Protective effect of trapidil and l-arginine against renal and hepatic toxicity induced by cyclosporine in rats

REFERENCES

• Ponticelli C. Cyclosporine: From renal transplantation to autoimmune diseases. Ann. N.Y. Acad. Sci. 2005;1051:551–558.
   PubMed Web of Science ®Google Scholar
• Amudha G, Josephino A, Varalakshmi P. Role of lipoic acid in reducing the oxidative stress induced by cyclosporine. Clinica Chimica Acta. 2007;372(1–2):134–139.
   Google Scholar
• Rezzani R. Exploring cyclosporine A- side effects and the protective role-played by antioxidants: The morphological and immunohistochemical studies, Histol. Histopathol. 2006;21:301–316.
   Google Scholar
• de Mattos AM, Olyael AJ, Bennett WM. Pharmacology of immunosuppressive drugs. Renal Failure. 1996;18:453–460.
   PubMedGoogle Scholar
• Kurus M, Esrefoglu M, Karabulut AB Sogutlu G, Kaya M, Otlu A. Oral l-arginine protects against cyclosporine – induced hepatoxicity in rats. Exp. Toxicol. Pathol. 2008;60(4–5):411–419.
   PubMedGoogle Scholar
• Atici A., Bozlu G, Turhan AH, The role of trapidil on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury. Early Human Develop. 2008;84(4):234–247.
   Google Scholar
• Joner M, Finn AV, Fab A, Vimani R. Pathology of drug eluting stents in humans: Delayed heating and late thrombosis risk. J Am Coli Cardial. 2006;48:193–202.
   PubMed Web of Science ®Google Scholar
• Kawamura T, Tikitani T, Okajima Y, Effect of trapidil on prostacyclin generation of arterial wall. Prostaglandins Med. 1980;5(2):113–121.
   PubMedGoogle Scholar
• Suzuki Y, Yamaguchi K, Shimada S, Kitamure Y, Ohnishi H. Antithrombotic activity and the mechanism of action of trapidil. Prostaglandins Lekat Med. 1982;9(6):685–695.
   PubMedGoogle Scholar
• Cheng Y, Liu P, Chen H, Zng F. Antiproliferative effects of trapidil in vascular smooth cells are associated by inhibition of MAPK and P34 (cdc 2) activity. J. Cardiovasc. Pharmacol. 2000;35(1):1–6.
   PubMed Web of Science ®Google Scholar
• Poon M, Cohen J, Siddiqui Z, Folton JT, Taubman MB. Trapidil inhibits monocyte chemoattractant protein-1 (MCP-1) and macrophage accumulation after ballon arterial injury in rabbits. Lab. Invest. 1999;79(11):1369–1375.
   PubMedGoogle Scholar
• Bagdtoglu C, Saray A, Surucu HS, Ozturk H, Tamer L. Effect of trapidil in ischemia reperfusion injury of peripheral nerves. Neurosurgery. 2002;51:212–220.
   PubMedGoogle Scholar
• Valdivielso JM, Blantz RC Acute renal failure: Is nitric oxide the bad guy? Antioxid. Redox. Signal. 2002;41(6):925–934.
   Google Scholar
• Steven Y, Jung T, Klotz LD, Schewe T, Grune T, Sies H. Protein modification elicited by oxidized low density lipoprotein (LDL) in endothelial cell. Protection by (–)-epicatechin. Free Rad. Biol. Med. 2007;42:955–970.
   PubMedGoogle Scholar
• Matsuno H, Stassen JM, Hoylaerts MF, Vermylen J, Deckmyn H. Fast and reproducible vascular neointima formation in the hamster carotid artery: Effect of trapidil and captopril. Thromb. Hemost. Dec. 1995;74(6):1591–1596.
   PubMedGoogle Scholar
• Tsao PS, McEvoy LM, Rexler HD, Butcher EC, Cooke JP. Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by l-arginine. Circulation. 1994;89(5):2176–2182.
   PubMed Web of Science ®Google Scholar
• Henry RJ. Clinical Chemistry, Principles and Technics. 2nd ed. Harper and Row;1974:625.
   Google Scholar
• Searcy RI, Reardon JE, Foreman JA. Enzymatic serum urea determination. Am. J. Med. Technol. 1967;33:15–20.
   PubMedGoogle Scholar
• Moshage H, Kok B, Huizenga JR, Jansen PLM. Nitric and nitrate determination in plasma: A critical evaluation. Clin. Chem. 1995;4(6):892–896.
   Google Scholar
• Zajkowska JM, Hermanowska-Szpakowiez T, Pancewicz SA, Kondrusik M, Swlerzbinska R, Grygorezuk S. Serum concentration of TNF-α and IL-1β in patient with chronic hepatitis treated with interferon alpha: A preliminary report. Rocz. Akad. Med. Bialymst. 2002;47:276–286.
