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Review Article

Cellular and Molecular Mechanisms of Chemically Induced Renal Carcinogenesis

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Pages 211-225 | Published online: 07 Jul 2009

References

  • National Cancer Institute. Cancer Rates and Risks. NIH Publ. No. 85–691, 1985; 118–121
  • National Cancer Institute. Cancer Statistics Review 1973–1986. 1989
  • Paulson D E, Perez C A, Anderson T. Cancer of the kidney and ureter. Cancer Principles & Practice of Oncology, V T DeVita, Jr, S Hellman, S A Rosenberg. JB Lippincott, Philadelphia 1985; 895–1007
  • IARC. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Overall evaluations of carcinogenicity: an updating of IARC Monographs, International Agency for Research on Cancer, Lyon 1987; Vols. 1–42, Suppl. 7
  • Tomatis L, Aitio A, Wilbourn J, Shuker L. Human carcinogens so far identified. Jpn J Cancer Res 1989; 80: 795–807
  • Silverberg S G. The autopsy and cancer. Arch Pathol Lab Med 1984; 108: 476–478
  • Holm-Nielsen P, Olsen T S. Ultrastructure of renal adenoma. Ultrastruct Pathol 1988; 12: 27–39
  • Haseman J K, Huff J E, Zeiger E, McConnell E E. Comparative results of 327 chemical carcinogenicity studies. Environ Health Perspect 1987; 74: 229–235
  • Huff J E, McConnell E E, Haseman J K, et al. Carcinogenesis studies: results of 398 experiments on 104 chemicals from the U.S. National Toxicology Program. Ann NY Acad Sci 1988; 534: 1–30
  • Huff J E, Eustis S L, Haseman J K. Occurrence and relevance of chemically induced benign neoplasma in long-term carcinogenicity studies. Cancer Metastasis Rev 1989; 8: 1–21
  • Bach P H, Gregg N J. Experimentally induced renal papillary necrosis and upper urothelial carcinoma. International Review of Experimental Pathology, G W Richter, K Solez. Academic Press, New York 1988; 1–54
  • Lipsky M M, Jr, Trump B F. Chemically induced renal epithelial neoplasia in experimental animals. International Review of Experimental Pathology, G W Richter, K Solez. Academic Press, New York 1988; 357–383
  • Chu K C, Cueto C, Jr, Ward J M. Factors in the evaluation of 200 National Cancer Institute carcinogen bioassays. J Toxicol Environ Health 1981; 8: 251–280
  • Griesemer R A, Cueto C, Jr. Toward a classification scheme for degrees of experimental evidence for the carcinogenicity of chemicals for animals. Molecular and Cellular Aspects of Carcinogenic Screening Tests, R Montesano, B L Tomatis. IARC Scientific Publ. No. 27, Lyon 1980; 259–281
  • Chhabra R S, Huff J E, Schwetz B S, Selkirk J. An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program. Environ Health Perspect 1990; 86: 313–321
  • Maronpot R R, Haseman J K, Boorman G A, Eustis S E, Rao G N, Huff J E. Liver lesions in B6C3F1 mice: The National Toxicology Program, experience and position. Arch Toxicol (Suppl) 1987; 10: 10–26
  • Huff J E, Bucher J R, Haseman J K, Cirvello J D. Chemicals associated with site-specific neoplasia in 1328 long-term carcinogenesis experiments in laboratory rodents. Environ Health Perspect 1991; 93: 247–270
  • Haseman J K, Huff J E. Species correlation in long-term carcinogenesis studies. Cancer Lett 1987; 37: 125–132
  • U.S. Environmental Protection Agency, Risk Assessment Forum, Alpha-2μ-globulin: synthesis, accumulation in hyaline droplets of the renal proximal tubule, and association with the production of renal toxicity and renal tumor formation in the male rat. In press
