3
Views
1
CrossRef citations to date
0
Altmetric
Original Article

In Vivo Effects of Antibodies to Immune Response Gene Products. II. Suppression of Humoral Immune Responses with Monoclonal Anti-I-A Is Due to Suppressor Cells

, &
Pages 333-344 | Published online: 10 Jul 2009

References

  • McDevitt H. O., Deak B. D., Shreffler D. C., Klein J., Stimpfling J. H., Snell G. D. Genetic control of the immune response. Mapping of the Ir-1 locus. J. Exp. Med. 1972; 135: 1259
  • Debre R., Kapp J. A., Benacerraf B. Genetic control of specific immune suppression. II. H-2 linked dominant genetic control of immune suppression by the random copolymer L-glutamic acid-L-tyrosine (GT). J. Exp. Med. 1975; 142: 1447
  • Rosenthal A. S., Barcinski M. A., Rosenwasser L. J. Function of macrophages in genetic control of immune responsiveness. Fed. Proc. 1978; 37: 79
  • Katz D. H., Benacerraf B. The Role of Products of the Histocompatibility Gene Complex in Immune Responses. Academic Press, New York 1976
  • Tada T., Taniguchi M., David C. S. Properties of antigen-specific suppressive T cell factor in the regulation of the antibody response of the mouse. IV Special subregion assignment of the gene(s) that code for the suppressive T cell factor in the H-2 histocompatibility complex. J. Exp. Med. 1976; 144: 713
  • Taussig M. J., Munro A. J., Campbell R., David C. S., Staines N. A. Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate against allogeneic barriers. J. Exp. Med. 1975; 142: 694
  • Mozes E., Isac R. Antigen specific T cell factors in the genetic control of the immune response to poly (tyr, glu) poly (pro)—poly (lys). Adv. Exp. Med. Biol. 1976; 66: 547
  • Cook R. G., Capra J. D., Bednarczyk J. L., Uhr J. W., Vitetta E. S. Structural studies on the murine la alloantigens. VI. Evidence that both subunits of the I-A alloantigen are encoded by the I-A subregion. J. Immunol. 1979; 123: 2799
  • Silver J., Russell W. A. Genetic mapping of the component chains of la antigens. Immunogenetics 1979; 8: 339
  • McMillan M., Frelinger J. A., Jones P. R., Murphy D. B., McDevitt H. O., Hood L. Structure of murine la antigens. Two-dimensional electrophoretic analyses and high-pressure liquid chromatography tryptic peptide maps of products of the I-A and I-E subregions and of an associated invariant polypeptide. J. Exp. Med. 1981; 153: 936
  • Jones R. P., Murphy D. B., McDevitt H. O. Two-gene control the expression of a murine la antigen. J. Exp. Med. 1978; 148: 925
  • Cook R. G., Vitetta E. S., Uhr J. W., Capra J. D. Structural studies on the murine la alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion. J. Exp. Med. 1979; 149: 981
  • Silver J., Russell W. A. Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval. Nature (London) 1979; 279: 437
  • Lonai P., Murphy D. B., McDevitt H. O. Inhibitory effect of anti-la sera on proliferative responses to (H.G)-A—L and (Phe-G)-A—L. Ir Genes and la Antigens, H. O. McDevitt. Academic Press, Inc., San Francisco 1978
  • Berzofsky J. A., Richman L. K. Genetic control of the immune response to myoglobins. IV. Inhibition of determinant-specific Ir gene controlled antigen presentation and induction of suppression by pretreatment of presenting cells with anti-la antibodies. J. Immunol. 1981; 126: 1898
  • Schwartz R. H., David C. S., Sachs D. H., Paul W. E. T lymphocyte-enriched murine peritoneal exudate cells. III. Inhibition of antigen-induced T lymphocyte proliferation with anti-la antisera. J. Immunol. 1976; 117: 531
  • Frelinger J. A., Niederhuber J. E., Shreffler D. C. Inhibition of immune responses in vitro by specific antiserums to la antigens. Science (Washington, DC) 1975; 188: 268
  • Shevach E. M., Green I., Paul W. E. Alloantiserum-induced inhibition of immune response gene product function. II. Genetic analysis of target antigens. J. Exp. Med. 1974; 139: 679
  • Davies D. A. L., Staines N. A. A cardinal role for I region antigens (la) in immunological enhancement, and clinical implications. Transplant. Rev. 1976; 30: 18
  • Greene M. I., Dorf M. E., Pierres M., Benacerraf B. Reduction of syngeneic tumor growth by an anti-I-J alloantiserum. Proc. Nat. Acad. Set. USA 1977; 74: 5118
  • Muruelo D., Flieger N., Smith D., McDevitt H. O. In vivo or in vitro treatments with anti-I-J alloantisera abolish immunity to AKR leukemia. Proc. Nat. Acad. Sci. USA 1980; 77: 2178
  • Green W. F., Colley D. G. Modulation of schistosoma masoni egg-induced granuloma formation: I-J restriction of T cell-mediated suppression in a chronic parasitic infection. Proc. Natl. Acad. Sci. USA 1981; 78: 1152
  • Perry L. L., Dorf M. E., Bach B. A., Benacerraf F., Greene M. I. Mechanisms of regulation of cell-mediated immunity. Anti-I-A alloantisera interfere with induction and expression of T-cell mediated immunity to cell bound antigen in vivo. Clin. Immunol. Immunopathol. 1980; 15: 279
  • Perry L. L., Greene M. I. T cell subset interactions in the regulation of syngeneic tumor immunity. Fed. Proc. 1981; 40: 39
  • Sprent J. Effects of blocking helper T cell induction in vivo with anti-la antibodies: possible role of I-A/E hybrid molecules as restriction elements. J. Exp. Med. 1980; 152: 996
