The Function of the CD4 Coreceptor in the Development of T Cells

References

• Fowlkes B. J., Pardoll D. M. Molecular and cellular events of T cell development. Adv. Immunol 1989; 44: 207–264
   PubMed Web of Science ®Google Scholar
• Parnes J. R. Molecular biology and function of CD4 and CD8. Adv. Immunol 1989; 44: 265–311
   PubMed Web of Science ®Google Scholar
• Paul W. E., Seder R. A. Lymphocyte responses and cytokines. Cell 1994; 76: 241–251
   PubMed Web of Science ®Google Scholar
• Reed S. G., Scott P. T-cell and cytokine responses in leishmaniasis. Curr. Opin. Immunol 1993; 5: 524–531
   PubMed Web of Science ®Google Scholar
• Gill R. G. T-cell-T-cell collaboration in allograft responses. Curr. Opin. Immunol 1993; 5: 782–787
   Google Scholar
• Fong T. A., Mosmann T. R. The role of IFN-gamma in delayed-type hypersensitivity mediated by Th1 clones. J. Immunol 1989; 143: 2887–2893
   PubMed Web of Science ®Google Scholar
• Fowell D., Mason D. Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes: characterization of the CD4+ T cell subset that inhibits this autoimmune potential. J. Exp. Med 1993; 177: 627–636
   PubMed Web of Science ®Google Scholar
• Salter R. D., Benjamin R. J., Wesley P. K., Buxton S. E., Garrett T. P., Clayberger C., Krensky A. M., Norment A. M., Littman D. R., Parham P. A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2. Nature 1990; 345: 41–46
   PubMed Web of Science ®Google Scholar
• König R., Huang L. -Y., Germain R. N. MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8. Nature 1992; 356: 796–798
   PubMed Web of Science ®Google Scholar
• Aldrich C. J., Hammer R. E., Jones-Youngblood S., Koszinowski U., Hood L., Stroynowski I., Forman J. Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the alpha 3 domain of MHC I molecules. Nature 1991; 352: 718–721
   PubMedGoogle Scholar
• Ingold A. L., Landel C., Knall C., Evans G. A., Potter T. A. Co-engagement of CD8 with the T cell receptor is required for negative selection. Nature 1991; 352: 721–723
   PubMedGoogle Scholar
• Killeen N., Moriarty A., Teh H. S., Littman D. R. Requirement for CD8-MHC class I interaction in positive and negative selection of developing T cells. J. Exp. Med 1992; 176: 89–97
   PubMedGoogle Scholar
• Fowlkes B. J., Schwartz R. H., Pardoll D. M. Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage. Nature 1988; 334: 620–623
   PubMed Web of Science ®Google Scholar
• MacDonald H. R., Hengartner H., Pedrazzini T. Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment. Nature 1988; 335: 174
   PubMed Web of Science ®Google Scholar
• Ramsdell F., Fowlkes B. J. Engagement of CD4 and CD8 accessory molecules is required for T cell maturation. J. Immunol 1989; 143: 1467–1471
   PubMedGoogle Scholar
• Zúfñga-Pflücker J. C., Jones L. A., Longo D. L., Kruisbeek A. M. CD8 is required during positive selection of CD4−/CD8+ T cells. J Exp. Med 1990; 171: 427–437
   Google Scholar
• Hogquist K. A., Gavin M. A., Bevan M. J. Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J. Exp. Med 1993; 177: 1469–1473
   PubMedGoogle Scholar
• Ashton-Rickardt P. G., Van Kaer L., Schumacher T. N., Ploegh H. L., Tonegawa S. Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus. Cell 1993; 73: 1041–1049
   Google Scholar
• Hogquist K. A., Jameson S. C., Bevan M. J. The ligand for positive selection of T lymphocytes in the thymus. Curr. Opin. Immunol 1994; 6: 273–278
   Google Scholar
• Chan S. H., Cosgrove D., Waltzinger C., Benoist C., Mathis D. Another view of the selective model of thymocyte selection. Cell 1993; 73: 225–236
   PubMed Web of Science ®Google Scholar
• van Meerwijk J. P., Germain R. N. Development of mature CD8+ thymocytes: selection rather than instruction?. Science 1993; 261: 911–915
