcription 3) pathway inhibits experimental autoimmune uveitis. PLoS ONE 2012;7:e29742.
  • Sun M, Yang P, Du L, Contribution of CD4+CD25+ T cells to the regression phase of experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci 2010;51:383–389.
  • Zhang L, Ma J, Takeuchi M, Suppression of experimental autoimmune uveoretinitis by inducing differentiation of regulatory T cells via activation of aryl hydrocarbon receptor. Invest Ophthalmol Vis Sci 2010;51:2109–2117.
  • Tu Z, Li Y, Smith D, Myeloid suppressor cells induced by retinal pigment epithelial cells inhibit autoreactive T-cell responses that lead to experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 2012;53:959–966.
  • Kerr EC, Raveney BJ, Copland DA, Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations. J Autoimmun 2008;31:354–361.
  • Ke Y, Sun D, Jiang G, eta l. IL-22-induced regulatory CD11b+ APCs suppress experimental autoimmune uveitis. J Immunol 2011;187:2130–2139.
  • Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol 2010;28:445–489.
  • Poppensieker K, Otte DM, Schurmann B, CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells. Proc Natl Acad Sci USA 2012;109:3897–3902.
  • Nian H, Shao H, O'brien RL, Activated gamma-delta T cells promote the activation of uveitogenic T cells and exacerbate EAU development. Invest Ophthalmol Vis Sci 2011;52:5920–5927.
  • Stubiger N, Crane IJ, Kotter I, Interferon alpha 2a in IRPB-derived peptide-induced EAU–part I. Adv Exp Med Biol 2003;528:537–540.
  • Tian L, Lei B, Shao J, AAV2-mediated combined subretinal delivery of IFN-alpha and IL-4 reduces the severity of experimental autoimmune uveoretinitis. PLoS One 2012;7:e37995.
  • Caspi RR. Experimental autoimmune uveoretinitis in the rat and mouse. Curr Protoc Immunol 2003;15: Unit 15.6.
  • Imrie FR, Dick AD. Biologics in the treatment of uveitis. Curr Opin Ophthalmol 2007a;18:481–486.
  • Imrie FR, Dick AD. Nonsteroidal drugs for the treatment of noninfectious posterior and intermediate uveitis. Curr Opin Ophthalmol 2007b;18:212–219.
  • Lee RW, Greenwood R, Taylor H, A randomized trial of tacrolimus versus tacrolimus and prednisone for the maintenance of disease remission in noninfectious uveitis. Ophthalmology 2012;119:1223–1230.
  • Chi W, Zhu X, Yang P, Upregulated IL-23 and IL-17 in Behcet patients with active uveitis. Invest Ophthalmol Vis Sci 2008;49:3058–3064.
  • Li F, Yang P, Liu X, Upregulation of interleukin 21 and promotion of interleukin 17 production in chronic or recurrent Vogt-Koyanagi-Harada disease. Arch Ophthalmol 2010;128:1449–1454.
  • Yeh S, Li Z, Forooghian F, CD4+Foxp3 +T-regulatory cells in noninfectious uveitis. Arch Ophthalmol 2009;127:407–413.
  • Dick AD, Tugal-Tutkun I, Foster S, Secukinumab in the treatment of noninfectious uveitis: results of three randomized, controlled clinical trials. Ophthalmology. 2012: (in press).
  • Plskova J, Greiner K, Muckersie E, Interferon-alpha: a key factor in autoimmune disease? Invest Ophthalmol Vis Sci 2006;47:3946–3950.
  • Plskova J, Greiner K, Forrester JV. Interferon-alpha as an effective treatment for noninfectious posterior uveitis and panuveitis. Am J Ophthalmol 2007;144:55–61.
  • Liu X, Yang P, Wang C, IFN-alpha blocks IL-17 production by peripheral blood mononuclear cells in Behcet's disease. Rheumatology (Oxford) 2011;50:293–298.
  • Medzhitov R, Janeway CA, Jr. An ancient system of host defense. Curr Opin Immunol 1998;10:12–15.
  • Medzhitov R, Janeway CA, Jr. Decoding the patterns of self and nonself by the innate immune system. Science 2002;296:298–300.
  • Matzinger P. Introduction to the series. Danger model of immunity. Scand J Immunol 2001;54:2–3.
  • Szanto E, Granfors K, Wretlind B. Acute anterior uveitis, arthritides and enteric antigens. Clin Rheumatol 1991;10:395–400.
  • Galeone M, Colucci R, D'erme AM, Potential infectious etiology of behcet's disease. Patholog Res Int 2012;2012:595380.
  • Scully C, Hodgson T, Lachmann H. Auto-inflammatory syndromes and oral health. Oral Dis 2008;14:690–699.
  • Forrester JV, Stott DI, Hercus KM. Naturally occurring antibodies to bovine and human retinal S antigen: a comparison between uveitis patients and healthy volunteers. Br J Ophthalmol 1989;73:155–159.
  • Caspi RR. A look at autoimmunity and inflammation in the eye. J Clin Invest 2010;120:3073–3083.
  • De Smet MD, Taylor SR, Bodaghi B, Understanding uveitis: the impact of research on visual outcomes. Prog Retin Eye Res 2011;30:452–470.
