Cytokines in the Neuroendocrine System

References

• Blalock J. E. A molecular basis for bidirectional communication between the immune and neuroendocrine systems. Physiol. Rev. 1989; 69: 1–32
   PubMed Web of Science ®Google Scholar
• Blalock J. E., Smith E. M. A complete regulatory loop between the immune and neuroendocrine systems. Fed. Proc 1985; 44: 108–111
   PubMedGoogle Scholar
• O'Dorisio M. S., Panerai A. Neuropeptides and immunopeptides: messengers in a neuroimmune axis. Annals of New York Academy of Sciences, New York 1990
   Google Scholar
• Besedovsky H. O., Del Rey A. Immune-neuroendocrine circuits: integrative role of cytokines. Frontiers in Neuroendocrinology. Raven Press Ltd, New York 1992; 61–94, Anonymous
   Google Scholar
• Gaillard R. C. Neuroendocrine-immune system interactions. The immune–hypothalamo–pituitary–adrenal axis. Trends Endocrinol. Metab. 1994; 5: 303–309
   PubMed Web of Science ®Google Scholar
• Karalis K., Mastorakos G., Chrousos G. P., Tolis G. Somatostatin analogs suppress the inflammatory reaction in vivo. J. Clin. Invest. 1994; 93: 2000–2006
   PubMed Web of Science ®Google Scholar
• Karalis K., Mastorakos G., Sano H., Wilder R. L., Chrousos G. P. Somatostatin may participate in the antiinflammatory actions of glucocorticoids. Endocrinology 1995; 136: 4133–4138
   Google Scholar
• Homo-Delarche F., Durant S. Hormones neurotransmitters and neuropeptides as modulators of lymphocyte functions. Immunopharmacology of Lymphocytes, M. Rola-Pleszczynski. Academic Press Limited, London 1994; 169–240
   Google Scholar
• Weigent D. A., Blalock J. E. Interactions between the neuroendocrine and immune systems: common hormones and receptors. Immunol. Rev. 1987; 100: 79–108
   PubMed Web of Science ®Google Scholar
• Chrousos G. P. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Eng. J. Med. 1995; 332: 1351–1362
   PubMed Web of Science ®Google Scholar
• Crofford L. J., Sano H., Karalis K. Corticotropin-releasing hormone in synovial fluids and tissues of patients with rheumatoid arthritis and osteoarthritis. J. Immunol. 1993; 151: 1587–1596
   PubMed Web of Science ®Google Scholar
• Ekman R. E., Servenius B., Castro M. G. Biosynthesis of corticotropin-releasing hormone in human T-lymphocytes. J. Neuroimmunol. 1993; 44: 7–13
   PubMedGoogle Scholar
• Koenig J. I. Presence of cytokines in the hypothalamic-Pituitary axis. Prog. Neuroendocr. Immunol. 1991; 4: 143–153
   Google Scholar
• Plata-Salaman C. R. Immunoregulations in the nervous system. Neurosci. Biobehav. Rev. 1991; 15: 185–215
   PubMed Web of Science ®Google Scholar
• Fontana A., Christensen F., Dubs R., Gemsa D., Weber E. Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells. J. Immunol. 1982; 129: 2413–2419
   PubMed Web of Science ®Google Scholar
• Hetier E., Ayala J., Denèfle P., Boussean A., Rouget P., Mallat M. Brain macrophages synthesize interleukin-1 and interleukin-1 mRNAs in vitro. Neurosci. Res. 1988; 21: 391–397
   Google Scholar
• Breder C. D., Tsujimoto M., Terano Y., Scott D. W., Saper C. B. Distribution and characterization of tumor necrosis factor-alpha-like immunoreactivity in the murine central nervous system. J. Comp. Neurol. 1993; 337: 543–567
   PubMed Web of Science ®Google Scholar
• Tada M., Suzuki K., Yamakawa Y., Sawamura Y., Abe H., van Meir E., de Tribolet N. Human glioblastoma cells produce 77 amino acid interleukin-8 (IL-8(77)). J. Neurooncol 1993; 16: 25–34
   Google Scholar
• Riccardi-Castagnoli P., Pirami L., Righi M., Sacerdote P., Locatelli V., Bianchi M., Sassano M., Valsasnini P., Shammah S., Panerai A. E. Cellular sources and effects of tumor necrosis factor-alpha on pituitary cells and in the central nervous system. Ann. N. Y. Acad. Sci. 1990; 594: 156–168
   Google Scholar
• Sébire G., Emilie D., Wallon C., Hery C., Devergne O., Delfraissy J. F., Galanaud P., Tardieu M. In vitro, production of IL-6, IL-1 beta and tumor necrosis factor-alpha by human embryonic microglial and neural cells. J. Immunol. 1993; 150: 1517–1523
   PubMed Web of Science ®Google Scholar
• Fabry Z., Fitzsimmons K. M., Herlein J. A., Moninger T. O., Dobbs M. B., Hart M. N. Production of the cytokines interleukin-1 and -6 by murine brain microvessel endothelium and smooth muscle pericytes. J. Neuroimmunol. 1993; 47: 23–34
   PubMed Web of Science ®Google Scholar
• Breder C D, Dinarello C. A., Sapler C. B. Interleukin-1 immunoreactive innervation of the human hypothalamus. Science 1988; 240: 321–324
   PubMed Web of Science ®Google Scholar
• Lechan R. M., Toni R., Clark B. D., Cannon J. G., Shaw A. R., Dinarello C. A., Reichlin S. Immunoreactive interleukin-1 localization in the rat forebrain. Brain Res. 1990; 514: 135–140
   PubMed Web of Science ®Google Scholar
• Schobitz B., Voorhuis D. A., De Kloet E. R. Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. Neurosci. Lett. 1992; 136: 189–192
   PubMed Web of Science ®Google Scholar
• Schobitz B., De Kloet E. R., Sutanto W., Holsboer F. Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. Eur. J. Neurosci. 1993; 5: 1426–1435
   PubMed Web of Science ®Google Scholar
• Navarra P., Pozzoli G., Becherucci C., Preziosi P., Grossman A. B., Parente L. Prostaglandin E2 and bacterial lipopolysaccharide stimulate bioactive interleukin-1 release from rat hypothalamic explants. Neuroendocrinology 1993; 57: 257–261
   Google Scholar
• Spangelo B. L., Judd A. M., MacLeod R. M., Goodman D. W., Isakson P. C. Endotoxin-induced release of interleukin-6 from rat medial basal hypothalami. Endocrinology 1990; 127: 1779–1785
   Google Scholar
• Yamaguchi M., Yoshimoto Y., Komura H., Koike K., Matsuzaki N., Hirota K. Interleukin-1 beta and tumor necrosis factor alpha stimulate the release of gonadotropin-releasing hormone and interleukin-6 by primary cultured rat hypothalamic cells. Acta. Endocrinol. (Copenh) 1990; 123: 476–480
   PubMedGoogle Scholar
• Lieberman A. P., Pitha P. M., Shin H. S., Shin M. L. Production of tumor necrosis factor and other cytokines by astrocyte stimulated with lipopolysaccharide or a neurotropic virus. Proc. Natl. Acad. Sci. USA 1989; 86: 6348–6352
   PubMed Web of Science ®Google Scholar
• Chung I. Y., Benveniste E. N. Tumor necrosis factor-alpha production by astrocytes: Induction by lipopolysaccharide, IFN-γ, and IL-1beta. Immunol. 1990; 144: 2999–3007
   Google Scholar
