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Original Article

Bone Marrow Pre-B Cells and the Clonal Anergy Theory of Immunologic Tolerance

Pages 321-338 | Published online: 10 Jul 2009

References

  • McKeam J. P., McCubrey J., Fagg B. Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors. Proc. Natl. Acad. Sci. U.S.A 1985; 82: 7414–7418
  • Alt F., Rosenberg N., Lewis S., Thomas E., Baltimore D. Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells. Cell 1981; 27: 381–390
  • Osmond D. G., Nossal G. J. V. Differentiation of lymphocytes in mouse bone marrow. II. Kinetics of maturation and renewal of antiglobulin-binding cells studied by double labeling. Cell. Immunol 1974; 13: 132–145
  • Burnet F. M. A modification of Jerne's theory of antibody production using the concept of clonal selection. Aust. J. Sci 1957; 20: 67
  • Lederberg J. Genes and antibodies: Do antigens bear instruction for antibody specificity or do they select cell lines that arise by mutation?. Science 1959; 129: 1649
  • Nossal G. J. V., Pike B. L. Evidence for the clonal abortion theory of B lymphocyte tolerance. J. Exp. Med 1975; 141: 904–917
  • Haas W., Layton J. E. Separation of antigen-specific lymphocytes. I. Enrichment of antigen-binding cells. J. Exp. Med 1975; 141: 1004–1014
  • Nossal G. J. V., Pike B. L. Mechanisms of clonal abortion tolerogenesis. I. Response of immature hapten-specific B lymphocytes. J. Exp. Med 1978; 148: 1161–1170
  • Pike B. L., Battye F. L., Nossal G. J. V. Effect of hapten valency and carrier composition on the tolerogenic potential of hapten-protein conjugates. J. Immunol 1981; 126: 89–94
  • Pike B. L., Nossal G. J. V. Mechanisms of clonal abortion tolerogenesis. III. Antigen abrogates functional maturation of surface immunoglobulin-negative adult bone marrow lymphocytes. Eur. J. Immunol 1979; 9: 708–714
  • Nossal G. J. V., Pike B. L., Battye F. L. Mechanisms of clonal abortion tolerogenesis. II. Clonal behaviour of immature B cells following exposure to anti-μ chain antibody. Immunology 1979; 37: 203–215
  • Pike B. L., Boyd A. W., Nossal G. J. V. Clonal anergy: The universally anergic B lymphocyte. Proc. Natl. Acad. Sci 1982; 79: 2013–2017
  • Nossal G. J. V., Pike B. L. Clonal anergy: Persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen. Proc. Natl. Acad. Sci 1981; 77: 1602–1606
  • Pike B. L., Abrams J., Nossal G. J. V. Clonal anergy: Inhibition of antigen-driven proliferation among single B lymphocytes from tolerant animals, and partial breakage of anergy by mitogens. Eur. J. Immunol 1983; 13: 214–220
  • Pike B. L., Nossal G. J. V. Growth and differentiation of B cell clones in vitro. B Lymphocyte Differentiation, J. Cambier. CRC Press, Boca Raton, FL, in press
  • Pike B. L., Kay T. W., Nossal G. J. V. Relative sensitivity of fetal and newborn mice to induction of hapten-specific B cell tolerance. J. Exp. Med 1981; 152: 1407–1412
  • Nossal G. J. V. Cellular mechanisms of immunological tolerance. Ann. Rev. Immunol 1983; 1: 33–62
  • Lawton A. R., Cooper M. D. Modification of B lymphocyte differentiation by anti-immunoglobulin. Contemp. Top. Immunobiol 1974; 3: 193
  • Metcalf E. S., Klinman N. R. In vitro tolerance induction of neonatal murine spleen cells. J. Exp. Med 1976; 143: 1327
  • Primi D., Hammarström L., Smith E., Möller G. Characterization of self-reactive B cells by polyclonal B-cell activators. J. Exp. Med 1977; 145: 21
  • Schrader J. W., Nossal G. J. V. Effector cell blockade—a new mechanism of immune hyporeactivity induced by multivalent antigens. J. Exp. Med 1974; 139: 1582–1598
  • Suter M., Pike B. L., Nossal G. J. V. An ELISA assay efficiently detects clonal antibody formation by single, hapten-specific B lymphocytes. J. Immunol. Methods 1985; 84: 327–341
  • Pike B. L., Nossal G. J. V. A high-efficiency cloning system for single hapten-specific B lymphocytes that is suitable for assay of putative growth and differentiation factors. Proc. Natl. Acad. Sci. U.S.A 1985; 82: 3395–3399
  • Good M. F., Nossal G. J. V. Functional clonal deletion and suppression as complementary mechanisms operative in adult hapten-induced cytotoxic T cell tolerance. J. Immunol 1983; 131: 2662–2669
  • Alt F. W., Yancopoulos G. D., Blackwell T. K., Wood C., Thomas E., Boss M., Coffman R., Rosenberg N., Tonegawa S., Baltimore D. Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J 1984; 3: 1209–1219
  • Yancopoulos G. D., Desiderio S. V., Paskind M., Kearney J. F., Baltimore D., Alt F. W. Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature 1984; 311: 727–733
  • Perlmutter R. M., Kearney J. F., Chang S. P., Hood L. E. Developmentally controlled expression of immunoglobulin VH Genes. Science 1985; 227: 1597–1601
  • Silverstein A. M., Uhr J. W., Kraner K. L., Lukes R. J. Fetal response to antigenic stimulus. II. Antibody production by the fetal lamb. J. Exp. Med 1963; 117: 799
  • Cancro M. P., Wylie D. E., Gerhard W., Klinman N. R. Patterned acquisition of the antibody repertoire: Diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c mice. Proc. Natl. Acad. Sci. U.S.A 1979; 76: 6577
  • Dresser D. W. Most IgM-producing cells in the mouse secrete autoantibodies (rheumatoid factor). Nature 1978; 274: 480
  • Steele E. J., Cunningham A. J. High proportion of Ig-producing cells making autoantibody in normal mice. Nature 1978; 274: 483
  • Holmberg D., Forsgren S., Ivars F., Coutinho A. Reactions among IgM antibodies derived from normal, neonatal mice. Eur. J. Immunol 1984; 14: 435–441
  • Dighiero G., Lymberi P., Holmberg D., Lundquist I., Coutinho A., Avrameas S. High frequency of natural autoantibodies in normal newborn mice. J. Immunol 1985; 134: 765–771
  • Prabhakar B. S., Saegusa J., Onodera T., Notkins A. L. Lymphocytes capable of making monoclonal autoantibodies that react with multiple organs are a common feature of the normal B cell repertoire. J. Immunol 1984; 133: 2815–2817
  • Underwood J. R., Pederson J. S., Chalmers P. J., Toh B. H. Hybrids from normal, germ free, nude and neonatal mice produce monoclonal autoantibodies to eight different intracellular structures. Clin. Exp. Immunol 1985; 60: 417–46
  • Schwartz R. S., Stollar B. D. Origins of anti-DNA autoantibodies. J. Clin. Invest 1985; 75: 321–327
  • Grabar P. Autoantibodies and the physiological role of immunoglobulins. Immunol. Tod 1983; 4: 337
  • Hayakawa K., Hardy R. R., Parks D. R., Herzenberg L. A. The Ly-1 B cell subpopulation in normal, immunodefective, and autoimmune mice. J. Exp. Med 1983; 157: 202
  • Hayakawa K., Hardy R. R., Herzenberg L. A. Progenitors for Ly-1 B cells are distinct from progenitors for other B cells. J. Exp. Med 1985; 161: 1554–1568

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