9
Views
1
CrossRef citations to date
0
Altmetric
Original Article

Peptide-MHC Interaction: A Rational Approach to Vaccine Design

, , , &
Pages 61-73 | Published online: 10 Jul 2009

References

  • Shimonkevitz R., Kappler J., Marrack P., Grey H. M. Antigen recognition by H-2 restricted T cells. I. Cell-free antigen processing. J. Exp. Med. 1983; 158: 303–316
  • Brown J. H., Jardetzky T., Saper M. A., Samroui B., Bjorkman P. J., Wiley D. C. A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules. Nature 1988; 332: 845–850
  • Schwartz R. H. The role of gene products of the major histocompatibility complex in T cell activation and cellular interactions. Fundamental Immunology, W. E. Paul. Raven, New York 1984; 379–438
  • Babbit B. P., Allen P. M., Matsueda G., Haber E., Unanue E. Binding of immunogenic peptides in la histocompatibility molecules. Nature 1985; 317: 359–361
  • Buus S., Sette A., Colon S. M., Miles C., Grey H. M. The relation between major histocompatibility complex (MHC) restriction and the capacity of la to bind immunogenic peptides. Science 1985; 235: 1353–1358
  • Buus S., Sette A., Colon S. M., Jenis D. M., Grey H. M. Isolation and characterization of antigen-la complexes involved in T cell recognition. Cell 1986; 47: 1071–1077
  • Rothbard J. B., Taylor W. R. A sequence pattern common to T cell epitopes. EMBO J. 1988; 7: 93–100
  • Sinigaglia F., Guttinger M., Gillessen D., Doran D. M., Takacs B., Matile H., Trzeciak A., Pink J. R. L. Epitopes recognized by human T lymphocytes on malaria circumsporozoite protein. Eur. J. Immunol. 1988; 18: 633–636
  • Kilgus J., Romagnoli P., Guttinger M., Adorini L., Sinigaglia F. Vaccine T-cell epitope selection by a peptide competition assay. Proc. Natl. Acad. Sci. USA 1989; 86: 1629–1633
  • Sinigaglia F., Guttinger M., Kilgus J., Doran D. M., Matile H., Etlinger H., Trzeciak A., Gillessen D., Pink J. R. L. A malaria T-cell epitope recognized in association with most mouse and human MHC molecules. Nature 1988; 336: 778–780
  • Pink J. R. L., Sinigaglia F. Characterizing T-cell epitopes in vaccine candidates. Immunol. Today 1989; 10: 408–409
  • Sinigaglia F., Matile H., Guttinger M., Pink J. R. L. An invariant, “universal” T cell epitope in the P. falciparum circumsporozoite protein. Bull. WHO, (in press)
  • Sinigaglia F., Kilgus J., Romagnoli R, Guttinger M., Pink J. R. L. Peptide binding to MHC class II molecules: applications to vaccine design. Progress in Immunology, F. Melchers, et al. Springer-Verlag, Berlin, Heidelberg, New York 1989; VII: 1137–1143
  • Berkower I., Buckenmeyer G. K., Berzofsky J. A. Molecular mapping of a histocompatibility-restricted immunodominant T cell epitope with synthetic and natural peptides: Implication for the T cell antigenic structure. J. Immunol. 1986; 136: 2498–2503
  • Rothbard J. B., Lechler R. I., Howland K., Bal V., Eckles D. D., Sekaly R., Long E. O., Taylor W. R., Lamb J. R. Structural model of HLA-DRI restricted T cell antigen recognition. Cell 1988; 52: 515–523
  • Sette A., Lamont A., Buus S., Colon S. M., Miles C., Grey H. M. Effect of conformational propensity of peptide antigens in their interaction with MHC class II molecules. Failure to document the importance of regular secondary structures. J. Immunol. 1989; 143: 1268–1273
  • Heber-Katz E., Hollosi M., Dietzschold B., Hudecz E., Fathman G. D. The T cell response to the glycoprotein D of the herpes simplex virus: the significance of antigen conformation. J. Immunol. 1985; 135: 1385–1390
  • Fox B. S., Chen C., Fraga E., French C. A., Singh B., Schwartz R. H. Functionally distinct agretopic and epitopic sites. Analysis of the dominant T cell determinant of moth and pigeon cytochromes c with the use of synthetic peptide antigens. J. Immunol. 1987; 139: 1578–1588
  • Ogasawara K., Maloy W. L., Beverly B., Schwartz R. H. Functional analysis of the antigenic structure of a minor T cell determinant from pigeon cytochrome C. Evidence against an α-helical conformation. J. Immunol. 1989; 142: 1448–1456
  • Bhayani H., Paterson Y. Analysis of peptide binding patterns in different major histocompatibility complex/T cell receptor complexes using pigeon cytochrome c-specific T cell hybridomas. Evidence that a single peptide binds major histocompatibility complex in different conformations. J Exp. Med. 1989; 170: 1609–1625
  • Nussenzweig V., Nussenzweig R. Rationale for the development of an engineered sporozoite malaria vaccine. Adv. Immunol. 1989; 45: 283–334
  • Tam J. P. Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. Proc. Natl. Acad. Sci. USA 1988; 85: 5409–5413
  • Tam J. P., Clavijo P., Lu Y. A., Nussenzweig V., Nussenzweig R., Zavala F. Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria. J. Exp. Med. 1990; 171: 299–306
  • Good M. F., Pombo D., Quakyi I. A., Riley E. M., Houghten R. A., Menon A., Alling D. W., Berzofsky J. A., Miller L. H. Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: Immunodominant T-cell domains map to the polymorphic regions of the molecule. Proc. Natl. Acad. Sci. USA 1988; 85: 1199–1203
  • Adorini L., Appella E., Doria G., Nagy Z. A. Mechanisms influencing the immunodominance of T cell determinants. J. Exp. Med. 1988; 168: 2091–2104
  • Panina-Bordignon P., Tan A., Termijtelen A., Demotz S., Corradin G., Lanzavecchia A. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur. J. Immunol. 1989; 19: 2237–2241
  • Rothbard J. B., Hill C. M., Hickling J., Busch R. Progress in Immunology, F. Melchers, et al. Springer, Berlin-Heidelberg, New York, VII: 1115
  • Deres K., Schild H., Wiesmuller K. H., Gunther J., Rammensee H. G. In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine. Nature 1989; 342: 561–564

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.