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Original Article

Interleukin 9 and its Receptor: An Overview of Structure and Function

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Pages 345-364 | Published online: 10 Jul 2009

References

  • Uyttenhove C., Simpson R. J., Van Snick J. Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity. Proc. Natl. Acad. Sci. USA 1988; 85: 6934–6938
  • Van Snick J., Goethals A., Renauld J.-C., Van Roost E., Uyttenhove C., Rubira M. R., Moritz R. L., Simpson R. J. Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40). J. Exp. Med. 1989; 169: 363–368
  • Hültner L., Moeller J., Schmitt E., Jäger G., Reisbach G., Ring J., Dormer P. Thiol-sensitive mast cell lines derived from mouse bone marrow respond to a mast cell growth-enhancing activity different from both IL-3 and IL-4. J. Immunol. 1989; 142: 3440–3446
  • Moeller J., Hültner L., Schmitt E., Dormer P. Partial purification of a Mast Cell Growth-enhancing activity and its separation from IL-3 and IL-4. J. Immunol. 1989; 142: 3447–3451
  • Moeller J., Hültner L., Schmitt E., Breuer M., Dormer P. Purification of MEA, a Mast Cell Growth-enhancing activity, to apparent homogeneity and its partial amino acid sequencing. J. Immunol. 1990; 144: 4231–4234
  • Hültner L., Druez C., Moeller J., Uyttenhove C., Schmitt E., Rude E., Dormer P., Van Snick J. Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIII (interleukin 9). Eur. J. Immunol. 1990; 20: 1413–1416
  • Yang Y., Ricciardi S., Ciarletta A., Calvetti J., Kelleher K., Clark S. C. Expression cloning of a cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-Cell Growth Factor P40. Blood 1989; 74: 1880–1884
  • Renauld J.-C., Goethals A., Houssiau F., Van Roost E., Van Snick J. Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40. Cytokine 1990; 2: 9–12
  • Donahue R. E., Yang Y. C., Clark S. C. Human P40 T cell growth factor (Interleukin-9) supports erythroid colony formation. Blood 1990; 75: 2271–2275
  • Houssiau F., Renauld J.-C., Stevens M., Lehmann F., Coulie P. G., Van Snick J. Human T cell lines and clones respond to IL-9. J. Immunol. 1993; 150: 2634–2640
  • Petit-Frère C., Dugas B., Braquet P., Mencia-Huerta J. M. Interleukin-9 potentiates the interleukin-4-induced IgE and IgGl release from murine B lymphocytes. Immunology 1993; 79: 146–151
  • Dugas B., Renauld J.-C., Pene J., Bonnefoy J. Y., Petit-Frère C., Braquet P., Bousquet J., Van Snick J., Mencia-Huerta J. M. Interleukin-9 potentiates the interleukin-4-induced immunoglobulin (IgG, IgM and IgE) production by normal human B lymphocytes. Eur. J. Immunol. 1993; 23: 1687–1692
  • Suda T., Murray R., Fischer M., Tokota T., Zlotnik A. Tumor Necrosis Factor-α and P40 induce day 15 murine fetal thymocyte proliferation in combination with IL-2. J. Immunol. 1990; 144: 1783–1787
  • Vink A., Renauld J.-C., Warmer G., Van Snick J. Interleukin 9 stimulates in vitro growth of mouse thymic lymphomas. Eur. J. Immunol. 1993; 23: 1134–1138
  • Mehler M. F., Rozental R., Dougherty M., Spray D. C., Kessler J. A. Cytokine regulation of neuronal differentiation of hippocampal progenitor cells. Nature 1993; 362: 62–65
  • Modi W. S., Pollock D. D., Mock B. A., Banner C., Renauld J.-C., Van Snick J. Regional localization of the human glutaminase (GLS) and interleukin-9 (IL9) genes by in situ hybridization. Cytogenet. Cell. Genet. 1991; 57: 114–116
