Apoptosis in Human Autoimmune Diseases

References

• Levine A. J. The tumor suppressor genes. Ann. Rev. Biochem. 1993; 62: 623–51
   PubMed Web of Science ®Google Scholar
• R Kerr J. F., Wyllie A. H., Currie A. R. Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br. J. Cancer 1972; 26: 239–57
   Google Scholar
• Savill J. Apoptosis: from worm to wonder-drug?. Br. J. Rheum. 1995; 34: 95–100
   PubMedGoogle Scholar
• Savill J., Fado K., Henson P., Haslett C. Phagocyte recognition of cells undergoing apoptosis. Immunol. Today 1993; 14: 131–36
   PubMedGoogle Scholar
• Vaishnaw A. K., Mc J. D., NallyElkon K. B. Apoptosis in the rheumatic diseases. Arthritis Rheum. 1997; 40: 1917–27
   PubMed Web of Science ®Google Scholar
• Carson D. A., Ribeiro J. M. Apoptosis and disease. Lancet 1993; 341: 1251–54
   PubMed Web of Science ®Google Scholar
• Roy C., Brown D. L., Little J. E., Valentine B. K., Walker P. R., Sikorska M., Leblanc J., Chaly N. The topoisomerase II inhibitor teniposide (VM-26) induces apoptosis in unstimulated mature murine lymphocytes. Exp. Cell Res. 1992; 200: 416–423
   PubMed Web of Science ®Google Scholar
• Ioannou Y. A., Chen F. W. Quantitation of DNA fragmentation in apoptosis. Nucleic Acids Research 1996; 24: 992–93
   PubMed Web of Science ®Google Scholar
• Darzynkiewicz Z., Bruno S., Del G., Bino Gorczyca W., Hotz M. A., Lassota P., Traganos F. Features of apoptotic cells measured by flow cylometry. Cytometry 1992; 13: 795–808
   PubMedGoogle Scholar
• Koopman G., Reutlingsperger C. P. M., Kuijten G. A. M., Keehnen R. M. J., Pals S. T., van Oers M. H. J. Annexin V for flow cytometry detection of phosphatidylser-ine expression on B cells undergoing apoptosis. Blood 1994; 84: 1415–20
   PubMed Web of Science ®Google Scholar
• Perandones C. E., Illera V. A., Peckham D., Stunz L. L., Ashman R. F. Regulation of apoptosis in vitro in murine spleen T cells. J. Immunol. 1993; 151: 3521–3529
   PubMed Web of Science ®Google Scholar
• Salgamc P., Varadhachary A. S., Primiano L. L., Fincke J. E., Muller S., Monestier M. An ELISA for detection of apoptosis. Nucleic Acids Research 1997; 25: 680–681
   Google Scholar
• Gold R., Schmid M., Giegerich G., Breitschope H., Hartung H. P., Toyka K. V., Lassman H. Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation technique. Lab. Invest. 1994; 71: 219–25
   PubMed Web of Science ®Google Scholar
• Tomlinson M. G., Williams A. F., Wright M. D. Epitope mapping of anti-rat CD53 monoclonal antibodies. Implications for the membrane orientation of the Transmembrane 4 Superfamily. Eur. J. Immunol. 1993; 23: 136–40
   PubMed Web of Science ®Google Scholar
• Reed J. C. Bcl-2 and the regulation of programmed cell death. J. Cell Biol. 1994; 124: 1–6
   PubMed Web of Science ®Google Scholar
• Oltvali Z. N., Milliman C. L., Korsmeyer S. J. Bcl-2 heterodimerises in vivo with a conserved homolog BAX, that accelerates programmed cell death. Cell 1993; 74: 609–19
   Google Scholar
• Xyin M., Oltvai Z. N., Korsmeyer S. J. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerisation with BAX. Nature 1994; 369: 321–3
   Google Scholar
• Boise L. H., Gonzalez C. E., GarciaPostema C. E., Ding L., Lindsten T., Turka L. A., Mao G., NunezThompson C. B. Bcl-x, a bcl-2 related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993; 74: 597–608
   PubMed Web of Science ®Google Scholar
• Kozopas K. M., Yang T., Buchan H. L., Zhou P., Craig R. W. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to bcl-2. Proc. Natl. Acad. Sci. USA 1993; 90: 3516–3520
   PubMed Web of Science ®Google Scholar