  • Borghoff S J, Short B G, Swenberg J A. Biochemical mechanisms and pathobiology of α2μ-globulin nephropathy. Annu Rev Pharmacol Toxicol 1990; 30: 349–367
  • NTP. Technical Report on the toxicology and carcinogenesis studies of d-limonene (CAS No. 5989–27-5) in F344/N rats and B6C3F1 mice (gavage studies). NIH Publ. No. 90–2802, January, 1990
  • Swenberg J A, Short B, Borghoff S, Strasser J, Charbonneau M. The comparative pathobiology of α2μ-globulin nephropathy. Toxicol Applied Pharmacol 1989; 97: 35–46
  • Roy A K, Neuhaus O W. Adrogenic control of a sex-dependent protein in the rat. Nature (London) 1967; 214: 618–620
  • Lehman-McKeeman L D, Rodriguez P A, Takigiku R, Caudill D, Fey M L. d-Limonene-induced male rat-specific nephrotoxicity: evaluation of the association between d-limonene and α2μ-globulin. Toxicol Applied Pharmacol 1989; 99: 250–259
  • Suiter M A, Churnesky P, Jayaraj A, Richardson A. Metabolic activation of chemical carcinogens by kidney from rats and mice of various ages. Comp Biochem Physiol 1982; 73C: 435–438
  • Hook J B, Hewitt W R. Toxic responses of the kidney. Casarett and Doull's Toxicology: The Basic Science of Poisons, C D Klaassen, M O Amdur, J Doull. Macmillan, New York 1986; 310–329
  • Berndt W O, Davis M E. Renal methods for toxicology. Principles and Methods of Toxicology, A W Hayes. Raven Press, New York 1989; 629–648
  • Hiasa Y, Ito N. Experimental induction of renal tumors. CRC Crit Rev Toxicol 1987; 17: 279–343
  • Goldstein R S, Tarloff J B, Hook J B. Age-related nephropathy in laboratory rats. FASEB J 1988; 2: 2241–2251
  • Kluwe W M, Abdo K M, Huff J. Chronic kidney disease and organic chemical evaluations of casual relationships in humans and experimental animals. Fundam Appl Toxicol 1984; 4: 889–901
  • Boyd J A, Barrett J C. Genetic and cellular basis of multistep carcinogenesis. Pharmacol Ther 1990; 46: 469–486
  • Pitot H C, Goldsworthy T, Moran S. The natural history of carcinogensis: implication of experimental carcinogenesis in the genesis of human cancer. J Supramol Struct Cell Biochem 1981; 17: 133–146
  • Barrett J C, Fletcher W F. Cellular and molecular mechanisms of multistep carcinogenesis in cell culture models. Mechanisms of Environmental Carcinogenesis: Multistep Models of Carcinogenesis, J C Barrett. CRC Press, Boca Raton, FL 1987; Vol. 2: 73–116, 1987
  • Weinberg R A. The action of oncogenes in the cytoplasm and nucleus. Science 1985; 230: 770–776
  • Bishop J M. The molecular genetics of cancer. Science 1987; 235: 305–311
  • Knudson A G, Jr. Hereditary cancer, oncogenes, and antioncogenes. Cancer Res 1985; 45: 1437–1443
  • Koi M, Afshari C, Annab L A, Barrett J C. Role of a tumor suppressor gene in the negative control of anchorage-independent growth of Syrian hamster cells. Proc Natl Acad Sci USA 1989; 86: 8773–8777
  • Weissman B E. Suppression of tumorigenicity in mammalian cell hybrids. Mechanisms of Environmental Carcinogenesis, J C Barrett. CRC Press, Boca Raton, FL 1987; 31–45
  • Klein G. The approaching era of the tumor suppressor genes. Science 1987; 238: 1539–1545
  • Cavanee W K, Dryja T P, Phillips R A, et al. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 1983; 305: 779–784
  • Murphree A L, Benedict W F. Retinoblastoma: clues to human oncogenesis. Science 1984; 223: 1028–1033
  • Gateff E. Malignant neoplasms of genetic origin in Drosophila melanogaster. Science 1978; 200: 1448–1459
  • Vogelstein B, Fearon E R, Hamilton S R, et al. Genetic alterations during colorectal tumor development. N Engl J Med 1988; 319: 525–532
