28
Views
38
CrossRef citations to date
0
Altmetric
Original Article

Antigen-Specific Tolerance as a Therapy for Experimental Autoimmune Encephalomyelitis

, , , &
Pages 203-222 | Received 26 May 1992, Published online: 10 Jul 2009

References

  • Paterson P. Y., Swanborg R. H. Demyehnating diseases of the central and peripheral nervous systems. Immunological Diseases, M. Sampter, D. W. Talmage, M. M. Frank, K. F. Austen, H. N. Claman. Little, Brown and Co., Boston 1988; 1877
  • Brown A., McFarlin D. E., Raine C. S. Chronologic neuropathology of relapsing experimental allergic encephalomyelitis in the mouse. Lab. Invest 1982; 46: 171
  • Brown A. M., McFarlin D. E. Relapsing experimental allergic encephalomyelitis in the SJL/J mouse. Lab. Invest 1981; 45: 278
  • Lublin F. D., Maurer P. H., Berry R. G., Tippett D. Delayed, relapsing experimental allergic encephalomyelitis in mice. J. Immunol 1981; 126: 819
  • Fritz R. B., Chou C. H., McFarlin D. E. Induction of experimental allergic encephalomyelitis in PL/J and (SJL/J × PL/J)F1 mice by myelin basic protein and its peptides: localization of a second encephalitogenic determinant. J. Immunol 1983; 130: 191
  • Trotter J. L., Clark H. B., Collins K. G., Wegeschiede C. L., Scarpellini J. D. Myelin proteolipid protein induces demyelinating disease in mice. J. Neurol. Sci 1987; 79: 173
  • Tabira T. Autoimmune demyelination in the central nervous system. Ann. N. Y. Acad. Sci 1988; 540: 187
  • Tliohy V. K., Lu Z., Sobel R. A., Laursen R. A., Lees M. B. Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J. Immunol 1989; 142: 1523
  • McRae B. L., Kennedy M. K., Tan L. J., Dal Canto M. C., Miller S. D. Induction of active and adoptive chronic-relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein. J. Neuroimmunol 1992; 38: 229
  • Pettinelli C. B., McFarlin D. E. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes. J. Immunol 1981; 127: 1420
  • Mokhtarian E., McFarlin D. E., Raine C. S. Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature 1984; 309: 356
  • van der Veen R C., Trotter J. L., Clark H. B., Kapp J. A. The adoptive transfer of chronic relapsing experimental allergic encephalomyelitis with lymph node cells sensitized to myelin proteolipid protein. J. Neuroimmunol 1989; 21: 183
  • Paterson P. Y. Transfer of allergic encephalomyelitis in rats by means of lymph node cells. J. Exp. Med 1960; 111: 119
  • Richert J. R., Driscoll B. E., Kies M. W., Alvord E. C., Jr. Adoptive transfer of experimental allergic encephalomyelitis: incubation of rat spleen cells with specific antigen. J. Immunol 1979; 122: 494
  • Swanborg R. H. Autoimmune effector cells. V. A monoclonal antibody specific for rat helper T lymphocytes inhibits adoptive transfer of autoimmune encephalomyelitis. J. Immunol 1983; 130: 1503
  • Ben-Nun A., Wekerle H., Cohen I. R. The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol 1981; 11: 195
  • Ben-Nun A., Cohen I. R. Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells. J. Immunol 1982; 129: 303
  • Paterson P. Y., Day E. D. Current perspectives of neuroimmunologic disease: multiple sclerosis and experimental allergic encephalomyelitis. Clin. Immunol. Rev 1981; 1: 581
  • Alvord E. C., Jr. Conclusion: is myelin basic protein the right antigen and experimental allergic encephalomyelitis the right model for multiple sclerosis?. Prog. Clin. & Biol. Res 1984; 146: 503
  • Acha-Orbea H., Mitchell D. J., Timmermann L., Wraith D. C., Tausch G. S., Waldor M. K., Zamvil S. S., McDevitt H. O., Steinman L. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 1988; 54: 263
  • Aharoni R., Teitelbaum D., Arnon R., Puri J. Immunomodulation of experimental allergic encephalomyelitis by antibodies to the antigen-la complex. Nature 1991; 351: 147
  • Zaller D. M., Osman G., Kanagawa O., Hood L. Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor V beta-specific antibodies. J. Exp. Med 1990; 171: 1943
  • Wraith D. C., Smilek D. E., Mitchell D. J., Steinman L., McDevitt H. O. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell 1989; 59: 247
  • Lamont A. G., Sette A., Fujinami R., Colon S. M., Miles C., Grey H. M. Inhibition of experimental autoimmune encephalomyelitis induction in SJL/J mice by using a peptide with high affinity for I-As molecules. J. Immunol 1990; 145: 1687
  • Ben-Nun A., Wekerle H., Cohen I. R. Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein. Nature 1981; 292: 60