   PubMedGoogle Scholar
• Chen W, Jin W, Cook M, Weiner HL, Wahl SM. Oral delivery of group A streptococcal cell walls augments circulating TGF-beta and suppresses streptococcal cell wall arthritis. J. Immunol. 1998;161(11):6297–6304.
   PubMedGoogle Scholar
• Ono K, Matsumori A, Furukawa Y, Igata H, Shioi T, Matsushima SS. Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. Lab Invest. 1999;79(2):195–203.
   PubMed Web of Science ®Google Scholar
• Reitman S, Frankel S. The colorimetric method for determination of serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase. Am. J. Clin. Pathol. 1957;28: 56–63.
   PubMed Web of Science ®Google Scholar
• Hassoun EA, Stohs SJ. Cadmium induced production of superoxide anion and nitric oxide DNA single standard breaks and lactate dehydrogenase leakage in J. 774 A-1 cultures. Toxicology. 1996;112(3):219–226.
   PubMedGoogle Scholar
• Babior BM, Kipnes RS, Curnutte ST. Biological defense mechanisms, the production by leukocytes of superoxide potential bactericidal agent. J. Clin. Invest. 1973;52(3):741–744.
   PubMed Web of Science ®Google Scholar
• Placer ZA, Cushman LL, Johnson BC. Estimation of lipid peroxidation (malondialdehyde) in biochemical systems. Anal. Biochem. 1966;16:359–365.
   PubMed Web of Science ®Google Scholar
• Chromy V, Fischer J. Photometric determination of total protein in lipemic sera. Clin. Chem. 1977;23(4):754–756.
   PubMedGoogle Scholar
• Marklund SL. Pyrogallol autooxidation. In: Greenwold RA, ed. Handbook of Methods for Oxygen Radical Research. Boca Raton, FL: CRC Press; 1985:243–247.
   Google Scholar
• Clairborne A. Catalase activity. In: Greenwold RA, ed. Handbook of Methods for Oxygen Radical Research. Boca, Ration, FL: CRC Press; 1985:283–284.
   Google Scholar
• Prophet EB, Mills B, Arrington JB, Sobin LH. Laboratory Methods in Histotechnology. Washington, DC: American Registry of Pathology; 1992.
   Google Scholar
• Steel RDG, Torrie JH. Principles and Procedures of Statistics: A Biometrical Approach. 2nd Ed.Singapore: McGraw-Hill; 1984, 4th print.
   Google Scholar
• Duncan DB. Multiple range test and multiple F test. Biometrics. 1955;1:1–42.
   Web of Science ®Google Scholar
• Grub S, Persohn E, Trommer WE, Wolf AE. Mechanisms of cyclosporine A-induced apoptosis in rat hepatocyte primary cultures. Toxicol. Appl. Pharmacol. 2000;163:209–220.
   PubMed Web of Science ®Google Scholar
• Rezzani R. Cyclosporine A and adverse effects on organs: Histochemical studies. Prog. Histochem. Cytochem. 2004;39: 85–128.
   PubMed Web of Science ®Google Scholar
• Ramesh G, Reaves WB. TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J. Clin. Invest. 2002;110(6):835–842.
   PubMed Web of Science ®Google Scholar
• Banas B, Luckow B, Moller M, Chemokine and chemokine receptor expression in a novel human mesangial cell line. J. Am. Soc. Nephrol. 1999;10(11):2314–2322.
   PubMedGoogle Scholar
• Funakoshi Y, Ichiki T, Shimokawa H, Rho-kinase mediates angiotensin II-induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells. Hypertension. 2001;38(1):100–111.
   PubMedGoogle Scholar
• Buyukafsar K, Yazar A, Dusmez D, Ozturk H, Polat G, Levent A. Effect of trapidil an antiplatelet and vasodilator agent on gentamicin-induced nephrotoxicity in rats. Pharmacol. Res. 2001;44(4):321–328.
   PubMedGoogle Scholar
• Turk G, Atessahin A, Sonmez M, Yuce A, Ceribasi AO. Lycopene protects against cyclosporine A-induced testicular toxicity in rats. Theriogenology. 2007; 67:778–785.
   PubMed Web of Science ®Google Scholar
• Colak T, Polat A, Bagdatoglu O, Kanik A, Turkmenoglu O, Aydin S. Effect of trapidil in ischemia/reperfusion injury on rat small intestine. J. Invest. Surg. 2003;16(3):167–176.