  • Sager R. Genetic expression of tumor formation: new frontier in cancer research. Cancer Res 1986; 46: 1573–1580
  • Koi M, Barrett J C. Loss of tumor-suppressive function during chemically induced neoplastic progression of Syrian hamster embryo cells. Proc Natl Acad Sci USA 1986; 83: 5992–5996
  • Oshimura M, Gilmer T M, Barrett J C. Nonrandom loss of chromosome 15 in Syrian hamster tumours induced by v-Ha-ras-plus v-myc oncogenes. Nature 1985; 316: 636–639
  • Fujita J, Kraus M H, Onoue H, et al. Activated H-ras oncogenes in human kidney tumors. Cancer Res 1988; 48: 5251–5255
  • Nanus D M, Mentle I R, Motzer R J, et al. Infrequent ras oncogene point mutations in renal cell carcinoma. J Urol 1990; 143: 175–178
  • Nanus D M, Ebrahim S AD, Bander N H, et al. Transformation of human kidney proximal tubule cells by ras-containing retroviruses. J Exp Med 1989; 169: 953–972
  • Kinouchi T, Saiki S, Naoe T, et al. Correlation of c-myc expression with nuclear pleomorphism in human renal cell carcinoma. Cancer Res 1989; 49: 3627–3630
  • Yao M, Shuin T, Misaki H, Kubota Y. Enhanced expression of c-myc and epidermal growth factor receptor (C-erbB-1) genes in primary human renal cancer. Cancer Res 1988; 48: 6753–6757
  • Slamon D J, de Kernion J B, Verma I M, Cline M J. Expression of cellular oncogenes in human malignancies. Science 1984; 224: 236–262
  • Karthaus H -FM, Schalken J A, Feitz W FJ, et al. Expression of the human fes cellular oncogene in renal cell tumors. Urol Res 1986; 14: 123–127
  • Tatosyan A G, Galetzki S A, Kisseljova N P, et al. Oncogene expression in human tumors. Int J Cancer 1985; 35: 731–736
  • Derynck R, Goeddel D V, Ullrich A, et al. Synthesis of messenger RNAs for transforming growth factors α and β and the epidermal growth factor receptor by human tumors. Cancer Res 1987; 47: 707–712
  • Gomella L G, Sargent E R, Wade T P, et al. Expression of transforming growth factor α in normal human adult kidney and enhanced expression of transforming growth factors α and β1 in renal cell carcinoma. Cancer Res 1989; 49: 6972–6975
  • Walter T A, Berger C S, Sandberg A A. The cytogenetics of renal tumors. Where do we stand, where do we go?. Cancer Genet Cytogenet 1989; 43: 15–34
  • Weaver D J, Michalski K, Miles J. Cytogenetic analysis in renal cell carcinoma: Correlation with tumor aggressiveness. Cancer Res 1988; 48: 2887–2889
  • Cin P D, Sandberg A A, Huben R, et al. New cytogenetic subtype of renal tumors. Cancer Genet Cytogenet 1988; 32: 313
  • Miles J, Michalski K, Kouba M, Weaver D J. Genomic defects in nonfamilial renal cell carcinoma. Possible specific chromosome change. Cancer Genet Cytogenet 1988; 34: 135–142
  • Vanni R, Nieddu M, Scarpa R M, et al. Trisomy 7 in a case of transitional cell carcinoma of the kidney. Cancer Genet Cytogenet 1989; 41: 149–151
  • Collard J G, van de Poll M, Scheffer A, et al. Location of genes involved in invasion and metastasis on human chromosome 7. Cancer Res 1987; 47: 666–6670
  • Cohen A J, Li F P, Berg S, Marchetto D J, et al. Hereditary renal cell carcinoma associated with a chromosomal translocation. N Engl J Med 1979; 301: 592–596
  • Pathak S, Strong L C, Ferrell R E, Trindade A. Familial renal cell carcinoma with a 3 11 chromosome translocation limited to tumor cells. Science 1982; 217: 939–941
  • Drabkin H A, Bradley C, Hart I, et al. Translocation of c-myc in the hereditary renal cell carcinoma associated with a t(3;8)(p14.2;q24.13) chromosomal translocation. Proc Natl Acad Sci USA 1985; 82: 6980–6984
