Processing of Self-Proteins and Its Impact on Shaping the T Cell Repertoire, Autoimmunity and Immune Regulation

References

• Kappler J. W., Roehm N., Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987; 49: 273–280
   PubMed Web of Science ®Google Scholar
• Kappler J. W., Staerz U. D., White J., Marrack P. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 1988; 332: 35–40
   PubMed Web of Science ®Google Scholar
• Kisielow R., Bluthmann H., Staerz U. D., Steinmetz M., Von Boehmer H. Tolerance in T cell Receptor transgenic mice involves deletion of immature CD4+ 8+ thymocytes. Nature 1988; 333: 742–746
   PubMed Web of Science ®Google Scholar
• MacDonald H. R., Schneider R., Lees R. K., Howe R. C., Acha Orbea H., Festenstein H., Zinkernagel R. K., Hengartner H. T cell Receptor Vβ use predicts Reactivity and tolerance to Mlsa-encoded antigens. Nature 1988; 332: 40–45
   PubMed Web of Science ®Google Scholar
• Sha W. C., Nelson C. A., Newberry R. D., Kranz D. M., Russell J. H., Loh D. Y. Positive and negative selection of an antigen Receptor on T cells in transgenic mice. Nature 1988; 336: 73–76
   PubMed Web of Science ®Google Scholar
• Bevan M. J., Fink P. J. The influence of thymus H-2 antigens on the specificity of maturing killer and helper cells. Immunol. Rev 1978; 42: 3–19
   Google Scholar
• Kaye J., Hsu M. -L., Sauron M. -E., Jameson S. C., Gascoigne N. R. J., Hedrick S. M. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen Receptor. Nature 1989; 341: 746–749
   PubMed Web of Science ®Google Scholar
• Nikolic-Zugic J., Bevan M. J. Role of self-peptides in positively selecting the T cell Repertoire. Nature 1990; 344: 65–67
   PubMed Web of Science ®Google Scholar
• Takahama Y., Shores E. W., Singer A. Negative selection of precursor thymocytes before their differentiation into CD4+CD8+ cells. Science 1992; 258: 653–656
   PubMedGoogle Scholar
• Winchester G., Sunshine G. H., Nardi N., Mitchison N. A. Antigen-presenting cells do not discriminate between self and nonself. Immunogenetics 1984; 19: 487–491
   Google Scholar
• Bikoff E. K., Yu H., Eckhardt L. A. T cell Recognition of endogenous IgG2a expressed in B lymphoma cells. Eur. J. Immunol 1988; 18: 341–348
   Google Scholar
• Weiss S., Bogen B. B-lymphoma cells process and present their endogenous immunoglobulin to major histocompatibility complex-restricted T cells. Proc. Natl. Acad. Sci. USA 1989; 86: 282–286
   PubMed Web of Science ®Google Scholar
• Wekerle H., Schwab M., Linington C., Meyermann R. Antigen presentation in the peripheral nervous system: Schwann cells present endogenous myelin autoantigens to lymphocytes. Eur. J. Immunol 1986; 16: 1551–1557
   Google Scholar
• Lorenz R. G., Allen P. M. Direct evidence for functional self-protein/Ia-molecule complexes in vivo. Proc. Natl. Acad. Sci. USA 1988; 85: 5220–5223
   PubMed Web of Science ®Google Scholar
• Stockinger B., Lin R. H. An intracellular self protein synthesized in macrophages is presented but fails to induce tolerance. International Immunol 1989; 1: 592–597
   Google Scholar
• Benichou G., Takizawa P. A., Ho P. T., Killion C. C., Olson C. A., McMillan M., Sercarz E. E. Immunogenicity and tolerogenicity of self-major histocompatibility complex peptides. J. Exp. Med 1990; 172: 1341–1346
   PubMedGoogle Scholar
• Calin-Laurens V., Forquet F., Lombard-Platet S., Bertolino P., Chretien I., Trescol-Biemont M. -C, Gerlier D., Rabourdin-Combe C. High efficiency of endogenous antigen presentation by MHC class II molecules. International Immunol 1992; 4: 1113–1121
   Google Scholar
• Sercarz E. E., Lehmann P. V., Ametani A., Benichou G., Miller A., Moudgil K. Dominance and crypticity of T cell antigenic determinants. Ann. Rev. Immunol 1993; 11: 729–766
   PubMed Web of Science ®Google Scholar
• Oki A., Sercarz E. T cell tolerance studies at the level of antigenic determinants. I. Latent Reactivity to lysozyme peptides that lack suppressogenic epitopes can be Revealed in lysozyme-tolerant mice. J. Exp. Med 1985; 161: 897–911
   Google Scholar
