Notch2/Hes-1 Pathway Plays an Important Role in Renal Ischemia and Reperfusion Injury-Associated Inflammation and Apoptosis and the γ-Secretase Inhibitor DAPT has a Nephroprotective Effect

References

• Togel F, Weiss K, Yang Y, Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am J Physiol Renal Physiol. 2007;292:1626–1635.
   PubMed Web of Science ®Google Scholar
• Thurman JM. Trigger of inflammation after renal ischemia/reperfusion. Clin Immunol. 2007;123:7–13.
   PubMed Web of Science ®Google Scholar
• Nakazawa J, Isshiki K, Sugimoto T, Renoprotective effects of asialoerythropoietin in diabetic mice against ischemia-reperfusion-induced acute kidney injury. Nephrology (Carlton). 2010;15(1):93–101.
   Google Scholar
• Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol. 2006;17:1503–1520.
   PubMed Web of Science ®Google Scholar
• Kinsey GR, Li L, Okusa MD. Inflammation in acute kidney injury. Nephron Exp Nephrol. 2008;109:102–107.
   PubMedGoogle Scholar
• Panzer U, Steinmetz OM, Turner J-E, Resolution of renal inflammation: A new role for NF-kappa B1 (p50) in inflammatory kidney diseases. Am J Physiol Renal Physiol. 2009;297:429–439.
   Google Scholar
• Ronco C, Bellomo R, Homel P, Effect of different doses in continuous veno-venous hemofiltration on outcomes of acute renal failure: A prospective randomized trial. Lancet. 2000;356:26–30.
   PubMed Web of Science ®Google Scholar
• Rusai K, Huang H, Sayed N. Administration of interleukin-1 receptor antagonist ameliorates renal ischemia-reperfusion injury. Transpl Int. 2008;21:572–575.
   PubMedGoogle Scholar
• Nechemia-Arbely Y, Barkan D, Pizov G, IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol. 2008;9:1106–1115.
   Google Scholar
• Choi DE, Jeong JY, Lim, BJ, Pretreatment with the tumor nerosis factor-α blocker etanercept attenuated ischemia-reperfusion renal injury. Transplant Proc. 2009;41:3590–3596.
   PubMed Web of Science ®Google Scholar
• Schweisguth F. Notch signaling activity. Curr Biol. 2004; 14:129–138.
   PubMed Web of Science ®Google Scholar
• McCright B. Notch signaling in kidney development. Curr Opin Nephrol Hypertens. 2003;12:5–10.
   Google Scholar
• Fleming V. Structural conservation of Notch receptors and ligands. Cell Dev Biol. 1998;l9:599–607.
   Google Scholar
• Deftos ML, Bevan MJ. Notch signaling in T cell development. Curr Opin Immunol. 2000;12:166–172.
   PubMed Web of Science ®Google Scholar
• Oswald F, Liptay S, Adler G. NF-kB2 is a putative target gene of activated Notch-1 via RBP-Jk. Mol Cell Biol. 1998;18:2077–2088.
   PubMedGoogle Scholar
• McLaughlin KA, Rones MS, Mercola M. Notch regulates cell fate in the developing pronephros. Dev Biol. 2000;227:567–580.
   Google Scholar
• Cheng H-T, Kim M, Valerius MT. Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development. 2007;134:801–811.
   PubMedGoogle Scholar
• Piscione, TD, Wu, MY, Quaggin, SE. Expression of hairy/enhancer of Split gene, hes1 and hes5, during murine nephron morphogenesis. Gene Expr Patterns. 2004;4:707–711.
   PubMed Web of Science ®Google Scholar
• Niranjan T, Bielesz B, Gruenwald A, The Notch pathway in podocytes plays a role in the development of glomerular disease. Nat Med. 2008;14:290–298.
   PubMed Web of Science ®Google Scholar
• Morrissey J, Guo G, Moridaira K, Transforming growth factor-beta induce renal epithelial Jagged1 expression in fibrotic disease. J Am Soc Nephrol. 2002;13:1499–1508.
   PubMed Web of Science ®Google Scholar
• Kang JH, Kim BS, Uhm TG, Gamma-secretase inhibitor reducesallergic pulmonary inflammation by modulating Th1 and Th2 responses. Am J Respir Crit Care Med. 2009;179:875–882.