  • Sokal G., Michaux J. L., Van Den Berghe H., Cordier A., Rodhain J., Ferrant A., Moriau M., De Bruyére M., Sonnet J. A new hematologic syndrome with a distinct karyotype: the 5q-chromosome. Blood 1975; 46: 519–533
  • Mock B. A., Krall M., Kozak C. A., Nesbitt M. N., McBride O. W., Renauld J.-C., Van Snick J. IL9 maps to mouse chromosome 13 and human chromosome 5. Immunogenetics 1990; 31: 265–270
  • Renauld J.-C., Goethals A., Houssiau F., Merz H., Van Roost E., Van Snick J. Human P40/IL-9: expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene. J. Immunol. 1990; 144: 4235–4241
  • Kruys V., Marinx O., Shaw G., Deschamps J., Huez G. Translational blockade imposed by cytokine-derived UA-rich sequences. Science 1989; 245: 852–855
  • Kelleher K., Bean K., Clark S. C., Leung W. Y., Yang-Feng T. L., Chen J. W., Lin P. F., Luo W., Yang Y. C. Human Interleukin-9: genomic sequences, chromosomal location, and sequences essential for its expression in human T cell leukemia Virus (HTLV)-I-transformed human T cells. Blood 1991; 77: 1436–1441
  • Schmitt E., van Brandwijk R., Van Snick J., Siebold B., Rude E. TCGFIII/P40 is produced by naive murine CD4+ T cells but is not a general T cell growth factor. Eur. J. Immunol. 1989; 19: 2167–2170
  • Gessner A., Blum H., Röllinghoff M. Differential regulation of IL-9 expression after infection with Leishmania major in susceptible and resistant mice. Immunobiol. 1993; 189: 419–435
  • Svetic A., Finkelman F. D., Jian Y. C., Dieffenbach C. W., Scott D. E., McCarthy K. F., Steinberg A. D., Gause W. C. Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J. Immunol. 1991; 147: 2391–2397
  • Svetic A., Madden K. B., Zhou X. D., Lu P., Katona I. M., Finkelman F. D., Urban J. F., Gause W. C. A primary intestinal helminthic infection rapidly induces a gut-associated elevation of TH2-associated cytokines and IL-3. J. Immunol. 1993; 150: 3434–3441
  • Houssiau F., Schandené L., Stevens M., Cambiaso C., Goldman M., Van Snick J., Renauld J.-C. A cascade of cytokines is responsible for IL-9 expression in human T cells. Involvement of IL-2, IL-4 and IL-10. J. Immunol. 1995; 154: 2624–2630
  • Houssiau F., Renauld J.-C., Fibbe W., Van Snick J. IL-2 dependence of IL-9 expression in human T lymphocytes. J. Immunol. 1992; 148: 3147–3151
  • Hauber I., Fisher M. B., Maris M., Eibl M. M. Reduced IL-2 expression upon antigen stimulation is accompanied by deficient IL-9 gene expression in T cells of patients with CVID. Scand. J. Immunol. 1995; 41: 215–219
  • Schmitt E., Germann T., Goedert S., Hoehn P., Huels C., Koelsch S., Kuhn R., Muller W., Palm N., Rude E. IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma. J. Immunol. 1994; 153: 3989–3996
  • Schmitt E., Beuscher H. U., Huels C., Monteyne P., van Brandwijk R., Van Snick J., Rude E. IL-1 serves as a secondary signal for IL-9 expression. J. Immunol. 1991; 147: 3848–3854
  • Flubacher M. M., Bear S. E., Tsichlis P. N. Replacement of Interleukin-2 (IL-2)-generated mitogenic signals by a mink cell focus-forming (MCF) or xenotropic virus-induced IL-9-dependent autocrine loop: implications for MCF virus-induced leukemogenesis. J. Virol. 1994; 68: 7709–7716
  • Uyttenhove C., Druez C., Renauld J.-C., Herin M., Noel H., Van Snick J. Autonomous growth and tumorigenicity induced by P40/Interleukin 9 cDNA transfection of a mouse P40-dependent T cell line. J. Exp. Med. 1991; 173: 519–522