  • Harris P, Morton C C, Guglielmi P, et al. Mapping by chromosome sorting of several gene probes, including c-myc, to the derivative chromosomes of a 3;8 translocation associated with familial renal cancer. Cytometry 1986; 7: 589–594
  • Yoshida M A, Ohyashiki K, Ochi H, et al. Cytogenetic studies of tumor tissue from patients with nonfamilial renal cell carcinoma. Cancer Res 1986; 46: 2139–2147
  • Teyssier J R, Henry I, Dozier C, et al. Recurrent deletion of the short arm of chromosome 3 in human renal cell carcinoma: shift of the c-raf 1 locus. J Natl Cancer Inst 1986; 77: 1187–1195
  • Kovacs G, Szücs S, De Riese W, Baumgartel H. Specific chromosome aberration in human renal cell carcinoma. Int J Cancer 1987; 40: 171–178
  • Teyssier J -R. What is the genetic mechanism underlying the recurrent 3p rearrangement in human renal cell carcinoma?. Cancer Genet Gytogenet 1987; 25: 179–181
  • van der Hout A H, Kok K, van den Berg A, et al. Direct molecular analysis of a deletion of 3p in tumors from patients with sporadic renal cell carcinoma. Cancer Genet Cytogenet 1988; 32: 281–285
  • Kovacs G, Frisch S. Clonal chromosome abnormalities in tumor cells from patients with sporadic renal cell carcinomas. Cancer Res 1989; 49: 651–659
  • Seizinger B R, Rouleau G A, Ozelius L J, et al. Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature 1988; 332: 268–269
  • Shimizu M, Yokota J, Mori N, et al. Introduction of normal chromosome 3p modulates the tumorigenicity of a human renal cell line YCR. Oncogene 1990; 5: 184–194
  • Kirkman H, Bacon R L. Estrogen-induced tumors of the kidney. I. Incidence of renal tumors in intact and gonadectomized male golden hamsters treated with diethylstilbestrol. J Natl Cancer Inst 1952; 13: 745–755
  • Li J J, Li S A, Oberley T, . Estrogen carcinogenicity: hormonal, morphologic and chemical interactions. Chemical Carcinogens. Activation Mechanisms, Structural and Electronic Factors, and Reactivity, P Politzer, F J Martin, Jr, et al. Elsevier, New York 1988; 312–321
  • Li J J, Li S A, Klicka J K, et al. Relative carcinogenic activity of various synthetic and natural estrogens in the Syrian hamster kidney. Cancer Res 1983; 43: 5200–5204
  • Liehr J G. 2-Fluoroestradiol: separation of estrogenicity from carcinogenicity. Mol Pharmacol 1983; 23: 278–281
  • Li S A, Klicka J K, Li J J. Estrogen 2- and 4-hydroxylase activity, catechol estrogen formation, and implication for estrogen carcinogenesis in the hamster kidney. Cancer Res 1985; 45: 181–185
  • Liehr J G. Modulation of estrogen-induced carcinogenesis by chemical modifications. Arch Toxicol 1983; 55: 119–122
  • McLachlan J A, Wong A, Degen G H, Barrett J C. Morphological and neoplastic transformation of Syrian hamster embryo cells by diethylstilbestrol and its analogs. Cancer Res 1982; 42: 3040–3045
  • Purdy R H. Carcinogenic potential of estrogen in some mammalian model system. Prog Cancer Res Ther 1984; 31: 401–415
  • Metzler M, McLachlan J A. Is diethylstilbestrol bioactivated through peroxidase-mediated oxidation?. J Environ Pathol Toxicol 1978; 1: 531–533
  • Metzler M, McLachlan J A. The metabolism of diethylstilbestrol. CRC Crit Rev Biochem 1981; 10: 171–212
  • Li J J, Li S A. High incidence of hepatocellular carcinomas after synthetic estrogen administration in Syrian golden hamsters fed α-naphthoflavone: a new tumor model. J Natl Cancer Inst 1984; 73: 543–547