  • Pierres M., Germain R. N., Dorf M. E., Benacerraf B. Potentiation of aprimary in vivo antibody response by alloantisera against gene products of the I region of the H-2 complex. Proc. Nat. Acad. Sci. USA 1977; 77: 3975
  • Rosenbaum J. T., Adelman N. E., McDevitt H. O. In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A. J. Exp. Med. 1981; 154: 1694
  • Perry L. L., Greene M. I. Conversion of immunity to suppression by in vivo administration of I-A subregion-specific antibodies. J. Exp. Med. 1982; 156: 480
  • Steinman L., Rosenbaum J., Sriram S., McDevitt H. O. In vivo effects of antibodies to immune response gene products: Prevention of EAE. Proc. Nat. Acad. Sci. USA 1981; 78: 7111
  • Sriram S., Steinman L. Anti-I-A antibody suppresses active encephalomyelitis: Treatment model for diseases linked to Ir genes. J. Exp. Med. 1983; 153: 1362
  • Adelman N. E., Watling D., McDevitt H. O. Treatment of NZB/W F1 disease with monoclonal anti-I-A antibodies. J. Exp. Med. 1983; 158: 1350
  • Waldor M., Sriram S., McDevitt H. O., Steinman L. In vivo therapy with monoclonal anti-I-A antibody suppresses immune responses to AChR. Proc. Nat. Acad. Sci. USA 1983; 80: 2713
  • McNichols J. M., Murphy D. B., Matis L. A., Schwartz R. H., Lerner E. A., Janeway C. A., Jones P. P. Immune response gene function correlates with the expression of an la antigen. I. Preferential association of certain, A., and E chains results in a quantitative deficiency in expression of an Ae:E complex. J. Exp. Med. 1982; 155: 490
  • Matis L. A., Jones P. P., Murphy D. B., Hedrick S. M., Lerner E. A., Janeway C. A., McNicholas J. M., Schwartz R. H. Immune response gene function correlates with the expression of an la antigen. II. A quantitative deficiency in Ae:E complex expression causes a corresponding defect in antigen presenting cell function. J. Exp. Med. 1982; 155: 508
  • Lerner E. A., Maris L. A., Janeway C. A., Jones P. P., Schwartz R. H., Murphy D. B. Monoclonal antibody against an Ir gene product?. J. Exp. Med. 1980; 152: 1085
  • Broder S., Mann D. L., Waldmann T. A. Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human la-like antigens (p. 23, 30). J. Exp. Med. 1980; 151: 257
  • Muchmore A. V., Blaese R. M., Decker J. M., Mann D. L., Broder S. Inhibition of antigen-specific proliferation by antisera recognizing antigens encoded by the human DR locus may be due to active suppression. Clin. Res. 1980; 28: 506, Abstr.)
  • Muchmore A. V., Decker J. M., Mann D. L. Evidence that antisera that reacts with products of human HLA-DR locus may block in vitro antigen-induced proliferation by inducing suppression. J. Immunol. 1982; 128: 2063
  • Lamb J. R., Eckels D. D., Ketterer E. A., Sell T. W., Woody J. N. Antigen-specific human T lymphocyte clones: Mechanisms of inhibition of proliferative responses by zenoantiserum to human non-polymorphic HLA-DR antigens. J. Immunol. 1982; 129: 1085
  • Markman M., Dickler H. B. Definitive mapping of the immune response gene(s) for (T.G)-A-L to the I-A subregion. J. Immunol. 1980; 124: 2909
  • McDevitt H. O., Chinitz A. Genetic control of the antibody response: relationship between immune response and histocompatibility (H-2) type. Science 1969; 163: 1207, Washington, DC)
  • Oi V. T., Jones P. P., Goding J. W., Herzenberg L. A., Herzenberg L. A. Properties of monoclonal antibodies to mouse Ig allotypes H-2 and la antigens. Curr. Top. Microbiol. Immunol. 1978; 81: 115
  • Julius M. H., Simpson E., Herzenberg L. A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur. J. Immunol. 1973; 3: 645
  • Kontiainen S., Feldmann M. Suppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells. Eur. J. Immunol. 1976; 6: 296
  • Ishizaka K., Adachi T. Generation of specific helper cells and suppressor cells in vitro for the IgE and IgG antibody response. J. Immunol. 1976; 117: 40
  • Ziegler K., Unanue E. R. Identification of a macrophage antigen-processing event required for I-region restricted antigen presentation to T lymphocytes. J. Immunol. 1981; 127: 1869
  • McDevitt H. O., Adelman N., Watling D., Steinman L., Sriram S. The use of monoclonal anti-la antibodies for haplotype specific immunosuppression in animal models of autoimmune disease. In. Immunogenetics: Its Application to Clinical Medicine 1984
  • Yagi J., Nonaka M., Abe R., Tada T. Ir gene expression on T cells: Effect of a monoclonal antibody directed against I-region-controlled determinants on T cells. Eur. J. Immunol. 1986; 16: 497
  • Kurlander R. J., Jones F. The effects of an anti-I-Ab antibody on murine host resistance to. Listeria monocytogenes. J. Immunol 1987; 138: 2679
  • Waldor M. K., Hardy R. R., Hayakawa K., Steinman L. W., Herzenberg L. A., Herzenberg L. A. Disappearance and reappearance of B cells after in vivo treatment with anti-I-A antibodies. Proc. Natl. Acad. Sci. USA 1984; 81: 2855
  • Klinman D. M., Lefkowitz M. D., Raveche E. S., Steinberg A. D. Effect of anti-la treatment on the production of anti-DNA antibody by NZB mice. Eur. J. Immunol. 1986; 16: 939

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.