• Amati B., Littlewood T. D., Evan G. I., Land H. The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J. 1993; 12: 5083–5087
   PubMed Web of Science ®Google Scholar
• Kretzner L., Blackwood E. M., Eisenman R. N. Myc and Max proteins possess distinct transcriptional activities. Nature 1992; 359: 426–429
   PubMed Web of Science ®Google Scholar
• Evan G. I., Wyllie A. H., Gilbert C. S., Littlewood T. D., Land H., Brooks M., Waters C. M., Penn L. Z., Hancock D. C. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992; 69: 119–128
   PubMed Web of Science ®Google Scholar
• Shi Y., Glunn J. M., Guilbert L. J., Cotter T. G., Bissonnette R. P., Green D. R. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 1992; 257: 212–214
   PubMed Web of Science ®Google Scholar
• Itoh N., Yonehara S., Ishii A., Yonehara M., Mizushima S. I., Sameshima M., Hase A., Seto Y., Nagata S. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 1991; 66: 233–243
   PubMed Web of Science ®Google Scholar
• Adachi M., Watanabe R., FunagaNagata S. Aberrant transcription caused by the insertion of an early transportable element in an intron of the Fas antigen gene of lpr mice. Proc. Natl. Acad. Sci. USA 1993; 90: 1756–1760
   PubMed Web of Science ®Google Scholar
• Mountz J. D., Talal N. Retroviruses, apoptosis and ongogenes. Immunol. Today 1993; 14: 532–536
   PubMedGoogle Scholar
• Suda T., Takahashi T., Golstein P., Nagata S. Molecular cloning and expression of the fas ligand, a novel member of the tumour necrosis factor family. Cell 1993; 75: 1169–1178
   PubMed Web of Science ®Google Scholar
• Klas C., Debatin K. M., Jonker R. R., Krammer P. M. Activation interferes with the APO-1 pathway in mature human T cells. Int. Immunol. 1993; 5: 625–630
   PubMed Web of Science ®Google Scholar
• Mysler E., Bini P., Drappa J., Ramos P., Friendman S., Karammer P. H., Elkon K. B. The apoptotis-1/fas protein in human systemic lupus erythematosus. J. Clin. Invest. 1994; 93: 1029–1034
   PubMed Web of Science ®Google Scholar
• Marx J. How p53 suppress cell growth. Science 1993; 262: 1644–1645
   PubMed Web of Science ®Google Scholar
• Eisenberg O., Faber A., ElmanGottlieb E., Oren M., Rotter V., Schwartz M. Direct involvement of p53 in programmed cell death of oligodendrocytes. EMBO J. 1995; 14: 1136–44
   Google Scholar
• Noguchi Y., Chen Y. T., Old L. J. A mouse mutant p53 product recognized by CD4+ and CD8+ T cells. Proc. Natl. Acad. Sci. USA 1994; 91: 3171–3175
   PubMed Web of Science ®Google Scholar
• Tuosto L., Chundari E., Montani M. S. G., Piccolella E. Analysis of susceptibility of mature human T lymphocytes to dexamethasone-induced apoptosis. Eur. J. Immunol. 1994; 24: 1061–1065
   PubMed Web of Science ®Google Scholar
• Zubiaga A. M., Eduardo M., Huber B. T. IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid-induced apoptosis. J. Immunol. 1992; 149: 107–112
   PubMed Web of Science ®Google Scholar
• Akbar A. N., Borthwick N. J., Wickremasinghe R. G., Panayoitidis P., Pilling D., Bofill M., Krajewski S., Reed J. C., Saimal M. Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to the growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression. Eur. J. Immunol. 1996; 26: 294–299
   PubMed Web of Science ®Google Scholar
• Elkon K. B., Marshak A., Rothstein B. cells in systemic autoimmune disease: recent insights from Fas-dependent mice and men. Curr. Opin. Immunol. 1996; 8: 852–859
   PubMed Web of Science ®Google Scholar
• Wyllie A. H. Apoptosis: an overview. British Medical Bulletin 1997; 53: 451–465