  • Metzler M. Diethylstilbestrol: reactive metabolites derived from a hormonally active compound. Biochemical Basis of Chemical Carcinogensis, H Greim, K Jung, M Karmer, et al. Raven Press, New York 1984; 69–75
  • Glatt H R, Metzler M, Oesch F. Diethylstilbestrol and 11 derivatives: a mutagenicity study with Salmonella typhimurium. Mutat Res 1979; 67: 113–121
  • Lang R, Redmann U. Non-mutagenicity of some sex hormones in the Arnes Salmonella/microsome mutagenicity test. Mutat Res 1979; 67: 361–365
  • Rudiger H W, Haenisch F, Metzler M, et al. Metabolites of diethylstilbestrol induce sister chromatid exchanges in human cultured fibroblasts. Nature 1979; 281: 392–394
  • Barrett J C, McLachlan J A, Elmore E. Inability of diethylstilbestrol to induce 6-thioguanine-resistant mutants and to inhibit metabolic cooperation of V79 Chinese hamster cells. Mutat Res 1982; 107: 427–432
  • Barrett J C, Wong A, McLachlan J A. Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci. Science 1981; 212: 1402–1404
  • Drevon C, Piccoli C, Montesano R. Mutagenicity assays of estrogenic hormones in mammalian cells. Mutat Res 1981; 89: 83–90
  • Kinsella A R. Elimination of metabolic co-operation and the induction of sister chromatid exchanges are not properties common to all promoting or co-carcinogenic agents. Carcinogenesis 1982; 3: 499–503
  • Myhr B, Bowers L, Caspary W J. Assays for the induction of gene mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells in culture. Progress in Mutation Research, J Ashby, F J deSerres. Elsevier, Amsterdam 1985; 555–568
  • Clive D, Johnson K O, Spector J FS, et al. Validation and characterization of the L5178Y TK+/- mouse lymphoma mutagen assay system. Mutat Res 1979; 59: 61–108
  • Martin C N, McDermid A C, Garnder R C. Testing of known carcinogens and non-carcinogens for their ability to induce unscheduled DNA synthesis in HeLa cells. Cancer Res 1978; 38: 2621–2627
  • Althaus F R, Lawrence S D, Sattler G L, et al. Chemical quantification of unscheduled DNA synthesis in cultured hepatocytes as an assay for the rapid screening of potential chemical carcinogens. Cancer Res 1982; 42: 3010–3015
  • Hill A, Wolff S. Increased induction of sister chromatid exchange by diethylstilbestrol in lymphocytes from pregnant and premenopausal women. Cancer Res 1982; 42: 893–896
  • Abe S, Sasaki M. Chromosome aberrations and sister chromatid exchanges in Chinese hamster cells exposed to various chemicals. J Natl Cancer Inst 1977; 58: 1635–1641
  • Tsutsui T, Degen G H, Schiffman D, et al. Dependence of exogenous metabolic activation for induction of unscheduled DNA synthesis in Syrian hamster embryo cells by diethylstilbestrol and related compounds. Cancer Res 1984; 44: 184–189
  • Degen G H, Wong A, Eling T E, et al. Involvement of prostaglandin synthetase in the peroxidative metabolism of diethylstilbestrol in Syrian hamster embryo fibroblast cell cultures. Cancer Res 1983; 43: 992–996
  • Naylor P H, Rabinder N K, Loring J M, Villee C A. The estrogen-induced/dependent renal adenocarcinoma of the Syrian hamster. Regulation of Gene Expression by Hormones, K W McKerns. Plenum Press, New York 1983; 39–50
  • Liehr J G, Randerath K, Randerath E. Target organ-specific covalent DNA damae preceding diethylstilbestrol-induced carcinogensis. Carcinogenesis 1985; 6: 1067–1069
  • Sato Y, Murai T, Tsumuraya M, et al. Disruptive effects of diethylstilbestrol on microtubules. Gann 1984; 75: 1046–1048
