9
Views
4
CrossRef citations to date
0
Altmetric
Original Article

Changes in the Intestinal Lymphoid Compartment Throughout Life: Implications for the Local Generation of Intestinal T Cells

&
Pages 13-25 | Published online: 10 Jul 2009

References

  • Goodman T., Lefrançois L. Expression of the γδ TCR on intestinal CD8+ lymphocytes. Nature 1988; 33: 855
  • Bonneville M., Janeway C., Ito K., Haser W., Ishida I., Nakanishi N., Tonegawa S. Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells. Nature 1988; 336: 479
  • De Geus B., Van Den Enden M., Coolen J., Rozing J. Localization and phenotype of CD3 associated γδ receptor expressing intestinal intraepithelial lymphocytes. Thymus 1989; 14: 31
  • DeGeus B., Van Den Enden M., Coolen J., Nagelkerken L., van der Heijden P., Rozing J. Phenotype of intraepithelial lymphocytes in euthymic and athymic mice: implications for differentiation of cells bearing a CD3 associated γδ T cell receptor. Eur. J. Immunol. 1990; 20: 291
  • Bonneville M., Itohara S., Krecko E. G., Mombaerts P., Ishida I., Katsuki M., Berns A., Farr A. G., Janeway C. A., Tonegawa S. Transgenic mice demonstrate that epithelial homing of γ/δ T cells is determined by cell lineages independent of T cell receptor specificity. J. Exp. Med. 1990; 171: 1015
  • Lefrancois L. Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J. Immunol. 1991; 66: 583
  • Goodman T., Lefrançois L. Intraepithelial lymphocytes: anatomical, not T cell receptor form, dictates phenotype and function. J. Exp. Med. 1989; 170: 1569
  • Guy-Grand D., Cerf-Bensussan N., Malissen B., Malissen-Seris M., Briottet C., Vassalli P. Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J. Exp. Med. 1991; 173: 471
  • Rocha B., Vassalli P., Guy-Grand D. The Vβ repertoire of mouse gut homodimeric α CD8+ intraepithelial T cell receptor αβ+ lymphocytes reveals a major extrathymic pathway of T cell differentiation. J. Exp. Med. 1991; 173: 483
  • Parrott D. M. V., Tait C., MacKenzie S., Mowat A. M., Davies M. D. J., Micklem W. S. Analysis of the effector functions of different populations of mucosal lymphocytes. Ann. NY Acad. Sci. 1983; 409: 307
  • Viney J. L., Kilshaw P. J., MacDonald T. T. Cytotoxic αβ+ and γδ+ T cells in murine intestinal epithelium. Eur. J. Immunol. 1990; 20: 1632
  • LeFrançois L. Extrathymic differentiation of intraepithelial lymphocytes: generation of a separate and unequal T-cell repertoire?. Immunol. Today 1991; 12: 436
  • Walker I. D., Hogarth P. M., Murray B. J., Lovering K., Classon B. J., Chambers G. W., McKenzie I. F. C. Ly antigen associated with T cell recognition and effector function. Immunol. Rev. 1984; 82: 47
  • Lefrancois L., LeCorre R., Mayo J., Bluestone J. A., Goodman T. Extrathymic selection of TCRγδ+ T cells by class II major histocompatibility complex molecules. Cell 1990; 63: 333
  • Bandeira A., Itohara S., Bonneville M., Burlen-Defranoux O., Mota-Santos T., Coutinho A., Tonegawa S. Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor γδ. Proc. Natl. Acad. Sci. USA 1991; 88: 43
  • Mosley R. L., Styre D., Klein J. R. Differentiation and functional maturation of bone marrow derived intestinal epithelial T cells expressing membrane T cell receptor in athymic radiation chimeras. J. Immunol. 1990; 145: 1369
  • Fujihashi K., Taguchi T., McGhee J. R., Eldridge J. H., Bruce M. G., Green D. R., Singh B., Kiyono H. Regulatory function for murine intraepithelial lymphocytes. Two subsets of CD3+ TCR-1+ intraepithelial lymphocyte T cells abrogate oral tolerance. J. Immunol. 1990; 145: 2010
  • Maloy K. J., Mowat A. M., Zamoyska R., Crispe I. N. Phenotypic heterogeneity of intraepithelial T lymphocytes from mouse small intestine. Immunology 1991; 72: 555
  • Aicher W. K., Fujihashi K., Taguchi T., McGhee J. R., Yamamoto M., Eldridge J. H., Gay S., Kiyono H. Intestinal intraepithelial lymphocyte T cells are resistant to Ipr gene-induced T cell abnormalities. Eur. J. Immunol. 1992; 22: 137
  • Fujihashi K., Yamamoto M., McGhee J. R., Beagley K. W., Kiyono H. Function of αβ TCR+ intestinal intraepithelial lymphocytes: Th1-and Th2-type cytokine production by CD4+CD8− and CD4+CD8+ T cells for helper activity. Int. Immunol. 1993; 5: 1473
  • Bianchi A., van der Heijden P., Stok W., Coolen J., Rozing J. Decrease of IgA-secreting cells in the lamina propria of mice during aging. Aging Imm. Infect. 1990; 2: 241