• Ban E., Marquette C., Sarrieau A., Fitspatrick F., Fillion G., Milon G., Rostene W., Haour F. Regulation of interleukin-1 receptor expression in mouse brain and pituitary by lipopolysaccharide and glucocorticoids. Neuroendocrinology 1993; 58: 581–587
   Google Scholar
• Marquette Cecaldi C.P.E., Ban E., Tsiang H., Haour F. Interleukin-1 receptors in brain and pituitary during rabies virus infection in mice. Arch. Virol. 1996; 141: 573–585
   Google Scholar
• Torres-Anjel M. J., Volz D., Torres M. J.R., Turk M., Tshikuka J. G. Failure to thrive, wasting syndrome, and immunodeficiency in rabies: a hypophyseal/hypothalamic/thymic axis effect of rabies virus. Rev. Infect. Dis. 1988; 10: S710–725
   PubMedGoogle Scholar
• Molenaar G. J., Berkenbosch F., Van Dam A. M., Lugard C. M.J.E. Distribution of interleukin-1 beta immunoreactivity within the porcine hypothalamus. Brain Res. 1993; 608: 169–174
   PubMed Web of Science ®Google Scholar
• Koenig J. I., Snow K., Clark B. D., Toni R., Cannon J. G., Shaw A. R., Dinarello C. A., Reichlin S., Lee S. L., Lechan R. M. Intrinsic pituitary interleukin-1 beta is induced by bacterial lipopolysaccharide. Endocrinology 1990; 126: 3053–3058
   Google Scholar
• Gatti S., Bartfai T. Induction of tumor necrosis factor-alpha mRNA in the brain after peripheral endotoxin treatment: comparison with interleukin-1 family and interleukin-6. Brain Res. 1993; 624: 291–294
   PubMed Web of Science ®Google Scholar
• Sauer J., Arzt E., Gumprecht H., Hopfner U., Stalla G. K. Expression of interleukin-1 receptor antagonist in human pituitary adenomas in vitro. J. Clin. Endocrinol. Metab. 1994; 19: 1857–1863
   Google Scholar
• Arzt E., Stelzer G., Renner U., Lange M., Muller O. A., Stalla G. K. Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures. J. Clin. Invest. 1992; 90: 1944–1951
   PubMedGoogle Scholar
• Vankelecom H., Carmeliet P., Van Damme J., Billiau A., Denef C. Production of interleukin-6 by folliculo-stellate cells of the anterior pituitary gland in a histiotypic cell aggregate culture system. Neuroendocrinology 1989; 49: 102–106
   PubMed Web of Science ®Google Scholar
• Vankelecom H., Matthys P., DammeVan J., Eremans H., Billiau A., Denef C. Immunocytochemical evidence that S-100 positive cells of the mouse anterior pituitary contain interleukin-6 immunoreactivity. J. Histochem. Cytochem. 1993; 41: 151–156
   PubMedGoogle Scholar
• Inoue K., Matsumoto H., Koyama C., Shibata K., Nakazato Y., Ito A. Establishment of a folliculo-stellate-like cell line from a murine thyrotropic pituitary tumor. Endocrinology 1992; 131: 3110–3116
   PubMed Web of Science ®Google Scholar
• Matusumoto H., Koyama C., Sawada T., Koike K., Hirota K., Miyake A., Arimura A., Inoue K. Pituitary folliculo-stellate-like cell line (TtT/GF) responds to novel hypophysiotropic peptide (pituitary adenylate cyclase-activating peptide), showing increased adenosine 3′,5′-monophosphate and interleukin-6 secretion and cell proliferation. Endocrinology 1993; 133: 2150–2155
   Google Scholar
• Yamaguchi M., Matsuzaki N., Hirota K., Miyake A., Tanizawa O. Interleukin 6 possibly induced by interleukin 1beta in the pituitary gland stimulates the release of gonadotropins and prolactin. Acta. Endocrinol. (Copenh) 1990; 122: 201–205
   Google Scholar
• Spangelo B. L., MacLeod R. M., Isakson P. C. Production of interleukin-6 by anterior pituitary cells in vitro. Endocrinology 1991; 126: 582–586
   Google Scholar
• Schobitz B., Holsboer F., Kikkert R., Sutanto W., De Kloet E. R. Peripheral and central regulation of IL-6 gene expression in endotoxin-treated rats. Endocr. Regul. 1992; 26: 103–109
   Google Scholar
• Schobitz B., Van Den Dobbelsteen M., Holsboer F., Sutanto W., De Kloet E. R. Regulation of interleukin 6 gene expression in rat. Endocrinology 1993; 132: 1569–1576
   Google Scholar
• Velkeniers B., Vergani P., Trouillas J., D'Haens J., Hooghe R. J., Hooghe Peters E. L. Expression of IL-6 mRNA in normal rat and human pituitaries and in human pituitary adenomas. J. Histochem. Cytochem. 1994; 42: 67–76
   Google Scholar
• Muramami N., Fukata J., Tsukada T., Kobayashi H., Ebisui O., Segawa H., Muro S., Imura H., Nakao K. Bacterial lipopolysaccharide-induced expression of interleukin-6 messenger ribonucleic acid in the rat hypothalamus, pituitary, adrenal gland, and spleen. Endocrinology 1993; 133: 2574–2578
   Google Scholar
• Spangelo B. L., Judd A. M., Isakson P. C., MacLeod R. M. Interleukin-1 stimulates interleukin-6 release from rat anterior pituitary cells in vitro. Endocrinology 1991; 128: 2685–2692
   Google Scholar
• Yamaguchi M., Koike K., Matsuzaki N., Yoshimoto Y., Taniguchi T., Miyake A., Tanizawa O. The interferon family stimulates the secretions of prolactin and interleukin-6 by the pituitary gland in vitro. J. Endocrinol. Invest. 1991; 14: 457–461
   Google Scholar
• Spangelo B. L., Jarvis W. D., Judd A. M., MacLeod R. M. Induction of interleukin-6 release by interleukin-1 in rat anterior pituitary cells in vitro,: evidence for an eicosanoid-dependent mechanism. Endocrinology 1991; 129: 2886–2894
   Google Scholar
• Tatsuno I., Somogyvari Vigh A., Mizuno K., Gottschall P. E., Hidaka H., Arimura A. Neuropeptide regulation of interleukin-6 production form the pituitary: stimulation by pituitary adenylate cyclase activating polypeptide and calcitonin gene-related peptide. Endocrinology 1991; 129: 1797–1804
   PubMedGoogle Scholar
• Carmeliet P., Vankelecom H., Van Damme J., Billiau A., Denef C. Release of interleukin-6 from anterior pituitary cell aggregates: developmental pattern and modulation by glucocorticoids and forskolin. Neuroendocrinology 1991; 53: 29–34
   PubMed Web of Science ®Google Scholar
• Sarlis N. J., Stephanou A., Knight R. A., Lightman S. L., Chowdrey H. S. Effects of glucocorticoids and chronic inflammatory stress upon anterior pituitary interleukin-6 mRNA expression in the rat. Br. J. Rheumatol. 1993; 32: 653–657
   Google Scholar
• Jones T. H., Daniels M., James R. A., Justice S. K., McCorkle R., Price A., Kendall-Taylor P., Weetman A. P. Production of bioactive and immunoactive IL-6 and expression of IL-6 mRNA by human pituitary adenomas. J. Clin. Endocrinol. Metab. 1994; 78: 180–187
   Google Scholar
• Tsagarakis S., Kontogeorgos G., Giannou P., Thalassinos N., Woolley J., Besser G. M., Grossman A. Interleukin-6, a growth promoting cytokine, is present in human pituitary adenomas: An immunocytochemical study. Clin. Endocrinol. 1992; 37: 163–167