  • Renauld J.-C., Vander Lugt N., Vink A., van Roon M., Godfraind C., Warmer G., Merz H., Feller A., Berns A., Van Snick J. Thymic lymphomas in interleukin 9 transgenic mice. Oncogene 1994; 9: 1327–1332
  • Rich B., Campos-Torres J., Tepper R., Moreadith R., Leder P. Cutaneous lymphoproliferation and lymphomas in IL-7 transgenic mice. J. Exp. Med. 1993; 177: 305–317
  • Renauld J.-C., Kermouni A., Vink A., Louahed J., Van Snick J. Interleukin-9 and its receptor: involvement in mast cell differentiation and T cell oncogenesis. J. Leukoc. Biol. 1995; 57: 353–360
  • Renauld J.-C., Vink A., Louahed J., Van Snick J. Interleukin-9 is a major ant-apoptotic factor for thymic lymphomas. Blood 1995; 85: 1300–1305
  • Merz H., Houssiau F., Orscheschek K., Renauld J.-C., Fliedner A., Herin M., Noël H., Kadin M., Mueller-Hermelink K. H., Van Snick J., Feller A. C. Interleukin-9 expression in human malignant lymphomas: unique association with Hodgkin's disease and Large Cell Anaplastic Lymphoma. Blood 1991; 78: 1311–1317
  • Gruss H. J., Brach M. A., Drexler H. G., Bross K. J., Herrman F. Interleukin 9 is expressed by primary and cultured Hodgkin and Reed-Sternberg cells. Cancer Res. 1992; 52: 1026–1031
  • Trümper L. H., Brady G., Bagg A., Gray D., Loke S. L., Griesser H., Wagman R., Graziel R., Gascoyne R. D., Vicini S., Iscove N. N., Cossman J., Mak T. W. Single cell analysis of Hodgkin and Reed-Sternberg cells: molecular heterogeneity of gene expression and p53 mutations. Blood 1993; 81: 3097–3115
  • Kubota S., Siomi H., Hatanaka M., Pomerantz R. J. Cis/trans-activation of the interleukin-9 receptor gene in an HTLV-I-transformed human lymphocytic cell. Oncogene 1996; 12: 1441–1447
  • Lehrnbecher T., Poot M., Orscheschek K., Sebald W., Feller A. C., Merz H. Interleukin 7 as interleukin 9 drives phytohemagglutinin-activated T cells through several cell cycles; no synergism between interleukin 7, interleukin 9 and interleukin 4. Cytokine 1994; 6: 279–284
  • Williams D. E., Morrissey P. J., Mochizuki D., de Vries P., Anderson D., Cosman D., Boswell H. S., Cooper S., Grabstein K. H., Broxmeyer H. E. T cell growth factor P40 promotes the proliferation of myeloid cell lines and enhances erythroid burst formation by normal murine bone marrow cells in vitro. Blood 1990; 76: 906–911
  • Eklund K. K., Ghildyal N., Austen K. F., Stevens R. L. Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases. J. Immunol. 1993; 151: 4266–4273
  • Louahed J., Kermouni A., Van Snick J., Renauld J.-C. IL-9 induces expression of Granzymes and high affinity IgE receptor in murine T helper clones. J. Immunol. 1995; 154: 5061–5070
  • Hültner L., Moeller J. Mast cell growth-enhancing activity (MEA) stimulates interleukin 6 production in a mouse bone marrow-derived mast cell line and a malignant subline. Exp. Hematol. 1990; 18: 873–877
  • Grencis R. K., Hültner L., Else K. J. Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes. Immunology 1991; 74: 329–332
  • Else K., Hültner L., Grencis R. Cellular immune responses to the murine nematode parasite Trichuris muris. II Differential induction of Th cell subsets in resistant mice versus susceptible mice. Immunology 1992; 75: 232–237
  • Else K., Hültner L., Grencis R. Modulation of cytokine production and response phenotypes in murine trichuriasis. Parasite Immunology 1992; 14: 441–449