   PubMed Web of Science ®Google Scholar
• Oberhammer F., Pavelka M., Sushitra S., Tiefenbacher R., Purchio A. F., Bursch W., Schult Herman W. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc. Natl. Acad. Sci. USA 1992; 89: 5408–5412
   PubMed Web of Science ®Google Scholar
• Alam R., Frorsythe P., Stafford S., Fukuda Y. Transforming growth factor β abrogate the effects of haematopoietins on eosinophils and induces their apoptosis. J. Exp. Med. 1994; 179: 1041–1045
   PubMed Web of Science ®Google Scholar
• Lotz M., Ranheim E., Kipps T. J. Transforming growth factor β as endogenous growth inhibitor of chronic lymphocytic leukemia B cells. J. Exp. Med. 1994; 179: 999–1004
   PubMed Web of Science ®Google Scholar
• Lotem J., Saches K. Haematopoietic cytokines inhibit apoptosis induced by transforming growth factor β1 and cancer chemotherapy compounds in myeloid leukemic cells. Blood 1992; 80: 1750–1757
   PubMed Web of Science ®Google Scholar
• Novelli Pierro F., Di F., Di Pierro P., Bertini S., Affaticati P., Garotta G., Forni G. Environmental signals influencing expression of the INF-7 receptor on human T cells control whether INF-7 promotes production or apoptosis. J. Immunol. 1994; 152: 496–504
   Google Scholar
• Rousset F., Garcia E., De France T., Peronne C., Vezzio N., Hsu D. H., Moore K. W., Banchereau J. Interleukin-10 is a potent growth and differentiation factor for cell death of B-chronic lymphocytic leukemia cells. J. Exp. Med. 1992; 179: 91–99
   Google Scholar
• Fluckiger A. C., Durand I., Banchereau J. Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukaemia cells. J. Exp. Med. 1995; 179: 91–99
   Google Scholar
• Levy Y., Brouet J. C. Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein. J. Clin. Invest. 1994; 93: 424–428
   PubMed Web of Science ®Google Scholar
• Taga K., Cherney B., Tosato G. IL-10 inhibits apoptotic cell death in human T cells starved of IL-2. Int. Immunol. 1993; 5: 1599–1608
   PubMed Web of Science ®Google Scholar
• Cambier J., Ransom J. T. Molecular mechanisms of transmembrane signalling in B lymphocytes. Ann. Rev. Immunol. 1987; 5: 175–199
   PubMed Web of Science ®Google Scholar
• Parry S. L., Hasbold J., Holman M., Klaus G. B. Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40. J. Immunol. 1994; 152: 2821–2829
   PubMed Web of Science ®Google Scholar
• Newell M. K., Vanderwall J., Beard K. S., Freed J. H. Ligation of major histocompatibility complex class II molecules mediates apoptotic cell death in resting B lymphocytes. Proc. Natl. Acad. Sci. USA 1993; 90: 10459–10463
   PubMed Web of Science ®Google Scholar
• Csurh D., Sprent J. T-cell apoptosis detected in situ during positive and negative selection in the thymus (see comments). Nature 1994; 372: 100–3
   Google Scholar
• Mombaerts P., Iacomini J., Johnson R. S., Herrup K., Tonegawa S., Papaioannou V. E. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992; 68: 869–77
   PubMed Web of Science ®Google Scholar
• Shinkai Y., Rathburn G., Lam K. P., Oity E. M., Stewart V., Mendelson M., Charron J., Datta M., Young F., Stall A. M. RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 1992; 68: 855–67
   PubMed Web of Science ®Google Scholar
• Punt J. A., Osborne B. A., Takahama Y., Sharrow S. O., Singer A. Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 1994; 179: 709–713
   PubMed Web of Science ®Google Scholar
• Schwartz R. H. Models of T cell anergy: is there a common molecular mechanism?. J. Exp. Med. 1996; 184: 1–8
   PubMed Web of Science ®Google Scholar