   Google Scholar
• Spangelo B. L., deHoll P. D., Kalabay L., Bond B. R., Arnaud P. Neurointer- mediate pituitary lobe cells synthesize and release interleukin-6 in vitro:, Effects of lipopolysaccharide and interleukin-1. Endocrinology 1994; 135: 556–563
   Google Scholar
• Ban E., Milon G., Prudhomme N., Fillion G., Haour F. Receptors for interleukin-1 (alpha and beta) in mouse brain: mapping and neuronal localization in hippocampus. Neuroscience 1991; 43: 21–30
   PubMed Web of Science ®Google Scholar
• Takao T., Culp S. G., Newton R. C., De Souza E. B. Type I interleukin-1 receptors in the mouse brain-endocrine-immune axis labelled with 125I recombinant human interleukin-1 receptor antagonist. J. Neuroimmunol. 1992; 41: 51–60
   Google Scholar
• Cunningham J. E.T., Wada E., Carter D. B., Tracey D. E., Battey J. F., De Souza E. B. In situ, histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse. J. Neurosci. 1992; 12: 1101–1114
   PubMed Web of Science ®Google Scholar
• Katsuura G., Gottschall P. E., Arimura A. Identification of a high-affinity receptor for interleukin-1 beta in rat brain. Biochem. Biophys. Res. Commun. 1988; 156: 61–67
   Google Scholar
• Cunningham J. E.T., Wada E., Carter D. B., Tracey D. E., Battey J. F., De Souza E. B. Localization of interleukin-1 receptor messenger RNA in murine hippocampus. Endocrinology 1991; 128: 2666–2668
   Google Scholar
• Takao T., Culp S. G., De Souza E. B. Reciprocal modulation of interleukin-1beta (IL-1beta) and IL-1 receptors by lipopolysaccharide (endotoxin) treatment in the mouse brain-endocrine-immune axis. Endocrinology 1993; 132: 1497–1504
   Google Scholar
• Marquette C., Van Dam A. M., Van Rooijen N., Berkenbosch F., Haour F. Peripheral macrophage depletion prevents down regulation of central interleukin-1 receptors in mice after endotoxin administration. Psychoneuroendocrinology 1994; 19: 189–196
   Google Scholar
• Reinisch N., Wolkersdorfer M., Kahler C. M., Ye K., Dinarello C. A., Wiedemann C. J. Interleukin-1 receptor type I mRNA in mouse brain as affected by peripheral administration of bacterial lipopolysaccharide. Neurosci. Lett. 1994; 166: 165–167
   PubMed Web of Science ®Google Scholar
• De Souza E. B. Corticotropin-releasing factor and interleukin-1 receptors in the brain-endocrine-immune axis. Role in stress response and infection. Ann. N. Y. Acad. Sci. 1993; 697: 9–27
   Google Scholar
• Araujo D. M., Lapchak P. A., Collier B., Quirion R. Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with cholinergic system. Brain Res. 1989; 498: 257–266
   PubMedGoogle Scholar
• Lapchak P. A., Araujo D. M., Quirion R., Beaudet A. Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain. Neuroscience 1991; 44: 173–184
   Google Scholar
• Lowenthal J. W., Castle B. E., Christiansen J., Schreurs J., Rennick D., Arai N., Hoy P., Takebe Y., Howard M. Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells. J. Immunol. 1988; 140: 456–464
   PubMed Web of Science ®Google Scholar
• Cornfield L. J., Sills M. A. High affinity interleukin-6 binding sites in bovine hypothalamus. Eur. J. Pharmacol. 1991; 202: 113–115
   Google Scholar
• Gadient R. A., Otten U. Differential expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat hypothalamus. Neurosci. Lett. 1993; 153: 13–16
   PubMed Web of Science ®Google Scholar
• Gadient R. A., Otten U. Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development. Brain Res. 1994; 637: 10–14
   PubMed Web of Science ®Google Scholar
• Kinouchi K., Brown G., Pasternak G., Donner D. B. Identification and characterization of receptors for tumor necrosis factor-alpha in the brain. Biochem. Biophys. Res. Commun. 1991; 18: 1532–1538
   Google Scholar
• Wolvers D. A., Marquette C., Berkenbosch F., Haour F. Tumor necrosis factor-alpha: specific binding sites in rodent brain and pituitary gland. Eur. Cytokine. Netw. 1993; 4: 377–381
   PubMedGoogle Scholar
• Chang Y., Albright S., Lee F. Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during development. J. Neuroimmunol. 1994; 52: 9–17
   PubMed Web of Science ®Google Scholar
• Constam D. B., Philipp J., Malipiero U. V., ten Diejke P., Schachner M., Fontana A. Differential expression of transforming growth factor beta 1, 2 and 3 by glioblastoma cells, astrocytes and microglia. J. Immunol. 1992; 148: 1404–1410
   PubMed Web of Science ®Google Scholar
• Haour G. H., Ban E. M., Milon G. M., Baran D., Fillion G. M. Brain interleukin-1 receptors: characterization and modulation after lipopolysaccharide injection. Progr. Neuroendocr. Immunol. 1990; 3: 196–204
   Google Scholar
• Takao T., Tracey D. E., Mitchell W. M., De Souza E. B. Interleukin-1 receptors in mouse brain: Characterization and neuronal localization. Endocrinology 1990; 127: 3070–3078
   PubMed Web of Science ®Google Scholar
• Benveniste E. Inflammatory cytokines within the central nervous system: sources, functions and mechanisms of action. Am. J. Physiol. 1992; 263: C1–C16
   Web of Science ®Google Scholar
• Dinarello C. A. The biology of interleukin-1. Chem. Immunol. 1992; 51: 1–32
   PubMedGoogle Scholar
• Dower S. K., Sims J. E., Cerretti D. P., Bird T. A. The interleukin-1 system: receptors, ligands and signals. Chem. Immunol. 1992; 51: 33–64
   PubMedGoogle Scholar
• Collotta F., Re F., Muzio M., Bertini R., Polentarutti N., Sironi M., Giri J. G., Dower S. K., Sims J. E., Mantovani A. Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science 1993; 261: 472–476
   Google Scholar
• Gabellec M. M., Griffais R., Fillion G., Haour F. Brain expression of interleukin-1 alpha and beta of interleukin-1 receptor antagonist mRNA in mouse brain: regulation by lipopolysaccharide (LPS) stimulation. Mol. Brain Res. 1995; 31: 122–130
   Google Scholar
• Gabellec M. M., Griffais R., Fillion G., Haour F. Interleukin-1 receptors type I and II in the mouse brain: kinetics of mRNA expressions after peripheral administration of bacterial lipopolysaccharide (LPS). J. Neuroimmunol. 1996; 66: 65–70
   Google Scholar
• Sawada M., Itoh Y., Suzumura A., Marunouchi T. Expression of cytokine receptors in cultured neuronal and glial cells. Neurosci. Lett. 1993; 160: 131–134
   PubMedGoogle Scholar
• Beutler B., van Huffel C. Unraveling function in the TNF ligand and receptor families. Science 1994; 264: 667–668