  • Perez P., Bluestone J. A., Stephany D., Segal A. Quantitative measurements of the specificity and kinetics of conjugate formation between cloned cytotoxic T lymphocytes and splenic target cells by dual parameter flow cytometry. J. Immunol. 1985; 134: 478
  • Carding S. R., Kyes S., Jenkinson E. J., Kingston R., Bottomly K., Owen J. J. T., Hayday A. C. Developmentally regulated fetal thymic and extrathymic T-cell receptor γδ gene expression. Genes Develop. 1990; 4: 1304
  • Hochstenbach F., Brenner M. B. T-cell receptor δ-chain can substitute for α to form a βδ heterodimer. Nature 1989; 340: 562
  • De Geus B. Differentiation and characterization of murine intestinal intraepithelial lymphocytes. Thesis. Leiden, The Netherlands 5412; ISBN90––0045
  • Barret T. A., Delvy M. L., Kennedy D. M., Lefrancois L., Matis L. A., Dent A. L., Hedrick S. M., Bluestone J. A. Mechanism of self-tolerance of γ/δ T cells in epithelial tissue. J. Exp. Med. 1992; 175: 65
  • Guy-Grand D., Vassalli P. Gut injury in mouse graft-versus-host reaction. J. Clin. Invest. 1986; 77: 1584
  • Hershberg R., Eghtesady P., Sydora B., Brorson K., Cheteroute H., Modlin R., Kronenberg M. Expression of the thymus leukemia antigen in mouse intestinal epithelium. Proc. Natl. Acad. Sci. USA 1990; 87: 9727
  • Wu M., Van Kaer L., Itohara S., Tonegawa S. Highly restricted expression of the thymus leukemia antigens on intestinal epithelial T cells. J. Exp. Med. 1991; 174: 213
  • Bleicher P A., Balk S. P., Hagen S. J., Blumberg R. S., Flotte T. J., Terhorst C. Expression of murine CD1 on Gastrointestinal epithelium. Science 1990; 250: 680
  • Bluestone J. A., Cron R. Q., Cotterman M., Houlden B. A., Matis L. A. Structure and specificity of T cell receptor γ/δ on major histocompatibility complex antigen-specific CD3+ CD4− CD8− T lymphocytes. J. Exp. Med. 1988; 168: 1899
  • Vidovic D., Roglic M., McKune K., Guerder S., MacKay C., Dembic Z. Qa-1 restricted recognition of foreign antigen by a γδ T-cell hybridoma. Nature 1989; 340: 646
  • Correa I., Bix M., Liao N., Zijlstra M., Jaenisch R., Raulet D. Most γδ T cells develop normally in β-2-microglobulin deficient mice. Proc. Natl. Acad. Sci. USA 1992; 89: 653
  • Zijlstra M., Bix M., Simister N. E., Loring J. M., Raulet D., Jaenisch R. β2-microglobulin deficient mice lack CD4−CD8+ cytolytic T cells. Nature 1990; 344: 742
  • Teh H. S., Kisielow P., Scott B., Kishi H., Uematsu Y., Bluthmann H., von Boehmer H. Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature 1988; 335: 229
  • Mixter P. F., Sydora B. C., Herschberg R. M., Kronenberg M. Depletion of mouse αβ T cell antigen receptor bearing lymphocytes by neonatal monoclonal antibody treatment. J. Immunol. 1991; 147: 4109
  • Carbone A., Harbeck R., Dallas A., Nemazee D., Finkel T., O'Brien R., Kubo R., Born W. αβ T-Lymphocyte depleted mice, a model for γδ T-lymphocyte functional studies. Immunol. Rev. 1991; 120: 35
  • Bandeira A., Mota-Santos T., Itohara S., Degermann S., Heusser C., Tonegawa S., Coutinho A. Localization of γ/δ cells to the intestinal epithelium is independent of normal microbial colonization. J. Exp. Med. 1990; 172: 239
  • Dobber R., Hertogh-Huijbregts A., Rozing J., Bottomly K., Nagelkerken L. The involvement of the intestinal microflora in the expansion of CD4+ T cells with a naive phenotype in the periphery. Develop. Immunol. 1992; 2: 141
  • Lefrancois L., Goodman T. In vivo modulation of cytolytic activity and Thy-1 expression of TcRγδ+ intraepithelial lymphocytes. Science 1989; 243: 1716
  • Takeuchi M., Miyazaki H., Mirokawa K., Yokokura T., Yoshikai Y. Age-related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice. Eur. J. Immunol. 1993; 23: 1409
  • Takimoto H., Nakamura T., Takeuchi M., Sumi Y., Tanaka T., Nomoto K., Yoshikai Y. Age-associated increase in number of CD4+CD8+ intestinal intraepithelial lymphocytes in rats. Eur. J. Immunol. 1992; 22: 159
  • Mosley R. L., Styre D., Klein J. R. CD4+CD8+ murine intestinal intraepithelial lymphocytes. Int. Immunol. 1990; 2: 361
  • Marsh M. N. Studies of intestinal lymphoid tissue. II. Aspects of proliferation and migration of epithelial lymphocytes in the small intestine of mice. Gut 1975; 16: 665
  • DeGeus B., Van den Enden M. H. M., De Heer C., Kleiweg A., Heidt P., Timmermans C., Rozing J. The intestinal intraepithelial lymphocyte population expressing the TcRαβ shows variation of Vβ usage between individual mice. From Gene to Man. Stichting Gerontologie en Geriatrie, Leiden 1990, C. F. A. Van Bezooijen R. Ravid A. A. J. Verhofstad 313315

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.