• Sebzda E., Wallace V. A., Mayer J., Young S. M., Mak T. W., Ohashi P. S. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 1994; 263: 1615–1618
   PubMed Web of Science ®Google Scholar
• Nagata S., Golstein P. The fas death factor. Science 1995; 267: 1449–1456
   PubMed Web of Science ®Google Scholar
• Nossal G. J. V. Clonal anergy of B cells: a flexible, reversible, and quantitative concept. J. Exp. Med. 1996; 183: 1953–1956
   Google Scholar
• Lens S. M., Tesselaar den B. F.K., Drijver van Oers M. H., van Lier R. A. A dual role for both CD40-ligand and TNF-α in controlling human B cell death. J. Immunol. 1996; 156: 507–14
   PubMed Web of Science ®Google Scholar
• Goodnow C. C. Transgenic mice and analysis of B cell tolerance. Annu. Rev. Immunol. 1992; 10: 489–518
   PubMed Web of Science ®Google Scholar
• Rathmell J. C., Townsend S. E., Xu J. C., Flavell R. A., Goodnow C. C. Expansion or elimination of B cells in vivo: dual roles for CD40 and Fas (CD95)-ligands modulated by the B cell antigen receptor. Cell 1996; 57: 319–329
   Google Scholar
• Koopman G., Keehnen R. M. J., Lindhout E., Newman W., Shimizu Y., Van Seventer G. A., De C., GrootPals S. T. Adhesion through the LFA-1 (CD11α CD18)-ICAM-1 (CD54) and the VLA-4 (CD49α)-VCAM-1 (CD106) pathways prevents apoptosis of germinal centre B Cells. J. Immunol. 1994; 152: 3760–3767
   PubMed Web of Science ®Google Scholar
• Flescher E., Talal N. Do viruses contribute to the development of Sjögren's syndrome?. Am. J. Med. 1991; 90: 283–285
   PubMedGoogle Scholar
• Henderson S., Rowe M., Gregory C., Croom D., CarterWang F., Longnecker R., Kieff E., Rickinson A. Induction of bcl-2 expression by Epstein-Bar virus latent membrane protein protects infected B cells from programmed cell death. Cell 1991; 65: 1107–1115
   PubMed Web of Science ®Google Scholar
• Watanabe R., FukunagaBrannan C. I., Copeland N. G., Jenkis N. A., Nagata S. Lymphoproliferation disorder in mice explained by defect in Fas antigen that mediates apoptosis. Nature 1992; 356: 314–17
   PubMed Web of Science ®Google Scholar
• Nagata S., Suda T. Fas and Fas ligand: Ipr and gld mutations. Immunol. Today 1995; 16: 39–43
   PubMedGoogle Scholar
• Ravirajan C. T., Sarraf C. E., Anilkumar T. V., Golding M. C. H., Alison M. R., Isenberg D. A. An analysis of apoptosis in lymphoid organs and lupus disease in murine systemic erithematosus (SLE). Clin. Exp. Immunol. 1996; 105: 306–12
   Google Scholar
• Cheng J., Zhou T., Liu C., Shapiro J. P., Brauer M. J., Kiefer M. C., Barr P. J., Mountz J. P. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 1994; 263: 1759–62
   PubMed Web of Science ®Google Scholar
• Canale V. C., Smith C. H. Chronic lymphadenopathy simulating malignant lymphoma. J. Pediatr. 1967; 70: 891–9
   PubMed Web of Science ®Google Scholar
• Le Seventer F., Emile J. F., Rieux F., LaucatBenkerrou M., Roberts I., Brousse N., Fischer A. Clinical immunological and pathological consequences of Fas-deficient conditions. Lancet 1996; 348: 719–23
   Google Scholar
• Rieux F., Lacat Le Deist F., Hivroz C., Roberts I. A. G., Debatin K. M., Fisher A., de Villartay J. P. Mutation in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 1995; 268: 1347–49
   PubMed Web of Science ®Google Scholar
• Fisher G. H., Rosenberg F. J., Straus S. E., Dale J. K., Middelton L. A., Lin A. Y., Strober W., Lenardo M. J., Puck J. M. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 1995; 81: 935–46
   PubMed Web of Science ®Google Scholar
• Emlen W., Niebur J., Kadera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J. Immunol. 1994; 152: 3685–92