   PubMed Web of Science ®Google Scholar
• Cheng B., Christakos S., Mattson M. P. Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron 1994; 12: 139–153
   PubMed Web of Science ®Google Scholar
• Hurwitz A. A., Lyman W. D., Guida M. P., Calderon T. M., Berman J. W. Tumor necrosis factor alpha induces adhesion molecules expression on human fetal astrocytes. J. Exp. Med. 1992; 176: 1631–1636
   PubMed Web of Science ®Google Scholar
• Aloisi F., Care A., Borsellino G., Gallo P., Rose S., Basani A. Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1beta and TNFalpha. J. Immunol. 1992; 149: 2358–2366
   PubMed Web of Science ®Google Scholar
• Lee S. C., Liu W., Dickson D. W., Brosnan C. F., Berman J. W. Cytokine production by human fetal microglia and astrocytes: Differential induction by lipopolysaccharide and IL-1beta. J. Immunol. 1993; 150: 2659–2667
   PubMed Web of Science ®Google Scholar
• Otero G. C., Merill J. E. Cytokine receptors on glial cells. Glia 1994; 11: 117–128
   Google Scholar
• Yong V. W., Moumdjian R., Young F. P., Ruijus T. G., Feedmen M. S., Cashman N., Antel J. P. Y-interferon promotes proliferation of adult human astrocytes in vitro, and reactive gliosis in the adult mouse brain in vivo. Proc. Natl. Acad. Sci. USA 1991; 88: 7016–7020
   PubMed Web of Science ®Google Scholar
• Cunningham E. T., Wada E., Carter D. B., Tracy D. E., Battery J. F., De Souza E. B. In situ, histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary and adrenal gland of the mouse. J. Neurosci. 1992; 3: 1101–1114
   Google Scholar
• Matta S. G., Linner K. M., Sharp B. M. Interleukin-1 alpha and interleukin-1 stimulated adrenocorticotropin secretion in the rat through a similar hypothalamic receptor(s): Effects of interleukin-1 receptor antagonist protein. Neuroendocrinology 1993; 57: 14–22
   Google Scholar
• Yabuuchi K., Minami M., Katsumata S., Satoh M. Localization of type I interleukin-1 receptor mRNA in the rat brain. Mol. Brain Res. 1994; 27: 27–36
   PubMedGoogle Scholar
• Rothwell N. J. Functions and mechanisms of interleukin-1 in the brain. Trends Pharmacol. Sci. 1991; 12: 430–436
   PubMed Web of Science ®Google Scholar
• Haour F., Marquette C., Ban E., Crumeyrolle-Arias M., Rostene W., Tsiang H., Fillion G. Receptors for interleukin-1 in the central nervous and neuroendocrine systems: role in infection and stress. Ann. Endocrinol. (Paris) 1995; 56: 173–179
   Google Scholar
• Parnet P., Brunke D. L., Goujon E., Mainard J. D., Biragyn A., Arkins S., Dantzer R., Kelley K. W. Molecular identification of two types of interleukin-1 receptors in the murine pituitary gland. J. Neuroendocrinol. 1993; 5: 213–219
   Google Scholar
• French R. A., Zachary J. F., Dantzer R., Frawley L. S., Chizzonite R., Parnet P., Kelley K. W. Dual expression of p80 type I and p68 type II interleukin-1 receptors on anterior pituitary cells synthesizing growth hormone. Endocrinology 1996; 137: 4027–4036
   Google Scholar
• Webster E. L., Tracey D. E., De Souza E. B. Upregulation of IL-1 receptors in mouse at T-20 pituitary tumor cells following treatment with corticotropin- releasing factor. Endocrinology 1991; 129: 2796–2798
   Google Scholar
• Payne L. C., Weigent D. A., Blalock J. E. Induction of pituitary sensitivity to interleukin-1: a new function for corticotropin-releasing hormone. Biochem. Biophys. Res. Commun. 1994; 198: 480–484
   Google Scholar
• Smith L. R., Brown S. L., Blalock J. E. Interleukin-2 inducton of ACTH secretion: presence of an interleukin-2 receptor alpha-chain-like molecule on pituitary cells. J. Neuroimmunol. 1989; 21: 249–254, 1989
   Google Scholar
• Ohmichi M., Hirota K., Koike K., Kurachi H., Ohtsuka S., Matsuzaki N., Yamaguchi M., Miyake A., Tanizawa O. Binding sites for interleukin-6 in the anterior pituitary gland. Neuroendocrinology 1992; 55: 199–203, 1992
   PubMedGoogle Scholar
• Taga T., Hibi M., Hirata Y., Yamasaki K., Yasukawa K., Matsuda T., Hirano T., Kishimoto T. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 1989; 58: 573–581
   PubMed Web of Science ®Google Scholar
• Hibi M., Murakami M., Saito M., Hirano T., Taga T., Kishimoto T. Molecular cloning of an IL-6 signal transducer, gp130. Cell 1990; 63: 1149–1157
   PubMed Web of Science ®Google Scholar
• Arzt E., Buric R., Stelzer G., Stalla J., Sauer J., Renner U., Stalla G. K. Interleukin involvement in anterior pituitary cell growth regulation: Effects of IL-2 and IL-6. Endocrinology 1993; 132: 459–467
   PubMedGoogle Scholar
• Tomida M., Yamamoto-Yamaguchi Y., Hozumi M. Purification of a factor inducing differentiation of mouse fibroblast L929 cells. J. Biol. Chem. 1984; 259: 10978–10982
   PubMed Web of Science ®Google Scholar
• Ferrara N., Winer J., Henzel W. J. Pituitary follicular cells secrete an inhibitor of aortic endothelial cell growth: Identification as leukemia inhibitory factor. Proc. Natl. Acad. Sci. USA 1992; 89: 698–702
   PubMed Web of Science ®Google Scholar
• Akita S., Webster J., Ren S. G., Takino H., Said J., Zand O., Melmed S. Human and pituitary expression of leukemia inhibitory factor. Novel intrapituitary regulation of adrenocorticotropin hormone synthesis and secretion. J. Clin. Invest. 1995; 95: 1288–1298
   PubMed Web of Science ®Google Scholar
• Carter D. A. Expression of leukemia inhibitory factor/cholinergic differentiation factor is linked to adrenoceptor stimulation. Biochem. Soc. Trans. 1994; 23: 114S
   Google Scholar
• Wang Z., Ren S. G., Melmed S. Hypothalamic and pituitary leukemia inhibitory factor gene expression in vivo:, a novel endotoxin-inducible neuroendocrine interface. Endocrinology 1996; 137: 2947–2953
   PubMedGoogle Scholar
• Rathjen P. D., Toth S., Willis A., Heath J. K., Smith A. G. Differentiation inhibiting activity is produced in matrix-associated and diffusible forms that are generated by alternate promoter usage. Cell 1990; 62: 1105–1114
   PubMed Web of Science ®Google Scholar
• Stahl N., Yancopoulos G. The alpha, beta and kinases of cytokine receptor complexes. Cell 1993; 74: 587–590
   PubMed Web of Science ®Google Scholar
• Webster J., Ren S. G., Melmed S. Leukemia inhibitory factor and oncostatin M stimulate ACTH secretion and POMC expression in mouse corticotroph tumor cells. J. Endocrinol. 1995; 144: 294
   Google Scholar
• Stefana B., Ray D. W., Melmed S. Leukemia inhibitory factor (LIF) induces differentiation of pituitary corticotroph function: a neuro-endocrine phenotypic switch. Proc. Natl. Acad. Sci. USA 1996; 93: 12502–12506