   PubMedGoogle Scholar
• Kato Y, Tsuda T, Hosaka Y, Effect of trapidil on effect or functions of monocytes related atherosclerotic plaque. Eur. J. Pharmacol. 2001;428(3):371–379.
   PubMedGoogle Scholar
• Deguchi H, Takeya H, Wada H, Dilazep an antiplatelet agent inhibits tissue factor expression in endothelial cells and monocytes. Blood. 1997;90(6):2345–2356.
   PubMed Web of Science ®Google Scholar
• Bonish D, Weber AA, Wittpoth M, Osinski M, Schror K. Antimitogenic effects of trapidil in coronary artery smooth muscle cells by direct activation of protein kinase A. Mol. Pharmacol. 1998;54:241–248.
   PubMedGoogle Scholar
• Nieder J, Claus P, Auguntin W. Effect of trapidil on PG 12 and TXA2 synthesis in human umbilical viens perfused in vitro. Prostaglandins. 1995;49:311–318.
   PubMedGoogle Scholar
• Ozaraz R, Tahan V, Aydin S, Uzun H, Kaya S, Senturk H. N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat. World J. Gastroenterol. 2003;9:125–128.
   PubMedGoogle Scholar
• Canoruc N, Cieck R, Atamer A, Dursun M, Turgut C, Guneli E. Protective effect of vitamin E selenium and alloporinol against stress induced ulcer formation in rats. Turk J. Med. Sci. 2001;31:199–203.
   Google Scholar
• Durak H, Ozbek H, Elgun S. Cyclosporine reduces hepatic antioxidant capacity: Protective roles of antioxidants. Int. Immunopharmacol. 2004;4:469–473.
   PubMed Web of Science ®Google Scholar
• Crooke JP, Tsao PS. Cytoprotective effects of nitric oxide. Circulation. 1993;88:2451–2454.
   PubMedGoogle Scholar
• Lee SK, Kim CS, Yang WS, Kim SB, Park SK, Park JS. Exogenous nitric oxide inhibitis tumor necrosis factor alpha or interleukin-1β induced monocyte chemoattractant protein-1 expression in human mesangial cells. Nephron. 2002;92(4):780–787.
   PubMedGoogle Scholar
• Saad SY, Najjar TA, Daba MH, Al-Rikabi AC. Inhibition of nitric oxide synthase aggravates cisplatin-induced nephrotoxicity effect of 2-amino-4-methylpyridine. Chemotherapy. 2002;48(6): 309–315.
   PubMed Web of Science ®Google Scholar
• Mansour M, Daba MH, Gado A, Al-Rikabi A, Al-Majed A. Protective effect of l-arginine against nephrotoxicity induced by cyclosporine in normal rats. Pharmacol. Res. 2002;45(6): 441–446.
   PubMedGoogle Scholar
• Tsao PS, Wang B, Buitrage R, Shyy JY, Cooke P. Nitric oxide regulate monocyte chemotactic protein-1. Circulation. 1997;96: 934–940.
   PubMed Web of Science ®Google Scholar
• Radi R, Becman JS, Bush KM, Freeman BA. Peroxynitrite oxidation of sulfhydryls: The cytotoxic potential of superoxide and nitric oxide. J. Biol. Chem. 1991;266:4244–4250.
   PubMed Web of Science ®Google Scholar
• Stamler JS, Simon DL, Osborne JA, S-Nitrosylation of proteins with nitric oxide: Synthesis and characterization of biologically active compounds. Proc Natl Acad Sci USA. 1992;89:444–448.
   PubMed Web of Science ®Google Scholar
• Hogg N, Kalyanaramer B, Strnck A. Inhibition of low density lipoprotein oxidation by nitric oxide potential role in atherogenesis. FEBS Lett. 1993;334:170–174.
   PubMed Web of Science ®Google Scholar
• Clancy RM, Leszczynska P, Piziak J, Abramson SB. Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on NADP oxidase. J Clin Invest. 1992;90:1116–1121.
   PubMed Web of Science ®Google Scholar
• Diao TJ, Yuan TY, Li YL. Immunologic role of nitric oxide in acute rejection of golden hamster for rat liver xenotransplantation. World J Gastroenterol. 2002;8:746–751.
   PubMedGoogle Scholar
• Aikio O, Pokela ML, Hallman M. Exhaled and nasal nitric oxide in mechanically ventilated preterm and term newborns. Acta Pediatr. 2002;91:1078–1986.
   PubMedGoogle Scholar
• Nakanishi H, Kaibori M, Teshima S, Yoshida H, Kwon AH, Kamiyama Y. Pirenldone inhibits the induction of I NOS stimulated by interleukin-1 beta at a step of NF-κB DNA binding in hepatocytes. J. Hepatol. 2004;41:730–736.
   PubMed Web of Science ®Google Scholar