  • Sharp D C, Parry J M. Diethylstilbestrol: the binding and effects of diethylstilbestrol upon the polymerisation of purified microtubule protein in vitro. Carcinogenesis 1985; 6: 865–872
  • Tucker R W, Barrett J C. Decreased numbers of spindle and cytoplasmic microtubules in hamster embryo cells treated with a carcinogen, diethylstilbestrol. Cancer Res 1986; 42: 2088–2095
  • Oshimura M, Barrett J C. Chemically induced aneuploidy in mammalian cells: mechanisms and biological significance in cancer. Environ Mutagen 1986; 8: 129–159
  • Kuchler R J, Graver R C. Effects of natural estrogens on L strain fibroblasts in tissue culture. Proc Soc Exp Biol Med 1982; 110: 287–292
  • Rao P N, Engelberg J. Structural specificity of estrogens in the induction of mitotic chromatid non-disjunction in HeLa cells. Exp Cell Res 1967; 48: 71–81
  • Lycette R R, Whyte S, Chapman C J. Aneuploid effects of oestradiol on cultured human synovial cells. N Z Med J 1970; 72: 114–117
  • Chrisman C L. Aneuploidy in mouse embryos induced by diethylstilbestrol diphosphate. Teratology 1974; 9: 229–232
  • Chrisman C L, Hinkle L L. Induction of aneuploidy in mouse bone marrow cells with diethylstilbestrol-diphosphate. Can J Genet Cytol 1974; 16: 831–835
  • Chrisman C L, Lasley J F. Effects of diethylstilbestrol diphosphate on mitotic activity in bovine lymphocyte cultures. Cytologia 1975; 40: 817–821
  • McGaughey R W. The culture of pig oocytes in minimal medium, and the influence of progesterone and estradiol-17β on meiotic maturation. Endocrinololgy 1977; 100: 39–45
  • Sawada M, Ishidate M, Jr. Colchicine-like effect of diethylstilbestrol (DES) on mammalian cells in vitro. Mutat Res 1978; 57: 175–182
  • Parry J M, Parry E M, Barrett J C. Tumour promoters induce mitotic aneuploidy in yeast. Nature 1981; 294: 263–265
  • Danford N, Parry J M. Abnormal cell division in cultured human fibroblasts after exposure to diethylstilbestrol. Mutat Res 1982; 103: 379–383
  • Tsutsui T, Maizumi H, McLachlan J A, Barrett J C. Aneuploidy induction and cell transformation by diethylstilbestrol: a possible chromosome mechanism in carcinogenesis. Cancer Res 1983; 43: 3814–3821
  • Barrett J C, Oshimura M, Tsutsui T, Tanaka N. Role of aneuploidy in early and late stages of neoplastic progression of Syrian hamster embryo cells in culture. Aneuploidy: Etiology and Mechanisms, V L Dellarco, R E Voytek, A Hollaender. Plenum Press, New York 1985; 523–538
  • Satya-Prakash K L, Hsu T C, Wheeler W J. Metaphase arrest, anaphase recovery and aneuploidy induction in cultured Chinese hamster cells following exposure to mitotic arrestants. Anticancer Res 1984; 4: 351–356
  • Barrett J C, Wong A, McLachlan J A. Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci. Science 1981; 212: 1402–1404
  • Pienta R J. Transformation of Syrian hamster embryo cells by diverse chemicals and correlation with their reported carcinogenic and mutagenic activities. Chemical Mutagens, F J deSerres. Plenum Publishing Corp., New York 1980; 175–202
  • Fu Y S, Robboy S J, Prat J. Nuclear DNA study of vaginal and cervical squamous cell abnormalities in DES-exposed progeny. J Obstet Gynecol 1978; 52: 129–137
  • Neuhaus O W, Flory W, Biswas N, Hollerman C E. Urinary excretion of α-2μ-globulin and albumin by adult male rats following treatment with nephrotoxic agents. Nephron 1981; 28: 133–140
  • Persner J, Reed R R, Feinstein P G, Synder S H. Molecular cloning of odorant-binding protein: member of a ligand carrier family. Science 1988; 241: 336–339