   PubMed Web of Science ®Google Scholar
• Ray D. W., Ren S. G., Melmed S. Leukemia inhibitory factor (LIF) stimulates propiomelanocortin (POMC) expression in a corticotroph cell line. Role of STAT pathway. J. Clin. Invest. 1996; 97: 1852–1859
   PubMed Web of Science ®Google Scholar
• Escary J. L., Perreau J., Dumenil D., Ezine S., Brulet P. Leukemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature 1993; 363: 361–364
   PubMed Web of Science ®Google Scholar
• Stewart C. L., Kaspar P., Brunet L. J., Bhatt H., Gadi I., Kontgen F., Abbondanzo J. S. Blastocyst implantation depends on maternal expression of leukemia inhibitory factor. Nature 1992; 359: 76–79
   PubMed Web of Science ®Google Scholar
• Akita S., Malkin J., Melmed S. Disrupted murine leukemia inhibitory factor (LIF) gene attenuates adrenocorticotropic hormone (ACTH) secretion. Endocrinology 1996; 137: 3140–3143
   PubMed Web of Science ®Google Scholar
• Bloom B. R., Bennett B. Mechanism of a reaction in vitro, associated with delayed-type hypersensitivity. Science 1996; 153: 80–82
   Google Scholar
• Bernhagen J., Calandra T., Mitchell R. A., Martin S. B., Tracey K. J., Voelter W., Manogue K. R., Cerami A., Bucala R. MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature 1993; 365: 756–759
   PubMed Web of Science ®Google Scholar
• Bernhagen J., Calandra T., Mitchell R. A., Martin S. B., Tracey K. J., Voelter W., Manogue K. R., Cerami A., Bucala R. MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature 1993; 365: 756–759
   PubMed Web of Science ®Google Scholar
• Nishino T., Bernhagen J., Shiiki H., Calandra T., Dohi K., Bucala R. Localization of macrophage migration inhibitory factor (MIF) to secretory granules within the corticotrophic and thyrotrophic cells of the pituitary gland. Mol. Med. 1995; 1: 781–788
   PubMedGoogle Scholar
• Chautard T., Steinmann M., Thompson N., Calandra T., Pralong F., Gaillard R. C., Waeber G. Transcriptional regulation of the MIF gene in AtT-20 and in primary rat pituitary cells. 79th Annual Meeting of the Endocrine Society, MinneapolisUSA, 1997, abstract
   Google Scholar
• Calandra T., Bernhagen J., Mitchell R. A., Bucala R. The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor. J. Exp. Med. 1994; 179: 1895–1902
   PubMed Web of Science ®Google Scholar
• Calandra T., Bernhagen J., Metz C. N., Spiegel L. A., Bacher M., Donnelly T., Cerami A., Bucala R. MIF as a glucocorticoid-induced modulator of cytokine production. Nature 1995; 377: 68–71
   PubMed Web of Science ®Google Scholar
• Bucala R. Identification of MIF as a new pituitary hormone and macrophage cytokine and its role in endotoxic shock. Immunol. Lett. 1994; 43: 23–26
   PubMedGoogle Scholar
• Kluger M. Fever: Role of endogenous pyrogens and cryogens. Physiol. Rev. 1991; 71: 93–127
   PubMed Web of Science ®Google Scholar
• Krueger J., Walter J., Dinarello C., Wolff S., Chedid L. Sleep promoting effects of endogenous pyrogen (interleukin-1). Am. J. Physiol 1984; 246: R994–R999
   PubMed Web of Science ®Google Scholar
• Besedovski H. O., Del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr. Rev. 1996; 17: 64–102
   PubMed Web of Science ®Google Scholar
• Banks W. A., Ortiz L., Plotkin S. R., Kastin A. J. Human interleukin-1 alpha, murine IL-1alpha and murine IL-1beta are transported from blood to brain in the mouse by a shared saturable mechanism. J. Pharmacol. Exp. Ther. 1991; 259: 988–996
   PubMed Web of Science ®Google Scholar
• Ulich T. R., Yi E. S., Yin S., Smith C., Remick D. Intratracheal administration of endotoxin and cytokines. VII: The soluble interleukin-1 receptor and the soluble tumor necrosis factor receptor II (p80) inhibit acute inflammation. Clin. Immunol. Immunopathol. 1994; 72: 137–140
   PubMedGoogle Scholar
• Banks W. A., Plotkin S. R., Kastin A. J. Permeability of the blood-brain barrier to soluble cytokine receptors. Neuroimmunomodulation 1995; 2: 161–165
   PubMed Web of Science ®Google Scholar
• Gutierrez E. G., Banks W. A., Kastin A. J. Blood-borne interleukin-1 receptor antagonist crosses the blood-brain barrier. J. Neuroimmunol. 1994; 55: 153–160
   PubMed Web of Science ®Google Scholar
• Coceani F., Lees J., Dinarello C. A. Occurence of interleukin-1 in cerebrospinal fluid of the conscious cat. Brain Res. 1988; 446: 245–250
   PubMed Web of Science ®Google Scholar
• Blatteis C. M., Dinarello C. A., Shibata M., Llanos Q., Quan N., Busija D. W. Does circulating IL-1 enter the brain?. Thermal Physiology, J. B. Mercer. Elsevier, New York 1989; 385
   Google Scholar
• McCoy J., Matta S., Sharp B. Prostaglandins mediate the ACTH response to interleukin-1-beta instilled into hypothalamic median eminence. Neuroendocrinology 1994; 60: 426–435
   Google Scholar
• Matta S. G., Singh J., Newton R., Sharp B. M. The adrenocorticotropin response to interleukin-1 beta instilled into the rat median eminence depends on the local release of catecholamines. Endocrinology 1990; 111: 2175–2182
   Google Scholar
• Spinedi E., Hadid R., Daneva T., Gaillad R. C. Cytokines stimulate the CRH but not the vasopressin neuronal system: evidence for a median eminence site of interleukin-6 action. Neuroendocrinology 1992; 56: 46–53
   PubMed Web of Science ®Google Scholar
• Navarra P., Pozzoli G., Brunetti L., Ragazzoni E., Besser G. M., Grossman A. Interleukin-1 beta and interleukin-6 specifically increase the release of prostaglandin E2 from rat hypothalamic explants in vitro. Neuroendocrinology 1992; 56: 61–68
   Google Scholar
• Katsuura G., Arimura A., Koves K., Gottschall P. E. Involvement of organum vasculosum of laminae terminalis and preoptic area in interleukin-1 beta-induced ACTH release. Am. J. Physiol. 1990; 258: E163–E171
   PubMedGoogle Scholar
• Blatteis C. M. Role of the OVLT in the febrile response to circulating pyrogens. Prog. Brain Res. 1992; 91: 409–412
   PubMed Web of Science ®Google Scholar
• Nakamori T., Morimoto A., Yamaguchi K., Watanabe T., Long N. C., Murakami N. Organum vasculosum laminae terminalis is a brain site to produce interleukin-1-beta during fever. Brain Res. 1993; 618: 155–159
   Google Scholar
• Stitt J. T., Bernheim H. A. Differences in endogenous pyrogen fevers induced by i.v. and i.c.v. routes in rabbits. J. Appl. Physiol. 1985; 59: 342–347
   Google Scholar