• Gammon G., Sercarz E. How some T cells escape tolerance induction. Nature 1989; 342: 183–185
   PubMedGoogle Scholar
• Cibotti R., Kanellopoulos J. M., Cabaniols J -P., Halle-Panenko O., Kosmatopoulos K., Sercarz E., Kourilsky P. Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants. Proc. Natl. Acad. Sci. USA 1992; 89: 416–420
   PubMed Web of Science ®Google Scholar
• Kourilsky R., Chaouat G., Rabourdin-Combe C., Claverie J. -M. Working principles in the immune system implied by the “peptidic self” model. Proc. Natl. Acad. Sci. USA 1987; 84: 3400–3404
   PubMed Web of Science ®Google Scholar
• Yurin V. L., Rudensky A. Y., Mazel S. M., Blechman J. M. Immunoglobulin-specific T-B cell interaction. II. T cell clones Recognize the processed form of B cell's own surface immunoglobulin in the context of the major histocompatibility complex class II molecules. Eur. J. Immunol 1989; 19: 1685–1691
   PubMed Web of Science ®Google Scholar
• Lorenz R. G., Allen P. M. Thymic cortical epithelial cells can present self-antigens in vivo. Nature 1989; 337: 560–562
   PubMedGoogle Scholar
• Stockinger B. Capacity of antigen uptake by B cells, fibroblasts or macrophages determines efficiency of presentation of a soluble self antigen (C5) to T lymphocytes. Eur. J. Immunol 1992; 22: 1271–1278
   PubMed Web of Science ®Google Scholar
• Babbitt B. P., Matsueda G., Haber E., Unanue E. R., Allen P. M. Antigenic competition at the level of peptide-Ia binding. Proc. Natl. Acad. Sci. USA 1986; 83: 4509–4513
   PubMed Web of Science ®Google Scholar
• Adorini L., Muller S., Cardinaux F. In vivo competition between self peptides and foreign antigens in T cell activation. Nature 1988; 334: 623–625
   PubMed Web of Science ®Google Scholar
• Lehmann P. V., Cardinaux F., Appella F., Muller S., Falcioni F., Adorini L., Nagy Z. A. Inhibition of T cell Response with peptides is influenced by both peptide-binding specificity of major histocompatibility complex molecules and susceptibility of T cells to blocking. Eur. J. Immunol 1989; 19: 1071–1077
   PubMed Web of Science ®Google Scholar
• Lorenz R. G., Blum J. S., Allen P. M. Constitutive competition by self proteins for antigen presentation can be overcome by Receptor-enhanced uptake. J. Immunol 1990; 144: 1600–1606
   PubMedGoogle Scholar
• Michalek M. T., Benacerraf B., Rock K. L. Two genetically identical antigen-presenting cell clones display heterogeneity in antigen processing. Proc. Natl. Acad. Sci. USA 1989; 86: 3316–3320
   PubMedGoogle Scholar
• Vidard L., Rock K. L., Benacerraf B. Heterogeneity in antigen processing by different types of antigen-presenting cells. Effect of cell culture on antigen processing ability. J. Immunol 1992; 149: 1905–1911
   PubMed Web of Science ®Google Scholar
• Maryanski J. L., Pala P., Corradin G., Jordan B. R., Cerottini J. C. H-2 Restricted cytolytic T cells specific for HLA can Recognize a synthetic HLA peptide. Nature 1986; 324: 578–579
   PubMed Web of Science ®Google Scholar
• De Koster H. S., Anderson D. C., Termijtelen A. T cells sensitized to HLA-DR3 peptide give evidence of continuous presentation of denatured HLA-DR3 molecules by HLA-DP. J. Exp. Med 1989; 169: 1191–1196
   Google Scholar
• Agarwal B., Manickasundari M., Fraga E., Singh B. T cells that Recognize peptide sequence of self MHC class II molecules exist in syngeneic mice. J. Immunol 1991; 147: 383–390
   Google Scholar
• Gammon G., Geysen H. M., Apple R. J., Pickett E., Palmer M., Ametani A., Sercarz E. E. T cell determinant structures: cores and envelopes and determinant envelopes in three mouse MHC haplotypes. J. Exp. Med 1991; 173: 609–617
   PubMed Web of Science ®Google Scholar
• Ben-Nun A., Lando Z. Detection of autoimmune cells proliferating to myelin basic protein and selection of T-cell lines that mediate experimental autoimmune encephalomyelitis (EAE). J. Immunol 1983; 130: 1205–1209
   Google Scholar
• Lehmann P. V., Forsthuber T., Miller A., Sercarz E. E. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 1992; 358: 155–157