  • Jovic NS, Nesovic M, Vranjesevic DN, The Vogt-Koyanagi-Harada syndrome: association with autoimmune polyglandular syndrome type 1. Postgrad Med J 1996;72:495–497.
  • Futagami Y, Sugita S, Fujimaki T, Bilateral anterior granulomatous keratouveitis with sunset glow fundus in a patient with autoimmune polyglandular syndrome. Ocul Immunol Inflamm 2009;17:88–90.
  • Lau AW, Biester S, Cornall RJ, Forrester JV. Lipopolysaccharide-activated IL-10-secreting dendritic cells suppress experimental autoimmune uveoretinitis by MHCII-dependent activation of CD62L-expressing regulatory T cells. J Immunol 2008;180:3889–3899.
  • Nussenblatt RB, Gery I, Weiner HL, Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial. Am J Ophthalmol 1997;123:583–592.
  • Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol 2011;30:16–34.
  • Hajishengallis G, Lambris JD. Microbial manipulation of receptor crosstalk in innate immunity. Nat Rev Immunol 2011;11:187–200.
  • Mills KH. TLR-dependent T cell activation in autoimmunity. Nat Rev Immunol 2011;11:807–822.
  • Liblau RS, Wekerle H, Tisch RM. Cumulative autoimmunity: T cell clones recognizing several self-epitopes exhibit enhanced pathogenicity. Front Immunol 2011;2:47.
  • Mason D. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol Today 1998;19:395–404.
  • Lanzavecchia A, Sallusto F. Understanding the generation and function of memory T cell subsets. Curr Opin Immunol 2005;17:326–332.
  • Singh R, Toor P, Parchand S, Quantitative polymerase chain reaction for Mycobacterium tuberculosis in so-called Eales’ disease. Ocul Immunol Inflamm 2012;20:153–157.
  • Yeh S, Sen HN, Colyer M, Update on ocular tuberculosis. Curr Opin Ophthalmol 2012;23:551–556.
  • Gupta V, Gupta A, Rao NA. Intraocular tuberculosis –an update. Surv Ophthalmol 2007;52:561–587.
  • Tanne A, Neyrolles O. C-type lectins in immunity to Mycobacterium tuberculosis. Front Biosci (Schol. Ed.) 2011;3:1147–1164.
  • Kleinnijenhuis J, Oosting M, Joosten LA, Innate immune recognition of Mycobacterium tuberculosis. Clin Dev Immunol 2011;2011:405310.
  • Su SB, Silver PB, Grajewski RS, Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity. J Immunol 2005;175:6303–6310.
  • Dennehy KM, Ferwerda G, Faro-Trindade I, Syk kinase is required for collaborative cytokine production induced through dectin-1 and toll-like receptors. Eur J Immunol 2008;38:500–506.
  • Van De Veerdonk FL, Teirlinck AC, Kleinnijenhuis J, Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1. J Leukoc Biol 2010;88:227–232.
  • Gringhuis SI, Kaptein TM, Wevers BA, Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1beta via a noncanonical caspase-8 inflammasome. Nat Immunol 2012;13:246–254.
  • Ulrichs T, Kaufmann SH. New insights into the function of granulomas in human tuberculosis. J Pathol 2006;208:261–269.
  • Harding JS, Schreiber HA, Sandor M. Granuloma transplantation: an approach to study Mycobacterium-host interactions. Front Microbiol 2011;2:245.
  • Davis JM, Ramakrishnan L. The role of the granuloma in expansion and dissemination of early tuberculous infection. Cell 2009;136:37–49.
  • Forrester JV, Xu H, Kuffova L, Dendritic cell physiology and function in the eye. Immunol Rev 2010;234:282–304.
  • Rustad TR, Sherrid AM, Minch KJ, Sherman DR. Hypoxia: a window into Mycobacterium tuberculosis latency. Cell Microbiol 2009;11:1151–1159.
  • Nahid P, Menzies D.). Update in tuberculosis and nontuberculous mycobacterial disease 2011. Am J Respir Crit Care Med 2012;185:1266–1270.
  • Silverstein AM. The immunologic modulation of infectious disease pathogenesis. Friedenwald Lecture, 1973. Invest Ophthalmol 1974;13:560–574.
  • Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animals to humans. Int J Parasitol 2000;30:1217–1258.
  • Isacsohn M, Smetana Z, Rones ZZ. A sero-epidemiological study of herpes virus type 1 and 2 infection in Israel. J Clin Virol 2002;24:85–92.
  • Malkin JE, Morand P, Malvy D, Seroprevalence of HSV-1 and HSV-2 infection in the general French population. Sex Transm Infect 2002;78:201–203.
  • Nabipour I, Vahdat K, Jafari SM, The association of metabolic syndrome and Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpes simplex virus type 1: the Persian Gulf Healthy Heart Study. Cardiovasc Diabetol 2006;5:25.
  • Silveira C, Vallochi AL, Rodrigues Da Silva U, Toxoplasma gondii in the peripheral blood of patients with acute and chronic toxoplasmosis. Br J Ophthalmol 2011;95:396–400.
  • Hu K, Johnson J, Florens L, Cytoskeletal components of an invasion machine –the apical complex of Toxoplasma gondii. PLoS Pathog 2006;2:e13.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.