• Chuluyan H. E., Saphier D., Rohn W. M., Dunn A. J. Noradrenergic innervation of the hypothalamus participates in adrenocortical response to interleukin-1. Neuroendocrinology 1992; 56: 106–111
   PubMed Web of Science ®Google Scholar
• Palazzolo D. L., Quadri S. K. Interleukin-1 inhibits serotonin release from the hypothalamus in vitro. Life Sci. 1992; 51: 1797–1802
   Google Scholar
• Ericsson A., Kovacs K. J., Sawchenko P. E. J. Neurosci. 1994; 14: 897–913
   PubMed Web of Science ®Google Scholar
• Quagliarello V., Wispelwey B., Long W., Scheld W. Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. J. Clin. Invest. 1991; 87: 1360–1366
   PubMed Web of Science ®Google Scholar
• Claudio L., Martiney J. A., Brosnan C. F. Ultra-structural studies of the blood-retina barrier after exposure to interleukin-1 beta or tumour necrosis factor-alpha. Lab. Invest 1994; 70: 850–861
   PubMed Web of Science ®Google Scholar
• Lustig S., Danenberg H. D., Kafri Y., Kobiler D., Ben-Nathan D. Viral Neuroinvasion and encephalitis induced by lipopolysaccharide and its mediators. J. Exp. Med. 1992; 176: 707–712
   Google Scholar
• Fleshner M., Goehler L., Herman J., Relton J., Maier S., Watkins L. Interleukin-1beta induced corticosterone elevation and hypothalamic NE depletion is vagally mediated. Brain Res. Bull. 1995; 37: 605–610
   PubMed Web of Science ®Google Scholar
• Day H. E.W., Akil H. Differential pattern of c-fos mRNA in rat brain following central and systemic administration of interleukin-1beta implications for mechanism of action. Neuroendocrinology 1996; 63: 207–218
   Google Scholar
• Goehler L., Busch C., Tartaglia N., Relton J., Sisk D., Maier S., Watkins L. Blockade of cytokine induced conditioned taste aversion by sub-diaphragmatic vagotomy: further evidence for vagal mediation of immune-brain communication. Neurosci. Lett. 1995; 185: 163–166
   PubMed Web of Science ®Google Scholar
• Layé S., Bluthé R.-M., Kent S., Combe C., Medina C., Parnet P., Kelley K., Dantzer R. Subdiaphragmatic vagotomy blocks induction of IL-1beta mRNA in mice brain in response to peripheral LPS. Am. J. Phys. 1995; 268: R1327–R1331
   PubMed Web of Science ®Google Scholar
• Niijima A. The afferent discharges from sensors for interleukin-1beta in the hepato-portal system in the anaesthetized rat. J. Physiol. 1991; 446: 236P
   Google Scholar
• Wan W., Wetmore L., Sorensen C., Greenberg Y., Nance D. Neural and biochemical mediators of endotoxin and stress-induced c-fos expression in the rat brain. Brain Res. Bull. 1994; 34: 7–14
   PubMed Web of Science ®Google Scholar
• Watkins L. R., Goehler L. E., Relton J. K., Tartaglia N., Sibert L., Martin D., Maier S. F. Blockade of interleukin-1 induced hyperthermia by sub-diaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci. Lett. 1995; 183: 27–31
   PubMed Web of Science ®Google Scholar
• Shintani F., Nakaki T., Kanba S., Kato R., Asai M. Role of interleukin-1 in stress responses. Mol. Neurobiol. 1995; 10: 47–71
   Google Scholar
• Barbanel G., Ixart G., Szafarczyk A., Malaval F., Assenmacher I. Intra-hypothalamic infusion of interleukin-1beta increases the release of corticotropin-releasing hormone (CRH-41) and adrenocorticotropic hormone (ACTH) in free-moving rats bearing a push-pull cannula in the median eminence. Brain Res. 1990; 516: 31–36
   PubMed Web of Science ®Google Scholar
• Suda T., Tozawa F., Ushiyama T., Sumitomo T., Yamada M., Demura H. Interleukin-1 stimulates corticotropin-releasing factor gene expression in rat hypothalamus. Endocrinology 1990; 126: 1223–1228
   Google Scholar
• Schöbitz B., De Kloet E. R., Holsboer F. Gene expression and function of interleukin 1, interleukin 6 and tumor necrosis factor in the brain. Prog. Neurobiol. 1994; 44: 397–432
   PubMed Web of Science ®Google Scholar
• Rothwell N. J., Hopkins S. J. Cytokines and the nervous system. II: Actions and mechanisms of action. Trends Neurosci. 1995; 18: 130–136
   PubMed Web of Science ®Google Scholar
• Turnbull A., Rivier C. Brain-periphery connections: do they play a role mediating the effect of central injected interleukin-1β on gonadal function?. Neuroimmunomodulation 1995; 2: 224–235
   Google Scholar
• Faggioni R., Benigni F., Ghezzi P. Proinflammatory cytokines as pathogenetic mediators in the central nervous system: brain-periphery connections. Neuroimmunomodulation 1995; 2: 2–15
   Google Scholar
• Gottschall P. E., Komaki G., Arimura A. Increased circulating interleukin-1 and interleukin-6 after intracerebroventricular injection of lipopolysaccharide. Neuroendocrinology 1992; 56: 935–938
   Google Scholar
• DeSimoni M. G., Sironi M., DeLuigi A., Manfridi A., Mantovani A., Ghezzi P. Intracerebroventricular injection of interleukin-1 induces high circulating levels of interleukin-6. J. Exp. Med. 1990; 171: 1773–1778
   Google Scholar
• DeSimoni M. G., DeLuigi A., Gemma L., Sironi M., Manfridi A., Ghezzi P. Modulation of systemic interleukin-6 induction by central interleukin-1. Am. J. Physiol. 1993; 265: R739–R742
   Google Scholar
• DeSimoni M. G., Del Bo R., De Luigi A., Simard S., Forloni G. Central endotoxin induces different patterns of interleukin (IL)-1beta and IL-6 messenger ribonucleic acid expression and IL-6 secretion in the brain and periphery. Endocrinology 1995; 136: 897–902
   Google Scholar
• Blalock J. E. The syntax of immune-neuroendocrine communication. Immunol. Today 1994; 15: 504–511
   PubMedGoogle Scholar
• Rivest S., Rivier C. The role of corticotropin-releasing factor and interleukin- 1 in the regulation of neurons controlling reproductive functions. Endocr. Rev. 1995; 16: 177–199
   PubMed Web of Science ®Google Scholar
• Besedovsky H., Del Rey A., Sorkin E., Dinarello C. A. Immuno-regulatory feedback between interleukin-1 and glucocorticoid hormones. Science 1986; 233: 652–654
   PubMed Web of Science ®Google Scholar
• Bateman A., Singh A., Krai T., Solomon S. The immune-hypothalamic- pituitary-adrenal axis. Endocr. Rev. 1989; 10: 92–112
   PubMed Web of Science ®Google Scholar
• Spangelo B. L., Judd A. M., Call G. B., Zumwalt J., Gorospe W. C. Role of the cytokines in the hypothalamic–pituitary–adrenal and gonadal axes. Neuro-immunomodulation 1995; 2: 299–312
   Google Scholar
• Woloski B. M.R.N.J., Smith E. M., Meyer W. J., III, Fuller G. M., Blalock J. E. Corticotropin releasing activity of monokines. Science 1985; 230: 1035–1037