   PubMed Web of Science ®Google Scholar
• Martin Lorenz H., Grunke M., Hieronymus T., Herrmann M., Kuhnel A., Manger B., Kalden J. R. In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and autoimmune diseases. Arthritis and Rheum. 1997; 40: 306–17
   Google Scholar
• Wu J., Wilson J., He J., Xiang L., Schur P. H., Mountz J. D. Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease. J. Clin. Invest. 1998; 98: 1107–13
   Google Scholar
• Rose L. M., Latchman D. S., Isenberg D. A. Elevate soluble Fas production in SLE correlates with HLA status not with disease. Lupus 1997; 6: 717
   Google Scholar
• Strasser A., Whittingham S., Vaux D. L., Bath M. L., Adams J. M., Cory S., Harris A. W. Enforced Bcl-2 expression in B lymphoid cells prolongs antibody response and elicits autoimmune disease. Proc. Natl. Acad. Sci, USA 1991; 88: 8661–65
   PubMed Web of Science ®Google Scholar
• Mc Donnell T. J., Deane N., Platt F. M., Nunez G., Jaeger U., Mc J. P., KearnKorsmeyer S. J. BCl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 1989; 57: 79–88
   Google Scholar
• Mc Donnell T. J., Nunez G., Platt F. M., Hockenbery D., London L., Mc J. P., KearnKorsmeyer S. J. Deregulated bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population. Mol. Cell. Biol. 1990; 10: 1901–7
   Google Scholar
• Armger M., Wintersberger W., Steiner C. W., Kiener H., Presterl E., Jaeger U., Smolen J. S., Graninger W. B. High levels of Bcl-2 protein in circulating T lymphocytes, but not B lympocytes of patients with systemic lupus erythematosus. Arthritis Rheum. 1994; 37: 1423–30
   Google Scholar
• Casciola L., RosenRosen A., Petri M., Schlissel M. Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implication for coagulation events and antigenic spread in systemic lupus erythematosus. Proc. Natl. Acad. Sci. USA 1996; 93: 1624–29
   Google Scholar
• Ravirajan C. T., Harmer I., Mc T., NallyHohmann A., Mackworth C. G., YoungIsenberg D. A. Phospholipid binding specificities and idiotype expression of hybridoma derived monoclonal autoantibodies from splenic cells of patients with systemic lupus erythematosus. Ann. Rheum. Dis. 1995; 54: 471–76
   Google Scholar
• Topfer F., Gordon T., Mc Cluskey J. Intra- and Intermolecular spreading of autoimmunity involving the nuclear self-antigens LA(SSB) and Ro (SSA). Proc. Natl. Acad. Sci. USA 1995; 92: 875–79
   Google Scholar
• Caciola L. A., RosenMiller D. K., Anhalt G. J., Rosen A. Specific cleavage of the 70 kD protein component of the Ul small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J. Biol. Chem. 1994; 269: 30757–60
   Google Scholar
• Jacobson D. J. Reactive oxygen species and programmed cell death. T.I.B.S. 1996; 21: 83
   Google Scholar
• Cross A. R., Jones O. T. G. Enzymatic mechanism of superoxide production. Biochim. Biophys. Acta. 1991; 1057: 281–98
   PubMed Web of Science ®Google Scholar
• Rosen A., Casciola R. L., Ahearn J. Novel packages of viral and self-antigens are generated during apoptosis. J. Exp. Med. 1995; 181: 1557–61
   PubMed Web of Science ®Google Scholar
• Korb L. C., Ahearn J. M. Clq binds directly and specifically to surface blebs of apoptotic human keratinocytes. J. Immunol. 1997; 158: 4525–28
   PubMed Web of Science ®Google Scholar
• Kawakami A., Eugushi K., Matsuoka N., Tsuboi M., Kawabe Y., Aoyagi T., Nagataki S. Inhibition of Fas antigen-mediated apoptosis of rheumatoid synovial cells in vitro by transforming growth factor β1. Arthritis Rheum. 1996; 39: 1267–76
   PubMedGoogle Scholar