   Google Scholar
• Crump A. L., Grusby M. J., Glimcher L. H., Cantor H. Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. Proc. Natl. Acad. Sci. USA 1993; 90: 10739–10743
   PubMed Web of Science ®Google Scholar
• von Boehmer H., Kisielow P. Lymphocyte lineage commitment: instruction versus selection. Cell 1993; 73: 207–208
   PubMedGoogle Scholar
• von Boehmer H. Positive selection of lymphocytes. Cell 1994; 76: 219–228
   PubMed Web of Science ®Google Scholar
• Davis C. B., Littman D. R. Thymocyte lineage commitment: is it instructed or stochastic?. Curr. Opin. Immunol 1994; 6: 266–272
   Google Scholar
• Robey E., Fowlkes B. J. Selective events in T cell development. Annu. Rev. Immunol 1994; 12: 675–705
   PubMed Web of Science ®Google Scholar
• Borgulya P., Kishi H., Muller U., Kirberg J., von Boehmer H. Development of the CD4 and CD8 lineage T cells: instruction versus selection. EMBO J 1991; 10: 913–918
   PubMedGoogle Scholar
• Robey E., Fowlkes B. J., Gordon J. W., Kioussis D., von Boehmer H., Ramsdell E., Axel R. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell 1991; 64: 99–107
   PubMedGoogle Scholar
• Seong R. H., Chamberlain J. W., Parnes J. R. Signal for T-cell differentiation to a CD4 cell lineage is delivered by a CD4 transmembrane region and/or cytoplasmic tail. Nature 1992; 356: 718–720
   PubMed Web of Science ®Google Scholar
• Davis C. B., Killeen N., Crooks M. E. C., Raulet D., Littman D. R. Evidence for a Stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 1993; 73: 237–247
   PubMedGoogle Scholar
• Itano A., Kioussis D., Robey E. Stochastic component to development of class I major histocompatibility complex-specific T cells. Proc. Natl. Acad. Sci. USA 1994; 91: 220–224
   Google Scholar
• Rahemtulla A., Fung-Leung W. P., Schilham M. W., Kundig T. M., Sambhara S. R., Narendran A., Arabian A., Wakeham A., Paige C. J., Zinkernagel R. M., Miller R. G., Mak T. W. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature 1991; 353: 180–184
   PubMed Web of Science ®Google Scholar
• Killeen N., Sawada S., Littman D. R. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J 1993; 12: 1547–1553
   PubMed Web of Science ®Google Scholar
• Sawada S., Scarborough J. D., Killeen N., Littman D. R. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 1994; 77: 917–929
   PubMedGoogle Scholar
• Cosgrove D., Gray D., Dierich A., Kaufman J., Lemeur M., Benoist C., Mathis D. Mice lacking MHC class II molecules. Cell 1991; 66: 1051–1066
   PubMedGoogle Scholar
• Grusby M. J., Johnson R. S., Papaioannou V. E., Glimcher L. H. Depletion of CD4+ T cells in major histocompatibility complex class H-deficient mice. Science 1991; 253: 1417–1420
   PubMed Web of Science ®Google Scholar
• Zijlstra M., Bix M., Simister N. E., Loring J. M., Raulet D. H., Jaenisch R. Beta 2-microglobulin deficient mice lack CD4–8+ cytolytic T cells. Nature 1990; 344: 742–746
   PubMed Web of Science ®Google Scholar
• Roller B. H., Marrack P., Kappler J. W., Smithies O. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science 1990; 248: 1227–1230
   PubMedGoogle Scholar
• Locksley R. M., Reiner S. L., Hatam E., Littman D. R., Killeen N. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 1993; 261: 1448–1451
   PubMed Web of Science ®Google Scholar
• Titus R. G., Milon G., Marchal G., Vassalli P., Cerottini J. C., Louis J. A. Involvement of specific Lyt-2+ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis. Eur. J. Immunol 1987; 17: 1429–1433
   PubMed Web of Science ®Google Scholar
• Locksley R. M., Scott P. Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunol. Today 1991; 12: A58–A61