   PubMed Web of Science ®Google Scholar
• Kehrer P., Turnill D., Dayer J. M., Muller A. F., Gaillard R. C. Human recombinant interleukin-1 beta and alpha, but not recombinant tumor necrosis factor alpha stimulate ACTH release from rat anterior pituitary cells in vitro, in a prostaglandin E2 and cAMP independent manner. Neuroendocrinology 1988; 48: 160–166
   Google Scholar
• Spangelo B. L., Judd A. M., Isakson P. C., MacLeod R. M. Interleukin-6 stimulates anterior pituitary hormone release in vitro. Endocrinology 1989; 125: 575–577
   PubMed Web of Science ®Google Scholar
• Spangelo B. L., Judd A. M., Ross P. C., Login I. S., Jarvis W. D., Badamchian M., Goldstein A. L., MacLeod R. M. Thymosin Fraction 5 stimulates prolactin and growth hormone release from anterior pituitary cells in vitro. Endocrinology 1987; 121: 2035–2053
   PubMed Web of Science ®Google Scholar
• Beach J. E., Smallridge R. C., Kinzer C. A., Bernton E. W., Holaday J. W., Fein U. G. Rapid release of multiple hormones from rat pituitaries perifused with recombinant Interleukin-1. Life Sci. 1987; 44: 1–7
   Google Scholar
• Berkenbosch F., Van Oers J., Del Rey A., Tilders F., Besedovsky H. Corticotropin-releasing activity of monokines. Science 1987; 230: 1035
   Google Scholar
• Tsagarakis S., Gillies G., Rees L. H., Besser M., Grossman A. Interleukin-1 directly stimulates the release of corticotropin releasing factor from rat hypothalamus. Neuroendocrinology 1989; 49: 98–101
   Google Scholar
• Uehara A., Gillis S., Arimura A. Effects of interleukin-1 on hormone release from normal rat pituitary cells in primary culture. Neuroendocrinology 1987; 45: 343–347
   Google Scholar
• Vankelecom H., Andries M., Billiau A., Denef C. Evidence that folliculostellate cells mediate the inhibitory effect of interferon-gamma on hormone secretion in rat anterior pituitary cell cultures. Endocrinology 1992; 130: 3537–3546
   Google Scholar
• Morand I., Fonlupt P., Guerrier A., Trouillas J., Calle A., Remy C., Rousset B., Munari-Silem Y. Cell-to-cell communication in the anterior pituitary: evidence for gap junction-mediated exchanges between endocrine cells and folliculostellate cells. Endocrinology 1996; 137: 3356–3367
   PubMed Web of Science ®Google Scholar
• Gaillard R. C., Turnill D., Sappino P., Muller A. F. Tumor necrosis factor alpha inhibits the hormonal response of the pituitary gland to hypothalamic releasing factors. Endocrinology 1990; 127: 101–106
   PubMed Web of Science ®Google Scholar
• Gaillard R. C. Pituitary-Immune System Interactions. Molecular and Clinical Advances in Pituitary disorders. A basic and clinical update, S. Melmed. Endocrine Research and Education, Inc., Beverly Hills, CAUSA 1993; 87–92
   Google Scholar
• Naitoh Y., Fukata J., Tominaga T., Nakai Y., Tamai S., Mori K., Imura H. Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious freely-moving rats. Biochem. Biophys. Res. Commun. 1988; 155: 1459–1463
   PubMed Web of Science ®Google Scholar
• Uehara A., Gottschall P. E., Dahl R. R., Arimura A. Interleukin-1 stimulates ACTH release by an indirect action which requires endogenous corticotropin releasing factor. Endocrinology 1987; 121: 1580–1582
   PubMedGoogle Scholar
• Berkenbosch F., Van Oers J., Del Rey A., Tilders F., Besedovsky H. Corticotropin-releasing factor producing neurons in the rat activated by interleukin-1. Science 1987; 238: 524–526
   PubMed Web of Science ®Google Scholar
• Sapolsky R., Rivier C., Yamamoto G., Plotsky P., Vale W. Interleukin-1 stimulates the secretion of hypothalamic corticotropin releasing factor. Science 1987; 238: 522–524
   PubMed Web of Science ®Google Scholar
• Suda T., Tozawa F., Ushiyama T., Sumitomo T., Yamada M., Demura H. Interleukin-1 stimulates corticotropin-releasing factor gene expression in rat hypothalamus. Endocrinology 1990; 126: 1223–1228
   Google Scholar
• Dunn A. J. Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism paralleling the increased plasma corticosterone. Life Sci. 1988; 43: 429–435
   PubMed Web of Science ®Google Scholar
• Dunn A. J. Interleukin-1 as a stimulator of hormone secretion. Prog. Neuroendocr. Immunol. 1990; 3: 26–34
   Google Scholar
• Matta S. G., Singh J., Newton R., Sharp B. M. The adrenocorticotropin response to interleukin-1 beta instilled into the rat median eminence depends on the local release of catecholamines. Endocrinology 1990; 127: 2175–2182
   Google Scholar
• Rivier C., Vale W., Brown M. In the rat, interleukin-1 alpha and beta stimulate adrenocorticotropin and catecholamine release. Endocrinology 1989; 125: 3096–3102
   PubMed Web of Science ®Google Scholar
• Bernardini R., Calogero A. E., Mauceri G., Chrousos G. P. Rat hypothalamic corticotropin-releasing hormone secretion in vitro, is stimulated by interleukin-1 in an eicosanoid-dependent manner. Life Sci. 1990; 47: 1601–1607
   Google Scholar
• Gold P. W., Chrousos G. P. Arachidonic acid metabolites modulate rat hypothalamic corticotropin-releasing hormone secretion in vitro. Neuroendocrinology 1989; 50: 708–715
   Google Scholar
• Navarra P., Tsagarakis S., Faria M. S., Rees L. H., Besser G. M., Grossman A. B. Interleukin-1 and -6 stimulate the release of corticotropin-releasing hormone-41 from rat hypothalamus in vitro, via the eicosanoid cyclooxygenase pathway. Endocrinology 1990; 128: 37–44
   Google Scholar
• Niimi M., Sato M., Wada Y., Takahara J., Kawanishi K. Effect of central and continuous intravenous injection of interleukin-1 beta on brain c-fos expression in the rat: involvement of prostaglandins. Neuroimmunomodulation 1996; 3: 87–92
   PubMed Web of Science ®Google Scholar
• Rivier C. Blockade of nitric oxide formation augments adrenocorticotropin released by blood-borne interleukin-1 beta: role of vasopressin, prostaglandins, and alpha 1-adrenergic receptors. Endocrinology 1995; 136: 3597–3603
   PubMedGoogle Scholar
• Linthorst A. C.E., Flachskamm C., Holsboer F., Reul J. M.H.M. Local administration of recombinant human interleukin-1 in the rat hippocampus increases serotonergic neurotransmission, hypothalamic-pituitary-adrenocortical axis activity, and body temperature. Endocrinology 1994; 135: 520–532
   PubMedGoogle Scholar
• Arévalo R., Sanchez F., Alonso J. R., Carretero J., Vazquez R., Aijon J. NADPH-diaphorase activity in the hypothalamic magnocellular neurosecretory nuclei of the rat. Brain Res. Bull. 1992; 28: 599–603