  • Beraud E., Lider O., Baharav E., Reshef T., Cohen I. R. Vaccination against experimental autoimmune encephalomyelitis using a subencephalitogenic dose of autoimmune effector cells. Characteristics of vaccination. J. Autoimmun 1989; 2: 75
  • Vandenbark A. A., Hashim G., Offner H. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 1989; 341: 541
  • Offner H., Hashim G. A., Vandenbark A. A. T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 1991; 251: 430
  • Bitar D. M., Whitacre C. C. Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein. Cell. Immunol 1988; 112: 364
  • Higgins P. J., Weiner H. L. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments. J. Immunol 1988; 140: 440
  • Kennedy M. K., Dal Canto M. C., Trotter J. L., Miller S. D. Specific immune regulation of chronic-relapsing experimental allergic encephalomyelitis in mice. J. Immunol 1988; 141: 2986
  • Kennedy M. K., Tan L. J., Dal Canto M. C., Miller S. D. Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. J. Immunol 1990; 145: 117
  • Kennedy M. K., Tan L. J., Dal Canto M. C., Tuohy V K., Lu Z. J., Trotter J. L., Miller S. D. Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to pro-teolipid protein and its encephalitogenic peptides. J. Immunol 1990; 144: 909
  • Tan L. J., Kennedy M. K., Miller S. D. Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. II. Fine specificity of effector T cell inhibition. J. Immunol 1992; 148: 2748
  • Sharma S. D., Nag B., Su X. -M., Green D., Spack E., Clark B. R., Sriram S. Antigen-specific therapy of experimental allergic encephalomyelitis by soluble class II major histocompatibility complex-peptide complexes. Proc. Natl. Acad. Sci. U. S. A 1991; 88: 11465
  • Kennedy M. K., Clatch R. J., Dal Canto M. C., Trotter J. L., Miller S. D. Monoclonal antibody-induced inhibition of relapsing EAE in SJL/J mice correlates with inhibition of neuroantigen-specific cell-mediated immune responses. J. Neuroimmunol 1987; 16: 345
  • Miller S. D., Claman H. N. The induction of hapten-specific T cell tolerance using hapten-modified lymphoid cells. I. Characteristics of tolerance induction. J. Immunol 1976; 117: 1519
  • Miller S. D., Wetzig R. P., Claman H. N. The induction of cell-mediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells. J. Exp. Med 1979; 149: 758
  • Cross A. H., Cannella B., Brosnan C. F., Raine C. S. Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis. Lab. Invest 1990; 63: 162
  • Raine C. S., Cannella B., Duijvestijn A. M., Cross A. H. Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination. Lab. Invest 1990; 63: 476
  • Kono D. H., Urban J. L., Horvath S. J., Ando D. G., Saavedra R. A., Hood L. Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice. J. Exp. Med 1988; 168: 213
  • Sakai K., Zamvil S. S., Mitchell D. J., Lim M., Rothbard J. B., Steinman L. Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein. J. Neuroimmunol 1988; 19: 21
  • Fritz R. B., Skeen M. J., Chou C. H., Zamvil S. S. Localization of an encephalitogenic epitope for the SJL mouse in the N-terminal region of myelin basic protein. J. Neuroimmunol 1990; 26: 239
  • Chou C H., Chou F. C., Kowalski T. J., Shapira R., Kibler R. E. The major site of guinea-pig myelin basic protein encephalitogenic in Lewis rats. J. Neurochem 1977; 28: 115
  • Mannie J. D., Paterson P. Y., U'Prichard D. C., Flouret G. The N- and C-terminal boundaries of myelin basic protein determinants required for encephalitogenic and proliferative responses of Lewis rat T cells. J. Neuroimmunol 1990; 26: 201
  • Pope L., Paterson P. Y., Miller S. D. Antigen-specific inhibition of the adoptive transfer of experimental autoimmune encephalomyelitis in Lewis rats. J. Neuroimmunol 1992; 37: 177
  • Miller S. D., Tan L. J., Kennedy M. K., Dal Canto M. C. Specific immunoregulation of the induction and effector stages of relapsing EAE via neuroantigen-specific tolerance induction. Ann. N. Y. Acad. Sci 1991; 636: 79
  • Tan L. -J., Kennedy M. K., Dal Canto M. C., Miller S. D. Successful treatment of paralytic relapses in adoptive experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance. J. Immunol 1991; 147: 1797
  • Perry L. L., Barzaga M. E. Kinetics and specificity of T and B cell responses in relapsing experimental allergic encephalomyelitis. J. Immunol 1987; 138: 1434