   PubMed Web of Science ®Google Scholar
• Lehmann P. V., Sercarz E. E., Forsthuber T., Dayan C. M., Gammon G. Determinant spreading and the dynamics of the autoimmune T cell Repertoire. Immunology Today 1993, May (In press)
   Google Scholar
• Ehrenstein M., Isenberg D. Autoimmunity associated with infection: leprosy, acute Rheumatic fever and Lyme disease. Current Opinions in Immunology 1991; 3: 930–935
   PubMed Web of Science ®Google Scholar
• Urban J. L., Kumar V., Kono D. H., Gomez C., Horvath S. J., Clayton J., Ando D. G., Sercarz E. E., Hood L. Restricted use of T cell Receptor V genes in murine autoimmune encephalomyelitis Raises possibilities for antibody therapy. Cell 1988; 54: 577–592
   PubMed Web of Science ®Google Scholar
• Lanzavecchia A., Roosnek E., Gregory T., Berman P., Abrignani S. T cells can present antigens such as HIV gp120 targeted to their own surface molecules. Nature 1988; 334: 530–532
   PubMedGoogle Scholar
• Benoist C., Mathis D. Regulation of many histocompatibility class II genes: X, Y, and other letters of the alphabet. Ann. Rev. Immunol 1990; 8: 681–715
   PubMed Web of Science ®Google Scholar
• Casten L. A., Kaumaya P., Pierce S. K. Enhanced T cell Responses to antigenic peptides targeted to B cell surface Ig, la, or class I molecules. J. Exp. Med 1988; 168: 171–180
   Google Scholar
• Donermeyer D. L., Allen P. M. Binding to la protects an immunogenic peptide from proteolytic degradation. J. Immunol 1989; 142: 1063–1068
   PubMedGoogle Scholar
• Pullen A. M., Wade T., Marrack P., Kappler J. W. Identification of the Region of the T cell Receptor B chain that interacts with the self-superantigen Mls-1a. Cell 1990; 61: 1365–1374
   PubMed Web of Science ®Google Scholar
• Fayolle C., Deriaud E., Leclerc C. in vivo induction of cytotoxic T cell Response by a free synthetic peptidase Requires CD4+ T cell help. J. Immunol 1991; 147: 4069–4073
   PubMed Web of Science ®Google Scholar
• Riblet R. J., Herzenberg L. A. Mouse lysozyme production by a monocytoma: isolation and comparison with other lysozymes. Science 1970; 168: 1595–1597
   Google Scholar
• The immune Response to structurally defined proteins: the lysozyme model, S. J. Smith-Gill, E. E. Sercarz. Adenine Press, Schenectady, New York 1989
   Google Scholar
• Moudgil K. D., Sercarz E. E. The pattern of crypticity of determinants within a self-protein. Proceedings of the 8th International Congress of Immunology, Budapest, 1992; 334, Abstract #30
   Google Scholar
• Molecular mimicry: cross-reactivity between microbes and host proteins as a cause of autoimmunity. Curr. Top. Microbiol. Immunol, M. B. A. Oldstone, 1989; 145
   Google Scholar
• Lin R. H., Mamula M. J., Hardin J. A., Janeway C. A., Jr. Induction of autoreactive B cells allows priming of autoactive T cells. J. Exp. Med 1991; 173: 1433–1439
   PubMedGoogle Scholar
• Van Eden W., Thole J. E. R., van der Zee R., Naardzij A., van Embden J. D. A., Hensen E. J., Cohen I. R. Cloning of the mycobacterial epitope Recognized by T lymphocytes in adjuvant arthritis. Nature (London) 1988; 331: 171–173
   PubMed Web of Science ®Google Scholar
• Gaston J. S. H., Life P. E., Bailey L. C., Bacon P. A. In vitro Responses to a 65 kilodalton mycobacterial protein by synovial T cells from inflammatory arthritis patients. J. Immunol 1989; 143: 2494–2500
   PubMed Web of Science ®Google Scholar
• Singh V. K., Kalra H. K., Yamaki K., Abe T., Donoso L. A., Shinohara T. Molecular mimicry between a uveitopathogenic site of S-antigen and viral peptides. Induction of experimental autoimmune uveitis in Lewis Rats. J. Immunol 1990; 144: 1282–1287
   PubMed Web of Science ®Google Scholar
• Zumla A. Superantigens T cells, and microbes. Clinical Infectious Diseases 1992; IS: 313–320
   Google Scholar
• Drake C. G., Kotzin B. L. Superantigens: biology, immunology, and potential Role in disease. J. Clin. Immunol 1992; 12: 149–162
   PubMed Web of Science ®Google Scholar
• Random House Dictionary of the English Language. Random House, New York, 564
   Google Scholar