   Google Scholar
• Rivier C., Shen G. In the rat, endogenous nitric oxide modulates the response of the hypothalamic-pituitary-adrenal axis to interleukin-1 beta, vasopressin and oxytocin. J. Neurosci. 1994; 14: 1985–1993
   PubMed Web of Science ®Google Scholar
• Turnbull A. V., Rivier C. Corticotropin-releasing factor, vasopressin, and prostaglandins mediate and nitric oxide restrains, the hypothalamic-pituitary-adrenal response to acute local inflammation in the rat. Endocrinology 1996; 137: 455–463
   PubMed Web of Science ®Google Scholar
• Rivest S., Rivier C. Interleukin-1beta inhibits the endogenous expression of the early gene c-fos located within the nucleus of LHRH neurons and interferes with hypothalamic LHRH release during proestrus in the rat. Brain Res. 1993; 613: 132–142
   PubMedGoogle Scholar
• Rivier C., Vale W. Cytokines act within the brain to inhibit LH secretion and ovulation in the rat. Endocrinology 1990; 127: 849–856
   PubMed Web of Science ®Google Scholar
• Rivier C., Vale W. In the rat, interleukin-1 alpha acts at the level of the brain and the gonads to interfere with gonadotropin and sex steroid secretion. Endocrinology 1989; 124: 2105–2109
   PubMed Web of Science ®Google Scholar
• Rivest S., Lee S., Attardi B., Rivier C. The chronic intracerebroventricular infusion of interleukin-1beta alters the activity of the hypothalamic-pituitary-gonadal axis of cycling rats. 1. Effect on LHRH and gonadotropin biosynthesis and secretion. Endocrinology 1993; 133: 2424–2430
   Google Scholar
• Rivest S., Rivier C. Centrally injected interleukin-1beta inhibits the hypothalamic LHRH secretion and circulating LH levels via prostaglandins in rats. J. Neuroendocrinal. 1993; 5: 445–450
   Google Scholar
• Bonavera J. J., Kalra S. P., Kalra P. S. Mode of action of interleukin-1 in suppression of pituitary LH release in castrated male rats. Brain Res. 1993; 612: 1–8
   PubMedGoogle Scholar
• Rettori V., Gimeno M. F., Karara A., Gonzalez M. C., McCann S. M. Interleukin-1 alpha inhibits prostaglandins E2 release to suppress pulsatile release of luteinizing hormone but not follicle-stimulating hormone. Proc. Natl. Acad. Sci. USA 1991; 88: 2763–2767
   PubMed Web of Science ®Google Scholar
• Bonavera J. J., Kalra S. P., Kalra P. S. Evidence that luteinizing hormone suppression in response to inhibitory neuropeptides, beta-endorphin, interleukin-1beta and neuropeptide-K, may involve excitatory amino acids. Endocrinology 1993; 133: 178–182
   Google Scholar
• Rivest S., Rivier C. Influence of te paraventricular nucleus of the hypothalamus in the alteration of neuroendocrine functions induced by intermittent footshock or interleukin. Endocrinology 1991; 129: 2049–2057
   PubMed Web of Science ®Google Scholar
• Rivier C., Rivier J., Vale W. Stress-induced inhibition of reproductive functions: Role of endogenous corticotropin-releasing factor. Science 1986; 231: 607–609
   PubMed Web of Science ®Google Scholar
• Hales D. B., Xiong Y., Tur-Kaspa I. The role of cytokines in the regulation of Leydig cell P450cl7 gene expression. J. Steroid. Biochem. Mol. Biol. 1992; 43: 907–914
   PubMed Web of Science ®Google Scholar
• Xiong Y., Hales D. B. Expression, regulation, and production of tumor necrosis factor-alpha in mouse testicular interstitial macrophages in vitro. Endocrinology 1993; 133: 2568–2573, 1993
   Google Scholar
• Tortorella C., Malendowicz L. K., Andreis P. G., Markowska A., Neri G., Mazzochi G., Nussdorfer G. G. Effects of interleukin-1beta on steroidogenesis in Leydig cells of the rat testis: in vivo, and in vitro, studies. Biomed Res. 1993; 14: 209–215
   Google Scholar
• Best C. L., Pudney J., Anderson D. J., Hill J. A. Modulation of human granulosa cell steroid production in vitro, by tumor necrosis factor alpha: implications of white blood cells in culture. Obstet. Gynecol. 1994; 84: 121–127
   Google Scholar
• Renner U., Newton C. J., Pagotto U., Sauer J., Arzt E., Stalla G. K. Involvement of interleukin-1 and interleukin 1 receptor antagonist in rat pituitary cell growth regulation. Endocrinology 1995; 136: 3186–3193
   Google Scholar
• Arzt E., Sauer J., Buric R., Stalla J., Renner U., Stalla G. K. Characterization of interleukin-2 (IL-2) receptor expression and action of IL-2 and IL-6 on normal anterior pituitary cell growth. Endocrine. 1995; 3: 113–119
   Google Scholar
• Kunert-Radek J., Radek A., Stepien H. Interleukin-2 stimulates cell proliferation of the growth hormone producing human pituitary adenoma in vitro. Biomed. Lett. 1994; 49: 259–264
   Google Scholar
• Sawada T., Koike K., Kanda Y., Ikegami H., Jikihara T., Maeda T., Osako Y., Hirota K., Miyake A. Interleukin-6 stimulates cell proliferation of rat pituitary clonal cell lines in vitro. J. Endocrinol. Invest. 1995; 18: 83–90
   Google Scholar
• Stepien H., Zerek-Melen G., Mucha S., Fryczak J. Interleukin-1beta stimulates cell proliferation in the intermediate lobe of the rat pituitary gland. J. Endocrinol. 1994; 140: 337–341
   Google Scholar
• Hanley N., Williams B. C., Nicol M., Bird I. M., Walke S. W. Interleukin-1beta stimulates growth of adrenocortical cells in primary culture. J. Mol. Endocrinol 1992; 8: 131–136
   Google Scholar
• Mine M., Tramontano D., Chin W. W., Ingbar S. H. Interleukin-1 stimulates thyroid cell growth and increase the concentration of the c-myc proto-oncogen mRNA in thyroid follicular cells in culture. Endocrinology 1987; 120: 1212–1214
   PubMed Web of Science ®Google Scholar
• Reichlin S. Neuroendocrine-immune interactions. N. Eng. J. Med. 1993; 329: 1246–1253
   PubMed Web of Science ®Google Scholar
• Munck A., Guyre P. M., Holbrook N. J. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr. Rev. 1984; 5: 25–44
   PubMed Web of Science ®Google Scholar
• Sternberg E. M., Hill J. M., Chrousos G. P. Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats. Proc. Natl. Acad. Sci. USA 1989; 86: 2374–2378
   PubMed Web of Science ®Google Scholar
• Sternberg E. M., Young W. S.I, Bernardini R. A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats. Proc. Natl. Acad. Sci. USA 1989; 86: 4771–4775
   PubMed Web of Science ®Google Scholar
• Chikanza I. C., Petrou P., Kingsley G., Chrousos G., Panayi G. S. Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis. Arthritis. Rheum. 1992; 35: 1281–1288
   PubMed Web of Science ®Google Scholar