  • Perry L. L., Barzaga-Gilbert E., Trotter J. L. T cell sensitization to proteolipid protein in myelin basic protein-induced experimental allergic encephalomyelitis. J. Neuroimmunol 1991; 33: 7
  • McCarron R. M., Fallis R. J., McFarlin D. E. Alterations in T cell antigen specificity and class II restriction during the course of chronic relapsing experimental allergic encephalomyelitis. J. Neuroimmunol 1990; 29: 73
  • Miller S. D., Gerety S. J., Kennedy M. K., Peterson J. D., Trotter J. L., Tuohy V. K., Waltenbaugh C., Dal Canto M. C., Lipton H. L. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. III. Failure of neuroantigen-specific immune tolerance to affect the clinical course of demyelination. J. Neuroimmunol 1990; 26: 9
  • Miller S. D., Sy M. S., Claman H. N. The induction of hapten-specific T cell tolerance using hapten-modified lymphoid membranes. II. Relative roles of suppressor T cells and clone inhibition in the tolerant state. Eur. J. Immunol 1977; 7: 165
  • Sherr D. H., Cheung N. K., Heghinian K. M., Benacerraf B., Dorf M. E. Immune suppression in vivo with antigen-modified syngeneic cells. II. T cell mediated nonresponsiveness to fowl gamma globulin. J. Immunol 1978; 122: 1899
  • Jenkins M. K., Schwartz R. H. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med 1987; 165: 302
  • Rammensee H. G., Kroschewski R., Frangoulis B. Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mlsa expressing cells. Nature 1989; 339: 541
  • Rowley D. A., Gowans J. L., Atkins R. C., Ford W. L., Smith M. E. The specific selection of recirculating lymphocytes by antigen in normal and preimmunized rats. J. Exp. Med 1972; 136: 499
  • Sprent J., Miller J. F. A. P. Effect of recent antigen priming on adoptive immune responses. II. Specific unresponsiveness of circulating lymphocytes from mice primed with heterologous erythrocytes. J. Exp. Med 1974; 139: 1
  • Naparstek Y., Ben-Nun A., Holoshitz J., Reshef T., Frankel A., Rosenberg M., Cohen I. R. T lymphocyte lines producing or vaccinating against autoimmune encephalomyelitis (EAE). Functional activation induces peanut agglutinin receptors and accumulation in the brain and thymus of line cells. Eur. J. Immunol 1983; 13: 418
  • Wekerle H., Linington C., Lassmann H., Meyermann R. Cellular immune reactivity with the CNS. Trends Neurosci 1986; 9: 271
  • Hickey W. F., Hsu B. L., Kimura H. T lymphocyte entry into the central nervous system. J. Neurosci. Res 1991; 28: 254
  • Panich H. S., McFarlin D. E. Experimental allergic encephalomyelitis: enhancement of cell-mediated transfer by concanavalin A. J. Immunol 1977; 119: 1134
  • Debre P., Waltenbaugh C., Dorf M. E., Benacerraf B. Genetic control of specific suppression. IV. responsiveness to the random copolymer L-glutamic acid50-L-tyrosine50 induced in BALB/c mice by cyclophosphamide. J. Exp. Med 1976; 144: 277
  • Jenkins M. K., Pardoll D. M., Mizuguchi J., Quill H., Schwartz R. H. T-cell unresponsiveness in vivo and in vitro: fine specificity of induction and molecular characterization of the unresponsive state. Immunol. Rev 1987; 95: 113
  • Mueller D. L., Jenkins J. K., Schwartz R. H. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Ann. Rev. Immunol 1989; 7: 445
  • Fallis R. J., Powers M. L., Sy M. S., Weiner H. L. Adoptive transfer of murine chronic-relapsing autoimmune encephalomyelitis. Analysis of basic protein-reactive cells in lymphoid organs and nervous system of donor and recipient animals. J. Neuroimmunol 1987; 14: 205
  • Cross A. H., Raine C. S. Serial adoptive transfer of murine experimental allergic encephalomyelitis: successful transfer is dependent on active disease in the donor. J. Neuroimmunol 1990; 28: 27
  • Sprent J. Effects of blocking helper T cell induction in vivo with anti-La antibodies. Possible role of I-A/E hybrid molecules as restricted elements. J. Exp. Med 1980; 152: 996
  • Steinman L., Rosenbaum J. T., Sriram S., McDevitt H. O. In vivo effects of antibodies to immune response gene products: prevention of experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 1981; 78: 7111
  • Brostoff S. W., Mason D. W. Experimental allergic encephalomyelitis: successful treatment in vivo with a monoclonal antibody that recognizes T helper cells. J. Immunol 1984; 133: 1938
  • Waldor M. K., Sriram S., Hardy R., Herzenberg L. A., Lanier L., Lim M., Steinman L. Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker. Science 1985; 227: 415
  • Benjamin R. J., Waldmann H. Induction of tolerance by monoclonal antibody therapy. Nature 1986; 320: 449