  • Urban J. F., Madden K. B., Svetic A., Cheever A., Trotta P. P., Gause W. C., Katona I. M., Finkelman F. D. The importance of TH2 cytokines in protective immunity to nematodes. Immunol. Rev. 1992; 127: 205–220
  • Wahid F. N., Behnke J. M., Grencis R. K., Else K. J., Ben-Smith A. W. Immunological relationships during primary infection with Heligmosomoides polygyrus: Th2 cytokines and primary response phenotype. Parasitology 1994; 108: 461–471
  • Finkelman F. D., Madden K. B., Cheever A. W., Katona I. M., Morris S. C., Gately M. K., Hubbard B. R., Gause W. C., Urban J. F. Effects of Interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J. Exp. Med. 1994; 179: 1563–1572
  • Hendrie P., Miyazawa K., Yang Y. C., Langefeld C., Broxmeyer H. Mast cell Growth Factor (c-kit ligand) enhances cytokine stimulation and proliferation of the human factor-dependent cell line, Mo7E. Exp. Hematol. 1991; 19: 1031–1037
  • Birner A., Hültner L., Mergenthaler H. G., Van Snick J., Dormer P. Recombinant murine Interleukin 9 enhances the Erythropoietin-dependent colony formation of human BFU-E. Exp. Hematol. 1992; 20: 541–545
  • Sonoda Y., Maekawa T., Kuzuyama Y., Clark S. C., Abe T. Human Interleukin-9 supports formation of a subpopulation of erythroid bursts that are responsive to Interleukin-3. Am. J. Hematol. 1992; 41: 84–91
  • Schaafsma M. R., Falkenburg J. H., Duinkerken N., Van-Snick J., Landegent J. E., Willemze R., Fibbe W. E. Interleukin-9 stimulates the proliferation of enriched human erythroid progenitor cells: additive effect with GM-CSF. Ann. Hematol. 1993; 66: 45–49
  • Lu L., Leemhuis T., Srour E., Yang Y. C. Human Interleukin 9 stimulates proliferation of CD34+++ DR+ CD33− erythroid progenitors in normal human bone marrow in the absence of serum. Exp. Hematol. 1992; 20: 418–424
  • Lemoli R. M., Fortuna A., Fogli M., Motta M. R., Rizzi S., Benini C., Tura S. Stem Cell Factor (c-kit ligand) enhances the Interleukin-9-dependent proliferation of human CD34+ and CD34+ CD33−DR− cells. Exp. Hematol. 1994; 22: 919–923
  • Holbrook S. T., Ohls R. K., Schribler K. R., Yang Y. C., Christensen R. D. Effect of Interleukin-9 on clonogenic maturation and cell-cycle status of foetal and adult hematopoietic progenitors. Blood 1991; 77: 2129–2134
  • Lemoli R. M., Fortuna A., Tafuri A., Fogli M., Amabile M., Grande A., Ricciardi M. R., Petrucci M. T., Bonsi L., Bagnara G., Visani G., Martinelli G., Ferrari S., Tura S. Interleukin-9 stimulates the proliferation of human myeloid leukemic cells. Blood 1996; 87: 3852–3859
  • Suda T., Murray R., Guidos C., Zlotnik A. Growth-promoting activity of IL-1α, IL-6 and Tumor Necrosis Factor-α in combination with IL-2, IL-4, or IL-7 on murine thymocytes. J. Immunol. 1990; 144: 3039–3045
  • Druez C., Coulie P., Uyttenhove C., Van Snick J. Functional and biochemical characterization of mouse P40/IL-9 receptors. J. Immunol. 1990; 145: 2494–2499
  • Renauld J.-C., Druez C., Kermouni A., Houssiau F., Uyttenhove C., Van Roost E., Van Snick J. Expression cloning of the murine and human interleukin 9 receptor cDNAs. Proc. Natl. Acad. Sci. USA 1992; 89: 5690–5694
  • Bazan F. Structural design and molecular evolution of a cytokine receptor super-family. Proc. Natl. Acad. Sci. USA 1990; 87: 6934–6938