• Tsuboi M., Eugushi K., Kawakami A., Matsuoka N., Kawabe Y., Aoyagi T., Maeda K., Nagataki S. Fas antigen expressiom on synovial cells was downregulated by interleukin 1. Biochem. Biophys. Res. Com. 1996; 218: 280–85
   Google Scholar
• Sugiyama M., Tsukazaki T., Yonekura A., Matsuzaki S., Yamashita S., Iwasaki K. Localization of apoptosis and expression of apoptosis-related molecules in the synovium of patients with rheumatoid arthritis. Ann. Rheum. Dis. 1996; 55: 442–49
   PubMedGoogle Scholar
• Firestein G. S., Nguyen K., Aupperle K. R., Yeo M., Zvaifler N. J. Apoptosis in rheumatoid arthritis. II. p53 overexpression in rheumatoid arthritis synovium. Am. J. Pathol. 1996; 149: 2143–51
   PubMed Web of Science ®Google Scholar
• Firestein G. S., Yeo M., Zvaifler N. J. Apoptosis in rheumatoid arthritis synovium. J. Clin. Invest. 1995; 1631–38
   Google Scholar
• Nakajima T., Aono H., Hasunuma T., Yamamoto K., Shirai T., Hirohata K., Nishioka K. Apoptosis and functional Fas antigen in rheumatoid arhtritis synoviocytes. Arthritis Rheum. 1995; 38: 485–91
   PubMed Web of Science ®Google Scholar
• Cantwell M. J., Hua T., Zvaifler N. J., Kipps T. J. Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis. Arthritis and Rheum. 1997; 40: 1644–52
   PubMedGoogle Scholar
• Salmon M., Scheel D., ToellnerHuissoon A. P., Pilling D., Shamsadeen N., Hyde H., Dupuy d'Angeac A., Bacon P. A., Emery P., Akbar A. N. Inhibition of T cell apoptosis in the rheumatoid synovium. J. Clin. Invest. 1997; 99: 439–46
   PubMed Web of Science ®Google Scholar
• Hasunuma T., Kayagashi N., Asahara H., Motokawa S., Kobata T., Yagita H., Aono H., Sumida T., Okomura K., Nishioka K. Accumulation of soluble Fas in inflammed joints of patients with rheumatoid arthritis. Arthritis and Rheum. 1997; 40: 80–86
   PubMed Web of Science ®Google Scholar
• Bell A. L., Magill M. K., Mc R., KaneIrvine A. E. Human blood and synovial fluid neutrophils cultered in vitro undergo programmed cell death which is promoted by the addition of synovial fluid. Ann. Rheum. Dis. 1995; 54: 910–15
   Google Scholar
• Kong L., Ogawa N., Nakabayashi T., Liu G. T., D'Souza E., Mc H. S., Guff Guerrero D., Talal N., Dang H. Fas and Fas ligand expression in the salivary glands of patients with primary Sjogren's syndrome. Arthritis and Rheum. 1997; 40: 87–97
   PubMed Web of Science ®Google Scholar
• Matsumura R., Kagami M., Tomioka H., Tanabe E., Sugiyama T., Sueishi M., Nakajima A., Azuma M., Okumura K. Expression of ductal Fas antigen in sialoadenitis of Sjogren's syndrome. Clin. Exp. Rheumatol. 1996; 14: 309–11
   PubMed Web of Science ®Google Scholar
• Kong L., Ogawa N., Masago R., Talal N., Dang H. Bcl-2 family in salivary gland from Sjögren syndrome: Bax may be involved in the distraction of SS salivary glandular epithelium. Arthritis and Rheum. 1996; 39(suppl. 9)S289
   Google Scholar
• Sumida T., Matsumoto I., Murata H., Namekawa T., Matsumura R., Tomioka H., Iwamoto I., Saito Y., Mizushima Y., Hasunuma T., Maeda T., Nishioka K. TCR in Fas-sensitive T cells from labial salivary glands of patients with Sjogren's syndrome. J. Immunol. 1997; 158: 1020–25
   PubMed Web of Science ®Google Scholar
• Snonc R., Gruschwitz M. S., Dietrich H., Recheis H., Gershwin M. E., Wick G. Endothelial cell apoptosis is a primary pathogenic event underlyining skin lesions in avian and human scleroderma. J. Clin. Invest. 1996; 98: 785–92
   Google Scholar
• Simantov R., La Sala J. M., Lo S. K., Gharavi A. E., Sammaritano L. R., Salmon J. E., Silverstein R. L. Activation of cultured vascular endothelial cells by antiphospholipid antibodies. J. Clin. Invest. 1995; 96: 2211–19
