2,215
Views
17
CrossRef citations to date
0
Altmetric
Case Report

Prolonged Hemodialysis for Severe Metformin Intoxication

, , &
Pages 459-461 | Received 07 Dec 2010, Accepted 23 Feb 2011, Published online: 30 Apr 2011

REFERENCES

  • Barrueto F, Meggs WJ, Barchman MJ. Clearance of metformin by hemofiltration in overdose. J Toxicol Clin Toxicol. 2002;40:177–180.
  • Pilmore HL. Review: Metformin: Potential benefits and use in chronic kidney disease. Nephrology. 2010;15:412–418.
  • Shaw JS, Wilmot RL, Kilpatrick ES. Establishing pragmatic estimated GFR thresholds to guide metformin prescribing. Diabet Med. 2007;24:1160–1163.
  • Bailey CJ, Turner RC. Metformin. N Eng J Med. 1996; 334:574–579.
  • Salpeter S, Greyber E, Pasternak G, Risk of fatal and non fatal lactic acidosis with metformin in type 2 diabetes mellitus. Cochrane Database Syst Rev. 2006;14:CD002967.
  • Seidowsky A, Nseir S, Houdret N, Fourrier F. Metformin-associated lactic acidosis: A prognostic and therapeutic study. Crit Care Med. 2009;37:2191–2196.
  • Dell'Aglio DM, Perino LJ, Kazzi Z, Acute metformin overdose; examining serum pH lactate level, and metformin concentration in survivors versus nonsurvivors: A systemic review of the literature. Ann Emerg Med. 2009;54:818–823.
  • Teale KFH, Devine A, Stewart H, Harper NJH. The management of metformin overdose. Anaesthesia. 1998; 53:691–701.
  • Dell'Aglio DM, Perino LJ, Todino JD, Metformin overdose with a resultant serum pH of 6.59: Survival without sequalae. J Emerg Med. 2010;39:e77–e80.
  • Giuliani E, Albertini G, Vaccari C, Barbieri A. pH 6.68 – Surviving severe metformin intoxication. Q J Med. 2010;103:887–890; advance access published 14 April 2010.
  • Lalau J-D, Race J-M. Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations. Drug Safe. 1999; 20:377–384.
  • Stades AM, Heikens JT, Erkelens DW, Metformin and lactic acidosis: Cause or coincidence? A review of case reports. J Intern Med. 2004;255:179–187.
  • Scheen AJ. Clinical pharmacokinetics of metformin. Clin Pharmacokinet. 1996;30:359–371.
  • Lalau JD, Andrejak M, Moriniere Ph, Hemodialysis in the treatment of lactic acidosis in diabetics treated by metformin: A study of metformin elimination. Int J Clin Pharmacol Ther and Toxicol. 1989;27:285–288.
  • Guo PY, Storsley LJ, Finkle SN. Severe lactic acidosis treated with prolonged hemodialysis: Recovery after massive overdoses of metformin. Semin Dial. 2006;19:80–83.
  • Harvey B, Hickman C, Hinson G, Severe lactic acidosis complicating metformin overdose successfully treated with high-volume venovenous hemofiltration and aggressive alkalinization. Pediatr Crit Care Med. 2005;6:598–601.
  • Bruijstens LA, van Luin M, Buscher-Jungerhans PMM, Bosch FH. Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment. Neth J Med. 2008;66:185–190.
  • Panzer U, Kluge S, Kreymann G, Wolf G. Combination of intermittent hemodialysis and high-volume continuous hemofiltration for the treatment of severe metformin-induced lactic acidosis. Nephrol Dial Tranplant. 2004;19:2157–2158.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.