Oxygen Free Radicals Are Not the Main Factor in Experimental Gentarnicin Nephrotoxicity

References

• Whelton A. Therapeutic initiative for the avoidance of aminoglycoside toxicity. J Clin Pharmacol 1985; 25: 67–81
   PubMed Web of Science ®Google Scholar
• Moench T R, Smith C R. Risk factors for aminoglycoside nephrotoxicity. The Aminoglycosides:Microbiology, Clinical Use, and Toxicology, A Whelton, H C Nev. Dekker, New York 1992; 401–415
   Google Scholar
• Kaloyanides G J. Drug-phospholipid interactions: Role in aminoglycoside nephrotoxicity. Renal Failure 1992; 14: 351–377
   PubMed Web of Science ®Google Scholar
• Baylis C, Rennke H, Brenner B M. Mechanisms of the defect in glomerular ultrafiltration associated with gentamicin administration. Kidney Int 1977; 12: 344–349
   PubMed Web of Science ®Google Scholar
• Bennet W M, Harmett M N, Gilbert D, Houghton D, Porter G A. Effects of sodium intake on gentamicin nephrotoxicity in the rat. Proc Soc Exp Biol Med 1976; 151: 736–738
   PubMedGoogle Scholar
• Adelman R D, Spangler W L, Beason F, Ishizaki G, Conzelman G M. Furosemide enhancement of experimental gentamicin nephrotoxicity: Comparison of functional and morphological changes with activities of urinary enzymes. J Infect Dis 1975; 140: 342–352
   Google Scholar
• Elliot W C, Parker R A, Houghton D C, Gilbert D N, Porter G A, De Fehr P J, Bennett W M. Effect of sodium bicarbonate and ammonium cloride ingestion in experimental gentamicin nephrotoxicity in the rat. Res Commun Chem Pathol Pharmacol 1980; 28: 483–495
   PubMedGoogle Scholar
• Whelton R, Stout R L, Bendush B, Carter C G, Herbst D V, Solez K. Hyperalimentation reduces cortical uptake of aminoglycoside but increases aminoglycoside nephrotoxicity. Kidney Int 1979; 16: 778A
   Google Scholar
• Humes H D, Sastrasinh M, Weinberg J M. Calcium is a competitive inhibitor of gentamicin-renal membrane binding interactions and dietary calcium supplementation protects against gentamicin nephrotoxicity. J Clin Invest 1984; 73: 134–139
   PubMed Web of Science ®Google Scholar
• Pavão Dos Santos O F, Boim M A, Barros E JG, Schor N. Role of platelet activating factor in gentamicin and cisplatin nephrotoxicity. Kidney Int 1991; 40: 742–747
   PubMedGoogle Scholar
• Block R, Luft F C, Rankin L. Protection from genlamicin nephrotoxicity by cephalothin and carbenicillin. Antimicrob Agents Chemother 1979; 15: 46–49
   PubMedGoogle Scholar
• Guidet B R, Shah S V. In vivo generation of hydrogen peroxide by rat kidney cortex and glomeruli. Am J Physiol 1989; 256: F158–F164
   PubMed Web of Science ®Google Scholar
• Shah S V, Walker P D. Reactive oxygen metabolites in toxic acute renal failure. Renal Failure 1992; 3: 363–370
   Google Scholar
• Ramsammy L S, Josepovitz C, Ling K Y, Lane B P, Kaloyanides G J. Effects of diphenyl-phenylenediamine on gentamicin-induced lipid peroxidation and toxicity in rat renal cortex. I. J Pharmacol Exp Ther 1986; 238(1)83–87
   PubMedGoogle Scholar
• Walker P D, Shah S V. Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats. J Clin Invest 1988; 81: 334–341
   PubMed Web of Science ®Google Scholar
• Ramsammy L S, Josepovitz C, Ling K Y, Lane B P, Kaloyanides G J. Failure of inhibition of lipid peroxidation by vitamin E to protect against gentamicin nephrotoxicity in the rat. Biochem Pharmacol 1987; 36: 2125–2132
   PubMedGoogle Scholar
• Meister A, Anderson M E. Glutathione. Ann Rev Biochem 1983; 52: 711–760
   PubMed Web of Science ®Google Scholar
• Schnellmann R G, Gilchrist S M, Mandell L J. Intracellular distribution and depletion of glutathione in rabbit renal proximal tubules. Kidney Int 1988; 34: 229–233
   PubMedGoogle Scholar
• McCoy R N, Hill K E, Ayon M A, Stein J H, Burk R F. Oxidant stress following renal ischemia: changes in the glutathione redox ratio. Kidney Int 1988; 33: 812–817
   PubMedGoogle Scholar
• Mandell L J, Schnellmann R G, Jacobs W R. Intracellular glutathione in the protection from anoxic injury in renal proximal tubules. J Clin Invest 1990; 85: 316–324
   PubMedGoogle Scholar
• McMurtry R J, Snodgrass W R, Mitchell G R. Renal necrosis, glutathione depletion, and covalent binding after acetaminophen. Toxicol Appl Pharmacol 1978; 46: 87–100
   PubMed Web of Science ®Google Scholar
• Hagen T M, Aw T Y, Jones D P. Glutathione uptake and protection against oxidative injury in isolated kidney cells. Kidney Int 1988; 34: 74–81
   PubMed Web of Science ®Google Scholar
• Weinberg J M. Glutathione and glycine in acute renal failure. Renal Failure 1992; 3: 311–319
   Google Scholar
• Ohkawa H, Ohishi N, Yagi K. Thiobarbituric acid assay. Anal Biochem 1979; 95: 351–362
   PubMed Web of Science ®Google Scholar
• Tietze F. Application to mammalian blood and other tissues. Anal Biochem 1969; 27: 502–522
   PubMed Web of Science ®Google Scholar
• Gornal A G, Bardawill C J, David M. Determination of serum proteins by means of the biuret reaction. J Biol Chem 1949; 177: 751–766
   PubMed Web of Science ®Google Scholar
• Peters J E, Schneider I, Haschen R J. Bestimmung der L-Alanyl-peptidhydrolase (Alanyl-aminopeptidase, Amino-saüre-Arylamidase) im menschlichen Harn. Clin Chem Acta 1972; 36: 289–301
   PubMedGoogle Scholar
• Teixeira R B, Kelley J, Alpert H, Pardo V, Vaamonde C A. Complete protection from gentamicin-induced acute renal failure in the diabetes mellitus rat. Kidney Int 1982; 21: 600–612
   PubMed Web of Science ®Google Scholar
• Gouves W L, Alpert H C, Kelly J, Pardo V, Vaamonde C A. Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats. Kidney Int 1989; 35: 1041–1048
   PubMedGoogle Scholar
• Heyman S N, Rosen S, Silva P, Spokes K, Egorin M J, Epstein F H. Protective action of glycine in cisplatin nephrotoxicity. Kidney Int 1991; 40: 273–279
   PubMedGoogle Scholar