   PubMed Web of Science ®Google Scholar
• Nakazawa M, Ishii H, Nakamura H, NFkappaB2 (p52) promoter activation via Notch signaling pathway in rheumatoid synoviocytes[J]. Int J Mol Med. 2001;7:31–35.
   PubMedGoogle Scholar
• Nakazawa M, Ishii H, Aono H, Role of Notch-1 intracellular domain in activation of rheumatoid synoviocytes. Arthritis Rheum. 2001;44:1545–1554.
   PubMedGoogle Scholar
• Gupta S, Li S, Abedin MJ, Effect of Notch activation on the regenerative response to acute renal failure. Am J Physiol Renal Physiol. 2010;298:209–215.
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Terada Y, Kuwana H, Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury. Kidney Int. 2008;73:1240–1250.
   Google Scholar
• Kara M, Tellioglu G, Sehirli O, Evaluation of gadolinium pre-treatment with or without splenectomy in the setting of renal ischemia reperfusion injury in rats. Ren Fail. 2009;31:956–963.
   PubMed Web of Science ®Google Scholar
• Sharyo S, Kumagai K, Yokota-Ikeda N, Amelioration of renal ischemia–reperfusion injury by inhibition of IL-6 production in the poloxamer 407–induced mouse model of Hyperlipidemia. J Pharmacol Sci. 2009;110:47–54.
   Google Scholar
• Niessen K, Karsan A. Notch signaling in the developing cardiovascular system. Am J Physiol Cell Physiol. 2007;293:1–11.
   PubMed Web of Science ®Google Scholar
• Xue Y, Gao X, Lindsell CE, Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Gen. 1999;8:723–730.
   PubMed Web of Science ®Google Scholar
• Swiatek PJ, Lindsell CE, del Amo FF, Notch1 is essential for Post implantation development in mice. Genes. 1994;8:707–719.
   Google Scholar
• Wang P, Pereira FA, Beasley D, Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis. Development. 2003;130:5019–5029.
   PubMed Web of Science ®Google Scholar
• Guan, E, Wang J, Laborda J, T cell leukemia-associated human Notch/translocation-associated Notch homologue has IkB-like activity and physically interacts with nuclear factor-kB proteins in T cells. J Exp Med. 1996;183:2025–2032.
   PubMedGoogle Scholar
• Tun T, Hamaguchi Y, Matsunam N, Recognition sequence of a highly conserved DNA binding protein, RBP-Jk. Nucleic Acids Res. 1994;22:965–971.
   PubMedGoogle Scholar
• Moran ST, Cariappa A, Liu H, Synergism between NF-{kappa}B1/p50 and Notch2 during the development of marginal zone B lymphocytes. J Immunol. 2007;179:195–200.
   PubMedGoogle Scholar
• Yoshida T, Kurella M, Beato F, Monitoring changes in gene expression in renal ischemia-reperfusion in the rat. Kidney Int. 2002;61:1646–1654.
   PubMed Web of Science ®Google Scholar
• Yang J, Liu X, Bhalla K, Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science. 1997;275:1129–1132.
   PubMed Web of Science ®Google Scholar
• Ye J, Li J, Yu Y, L-carnitine attenuates oxidant injury in HK-2 cells via ROS-mitochondria pathway. Regul Pept. 2010; 161:58–66.
   PubMed Web of Science ®Google Scholar
• Wu HH, Hsiao TY, Chien CT. Ischemic conditioning by short periods of reperfusion attenuates renal ischemia/reperfusion. J Biomed Sci. 2009;11:16–19.
   Google Scholar
• Wang M, Wu L, Wang L, Down-regulation of Notch1 by gamma-secretase inhibition contributes to cell growth inhibition and apoptosis in ovarian cancer cells A2780. Biochem Biophys Res Commun. 2010;393:144–149.
   Google Scholar
• Sheng B, Gong K, Niu Y, Inhibition of γ-secretase activity reduces Aβ production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease. Free Radic Biol Med. 2009;46:1362–1375.
   PubMed Web of Science ®Google Scholar