  • Kermouni A., Van Roost E., Arden K. C., Vermeesch J. R., Weiss S., Godelaine D., F'lint J., Lurquin C., Szikora J. P., Higgs D. R., Marynen P., Renauld J.-C. The IL-9 receptor gene: genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes and identification of IL-9R pseudogenes at 9qter, 10pter, 16pter and 18pter. Genomics. 1995; 29: 371–382
  • Kozak M. An analysis of vertebrate mRNA sequences: intimations of translational control. J. Cell. Biol. 1991; 115: 887–903
  • Vermeesch J. R., Petit P., Kermouni A., Renauld J.-C., Van Den Berghe H., Marynen P. The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal region, has an autosomal origin and escapes X inactivation. Hum. Mol. Genet. 1997; 6: 1–8
  • Chang M. S., Engel G., Benedict C., Basu R., McNimch J. Isolation and characterization of the human Interleukin-9 receptor gene. Blood 1994; 83: 3199–3205
  • Biessmann H., Mason J. M. Genetics and molecular biology of telomeres. Adv. Genet. 1992; 30: 185–249
  • Pays E., Steinert M. Control of antigen gene expression in african Trypanosomes. Annu. Rev. Genet. 1988; 22: 107–126
  • Kishimoto T., Taga T., Akira S. Cytokine signal transduction. Cell 1994; 76: 253–262
  • Kimura Y., Takeshita T., Kondo M., Ishii N., Nakamura M., Van Snick J., Sugamura K. Sharing of the IL-2 receptor 7 chain with the functional IL-9 receptor complex. Int. Immunol. 1995; 7: 115–120
  • Demoulin J. B., Uyttenhove C., Van Roost E., de Lestré B., Donckers D., Van Snick J., Renauld J.-C. A single tyrosine of the Interelukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. Mol. Cell. Biol. 1996; 16: 4710–4716
  • Murakami M., Narazaki M., Hibi M., Yawata H., Yasukawa K., Hamaguchi M., Taga T., Kishimoto T. Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family. Proc. Natl. Acad. Sci. USA 1991; 88: 11349–11353
  • Lik-Shing Yin T., Tsang M., Yang Y.-C. Jak1 kinase forms complexes with Interleukin-4 receptor and 4PS/Insulin receptor substrate-1-like protein and is activated by Interleukin-4 and Interleukin-9 in T lymphocytes. J. Biol. Chem. 1994; 269: 26614–26617
  • Russel S. M., Johnston J. A., Noguchi M., Kawamura M., Bacon C. M., Friedman M., Berg M., McVicar D. W., Witthuhn B. A., Silvennonien O., Goldmann A. S., Schmalstieg F. C., Ihle J. M., O'Shea J. J., Leonard W. J. Interaction of IL-2Rβ and γc chains with Jak1 and Jak3: implications for XSCID and XCID. Science 1994; 266: 1042–1045
  • Miyazawa K., Hendrie P., Kim Y. J., Mantel C., Se Yang Y. C., Kwon B., Broxmeyer H. Recombinant human Interleukin-9 induces protein tyrosine phosphorylation and synergizes with Steel Factor to stimulate proliferation of the human factor-dependent cell line, Mo7E. Blood 1992; 80: 1685–1692
  • Brennscheidt U., Riedel D., Kölch W., Bonifer R., Brach M. A., Ahlers A., Mertelsmann R. H., Herrmann F. Raf-1 is a necessary component of the mitogenic response of the human megakaryoblastic leukemia cell line Mo7 to human Stem Cell Factor, Granulocyte-Macrophage Colony-stimulating Factor, Interleukin-3, and Interleukin-9. Cell Growth and Differ. 1994; 5: 367–372
  • Yin T., Keller S. R., Quelle F. W., Witthuhn B. A., Lik-Shing Tsang M., Lienhard G. E., Ihle J. N., Yang Y.-C. Interleukin-9 induces tyrosine phosphorylation of Insulin Receptor Substrate-1 via Jak tyrosine kinases. J. Biol. Chem. 1995; 270: 20497–20502
  • Keegan A., Nelms K., Wang L. M., Pierce J., Paul W. Interleukin-4 receptor: signaling mechanisms. Immunol. Today 1994; 15: 423–432

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