   Google Scholar
• Locksley R. M., Louis J. A. Immunology of leishmaniasis. Curr. Opin. Immunol 1992; 4: 413–418
   PubMed Web of Science ®Google Scholar
• Wang Z. E., Reiner S. L., Hatam F., Heinzel F. P., Bouvier J., Turck C. W., Locksley R. M. Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis. J. Immunol 1993; 151: 2077–2086
   PubMed Web of Science ®Google Scholar
• Guidos C. J., Weissman I. L., Adkins B. Intrathymic maturation of murine thymocytes from CD8+ precursors. Proc. Natl. Acad. Sci. USA 1989; 86: 7542–7546
   PubMedGoogle Scholar
• Turner J. M., Littman D. R. Function of CD4 and CD8 in T cell activation and differentiation. Advances in Regulation of Cell Growth, J. Mond, A. Weiss, J. Cambier. Raven Press, New York 1991; Vol 2., in press
   Google Scholar
• Veillette A., Davidson D. Src-related protein tyrosine kinases and T-cell receptor signalling. Trends Genet 1992; 8: 61–66
   PubMedGoogle Scholar
• Veillette A., Abraham N., Caron L., Davidson D. The lymphocyte-specific tyrosine protein kinase p56Ick. Semin. Immunol 1991; 3: 143–152
   PubMedGoogle Scholar
• Weiss A., Littman D. R. Signal transduction by lymphocyte antigen receptors. Cell 1994; 76: 263–274
   PubMed Web of Science ®Google Scholar
• Julius M., Maroun C. R., Haughn L. Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signalling. Immunol. Today 1993; 14: 177–183
   Google Scholar
• Shaw A. S., Amrein K. E., Hammond C., Stern D. E., Sefton B. M., Rose J. K. The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain. Ceil 1989; 59: 627–636
   PubMed Web of Science ®Google Scholar
• Turner J. M., Brodsky M. G., Irving B. A., Levin S. D., Perlmutter R. M., Littman D. R. Interaction of the unique N-terminal region of tyrosine kinase p56Ick with cytoplasmic domains of CD4 and CD8 is mediated by cytoseine motifs. Cell 1990; 60: 755–765
   PubMed Web of Science ®Google Scholar
• Shaw A. S., Chalupny J., Whitney J. A., Hammond C., Amrein K. E., Kavathas P., Sefton B. M., Rose J. K. Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56Ick tyrosine protein kinase. Molec. Cell. Biol 1990; 10: 1853–1862
   PubMed Web of Science ®Google Scholar
• Glaichenhaus N., Shastri N., Littman D. R., Turner J. M. Requirement for association of p56Ick with CD4 in antigen-specific signal transduction in T cells. Cell 1991; 64: 511–520
   PubMed Web of Science ®Google Scholar
• Collins T. L., Uniyal S., Shin J., Strominger J. L., Mittler R. S., Burakoff S. J. p56Ick association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation. J. Immunol 1992; 148: 2159–2162
   PubMed Web of Science ®Google Scholar
• Killeen N., Littman D. R. Helper T cell development in the absence of CD4-p56Ick association. Nature 1993; 364: 729–732
   PubMed Web of Science ®Google Scholar
• Killeen N., Davis C. B., Chu K., Crooks M. E. C., Sawada S., Scarborough J. D., Boyd K. A., Stuart S. G., Xu H., Littman D. R. CD4 function in thymocyte differentiation and T cell activation. Phil. Trans. R. Soc. Lond. B 1993; 342: 25–34
   Google Scholar
• Xu H., Littman D. R. A kinase-independent function of Lck in potentiating antigen-specific T cell activation. Cell 1993; 74: 633–643
   PubMedGoogle Scholar
• Triebel F., Jitsukawa S., Baixeras E., Roman-Roman S., Genevee C., Viegas-Pequignot E., Hercend T. LAG-3, a novel lymphocyte activation gene closely related to CD4. J. Exp. Med 1990; 171: 1393–1405
   PubMed Web of Science ®Google Scholar
• Baixeras E., Huard B., Miossec C., Jitsukawa S., Martin M., Hercend T., Auffray C., Triebel E., Piatier-Tonneau D. Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. J. Exp. Med 1992; 176: 327–337
   PubMed Web of Science ®Google Scholar