  • Goronsky J., Weyland C. M., Fathman C. G. Long-term humoral unresponsiveness in vivo, induced by treatment with monoclonal antibody against L3T4. J. Exp. Med 1986; 164: 911
  • Hirsch R., Eckhaus M., Auchincloss H., Sachs D. H., Bluestone J. A. Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses. J. Immunol 1988; 140: 3766
  • Ben-Nun A., Cohen I. R. Vaccination against autoimmune encephalomyelitis (EAE): attenuated autoimmune T lymphocytes confer resistance to induction of active EAE but not to EAE mediated by the intact T lymphocyte line. Eur. J. Immunol 1981; 11: 949
  • Lider O., Reshef T., Beraud E., Ben-Nun A., Cohen I. R. Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. Science 1988; 239: 181
  • Lohse A. W., Mor F., Karin N., Cohen I. R. Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells. Science 1989; 244: 820
  • Zamvil S. S., Mitchell D. J., Lee N. E., Moore A. C., Waldor M. K., Sakai K., Rothbard J. B., McDevitt H. O., Steinman L., Acha-Orbea H. Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis. J. Exp. Med 1988; 167: 1586
  • Burns F. R., Li X. B., Shen N., Offner H., Chou Y. K., Vandenbark A. A., Heber-Katz E. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J. Exp. Med 1989; 169: 27
  • Owhashi M., Heber-Katz E. Protection from experimental allergic encephalomyelitis conferred by a monoclonal antibody directed against a shared idiotype on rat T cell receptors specific for myelin basic protein. J. Exp. Med 1988; 168: 2153
  • Heber-Katz E., Acha-Orbea H. The V-region disease hypothesis: evidence from autoimmune encephalomyelitis. Immunol. Today 1989; 10: 164
  • Howell M. D., Winters S. T., Olee T., Powell H. C., Carlo D. J., Brostoff S. W. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 1989; 246: 668
  • Stevens D. B., Karpus W J., Gould K. E., Swanborg R. H. Studies of Vβ8 T cell receptor peptide treatment in experimental autoimmune encephalomyelitis. J. Neuroimmunol 1992; 37: 123
  • Hashim G. A., Vandenbark A. A., Galang A. B., Diamanduros T., Carvalho E., Srinivasan J., Jones R., Vainiene M., Morrison W. J., Offner H. Antibodies specific for VB8 receptor peptide suppress experimental autoimmune encephalomyelitis. J. Immunol 1990; 144: 4621
  • Desquenne-Clark L., Esch T. R., Otvos L., Jr., Heber-Katz E. T-cell receptor peptide immunization leads to enhanced and chronic experimental allergic encephalomyelitis. Proc. Natl. Acad. Sci. USA 1991; 88: 7219
  • Kawano Y. I., Sasamoto Y., Kotake S., Thurau S. R., Wiggert B., Gery I. Trials of vaccination against experimental autoimmune uveoretinitis with a T-cell receptor peptide. Curr. Eye Res 1991; 10: 789
  • Oksenberg J. R., Stuart S., Begovich A. B., Bell R. B., Erlich H. A., Steinman L., Bernard C. C. Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature 1990; 345: 344
  • Wucherpfennig K. W., Ota K., Endo N., Seidman J. G., Rosenzweig A., Weiner H. L., Hafler D. A. Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science 1990; 248: 1016
  • Martin R., Howell M. D., Jaraquemada D., Flerlage M., Richert J., Brostoff S., Long E. O., McFarlin D. E., McFarland H. F. A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis. J. Exp. Med 1991; 173: 19
  • Adorini L., Nagy Z. Inhibition of T cell activation by MHC blockade. Intern. Rev. Immunol 1990; 6: 23
  • Zamvil S. S., Mitchell D. J., Moore A. C., Kitamura K., Steinman L., Rothbard J. B. T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 1986; 324: 258
  • Smilek D. E., Wraith D. C., Hodgkinson S., Dwivedy S., Steinman L., McDevitt H. O. A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 1991; 88: 9633
  • Sakai K., Zamvil S. S., Mitchell D. J., Hodgkinson S., Rothbard J. B., Steinman L. Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins. Proc. Natl. Acad. Sci. USA 1989; 86: 9470
  • Whitacre C. C., Gienapp I. E., Orosz C. G., Bitar D. M. Oral tolerance in experimental autoimmune encephalomyelitis: III. Evidence for clonal anergy. J. Immunol 1991; 147: 2155
  • Miller A., Lider O., Weiner H. L. Antigen-driven bystander suppression after oral administration of antigens. J. Exp. Med 1991; 174: 791
  • Miller A., Lider O., Roberts A. B., Sporn M. B., Weiner H. L. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor 8 after antigen-specific triggering. Proc. Natl. Acad. Sci. U.S.A 1992; 89: 421

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.