  • Cavaggioni A, Sorbl R T, Heen J N, Pappin D JC, Findlay C BC. Homology between the pyrazine-binding protein from nasal mucosa and major urinary proteins. FEBS Lett 1987; 212: 225–226
  • Halder C A, Holdsworth C E, Cockrell B Y, Piccirillo V J. Hydrocarbon nephropathy in male rats: identification of the nephrotoxic components of unleaded gasoline. Toxicol Indust Health 1985; 1: 67–87, 128
  • HEI: An update on gasoline vapor exposure and human cancer—An evaluation of scientific information published between 1985 and 1987. Health Effects Institute, Report of the Institute's Health Review Committee, January 6, 1988
  • Goldsworthy T L, Lyght O, Burnett V L, Popp J A. Potential role of α-2μ-globulin, protein droplet accumulation, and cell replication in the renal carcinogenicity of rats exposed to trichloroethylene, perchloroethylene, and pentachloroethane. Toxicol Appl Pharmacol 1988; 96: 367–379
  • Moolgavkar S H, Knudson A G, Jr. Mutation and cancer: a model for human carcinogenesis. J Natl Cancer Inst 1981; 66: 1037–1052
  • Clayson D B, Nera E A, Lok E. The potential for the use of cell proliferation studies in carcinogen risk assessment. Regul Toxicol Pharmacol 1989; 9: 284–295
  • Barrett J C. A multistep model for neoplastic development: role of genetic and epigenetic changes. Mechanisms of Environmental Carcinogenesis: Multistep Models of Carcinogenesis, J C Barrett. CRC Press, Boca Raton, FL 1987; Vol. 2: 117–126
  • Vesselinovitch S D, Rao K VN, Mihailovich N. Neoplastic response of mouse tissue during perinatal age periods and its significance in chemical carcinogenesis. J Natl Cancer Inst 1979; 51: 239–245
  • Ames B N. Endogeneous oxidative DNA damage aging, and cancer. Free Rad Res Commun 1989; 7: 121–128
  • Loeb L A. Endogenous carcinogenesis: molecular oncology into the twenty-first century—presidential address. Cancer Res 1989; 49: 5489–5496
  • Hoel D G, Haseman J K, Hogan M D, et al. The impact of toxicity on carcinogenicity studies: implications for risk assessment. Carcinogenesis 1988; 9: 2045–2052
  • Ledda-Columbano G M, Columbano A, Curto M, et al. Further evidence that mitogen-induced proliferation does not support the formation of enzyme-altered islands in rat liver by carcinogens. Carcinogenesis 1989; 10: 847–850
  • Eker R, Mossige J, Johannessen J V, Aars H. Hereditary renal adenomas and adenocarcinornas in rats. Diagnostic Histopathology 1981; 4: 99–110
  • Barrett J C, Huff J E. Cellular and molecular mechanisms of chemically induced renal carcinogenesis. Nephrotoxicity: Mechanisms, Early Diagnosis, and Therapeutic Management, P H Bach, N J Gregg, M F Wiks, L Delacruz. Dekker, New York 1991; 287–306
  • Huff J E. Carcinogenicity of ochratoxin A in experimental animals. Mycotoxins, Endemic Nephropathy, and Urinary Tract Tumours. IARC Sci. Pub. 113, International Aency for Research on Cancer, LyonFrance, 1–16
  • Barrett J C. Mechanism of action of known human carcinogenes. Mechanisms of Carcinogenesis in Risk Evaluation, H Vainio, P Magee, D McGregor, A J McMichael. IARC Sci. publ. 116, International Agency for Research on Cancer, LyonFrance 1992, in press
  • Huff J E. Chemical toxicity and chemical caricnogenesis. Is there a causal connection?. Mechanisms of Caricnogenesis in Risk Evaluation, H Vainio, P Magee, D McGregor, A J McMichael. IARC Sci. Publ. 116, International Gency for Research on Cancer, LyonFrance 1992, in press

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