   PubMed Web of Science ®Google Scholar
• Gross W. L., Schmitt W. H., Csernok E. ANCA and associated diseases: immunodiagnostic and pathogenic aspects. AU. Clin. Exp. Immunol. 1993; 91: 1–12
   PubMed Web of Science ®Google Scholar
• D'Amico G., Sinico R. A., Ferrano F. Renal vasculitis. Nephrol. Dial. Transplant. 1996; 11: 69–74
   Google Scholar
• Gilligan H. M., Bredy B., Brady H. R., Hebert M. J., Slayter H. S., Xu Y., Rauch J., Shia M. A., Koh J. S., Levine J. S. Antineutrophil cytoplasmic autoantibodies interact with primary granule constituents on the surface of apoptotic neutrophils in the absence of neutrophil priming. J. Exp. Med. 1996; 184: 2231–41
   PubMed Web of Science ®Google Scholar
• Hammond L. J., Lowdell M. W., Cerrano P. G., Goode A. W., Bottazzo G. F., Mirakian R. Analysis of apoptosis in relation to tissue destruction associated with Hashimoto's autoimmune thyroiditis. J. Pathol. 1997; 182: 138–44
   PubMedGoogle Scholar
• Dremier S., Goistein J., Mosselmans R., Dumont J. E., Galand P., Robaye B. Apoptosis in dog thyroid cells. Biochem. Biophys. Res. Commun. 1994; 200: 52–58
   PubMedGoogle Scholar
• Griffith T. S., Brunner T., Fletcher S. M. D. R. Green and T. A. Ferguson. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 1995; 270: 1189–92
   PubMed Web of Science ®Google Scholar
• Giordano C., Stassi G., De Maria R., Todaro M., Richiusa P., Papoff G., Ruberti G., Bagnasco M., Testi R., Galluzzo A. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. Science 1997; 275: 960–63
   PubMed Web of Science ®Google Scholar
• Chervonsky A. V., Wang Y., Wong F. S., Visintin I., Flavell R. A., Janeway C. A., Matis L. A. The role of Fas in autoimmune diabetes. Cell 1997; 89: 17–24
   PubMed Web of Science ®Google Scholar
• Kurrer M. O., Symasundar V., Pakala S. V., Hanson H. L., Katz J. D. B cell apoptosis in T cell-mediated autoimmune diabetes. Proc. Natl. Acad. Sci USA 1997; 94: 213–18
   PubMed Web of Science ®Google Scholar
• Raine C. S. The Norton lecture: a review of the oligodendorcytes of in the multiple sclerosis lesion. J. Neuroimmunol. 1997; 77: 135–52
   Google Scholar
• Sabelko K. A., Kelly K. A., Naham M. H., Cross A. H., Russell J. H. Fas and Fas ligand enhance the pathogenesis of experimental allergic encephalomyclitis, but are not essential for immune privilege in the central nervous system. J. Immunol. 1997; 159: 3096–99
   Google Scholar
• Waldner H., Sobel R. A., Howard E., Kuchro V. K. Fas and FasL deficient mice are resistent to induction of autoimmune encephalomyclitis. J. Immunol. 1997; 159: 3100–3
   PubMed Web of Science ®Google Scholar
• D'Souza S. D., Bonetti B., Balasingam V., Cashamn N. R., Baker P. A., Troutt A. B., Raine C. S., Antel J. P. Multiple sclerosis: Fas signalling in olygodendrocyte cell death. J. Exp. Med. 1996; 184: 2361–70
   PubMed Web of Science ®Google Scholar
• Bonetti B., Raine C. S. Multiple Sclerosis: oligodendrocytes display ceil death-related molecules in situ but do not undergo apoptosis. Ann. Neurol. 1997; 42: 74–84
   PubMed Web of Science ®Google Scholar
• Lucchinetti C. F., Bruck W., Rodriguez M., Lassmann H. Distinct pattern of multiple sclerosis pathology indicates heterogeneity in pathogenesis. Brain Pathol. 1996; 6: 259–74
   PubMed Web of Science ®Google Scholar
• Gold R., Hartung H. P., Lassmann H. T cell apoptosis in autoimmune diseases: termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms. Trends Neurosci. 1997; 20: 399–404
   PubMed Web of Science ®Google Scholar